Chemistry of Heterocyclic Compounds
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2018
·Vol. 54
·期 2
·125-129
·
IF 1.201
Gao Huiqin,Wu Xiangwen
A 3-hydroxyflavone derivative as fluorescence chemosensor for copper and zinc ions has been synthesized. Its recognition properties for copper and zinc ions in aqueous solution were investigated based on UV-vis absorption and fluorescence spectra change. The compound exhibits color change from colorless to yellow and quenching of green fluorescence in the presence of copper ions in aqueous solution due to coordination reaction. In turn, the addition of zinc ions induces the color change from colorless to green and fluorescence enhancement of the compound. The complex ratios between the sensor molecule and copper(zinc) ions are 1:1 and 1:2, respectively, based on the Job's plots and in situ mass spectra. Thus, this compound can selectively recognize copper and zinc ions, and the recognition also can be observed by naked eye.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 54
·期 4
·3319-3330
·
IF 2.993
Sun Ning,Lei Rong,Xu Jianghui,Kundu Subhas C.,Cai Yurong,Yao Juming,Ni Qingqing
To improve the roles of tumor drug, porous silk fibroin particles have been designed as drug carriers. Doxorubicin (DOX) is encapsulated during the fabrication process of the silk fibroin particles to form DOX loaded silk fibroin particles (SFPs-DOX). Folic acid (FA) is covalently grafted to the surface of the silk fibroin particles (FA-SFPs-DOX) as a target group to the folate receptor of tumor cells.
The experimental results showed that under the conditions of low pH, high ionic strength and high enzyme concentration, the release of loaded drugs in particles has stimulus response under various conditions. The synthesized silk fibroin particles have good biocompatibility. The specific binding of fibroin particles to folate receptors provides the particles to with target functions to the tumor cells. The job develops potential application of silk fibroin particles as smart drug carriers for the targeted therapy of tumor.
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高影响因子
IRANIAN POLYMER JOURNAL
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2018
·Vol. 27
·期 12
·951-963
·
IF 1.278
Gao Jiao,Luo Peng,Yan Xingyan,Hou Linxi
N -Isopropylacrylamide (NIPAM) was successfully grafted on reduced graphene oxide (RGO) by free radical polymerization and characterized by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, transmission electron microscope (TEM) measurements, thermogravimetric analysis and ultraviolet–visible transmission spectroscopy. The synthesized poly( N -isopropylacrylamide)–reduced graphene oxide (PNIPAM–RGO) was used to improve the properties of polysulfone (PSF) membranes with different PNIPAM–RGO weight fractions. The structure and properties of PNIPAM–RGO/PSF membrane were characterized by X-ray photoelectron spectroscopy, scanning electron microscopy, atomic force microscope, contact angle and tensile testing. The water permeability, self-cleaning recovery rate and water flux decline factor were tested. The blend membrane with 0.4 wt% PNIPAM–RGO possessed the optimal rejection and exhibited an impressive self-cleaning recovery rate and fracture strain of 98.6 and 72.2%, showing a 67.4 and 76.5% enhancement compared to that of pure PSF membrane (58.9 and 40.9%), respectively. Meanwhile, the water flux decline factor decreased from 21.0 to 7.8%. The drastic change of permeability to aqueous solution, observed around lower critical solution temperature of PNIPAM–RGO, proved the thermal sensitivity of the blend membrane. The NIPAM grafted onto RGO by free radical polymerization and utilizing the advantages of both PNIPAM and RGO, which was used as an additive in the membrane, and very hard to lose during the membrane formation and application. The resulting membrane exhibited a significant increase in self-cleaning recovery rate, hydrophilicity, mechanical strength and thermosensitivity.
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高影响因子
NPG Asia Materials
·
2018
·Vol. 10
·期 10
·1002-1015
·
IF 7.208
Huang Yanyu,Mei Chaoming,Tian Yiqiao,Nie Tianqi,Liu Zhuang,Chen Tianfeng
Rational design of smart nanosystems with high biological safety is a critical milestone for realizing precise imaging-guided cancer theranostics. Herein, a bioinspired nanosystem was designed by camouflaging SPIO@DOX-ICG nanoparticles with cancer cell membrane (CCM) to realize precise cancer treatment through simultaneous chemotherapy, hyperthermia-therapy, and radiotherapy. CCM surface decoration preserves the cancer adhesion molecules and surface antigens in the nanosystem, endowing the nanosystem with tumor-homing ability and high biocompatibility. Guided by dual-modal imaging, the nanosystem specifically accumulated in the tumor region and achieved synergistic anticancer effects after combined treatment, without causing toxic side effects in major organs. Interestingly, the combined treatment also antagonized tumor hypoxia and reprogrammed the polarization of tumor associated macrophages to the antitumor M1 phenotype. Taken together, this study offers a smart strategy for designing a bioinspired tumor-homing nanosystem for precise cancer therapy.
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高影响因子
AMB Express
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2018
·Vol. 8
·期 1
·1-12
·
IF 1.719
Hu Xingcui,Cheng Tao,Liu Jianhua
Biosurfactants emulsify lipids, facilitating their exposure to microorganisms in water. Secretion of biosurfactant together with lipase can enhance oil assimilation by microorganisms. In this study, we show the analysis of the biosurfactant and lipase producing microbe originating from oil-sludge. The enrichment of the biosurfactant-producing ZS6 strain from the mixed culture of sludge-derived microbes in medium with olive oil as sole carbon source was monitored using the modified T-RFLP (or mT-RFLP) methodology. Phylogenetic tree analysis based on 16S rDNA sequences suggested that ZS6 belonged to a member of Serratia sp. Serratia sp. ZS6 secreted both a serrawettin-type biosurfactant and lipase in medium with olive oil as sole carbon source. By using an in-gel lipase assay followed by LC–MS/MS analysis, we identified the amino acid sequences of the ZS6 lipase, which belonged to the lipase subfamily III of the family I. Its lipolytic activity was found to be enhanced by salinity, calcium, and methanol. Together, we show that the novel isolate Serratia sp. ZS6 secretes both biosurfactant and lipase which makes it useful for applications such as in food industry wastewater treatment and biodiesel production.
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PubMed
高影响因子
COLLOID AND POLYMER SCIENCE
·
2018
·Vol. 296
·期 5
·895-906
·
IF 1.967
Zhang Ming,Chen Mingqing,Ni Zhongbin
We investigated the rheology behaviors of diglycidyl ether of bisphenol-A (epoxy resin) composite pastes with various biscarbamates and compared them with those of epoxy composites with fumed SiO 2 . Thermal and rheological measurements showed thermal reversible rheology behaviors of shear thinning for all epoxy composites with various biscarbamates. Some biscarbamates endowed their epoxy composites’ stronger shear thinning behaviors than fumed silica did even at the low concentrations. Polarized microscopic, FT-IR, and DSC analyses demonstrated that excellent rheological responses of biscarbamates in epoxy composite pastes could be attributed to their various crystallization self-assemblies formed in epoxy matrix by the intermolecular interactions mainly including hydrogen bonding and van der Waals interactions, and these interactions were closely related to the molecular structures of biscarbamates.
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高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
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2018
·Vol. 20
·期 3
·1-15
·
IF 2.127
Feng Jun,Bao Wenyuan,Li Lijun,Cheng Hao,Huang Wenyi,Kong Hongxing,Li Yanqing
We synthesized titanium dioxide (TiO 2 ) and nitrogen-doped TiO 2 nanoparticles (N-TiO 2 NPs) via a sol-hydrothermal method using ammonium chloride (NH 4 Cl) as the nitrogen (N) source. Furthermore, an N-TiO 2 /4-mercaptobenzoic acid (4-MBA)/silver (Ag) nanocomplex served as an active substrate for surface-enhanced Raman scattering (SERS) and was prepared by self-assembly. During SERS, the Raman signals of 4-MBA of the N-TiO 2 /MBA/Ag nanocomplexes exhibited higher intensity and sensitivity than pure TiO 2 /MBA/Ag, with 1% N doping in N-TiO 2 , producing the strongest Raman signals. We characterized the N-TiO 2 hybrid materials by transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and ultraviolet-visible diffuse reflectance spectra. N doping did not influence the phase of the TiO 2 crystal. The doped N entered into the crystal lattice of the TiO 2 , replacing some oxygen (O) to form Ti-O-N or Ti-N-O linkage. The results indicated that an appropriate amount of N doping could enhance the SERS performance of the TiO 2 SERS substrate via N substitution doping. These doping forms were beneficial to the molecular charge transfer (CT), and this resulted in improved SERS performance for N-doped TiO 2 NPs. We attributed this improvement to the formation of N-doping energy levels that were beneficial to the process of TiO 2 to MBA molecule CT. This work not only enriched the nonmetal-doped CT mechanism in SERS but also provided several reference values for practical applications.
N-doped TiO 2 nanoparticles were synthesized. Whereafter, N-TiO 2 /MBA/Ag nanocomplexes were prepared and served as a SERS-active substrate. An appropriate amount of N doping can enhance the SERS properties of TiO 2 SERS-active substrate by nitrogen substitution doping. The nonmetal doping TiO 2 -to-molecule CT mechanism and the synergistic effect in N-TiO 2 /MBA/Ag charge transfer systems have been studied.
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高影响因子
Frontiers of Chemical Science and Engineering
·
2018
·Vol. 12
·期 3
·457-466
·
IF 2.643
Shang Jiaojiao,Yao Guo,Guo Ronghui,Zheng Wei,Gu Long,Lan Jianwu
Biodegradable poly(ether-imide-ester) elastomers were synthesized from succinic acid, 1,4-butanediol, polyethylene glycol 1000 and N ′, N -bis(2-carboxyethyl)- pyromellitimide which was derived from pyromellitic dianhydride and glycine. The chemical structures, crystallinities, thermal stabilities, mechanical properties, hydrophilicities and biodegradabilities of these elastomers were investigated. The hard segments of the linear aliphatic poly (ether-ester) exhibited monoclinic chain packing. Increasing the amount of aromatic bisimide moieties in the poly (ether-ester) reduced the crystallinity of the material and improved the thermal stability and tensile strength of the elastomers. In addition, introducing a suitable amount of aromatic bisimide moieties into the poly(ether-ester) backbones endowed the elastomers with improved biodegradability but too many aromatic bisimide groups reduced the biodegradability of the elastomers.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 54
·期 2
·1539-1548
·
IF 2.993
Wang Chao,Ping Hang
Biomineralization-associated proteins are responsible for the structure-forming process of biominerals. Aiming to regulate the synthesis of nanostructured TiO 2 anatase, an artificial protein 5R5 derived from silaffins was displayed on Escherichia coli surface through genetic manipulation. The genetically modified bacterial cells serve as the framework for the formation of rod-shaped TiO 2 , assembled by nanoparticles, as well as provide a carbon source in situ during the carbonization process. The particle size and carbon content were controllable by changing the heating temperature and time. The electrode annealed at 800 °C for 1 h shows the highest reversible capacity of 160.2 mA h g −1 after 200 cycles at a current rate of 1C. This unique nanostructured anatase not only shortens the diffusion pathway of lithium ions and electrons, but also improves the electric conductivity and tolerates the volume change during charging/discharging owing to carbon coating. However, the larger particle size and high carbon content were not advantageous to improve lithium storage performance.
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高影响因子
CATALYSIS LETTERS
·
2018
·Vol. 148
·期 11
·3402-3412
·
IF 2.911
Bao Qiang,Qi Hui,Zhang Chunlei,Ning Chunli,Zhang Yi,Jiang Ye,Wu Yifan,Gui Wenying,Wang Zhenlu
Abstract In this work, titanium-doped mesoporous Al 2 O 3 (γ-Ti–Al 2 O 3 ) was prepared by an evaporation-induced self-assembly method and used as a carrier of Ba/γ-Ti–Al 2 O 3 catalyst to catalyze the aldol condensation of methyl acetate with formaldehyde to methyl acrylate in a fixed-bed reactor. The catalysts were characterized by X-ray diffraction, X-ray photoelectron spectroscopy, N 2 adsorption–desorption, pyridine absorption performed via Fourier transform infrared spectroscope (Py-IR), and NH 3 and CO 2 temperature-programmed desorption (NH 3 and CO 2 -TPD). Experimental results indicated that the doping of the titanium species into the frame work of mesoporous Al 2 O 3 (γ-Ti–Al 2 O 3 ) had a significant influence on the catalytic activity via modifying the acid–base surface properties of the catalyst. Furthermore, the Ba/γ-Ti–Al 2 O 3 catalyst demonstrated excellent catalytic performance, with a methyl acetate conversion rate of 50% and methyl acrylate selectivity up to 90.2%. Compared with the Ba/Al 2 O 3 catalyst, the Ba/γ-Ti–Al 2 O 3 catalyst had better catalytic activity, stability and potential for practical application, which was likely due to an increased number of Lewis acid sites, especially the medium acid sites. Graphical Abstract Barium supported mesoporous γ-Ti–Al 2 O 3 catalyst was found to be an effective catalyst for vapor phase aldol condensation of methyl acetate with formaldehyde.
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高影响因子
MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 5
·1-9
·
IF 5.705
Yu Xinhui,Lin Yaohui,Wang Xusheng,Xu Liangjun,Wang Zongwen,Fu FengFu
An exonuclease-assisted multicolor aptasensor was developed for the visual detection of ochratoxin A (OTA). It is based on the etching of gold nanorods (AuNRs) mediated by a G-quadruplex-hemin DNAzyme. A DNA sequence (AG4-OTA) was designed that comprises a hemin aptamer and an OTA aptamer. OTA binds to AG4-OTA to form an antiparallel G-quadruplex, which halts its digestion by exonuclease I (Exo I) from the 3′-end of AG4-OTA. Thus, the retained hemin aptamer can bind to hemin to form a G-quadruplex-hemin DNAzyme. This DNAzyme has peroxidase-like activity that catalyzes the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by H 2 O 2 to produce its diimine derivative (TMB 2+ ) in acidic solution. TMB 2+ can etch the AuNRs by oxidizing Au(0) into Au(I). This results in the generation of rainbow-like colors and provides a multicolor platform for the visual detection of OTA. The assay is based on the use of a single isolated aptamer and possesses obvious advantages such as multi-color visual inspection, relatively high sensitivity and accuracy. It can be used to detect as little as 30 nM concentrations of OTA by visual observation and even 10 nM concentrations by spectrophotometry. The method was successfully applied to the determination of OTA in spiked beer where it gave recoveries of 101–108%, with a relative standard deviation (RSD, n = 5) of <5%.
Schematic of an exonuclease-assisted multicolor bioassay based on the G-quadruplex-hemin DNAzyme-mediated etching of gold nanorods (AuNRs). It enables visual detection of ochratoxin A (OTA) with a detection limit of 30 nM.
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PubMed
高影响因子
Frontiers of Chemical Science and Engineering
·
2018
·Vol. 12
·期 4
·798-805
·
IF 2.643
Duan Peizhen,Shen Juan,Zou Guohong,Xia Xu,Jin Bo
Nanorod hydroxyapatite (NRHA)/graphene oxide (GO) composites with weight ratios of 0.4, 1.5, and 5 have been fabricated by a facile ultrasonic-assisted method at room temperature and atmospheric pressure. The chemical structure properties and morphology of the composites were characterized by field emission source scanning electron microscope, X-ray diffraction, transmission electron microscopy, and high-resolution transmission electron microscopy. The results indicate that the NRHA/ GO composites have an irregular surface with different degree wrinkles and are stable, and NRHA are well combined with GO. In addition, the biomimetic mineralization mechanism of hydroxyapatite on the NRHA/GO composites in simulated body fluid (SBF) is presented. The presence of a bone-like apatite layer on the composite surface indicate that the NRHA/GO composites facilitate the nucleation and growth of hydroxyapatite crystals in SBF for biomimetic mineralization. Moreover, the NRHA- 1.5/GO composite and pure GO were cultured with MC3T3-E1 cells to investigate the proliferation and adhesion of cells. In vitro cytocompatibility evaluation demonstrated that the NRHA/GO composite can act as a good template for the growth and adhesion of cells. Therefore, the NRHA/GO composite could be applied as a GO-based, free-template, non-toxic, and bioactive composite to substitute for a damaged or defect bone.
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