ADSORPTION SCIENCE & TECHNOLOGY
·
2013
·
IF 0.559
Guifen Zhu,Jing Fan,Xia Gao,Jianji Wang
A newly designed surface molecularly imprinted polymer (MIP) was developed using 4-methylimidazole as the template and ethylenediaminepoly (styrene-divinylbenzene) particles as the support material. The resulting MIP material was characterized with scanning electron microscopy, infrared spectrum, surface area, pore-size and thermal property measurements. Static adsorption, solid-phase extraction (SPE) and high-performance liquid chromatography were combined to study the adsorption characteristics and selective recognition performance of the polymer for 4-methylimidazole and its structural analogues. It was shown that the maximum binding capacities of 4-methylimidazole on the MIP and the non-imprinted polymer (NIP) were 416 and 227 µmol g−1 respectively. The binding process could be described by pseudo-second-order kinetics, and the adsorption equilibrium was achieved in 40 minutes. Compared with the corresponding NIP, the MIP exhibited much higher adsorption performance and selectivity for the template. After the separation of a mixture of 4-methylimidazole, benzimidazole and nitrophenol on the MIP–SPE and the NIP–SPE columns, the recoveries of 4-methylimidazole on the MIP–SPE and NIP–SPE columns were 96–102% and 34–39%, respectively, whereas those of benzimidazole and nitrophenol were below 19% on the two columns. In addition, more than 99% of 4-methylimidazole could be obtained on the MIP–SPE column from water and soil samples.
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DOI
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2021
·
IF 0.782
Fangmin Chen,Chichi Zhou,Yan Li,Xiuqing Zhang
Three coordination polymers—{[Ag2(SIP)(4-pp)]·[Ag(4-pp)2]·H2O}n, [Pb4(SIP)2(μ3-OH)2(H2O)2]n, and {[Zn2(SIP)2(4-pp)4][Zn(4-pp)2(H2O)4]·4H2O}n (SIP = 5-sulfoisophthalic acid anion, 4-pp = 4-phenylpyridine)—are constructed under hydrothermal or solvothermal conditions using sodium m-phthalate 5-sulfonate (NaH2SIP) and 4-phenylpyridine as ligands. The structures of the three complexes are determined by single-crystal X-ray diffraction, powder X-ray diffraction, thermogravimetric analyses, Fourier-transform infrared analysis, and photoluminescence. The fluorescent properties of the complexes in the solid state are investigated at room temperature, and the results indicate that they all show photoluminescent properties.
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高影响因子
JOURNAL OF ORGANIC CHEMISTRY
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2021
·
IF 4.354
Yinbo Wan,Yang Zhu,Haiyun Peng,Guisheng Deng
An efficient method for the preparation of tetrasubstituted furans, which contains a nitromethyl group at the 4-position, has been developed. The applications of 4-(nitromethyl)furans on the synthesis of highly functionalized bis(furyl)oxime were explored for the first time.
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DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2022
·Vol. 24
·期 30
·5519-5526
·
IF 3.756
Lu Zhang,Wen-Shuai Dong,Zu-Jia Lu,Ting-Wei Wang,Chao Zhang,Zun-Ning Zhou,Jian-Guo Zhang
Energetic metal organic frameworks (EMOFs) are increasingly developed and have proven to be candidates for novel high energy density materials (HEDM). Here, two energetic metal complexes based on 3,5-diaminopyrazolone-4-oxime (DAPO) ligands were synthesized by simple steps and fully characterized by NMR and IR spectroscopy, X-ray single-crystal diffraction, and DSC-TG. The detonation performance was calculated using the Kamlet–Jacobs formula. The crystal densities of these complexes (C6H14N12O10Co (2) and C6H14N12O10Cd (3) are as high as 1.945 g cm−3 at 163 K and 2.072 g cm−3 at 298 K, respectively. Thermal analysis by the DSC-TG test shows that they all have good thermal stability with the highest decomposition temperatures of 287 °C and 344 °C, respectively. These two as-synthesized complexes exhibit excellent detonation performance; 2 (D = 8682 m s−1, P = 34.98 GPa) and 3 (D = 8383 m s−1, P = 33.78 GPa) have good detonation velocity and detonation pressure that are superior to those of TNT, which is widely used today. Thus, they show great promise for potential applications as thermally stable energetic materials.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Jiewen Tan,Xin Ao,Hao Zhuo,Libin Zhuang,Xiao Huang,Chenliang Su,Wei Tang,Xinwen Peng,Bingbing Tian
Solid polymer electrolytes (SPEs) are promising candidates for all-solid-state lithium batteries (ASSLBs) due to their advantages of good interfacial adhesion and shape flexibility. However, the low ionic conductivity at room temperature (RT) and inferior electrochemical stability at high voltages limit the practical applications of SPEs. In this work, we demonstrate a cryogenic engineering to improve PEO-based SPEs for ASSLBs operated at RT. The rapid in situ cooling process will lead to the uniform formation of PEO crystal nuclei, which can limit the PEO crystal growth in SPEs. The novel crystallization structure could promote the ionic conductivity of SPEs effectively. Such improved cryogenic SPEs display a superior ionic conductivity of 2.17 × 10 −5 S cm −1 and a superior electrochemical stability at RT. A discharge capacity of 154.9 mAh g −1 can be achieved at 0.1 C and RT when LiFePO 4 (LFP) is used as the cathode. The discharge capacity can remain at ~98%, even after 100 cycles performed at 0.1 C. Notably, cryogenic SPEs can be utilized in 4 V-class ASSLBs. A high discharge capacity of 118 mAh g −1 can be achieved at 0.2 C and RT with the LiNi 0.6 Co 0.2 Mn 0.2 O 2 (NCM622) as the cathode and can retain a 94.1% capacity even after 100 cycles. These extraordinary performances of cryogenic SPEs break new ground for the fabrication of ASSLBs operated at RT and high voltages.
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高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2013
·
IF 0.596
Zhiping Du,Tianhua Shen,Haibo Dang,Zhenfang Fu,Qingbao Song
A simple efficient method for synthesis of Schiff bases in good yields from aromatic aldehydes and 2-(4-aminophenyl)acetonitrile catalysed by 3,5-difluoroarylboric acid at room temperature for 2 hours is reported.
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DOI
高影响因子
ARCHIV DER PHARMAZIE
·
2019
·Vol. 353
·期 2
·1900231
·
IF 2.145
Xiujie Liu,Xin Chen,Kai Qiu,Zhihao Zhang
A series of 4-methoxy-3-arylamido- N -(substitutedphenyl)benzamides 6a – u were designed according to the splicing principle of structural design in the medicinal chemistry theory and were synthesized in five steps: nitration, acylation, ammoniation, reduction, and secondary ammoniation. The structures of the target compounds were characterized and verified by infrared, 1 H nuclear magnetic resonance (NMR), 13 C NMR, and electron spray ionization spectroscopy. Their in vitro antiplatelet aggregation activities induced by adenosine diphosphate (ADP) or arachidonic acid (AA) were assessed by Born's method. The biological evaluation revealed that all compounds exhibited certain levels of activities in both of the antiplatelet aggregation assays; compounds 6c (IC 50 = 3.84 μM) and 6f (IC 50 = 3.12 μM) displayed the strongest antiplatelet aggregation activities in the ADP-induced and AA-induced assay, separately. Moreover, compounds that had stronger activities were chosen for cell toxicity testing via the cell counting kit-8 assay. The results indicated that none of the compounds had obvious cell toxicity against L929 cells at the doses of 10 and 20 μM. It is worth pointing out that compound 6c showed the highest antiplatelet activity and the lowest cell toxicity. In general, 4-methoxy-3-arylamido- N -(substitutedphenyl)benzamides have the potential to become a kind of safer and more effective antiplatelet agents.
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DOI
PubMed
高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2025
·
IF 6.1
Xiaona Ren,Zhipei Chen,Peng Wang,Wenchang Wang,Yao Wang,Changchun Ge
Rare earth oxide (CeO₂/Y₂O₃) reinforced AlCrFeNiCu high-entropy alloy coatings with a Mo interlayer (designated as Mo/CeO₂-AlCrFeNiCu and Mo/Y₂O₃-AlCrFeNiCu) were successfully deposited onto a Zr-4 substrate via high-speed laser cladding. The microstructural characteristics and properties of the composite coatings were comprehensively investigated. The results demonstrate that the Mo interlayer alleviates the thermal mismatch between the substrate and the HEA coatings and, to a certain degree, counteracts the grain refinement effect induced by the rare earth oxides. Overall, it plays a critical role in enhancing interfacial structural stability, mitigating thermal stress, and improving overall coating performance. It effectively optimizes the coating-substrate bonding integrity, reduces susceptibility to high-temperature fretting fatigue and plastic deformation, and significantly lowers the specific wear rate. Furthermore, the Mo interlayer enhances the compactness and continuity of the interface, suppresses the formation of corrosive pathways, and promotes the formation of a thicker, more stable passive film on the coating surface.
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Ming Wang,Jianlin Li,Wenjie Pan,Jiaqi Li,Wu Xu,Zhenshan Ding,Qingsong Yu,Zhihua Gan,Zhibo Li,Ni Jiang
The use of physical barriers is an effective strategy for preventing postoperative adhesion, a prevalent complication in clinical abdominal surgeries. However, the current anti-adhesion barriers face limitations in precisely regulating key cellular responses during tissue repair. In this study, a multi-modal synergistic degradable anti-adhesion membrane was developed via coaxial electrospinning of poly(4-hydroxybutyrate) (P4HB), polyglycolic acid (PGA), and diclofenac sodium (DS). The designed membrane features a densely packed fibrous architecture, exhibiting over 97 % inhibition efficiency against fibroblasts interlayer penetration in vitro. The rapid initial release of DS synergizes with PGA-mediated biological functions to suppress fibroblast-to-myofibroblast differentiation, and to significantly mitigate early-stage pathological changes. This cascade effect ultimately leads to reduced collagen deposition and significantly diminished adhesion formation, as demonstrated in a mouse cecal and peritoneal abrasion model. Furthermore, the membrane demonstrates exceptional flexibility and enhanced hydrophilicity, ensuring conformal coverage of complex three-dimensional wounds. The integration of structural design, controlled drug release, and dynamic biological modulation renders this multifunctional barrier as a promising candidate for next-generation clinical anti-adhesion applications.
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产品关联
DOI
高影响因子
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
·
2025
·
IF 5.4
Wen Xu,Yujing Zhang,Qianqian Xu,Haibo Zhao,Qun Gao,Xinyu Zhao,Hongfei Jiang,Chao Wang
Microtubules, composed of tubulin subunits, represent a critical target in anticancer drug discovery. The design and evaluation of small-molecule inhibitors targeting tubulin polymerisation continue to hold significant promise for advancing cancer therapeutics. Based on structural insights into tubulin polymerisation inhibitors and tubulin interaction models, a novel series of 3-aryl-4-(3,4,5-trimethoxyphenyl)selenophene derivatives were designed as potential tubulin polymerisation inhibitors. Among the synthesised analogs, compound 7i, featuring a selenophene linker, demonstrated superior antiproliferative activity against Huh7, MCF-7, and SGC-7901 cancer cell lines, with IC50 values slightly lower than those of combretastatin A-4 (CA-4). Structure-activity relationship studies revealed that electron-donating substituents at the para-position of the B-ring significantly enhanced cytotoxic potency. Mechanistic studies revealed that compound 7i effectively inhibited tubulin polymerisation, disrupted microtubule networks, induced G2/M cell cycle arrest, and triggered apoptosis in cancer cells. These results underscore the potential of incorporating selenophene into the CA-4 scaffold as a promising strategy for developing potent tubulin polymerisation inhibitors, offering new avenues for cancer therapy.
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DOI
PubMed
高影响因子
JOURNAL OF STRUCTURAL CHEMISTRY
·
2018
·Vol. 59
·期 3
·744-747
·
IF 0.521
Sun S.-W.,Wang G.-F.
The synthesis of a novel Cu(I) complex with V-shaped bidentate ligands {[Cu(BIPMO)]×[CuBr 2 ]} n where BIPMO = bis(4-(1 H -imidazol-1-yl)phenyl)methanone is reported. It is characterized by IR spectroscopy, elemental analysis, and single crystal X-ray diffraction. Copper(I) ions in the complex are in a distorted environment in which donor atoms are provided by the bromide anion and nitrogen atoms of BIPMO ligands, respectively. Infinite anion chains formed by CuX 4 (X = Br or N) polyhedra are linked by BIPMO ligands to give rise to layers. Furthermore, the layers are linked into 3D networks through weak intermolecular interactions.
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DOI
高影响因子
SOLAR ENERGY
·
2021
·
IF 5.742
Yulin Liu,Bin Xu,Xiaoshuang Lu,Xiatong Qin,Pingxiong Yang,Junhao Chu,Ye Chen,Lin Sun
Excellent crystallinity and uniform composition distribution of the Cu 2 ZnSn(S,Se) 4 (CZTSSe) absorber are indispensable factors for the fabrication of photovoltaic device with excellent performance. Here, a facile and effective method is developed to improve the composition uniformity of CZTSSe absorber. It is inspiring that by replacing the acetates with chlorides as the solutes in the precursor solution , the issue of the composition non-uniformity especially for the distribution of Cu and Sn, which is ascribed to the rich-carbon in the acetate-based CZTSSe absorber, is able to be avoided. Due to less organic residues and composition uniformity, the grain size and the crystallinity of absorber could be significantly enhanced, and the photovoltaic performance of chloride-based CZTSSe solar cell is improved remarkably. Furthermore, substituting CuCl 2 with CuCl as the copper source in the precursor solution is able to obtain a stable solution, and the quality of CZTSSe absorber is further improved. As a consequence, 8.48% efficient CZTSSe solar cell has been yield.
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高影响因子
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