MOLECULES
·
2022
·Vol. 27
·期 12
·3738
·
IF 4.927
Xia Niu,Yanan Meng,Yucheng Wang,Guiling Li
As a global health problem, liver fibrosis still does not have approved treatment. It was proved thatN-(3,4,5-trichlorophenyl)-2(3-nitrobenzenesulfonamide) benzamide (IMB16-4) has anti-hepatic fibrosis activity. However, IMB16-4 displays poor water solubility and poor bioavailability. We are devoted to developing biodegraded liposome-coated polymeric nanoparticles (LNPs) as IMB16-4 delivery systems for improving aqueous solubility, cellular uptake, and anti-fibrotic effects. The physical states of IMB16-4−LNPs were analyzed using a transmission electron microscope (TEM), high-performance liquid chromatography (HPLC), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and differential scanning calorimeter (DSC). The results show that IMB16-4−LNPs increased the drug loading compared to liposomes and enhanced cellular uptake behavior compared with IMB16-4−NPs. In addition, IMB16-4−LNPs could repress the expression of hepatic fibrogenesis-associated proteins, indicating that IMB16-4−LNPs exhibited evident anti-fibrotic effects.Keywords:liposome-coated polymeric nanoparticles;IMB16-4;liver fibrosis;hepatic stellate cells;cell uptake
✓ 已验证
DOI
PubMed
高影响因子
Biomed Research International
·
2022
·
IF 3.246
Cheng Shi,Fei Yuan,Zhilong Li,Zhenhua Zheng,Changliang Yuan,Ziyang Huang,Jianping Liu,Xuping Lin,Taoyi Cai,Guofeng Huang,Zhenqi Ding
Background. The microenvironment of bone defects displayed that M2 polarization of macrophagocyte could promote the osteoblast growth and benefit the wound healing. Bone scaffold transplantation is considered to be one of the most promising methods for repairing bone defects. The present research was aimed at constructing a kind of novel bone scaffold nanomaterial of [email protected] for treating bone defects responding to the wound microenvironment of bone defects and elucidating the mechanics of [email protected] treating bone defect via controlling release of IL-4, inducing M2 polarization and active factor release of macrophagocyte, and eventually relieving osteoblast injury. Methods. [email protected] was firstly fabricated and its release of IL-4 was assessed in vitro. Following, the effects of [email protected] nanocomplex on the release of active factors of macrophage were examined using Elisa assay and promoting M2 polarization of the macrophage by immunofluorescence staining. And then, the effects of active factors from macrophage supernatant induced by [email protected] on osteoblast growth were examined by CCK-8, flow cytometry, and western blot assay. Results. The release curve of IL-4 in vitro displayed that there was more than 80% release ratio for 30th day with a sustained manner in pH 5.5. Elisa assay data showed that [email protected] nanocomplex could constantly promote the release of proproliferative cytokine IL-10, SDF-1α, and BMP-2 in macrophagocyte compared to only IL-4 treatment, and immunofluorescent image showed that [email protected] could promote M2 polarization of macrophagocytes via inducing CD206 expression and suppressing CD86 expression. Osteoblast injury data showed that the supernatant from macrophagocyte treated by [email protected] could promote the osteoblast proliferation by MTT assay. Flow cytometry data showed that the supernatant from macrophagocyte treated by [email protected] could suppress the osteoblast apoptosis from 22.1% to 14.6%, and apoptosis-related protein expression data showed that the supernatant from macrophagocyte treated by [email protected] could suppress the expression of Bax, cleaved caspase 3, and cleaved caspase 8. Furthermore, the immunofluorescent image showed that the supernatant from macrophagocyte treated by [email protected] could inhibit nucleus location of p65, and western blot data showed that the supernatant from macrophagocyte treated by [email protected] could suppress the phosphorylation of IKK and induce the expression of IκB. Conclusion. [email protected] could control the sustaining release of IL-4, and it exerts the protective effect on osteoblast injury via inducing M2 polarization and proproliferative cytokine of macrophagocyte and following inhibiting the apoptosis and NF-κB pathway-associated inflammation of osteoblast.
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Ming Wang,Jianlin Li,Wenjie Pan,Jiaqi Li,Wu Xu,Zhenshan Ding,Qingsong Yu,Zhihua Gan,Zhibo Li,Ni Jiang
The use of physical barriers is an effective strategy for preventing postoperative adhesion, a prevalent complication in clinical abdominal surgeries. However, the current anti-adhesion barriers face limitations in precisely regulating key cellular responses during tissue repair. In this study, a multi-modal synergistic degradable anti-adhesion membrane was developed via coaxial electrospinning of poly(4-hydroxybutyrate) (P4HB), polyglycolic acid (PGA), and diclofenac sodium (DS). The designed membrane features a densely packed fibrous architecture, exhibiting over 97 % inhibition efficiency against fibroblasts interlayer penetration in vitro. The rapid initial release of DS synergizes with PGA-mediated biological functions to suppress fibroblast-to-myofibroblast differentiation, and to significantly mitigate early-stage pathological changes. This cascade effect ultimately leads to reduced collagen deposition and significantly diminished adhesion formation, as demonstrated in a mouse cecal and peritoneal abrasion model. Furthermore, the membrane demonstrates exceptional flexibility and enhanced hydrophilicity, ensuring conformal coverage of complex three-dimensional wounds. The integration of structural design, controlled drug release, and dynamic biological modulation renders this multifunctional barrier as a promising candidate for next-generation clinical anti-adhesion applications.
✓ 已验证
产品关联
DOI
高影响因子
Agriculture-Basel
·
2025
·Vol. 15
·期 8
·
IF 3.6
Zhiyun Yang,Xiao Ding,Junbo Yang,Mehboob Hussain,Yanan Ruan,Xi Gao,Guoxing Wu
Current management ofAgeratina adenophora, a highly invasive weed, relies on synthetic herbicides with environmental and resistance risks, necessitating eco-friendly alternatives. This study evaluated seven phenyl derivatives for phytotoxic activity againstA. adenophoravia in vitro bioassays. Methyl 4-hydroxyphenylacetate exhibited potent herbicidal efficacy, achieving 100% mortality in 2-month-old seedlings at 30 mM, 3-month-old seedlings at 100 mM, and wild adult/6-month-old plants at 200 mM within 48 h. At 250 mM, the compound reduced CO2assimilation by 113.6% and stomatal conductance by 92.2%, indicating severe photosynthetic and transpirational disruption via oxidative stress-mediated chloroplast degradation and stomatal dysfunction. Hormonal profiling revealed significant declines in IAA-ASP, GA1, TZeatin, and TZR, alongside elevated ABA levels, while GA3 remained stable. These hormonal shifts likely drive stomatal closure and metabolic collapse, culminating in plant death. This study provides the first evidence of methyl 4-hydroxyphenylacetate’s dual-action phytotoxicity—targeting both stomatal regulation and hormonal balance—positioning it as a sustainable biocontrol agent forA. adenophoraand potentially other invasive weeds.
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 5
·2335-2350
·
IF 3.925
Wen-Yan Wang,Zi-Hui Yang,A-Liang Li,Qing-Song Liu,Yue Sun,Wen Gu
A series of novel 2-amino-4-aryl-pyrimidine derivatives of ursolic acid were designed, synthesized, and evaluated for their anticancer activities against four cancer cell lines (MCF-7, HeLa, HepG2, and A549) and a human hepatocyte cell line (LO2) via MTT assay. Among these derivatives, compound 7b exhibited potent cytotoxic activity against MCF-7 and HeLa cells with IC50 values of 0.48 ± 0.11 and 0.74 ± 0.13 μM, respectively, and substantially lower cytotoxicity to LO2 cells. Further cellular mechanism studies in MCF-7 cells elucidated that compound 7b could inhibit cell migration, induce cell cycle arrest at S phase and trigger mitochondrial-related apoptosis by increasing the generation of intracellular ROS and decreasing the mitochondrial membrane potential (MMP), which was associated with upregulation of the protein expression level of Bax and downregulation the level of Bcl-2 and the activation of caspase cascade. Western blot analyses also revealed that compound 7b could simultaneously suppress RAS/Raf/MEK/ERK and PI3K/AKT/mTOR signaling pathways, which could be responsible for the induction of apoptosis. Molecular docking study revealed that MEK1 kinase could be one of the possible targets of the title compounds. These results offered a promising scaffold for the investigation of novel targeted anticancer agents.
✓ 已验证
DOI
高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2025
·
IF 6.1
Xiaona Ren,Zhipei Chen,Peng Wang,Wenchang Wang,Yao Wang,Changchun Ge
Rare earth oxide (CeO₂/Y₂O₃) reinforced AlCrFeNiCu high-entropy alloy coatings with a Mo interlayer (designated as Mo/CeO₂-AlCrFeNiCu and Mo/Y₂O₃-AlCrFeNiCu) were successfully deposited onto a Zr-4 substrate via high-speed laser cladding. The microstructural characteristics and properties of the composite coatings were comprehensively investigated. The results demonstrate that the Mo interlayer alleviates the thermal mismatch between the substrate and the HEA coatings and, to a certain degree, counteracts the grain refinement effect induced by the rare earth oxides. Overall, it plays a critical role in enhancing interfacial structural stability, mitigating thermal stress, and improving overall coating performance. It effectively optimizes the coating-substrate bonding integrity, reduces susceptibility to high-temperature fretting fatigue and plastic deformation, and significantly lowers the specific wear rate. Furthermore, the Mo interlayer enhances the compactness and continuity of the interface, suppresses the formation of corrosive pathways, and promotes the formation of a thicker, more stable passive film on the coating surface.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2014
·Vol. 49
·期 20
·7181-7191
·
IF 2.305
Mu Bin,Zhang Wenbo,Wang Aiqin
A novel superparamagnetic gold/halloysite nanotubes/Fe 3 O 4 (Au/HNTs/Fe 3 O 4 ) nanocomposite with coaxial structure was designed and fabricated by selective decoration of the inner lumen and the external wall of halloysite nanotubes (HNTs) based on the difference inside/outside surface charges. The structure and composition of Au/HNTs/Fe 3 O 4 were characterized by transmission electron microscope, powder X-ray diffraction, and X-ray fluorescence. The results indicated that Au nanorods selectively generated within the lumen of HNTs, while Fe 3 O 4 nanoparticles uniformly deposited on the external wall. It was particularly worth mentioning that the structure of HNTs was not destroyed in the preparation process of Au/HNTs/Fe 3 O 4 nanocomposites. The catalytic activity of the as-prepared Au/HNTs/Fe 3 O 4 was investigated for the reduction of 4-nitrophenol in the presence of NaBH 4 . The Au/HNTs/Fe 3 O 4 nanocomposites exhibited excellent catalytic activity and cycling stability according to the kinetic data of the catalytic reduction reaction. In addition, the Au/HNTs/Fe 3 O 4 catalysts can be easily manipulated by an external magnetic field for recycling.
✓ 已验证
DOI
高影响因子
CATALYSIS TODAY
·
2023
·
IF 5.3
Yue Hua,Jingsen Zhang,Tengda Zhang,Aimin Zhu,Guangqing Xia,Xiuling Zhang,Lanbo Di
Catalytic removal of 4-nitrophenol (4-NP) in wastewater remains a significant challenge due to the poor activity and stability of the catalysts. Herein, low-cost graphite oxide (GO) supported Pd and Ni NPs (PdNi/GO) with enhanced catalytic activity and stability for 4-NP reduction were synthesized by a plasma method in the aqueous solution of Pd(NO 3 ) 2 , Ni(NO 3 ) 2 , and GO. The normalized rate constant k nor over the PdNi/GO with Pd/Ni= 1.8:0.2 for 4-NP reduction was as high as 5480 min −1 ·g −1 ·L, which was comparable with that of Pd/GO, and it was about 50.7 times higher than that of Pd/rGO-H prepared by traditional thermal reduction method. Importantly, after six reaction cycles, it only decreased to 74.8% of the initial value, which was much higher than that of the Pd/GO catalyst (59.8%). The characterization results indicated that plasma synthesized Pd/GO catalyst can keep the oxygen-containing groups (OCGs) on the GO surface , generate abundant defects, and facilitate the adsorption of the 4-NP. Interestingly, the addition of Ni could keep these merits, and the formed PdNi alloyed structure may facilitate the electron transfer between PdNi NPs and GO, contribute to the strong adsorption of 4-NP and the rapid generation of active hydrogen. Consequently, the PdNi/GO catalyst exhibited outstanding catalytic activity and stability for 4-NP reduction. This work provided a fast, facile, environmentally friendly, and easy to scale up plasma method for synthesizing high performance Pd-based catalysts.
✓ 已验证
DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2021
·Vol. 27
·期 55
·13819-13827
·
IF 5.236
Pan Liang,Wen-Li Lian,Zhi-Hong Liu
Highly efficient inorganic phosphors are crucial for solid-state lighting. In this paper, a new method of low-temperature self-reduction was used for preparing a highly efficient deep blue-emitting phosphor of Ca[B 8 O 11 (OH) 4 ] : Eu 2+ (CBH : Eu 2+ ). The crystal structure, morphology, chemical state, and photoluminescence (PL) properties of the CBH : Eu 2+ phosphor have been investigated. By using the screened hybrid function (HSE06), the band gap ( E g ) of CBH was calculated to be 7.48 eV, which is a necessary condition for achieving high quantum yield phosphors. The experiment results show that almost all the added raw materials of Eu 3+ can be reduced to Eu 2+ in CBH crystal under a non-reducing atmosphere. The CBH : Eu 2+ phosphor shows a broad excitation spectrum centered at 277 and 327 nm in the range of 220 to 400 nm, and a narrow-band emission spectrum centered at 428 nm in the range of 400 to 500 nm, with a full width at half maximum (fwhm) of 42.35 nm. Under UV radiation, the CBH : 2 %Eu 2+ exhibits high photoluminescence quantum yield (PLQY=95.0 %), high external quantum efficiency (EQE=31.1 %), and ultra-high color purity (97.6 %). The PL intensity of CBH : 2 %Eu 2+ remains 62.6 % of the initial intensity at 150 °C. Finally, the white light-emitting diodes (WLED) fabricated by CBH : 2 %Eu 2+ , excited by a 365 nm chip, presents outstanding performances with a luminous efficacy (LE) of 13.9 lm/W, a color rendering index (CRI) of 89.4, and a correlated color temperature (CCT) of 5825 K. The above results show that CBH : Eu 2+ can be used as a promising blue phosphor for WLED. This new method of low-temperature self-reduction can be applied to design and prepare other new types of highly efficient phosphors. Graphical Through a new method of low-temperature (only 350 °C) self-reduction, a highly efficient deep blue-emitting phosphor Ca[B 8 O 11 (OH) 4 ] : Eu 2+ was prepared, with a high PLQY of 95 % and a color purity of 97.6 %. Then, a WLED fabricated by the as-prepared CBH : 2 %Eu 2+ presents outstanding performance with a luminous efficacy (LE) of 13.9 lm/W, a color rendering index (CRI) of 89.4, and a correlated color temperature (CCT) of 5825 K.
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2016
·
IF 3.15
Ruixin Ma,Fan Yang,Shina Li,Xiaoyong Zhang,Xiang Li,Shiyao Cheng,Zilin Liu
CZTSSe is an important earth abundant collection of materials for the development of low cost and high efficiency thin film solar cells. This work developed a simple non-vacuum-based route to fabricate CZTSSe absorber films. This was demonstrated by first synthesizing Cu 2 ZnSnS 4 (CZTS) nano-crystalline based on solid-phase synthesis. Then a stable colloidal ink composed of CZTS nano-crystalline was blade coated on Mo-coated substrates followed by an annealing process under Ar atmosphere. After CZTS films formation, the films were sintered into CZTSSe absorber films by exposing them under Selenium vapor. The formation of a kesterite type CZTS was confirmed using X-ray diffraction and Raman scattering measurements. The band gap of CZTSSe absorber films was determined to be 1.26 eV, which was appropriate for use as an absorber layer in thin film solar cells. The CZTSSe absorber films showed a good photovoltatic performance, demonstrating this simple approach had great potential for CZTSSe solar cell production.
✓ 已验证
DOI
高影响因子
BIORESOURCE TECHNOLOGY
·
2014
·
IF 5.039
Fanying Kong,Aijie Wang,Hong-Yu Ren,Liping Huang,Meiying Xu,Huchun Tao
A new approach that improved the dechlorination and mineralization of 4-chlorophenol (4-CP) was demonstrated in a sequential biocathode–bioanode bioelectrochemical system (BES) with mixed photosynthetic bacteria (PSB). The biocathode with additional PSB inoculation showed higher 4-CP dechlorination efficiency (DE) and maximum current (81.8 ± 2.9%, 0.021 ± 0.002 A) than that at abiotic cathode (45.3 ± 3.7%, 0.011 ± 0.002 A) ( P < 0.005). Light response in biocathode BES with or without PSB ascertained the important role of PSB played in the dechlorination and current generation. Dechlorination and mineralization of 4-CP was achieved in the sequential biocathode–bioanode BES, which could be further enhanced with PSB inoculation in both cathode chamber and anode chamber. 4-CP DE in the cathode chamber was improved from 55.0 ± 2.0% to 78.8 ± 4.9%, and the phenol degradation in the anode chamber was improved from 65.3 ± 2.1% to 71.3 ± 1.4%. This study directed a new way for improving dechlorination at biocathode and product degradation at bioanode with PSB inoculation in BES.
✓ 已验证
DOI
高影响因子
Nanocomposites
·
2023
·
IF 4.6
Lin Wu,Tao Pang,Laxia Wu,Yebin Guan,Liwei Yin
This work presents a facile strategy for the generation of Fe3O4@poly(4-vinylpyridine)-block-polystyrene (Fe3O4@P4VP-b-PS) magnetic polymer nanocomposites. P4VP-b-PS nanoparticles prepared by dispersion RAFT polymerization of styrene in methanol/water in the presence of macro-P4VP chain transfer agent was employed as templates to grow Fe3O4 on polymeric network templates. With the following addition of FeCl3 into the above polymer colloids, pyridyl moieties in P4VP block of nanoparticles could further react with Fe3+ through a coordination reaction to generate Fe3+@P4VP-b-PS nanoparticles. After the subsequent addition of FeCl2 and NH3⋅H2O, the co-precipitation reaction occurred on the surface of the polymeric nanoparticle to form Fe3O4@P4VP-b-PS magnetic polymer nanocomposites. Herein, FT-IR, XRD, TGA, XPS, TEM and VSM were applied to characterize the morphology, structure and magnetism performance of the synthesized magnetic polymeric nanocomposites.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）