JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2022
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IF 6.364
Xiaoliang Sun,Gang Yang,Zhengkai Tian,Wenxia Zhu,Dong Su
Silicon oxycarbide (SiOC) ceramic has attracted great attention as fascinating candidate of high-temperature material, however, its thermal stability is significantly limited by the phase separation at high temperature. Here, a TiC/SiOC ceramic was prepared by pyrolysis of a tetrabutyl titanate modified carbon-rich polysiloxane (TBT/PSO) precursor. The TiC phase is in-situ formed by the carbothermal reaction of TBT-derived amorphous TiO 2 phase with excess free-carbon phase during pyrolysis, and its size and amount increase with the pyrolysis temperature. The SiC phase appears at a higher temperature than the TiC phase and is hindered by the increased Ti content in the TBT/PSO precursor. Thus, the TiC/SiOC ceramic exhibits better thermal stability and crystallization resistance than the TiC-free SiOC ceramic under the thermal treatment (1500 °C) in argon atmosphere. The in-situ formation of metal carbide into the carbon-rich SiOC ceramic would further expand its application at high temperature environments.
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CARBOHYDRATE POLYMERS
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2021
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IF 9.381
Qingran Guan,Qisan Ma,Yanna Zhao,Xinxin Jiang,Huaizhen Zhang,Min Liu,Zhengping Wang,Jun Han
Amorphous solid dispersions (ASDs) are regarded as one of the most promising techniques for poorly-soluble active pharmaceutical ingredients (API). However, the thermodynamic instability of ASDs at supersaturated state makes them easy to recrystallize in aqueous media. In this study, ritonavir (RTV) was selected as a model drug for evaluating the solubility enhancement and recrystallization inhibition effect of various cellulose derivatives and the combinations of them with typical surfactants. Combination of HPMCAS-HF/SLS was filtrated for preparing ternary RTV solid dispersions (RTV SD) via solvent evaporation method. RTV SD exhibited enhanced dissolution manner, while the oral bioavailability of RTV SD was equivalent with the Reference Standard Norvir® but increased significantly compared to the ternary physical mixture. Thus, the ternary SD system might be promisingly employed as efficient drug delivery system for RTV, while the HPMCAS-HF/SLS combination could be recommended as effective excipient for fabricating steady solid dispersions loading poorly soluble API.
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高影响因子
Advanced Optical Materials
·
2021
·Vol. 10
·期 1
·2101535
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IF 9.926
Chen Zhao,Cailing Chen,Ran Wei,Yuting Zou,Wenchi Kong,Tao Huang,Zhi Yu,Jianjun Yang,Feng Li,Yu Han,Chunlei Guo,Weili Yu
Halide perovskites are widely explored as efficient photoresponsive materials for optoelectronic devices. However, understanding and controlling their underlying optical and electrical properties remains limited. Here, a novel approach is developed by introducing silver sulfide (Ag 2 S) quantum dots (QDs) into an MAPbBr 3 single crystal. The high-quality Ag 2 S-quantum-dot-in-perovskite (Ag 2 S-QDiP) matrixes synthesized through a laser-assisted inverse temperature crystallization (LA-ITC) strategy show broadband light-sensitive wavelength from 550 to over 1000 nm, and a balanced carriers mobility facilitates their transmission and collection. A Ag 2 S-QDiP-enabled photodetector is demonstrated, which exhibits considerably enhanced responsivity and detectivity of 1.17 A W −1 and 6.24 × 10 14 Jones at 532 nm, and 57.69 mA W −1 and 1.03 × 10 11 Jones at 1064 nm, respectively. The enhanced performance in the near-infrared (NIR) region can be attributed to the discrete heterojunction formed between MAPbBr 3 and Ag 2 S QDs, which enhances the light absorption in the NIR range and facilitates photogenerated excitons’ separation at the interface. The facile synthesis process, the more balanced transport behavior, and the ensuing improved device performance highlight introducing QDs into perovskite single crystal as an efficient strategy for tuning fundamental properties of perovskite and for developing high-efficiency broadband electronic and optoelectronic devices.
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Food Structure-Netherlands
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2021
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IF 3.769
Gege Sun,Fei Liu,Runan Zhao,Yan Hu,Bin Li,Shilin Liu,Yan Li,Bakht Ramin Shah
Polymethoxylated flavones (nobiletin, tangeretin, etc) have excellent bioactivity, but low water-solubility and high crystallization. We developed the cinnamaldehyde (CA)-modified whey protein (WPC)-stabilized microcapsules (WPC/CA microcapsules) to encapsulate nobiletin. Microcapsules showed spherical structure and mono-modal particle size distribution after dispersing in water regardless of CA concentration. The presence of CA increased the stability of nobiletin in emulsions and microcapsules, and inhibited the formation of nobiletin crystals. in vitro digestion results demonstrated that nobiletin in microcapsules had much higher bioaccessibility (82 %–94 %) than that in emulsions (68 %–83 %). The presence of CA maintained or increased the bioaccessiiblity of nobiletin both in emulsions as well as microcapsules. The formation of nobiletin crystals in stomach decreased in WPC/CA microcapsules. The results suggested that nobiletin-fortified yogurts could be produced by adding WPC/CA microcapsules, rather than WPC/CA emulsions. Also, microcapsules-incorporated yogurt would have better physical stability, if the amount of WPC/CA microcapsules and nobiletin was carefully designed. The optimized amount of CA-loaded microcapsules was 2 %–4 % in yogurt and the nobiletin content was 13−26 mg/100 g yogurt. This knowledge can be of great significance for the development of delivery systems of polymethoxylated flavones and their functional foods.
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WATER RESEARCH
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2021
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IF 11.236
Yonghai Gan,Li Zhang,Shujuan Zhang
Coagulation is a conventional method in water treatment. In recent decades, with the rapid development of membrane filtration, the use of coagulation is facing some new challenges. How to minimize the membrane fouling became a leading-edge topic in the study of coagulation. Here, the performances of three types of titanium coagulants were evaluated in terms of both the coagulation removal of toxic micropollutants and the alleviation of membrane fouling. Three oxysalts and two antibiotics were taken as representatives of inorganic and organic micropollutants. As compared with titanium tetrachloride (TiCl 4 ) and polytitanium chloride (PTC), titanium xerogel (TXC) with a higher polymerization degree showed much better performances in direct coagulation removal of oxysalts and antibiotics and in pre-coagulation for mitigating membrane fouling in both coagulation-sedimentation-ultrafiltration (CSUF) and in-line coagulation-ultrafiltration (CUF) processes. In the CSUF system, the membrane permeate flux with TXC pre-coagulation (89.5%) was much higher than those of TiCl 4 (56.1%) and PTC (57.4%). After a 5 day continuous operation, the transmembrane pressure in the CUF system with TXC coagulation was increased only to 4.9 kPa, while those of PTC and TiCl 4 were 12.2 and 18.5 kPa, respectively. The results here demonstrate that TXC is a promising coagulant for pollutant removal and membrane fouling alleviation, due to the following merits: better floc properties, weaker pH-dependence, and higher resistance to coordination with organic pollutants. The observation shed new lights on the fabrication and application of coagulants in a wide variety of scenarios.
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高影响因子
XENOBIOTICA
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2021
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IF 1.908
Yilin Li,Yang Wang,Na Zhang,Shenzhi Zhou,Ying Peng,Jiang Zheng
Venlafaxine (VLF), an antidepressant agent, is widely used to combat major depressive disorders, particularly for the treatment of selective serotonin reuptake inhibitor-resistant depression. VLF has been shown to cause liver injury. The present study aimed to investigate the metabolic activation of VLF and explore the mechanisms of hepatotoxicity induced by VLF.One glutathione (GSH) conjugate and one cysteine conjugate were both detected in mouse and human liver microsomal incubations containing VLF and GSH or cysteine. The two conjugates were also detected in cultured mouse primary hepatocytes and bile of rats after exposure to VLF. The in vitro and in vivo studies demonstrated that VLF was metabolized to a quinone methide intermediate reactive to GSH and cysteine residues of hepatic protein. The observed protein covalent binding revealed dose-dependency. The metabolic activation of VLF was P450-dependent, and CYP3A4 was found as the predominant enzyme involved in the bioactivation process.These findings facilitate better understanding of the metabolic activation-hepatotoxicity relationship of VLF and provide chemists with information about new potential structural alerts during drug design process.
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高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2021
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IF 5.875
Yingying Liu,Xiaoshu Lai,Yao Zhu,Fengjuan Guo,Lili Su,Gulzira Arkin,Tianzhen He,Jinfeng Xu,Haitao Ran
Traditional encapsulated microbubbles are recently used as delivery carriers for drugs and genes, but they have low efficiency. If the local microbubble concentration could be increased, this might be able to improve the therapeutic efficacy of diseases. In this study, we developed novel cationic magnetic microbubbles (MB M ), which could simultaneously realize targeted aggregation under a magnetic field as well as ultrasonographic real-time visualization. Their physicochemical properties, biocompatibility , ultrasonography, magnetic response characteristics, and biodistribution were systematically evaluated. Here, the MB M were 2.55 ± 0.14 µm in size with a positive zeta potential , and had a good biocompatibility. They were able to enhance ultrasonographic contrast both in vitro and in vivo. MB M could be attracted by an external magnet for directional movement and aggregation in vitro. We confirmed that MB M also had a great magnetic response in vivo, by means of fluorescence imaging and contrast-enhanced ultrasound imaging. Following intravenous injection into tumor-bearing mice, MB M showed excellent stability in the internal circulation, and could accumulate in the tumor vasculature through magnetic targeting. With the excellent combination of magnetic response and acoustic properties, cationic magnetic microbubbles (MB M ) have promising potential for use as a new kind of drug/gene carrier for theranostics in the future.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2021
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IF 5.279
Jing Zhou,Ji Zhang,Jiayi Li,Yiqiu Guan,Ting Shen,Fu Li,Xueqin Li,Xiaojun Yang,Weicheng Hu
Ginsenoside F2 (GF2) is a protopanaxdiol saponin from Panax ginseng leaves and possesses many potential pharmacological properties. GF2 may prevent obesity by directly binding to the peroxisome proliferator-activated receptor-γ (PPARγ) and inhibiting adipocyte differentiation. However, the mechanism by which GF2 alleviates obesity is unknown. We therefore explored the anti-adipogenesis and anti-obesity effects of GF2 in vitro and in vivo. GF2 inhibited differentiation and reduced the triglyceride (TG) content of 3T3-L1 preadipocytes in the early stage of adipogenesis. Administration of GF2 (50 and 100 mg/kg) to obese mice for 4 weeks reduced the body weight gain, weight of adipose tissues, adipocyte size, and total cholesterol, TG, and AST levels in serum. RNA sequencing and real-time quantitative PCR indicated that GF2 decreased the expression levels of adipokines, including PPARγ, fatty acid synthase, and adiponectin. KEGG enrichment and western blot analyses demonstrated that GF2 accelerated the phosphorylation of AMPK and ACC in vitro and in vivo. Moreover, GF2 promoted the biosynthesis of mitochondria in 3T3-L1 adipocytes and increased the expression of antioxidant enzymes such as SOD and GSH-Px in the liver of obese mice. Therefore, GF2 suppressed adipogenesis and obesity by regulating the expression of adipokines and activating the AMPK pathway. Hence, the findings suggest that GF2 may have potential therapeutic implications to treat obesity.
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高影响因子
ACS Applied Energy Materials
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2021
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IF 6.024
Meiwan Chen,Dechao Niu,Jiayi Mao,Guangyu Jiang,Kaiyuan Li,Gaoxu Huang,Xiaopan Jin,Yongsheng Li
Though great progresses have been made on improving the volume effect and electronic conductivity of anode materials in sodium-ion batteries (SIBs), the electrical performance at high current density for long cycling stability is still a huge challenge. To address this, a facile confined-impregnation/crystallization strategy is developed to construct a movable Fe2O3 core in nitrogen-doped hierarchical porous carbon nanospheres (MFe2O3@N-HCNs) for ultrafast intercalation/deintercalation of SIBs. The as-prepared MFe2O3@N-HCNs not only exhibit a connected and hierarchal porous structure with large surface specific area (∼367 m2 g–1) but also possess a highly dispersed and moveable Fe2O3 core (∼5 nm) for the tolerance of volume expansion during the intercalation/deintercalation process of sodium ions. As SIBs anode materials, the MFe2O3@N-HCNs anode exhibits a capacity of 417 mAh g–1 at 0.1 A g–1 after 100 cycles and of 364 mAh g–1 at 2 A g–1 with 4500 cycles. Especially, a prominent discharge capacity of 102 mAh g–1 is still obtained at 5 A g–1 after 10000 cycles. Such remarkable performances should be attributed to the unique highly dispersed and moveable Fe2O3 core and conductive nitrogen-doped hierarchical porous carbon framework with large surface area. Consequently, this study develops a facile methodology to promote the energy storage and long cycling performance of hierarchically porous carbon@transition-metal oxide (TMO) composite anode materials for SIBs, especially at high current density.
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Advanced Optical Materials
·
2021
·Vol. 9
·期 12
·2100434
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IF 9.926
Xingwen Cheng,Renfu Li,Wei Zheng,Datao Tu,Xiaoying Shang,Zhongliang Gong,Jin Xu,Siyuan Han,Xueyuan Chen
All-inorganic lead-free metal halides doped with ns 2 -metal ions have shown great promise in optoelectronics and photovoltaics owing to their superior optical properties. Herein, a strategy is reported for tailoring the optical properties of 0D A 2 InX 5 ⋅H 2 O and A 3 InX 6 (A = Cs, Rb; X = Cl, Br) crystals via Sb 3+ doping, and the excited-state dynamics of Sb 3+ is unveiled through temperature-dependent photoluminescence (PL) and femtosecond transient absorption spectroscopies. Owing to the spatially confined 0D structure of the In-based halides, Sb 3+ ions experience a strong Jahn–Taller distortion on the excited state, which results in intense PL from Sb 3+ with a broad emission band and a large Stokes shift. Through the control of A cation and the octahedral unit, tunable Sb 3+ emissions (490−750 nm) with PL quantum yields up to 91.8% are achieved in these 0D In-based halides. These findings provide fundamental insights into the excited-state dynamics of Sb 3+ in 0D metal halides, thus laying a foundation for future design of luminescent lead-free 0D metal halides through ns 2 -metal doping towards versatile applications.
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CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Zhuo-Yu Li,Yu-Lei Liu,Pei-Nan He,Xin Zhang,Lu Wang,Hai-Teng Gu,Hao-Chen Zhang,Jun Ma
Hydroxylamine is commonly known to enhance the performance of Fe(II)-based advanced oxidation processes (AOPs) by promoting Fe(II) regeneration from Fe(III). Recently, ferryl ion (Fe(IV)) was found as an important reactive specie in Fe(II)/peroxydisulfate (PDS) system, while the interaction between hydroxylamine and Fe(IV) in Fe(II)/hydroxylamine/PDS system was still ambiguous. Therefore, the role of hydroxylamine, especially in interaction with reactive species, was systematically studied therein. With methyl phenyl sulfoxide (PMSO) as a probe compound, an original function of hydroxylamine to transform the major reactive species from Fe(IV) to radicals (SO 4 - and OH) for potential pollutants oxidation was clarified. Experimental results combined with Density Functional Theory (DFT) calculations showed that SO 4 - , OH and Fe(IV) all contributed to PMSO oxidation. Hydroxylamine showed the greatest promotional effect on the production of SO 4 - , while the production of Fe(IV) was inhibited with concentrations of hydroxylamine increasing from 0.2 to 1.4 mM. Compared with PMSO, hydroxylamine showed stronger scavenging ability towards Fe(IV) than SO 4 - and OH. Thus, more than 50% of radicals was consumed by PMSO and Fe(IV) mainly reacted with hydroxylamine to regenerate Fe(II). In a word, hydroxylamine played a dual role during potential pollutants oxidation in Fe(II)/hydroxylamine/PDS system, namely (1) transforming the major reactive species from Fe(IV) to radials (SO 4 - and OH) and (2) regenerating Fe(II) from both Fe(IV) and Fe(III). This study provides an insight into the role of hydroxylamine and its interactions with Fe(IV), which advances our understanding on similar Fe(II)/reductants/PDS systems.
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Journal of Biomedical Research
·
2021
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IF 0
Siwan Wang,Hui Jiang,Jia Wang,Haisi Wu,Ting Wu,Mengnan Ni,Qianqian Zhao,You Ji,Ziting Zhang,Chunming Tang,Huae Xu
As a well-known anticancer drug, paclitaxel (PTX), a first-line chemotherapeutic agent, remains unsatisfactory for gastric cancer therapy. It is reported that triptolide (TPL) could enhance the anti-gastric cancer effect of PTX. Considering the poor solubility of both drugs, we developed a red blood cell membrane-biomimetic nanosystem, an emerging tool in drug delivery, to co-load paclitaxel and triptolide (red blood cell membrane coated PTX and TPL co-loaded poly(lactic- co -glycolic acid) [PLGA] nanoparticles, RP(P/T)). The successful preparation was confirmed in terms of particle size, morphology, and surface markers assays. This biomimetic system could prolong circulation and escape immune surveillance. And these properties were verified by stability, in vitro drug release, and cellular uptake assays. Moreover, the MTT and colony formation assays demonstrated the superior anti-proliferation effect of the RP(P/T) to free drugs. The enhanced antitumor effects of RP(P/T) on migration and invasion were also evaluated by wound-healing and transwell assays. Overall, the bionic co-delivery nanoplatform with improved efficacy in vitro is a promising therapy for gastric cancer.
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