Journal of Environmental Chemical Engineering
·
2026
·
IF 7.5
Qinjuan Cao,Jian Jian,Yixiao Dan,Yuxin Liu,Zihao He,Weijie Sun,Zhengqiu Yuan,Yusheng Zhang,LeLin Zeng,Xiaowen Zhang,Hu Zhou
A novel "sheet-on-particle" Z-scheme Bi 2 MoO 6 @BiOBr heterojunction was structurally engineered and immobilized within a porous polyvinylidene fluoride membrane using an integrated ultrasonic-assisted in-situ precipitation and hydrothermal approach. The Bi 2 MoO 6 nanoparticles are uniformly distributed on the BiOBr nanosheets, establishing abundant heterogeneous interfaces that facilitate efficient Z-scheme charge transfer. This configuration enhances the visible light response and reduces carrier recombination. The composite membrane demonstrates exceptional photocatalytic activity, achieving a 98.71% degradation rate of ofloxacin through the predominant action of •O 2 ⁻ and h⁺ species. Its adaptability across a wide pH range and its capability for broad-spectrum pollutant degradation highlight its strong potential for scalable photocatalytic wastewater treatment applications.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Rui Zhou,Tong Wang,Fei Wang,Dongnian Zhang,Zhihong Hu,Huaizhu Li,Na Huang,Sa Ban,Chuncai Kong,Zhimao Yang,Xiaojun Jia,Hao Zhu
The citrate sol-gel method was used to synthesize LaNi 0.6 Co 0.4 O 3 anchored at ZnO (LaNi 0.6 Co 0.4 O 3 /ZnO) for activation of peroxymonosulfate to degrade ofloxacin in simulated wastewater. LaNi 0.6 Co 0.4 O 3 nanoparticles were uniformly and firmly dispersed on ZnO support during the synthesis process. LaNi 0.6 Co 0.4 O 3 /ZnO had a rapid catalytic rate with an efficiency of 90% in 10 min, which was higher than that of LaNi 0.6 Co 0.4 O 3 (87.7%). Meanwhile, LaNi 0.6 Co 0.4 O 3 /ZnO significantly inhibited metal ion leaching compared to LaNi 0.6 Co 0.4 O 3 (Ni leaching: 0.128 mg/L to 0.022 mg/L, Co leaching: 0.083 mg/L to 0.012 mg/L). The composite material maintained great cyclic stability with efficiency of 93% after 5 cycles. Based on electron paramagnetic resonance studies and the quenching experiments, SO 4 ·− 、 · OH、 · O 2 − and 1 O 2 were the main reactive oxygen species involved in the reaction. The degradation intermediates of ofloxacin were detected by ICP-MS to propose the possible degradation pathways. This work provides an insight for perovskite catalyst for the activation of PMS to treat pharmaceutical wastewater.
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ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
·
2022
·
IF 5.785
Jing Zhang,Yungu Zheng,Zhenyang Yu
The reproductive toxicities over generations are essential to assess the long-term impacts environmental fluoroquinolone antibiotics (FQs). In the present study, the multi-generational effects of ofloxacin (OFL) and norfloxacin (NOR) on reproduction were studied on Caenorhabditis elegans from 9 successive generations (F1-F9). Results showed that OFL showed no effects in F1, stimulation in F2 to F4, and inhibition F5 to F9. The effects of NOR also showed oscillation between stimulation and inhibition across generations. Further biochemical analysis demonstrated that the reproductive toxicities of OFL and NOR were more closely connected with total cholesterol (TCHO), progesterone (P) and testosterone (T), than major sperm protein (MSP) and vitellogenin (Vn). Moreover, OFL and NOR also showed significant trans-generational reproductive toxicities in T4 and T4′, the great-grand-daughter of F1 and F9. Differences between T4 and T4′ and between OFL and NOR, indicated influences of multi-generational exposure and urged more exploration on different mechanisms between FQs.
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WATER ENVIRONMENT RESEARCH
·
2021
·Vol. 93
·期 8
·1361-1369
·
IF 1.946
Shengkai Xu,Jiaxin Yang,Rafaat Hussein,Guangqing Liu,Bensheng Su
In this study, the performance of ofloxacin (OFX) degradation in synthetic wastewater using synthesized MnO x -CeO x /γ-Al 2 O 3 as a heterogeneous ozonation catalyst was evaluated. The removal rates of OFX and chemical oxygen demand (COD) during 15-day continuous-flow experiments were 98.2% and 76.7% on average, respectively. An ozone index (mgCOD/mgO 3 ) of 1.09 with a high ozone utilization efficiency of 91.39% was achieved. The pseudo-first-order rate constant of ofloxacin degradation reached 15.216 × 10 −2 min −1 , which was five times that (3.085 × 10 −2 min −1 ) without catalysts. The results of gas chromatography-mass spectrometry (GC-MS) demonstrated that a variety of small-molecule organics occurred in the final oxidation products, such as 4-hydroxyl-4-methyl-2-pentanone and 2-oxoadipic acid in addition to homologs of OFX. The results of this study suggested that hydroxyl radicals played critical roles in the degradation and mineralization of OFX via four main pathways: (a) electrophilic addition of nitrogen; (b) breakdown of carbon-carbon double bonds; (c) hydrolysis of ether rings; and (d) halodecarboxylation of carboxyl groups. The biodegradability (BOD 5 /COD) of OFX after catalytic ozonation reached 0.54. Practitioner points Ofloxacin wastewater was treated using catalytic ozonation in a 15-day continuous experiment with MnO x -CeO x /γ-Al 2 O 3 as a catalyst. The ozone index reached 1.09 mgCOD/mgO 3 during ozonation of ofloxacin. The presence of the catalyst increased the reaction rate constant by a factor of five. 4-hydroxy-4-methyl-2-pentanone was the primary ofloxacin oxidation product.
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ENVIRONMENTAL POLLUTION
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2015
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IF 4.143
Hongbo Peng,Ni Liang,Hao Li,Fangyuan Chen,Di Zhang,Bo Pan,Baoshan Xing
Sorption of organic contaminants on organo-mineral complexes has been investigated extensively, but the sorption contribution of mineral particles was not properly addressed before calculating K OC , especially for ionic organic contaminants. We measured the surface coverage of a humic acid (HA) on nano iron oxides (n-Fe 2 O 3 ) in a series of synthesized organo-mineral complexes. The contribution of the coated HA to ofloxacin (OFL) and norfloxacin (NOR) sorption in HA–n-Fe 2 O 3 complexes was over 80% of the total sorption with the surface coverage of 36% and f OC of 1.6%. All the coated HA showed higher sorption to NOR and OFL in comparison to the original HA, suggesting HA fractionation and/or physical re-conformation during organo-mineral complex formation. The decreased K OC with multilayer coating may suggest the importance of site-specific interactions for OFL sorption, while the increased K OC with multilayer coating may suggest the importance of partitioning in hydrophobic region for NOR sorption.
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CARBOHYDRATE POLYMERS
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2013
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IF 3.479
Qin Wang,Junping Zhang,Bin Mu,Ling Fan,Aiqin Wang
Magnetic microspheres, 2-hydroxypropyltrimethyl ammonium chloride chitosan/Fe 3 O 4 /halloysite nanotubes/ofloxacin (HACC/Fe 3 O 4 /HNTs/OFL), for the controlled release of OFL were prepared by in situ crosslinking with glutaraldehyde in the spray-drying process. The magnetic microspheres were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis and a magnetometer. Various parameters influencing the encapsulation efficiency, drug loading and in vitro controlled release properties of the magnetic microspheres for OFL were also studied. Many stripes were formed and some tubular HNTs could be seen at higher magnification on the surface of the HACC/Fe 3 O 4 /HNTs/OFL magnetic microspheres. The magnetic microspheres show superparamagnetic property and fast magnetic response. The encapsulation efficiency and the cumulative release of OFL are closely related to HACC concentration, HNTs contents and crosslinking density. The release of OFL follows the first-order kinetics.
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ANALYTICA CHIMICA ACTA
·
2014
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IF 4.517
Tong Zhao,Xiujuan Guan,Wanjin Tang,Ying Ma,Haixia Zhang
A kind of new temperature sensitive molecularly imprinted polymer (MIP) with ofloxacin (OFL) as template was prepared for the coating of solid phase microextraction (SPME). Dopamine was self-polymerized on stainless steel fiber (SSF) as the SPME support followed by silanization. Then MIP was synthesized as SPME coating on the modified SSF in a capillary, with N -isopropyl acrylamide as temperature sensitive monomer and methacrylic acid as functional monomer. The synthesis could be well repeated with multiple capillaries putting in the same reaction solution. The obtained MIP fiber was evaluated in detail with different techniques and various adsorption experiments. At last the MIP fiber was used to extract the OFL in milk. Satisfied recoveries between 89.7 and 103.4% were obtained with the limit of quantification (LOQ LC ) of 0.04 μg mL −1 by the method of SPME coupled with high performance of liquid chromatography (HPLC).
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CHIRALITY
·
2024
·Vol. 36
·期 3
·e23661
·
IF 2.8
Lixia Chen,Xiangjun Li
Given the markedly different pharmacological activities between enantiomeric isomers, it is crucial to encourage the stereoselective determination of chiral drugs in the biological and pharmaceutical fields, and the combination of drugs makes this analysis more complicated and challenging. Herein, a capillary electrophoresis (CE) method for the enantioseparation of ofloxacin and duloxetine was established, enabling the simultaneous identification of four isomers in nonracemic mixtures with enantiomeric excess (ee%) values exceeding 5%. This was achieved through the integration of theoretical simulation and electron circular dichroism (ECD), all without reliance on individual standards. Molecular modeling explained and verified the migration time differences of these isomers in electrophoretic separation. Moreover, the correlation coefficients ( R 2 ) between the enantiomeric peak area differentials and ee% were both above 0.99. Recovery rates were quantified using bovine serum as the matrix, with results ranging from 93.32% to 101.03% (RSD = 0.030) and 92.69% to 100.52% (RSD = 0.028) for these two chiral drugs at an ee value of 23.1%, respectively.
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JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Xiangyu Chen,Juanjuan Yao,Bin Xia,Jingye Gan,Naiyun Gao,Zhi Zhang
The influence of pH and dissolved oxygen (DO) on the degradation of ofloxacin (OFX) in water by UVA-LED/TiO 2 nanotube arrays photocatalytic fuel cell (UVA-LED/TNA PFC) was investigated. The degradation pathway depended on the location of OFX frontier orbital with different ionization states and the role of reactive oxidative species (ROSs) played with varied pH and DO values. In presence of DO, the quencher tests revealed that O 2 − played a key role at pH 3.0, 7.0 and 11.0, while OH made its greatest contribution at pH 3.0 and the effect of h + was largely inhibited at pH 11.0. Hydroxylation for cationic OFX was more significant, while demethylation and piperazinyl ring oxidation for anionic OFX occurred more quickly compared to other forms. Besides, zwitterionic OFX underwent decarboxylation and combination of demethylation & hydroxylation more easily. Much higher power generation was observed in presence of DO at pH 7.0, probably due to the enhanced adsorption of OFX on the TNA, and DO could amplify the electric potential between the two electrodes. The degradation efficiencies were almost the same in presence or absence of DO, but the pathways were different and e- aq may replace O 2 - as the leading ROSs in absence of DO.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Shilan A. Fatah,Khalid M. Omer
Ofloxacin (OFL), a broad-spectrum fluoroquinolone antibiotic, is widely utilized for treating bacterial infections. Accurate detection of OFL is essential for pharmaceutical quality control and environmental monitoring, particularly in wastewater. This study introduces a novel fluorescence-based detection method using sumac-derived carbon dots (S-CDs), synthesized via a simple hydrothermal approach. The S-CDs exhibited spherical morphology (20–30 nm) with blue fluorescence emission and a quantum yield of 1.4 %. Upon interaction with OFL, a remarkable fluorescence enhancement was observed, resulting in a 45-fold increase in quantum yield (45.0 %) accompanied by a red shift in the emission. This strong enhancement and red-shift emission enabled to design off–on mode for detection of OFL. The fluorescence intensity showed a strong linear correlation with OFL concentration (R 2 = 0.98) in the range of 1–90 nM, with a limit of detection (LOD) of 0.7 nM and a limit of quantification of 2.3 nM. Furthermore, a smartphone-assisted visual detection method was developed based on an off–on fluorescence mechanism. RGB analysis enabled real-time quantification of OFL, exhibiting a linear detection range of 20–80 µM with an LOD 0.97 µM. The method was successfully applied to detect OFL in eye drop formulations and tap water, demonstrating high accuracy and precision. These findings underscore the potential of S-CDs as a cost-effective, portable, and efficient tool for OFL detection, suitable for pharmaceutical and environmental monitoring applications.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Minghui Li,Daqi Chen,Yuhuai Guo,Tianxu Li,Wenjie Guo,Rui Feng,Dien Shao,Ziqi Jiang,Ye Li,Jie Zan
Residual quinolone antibiotics (lomefloxacin [LOM], ofloxacin [OFL], pefloxacin [PEF]) in food matrices present significant public health risks due to bioaccumulation and toxicity, necessitating field-deployable methods with superior sensitivity over conventional laboratory techniques. We developed a dual-mode lateral flow immunoassay (LFIA) integrating antibody-conjugated Au@4-ATP@AgNPs nanoprobes with machine learning (ML)-enhanced multi-peak surface-enhanced Raman scattering (SERS) analysis (1071, 1142, 1392, 1442, 1576 cm -1 ) for simultaneous quantification in milk. Results showed the dual-mode SERS-LFIA platform achieved limits of detection (LODs) of 2.94 pg/mL (LOM), 264 pg/mL (OFL), and 1.05 ng/mL (PEF)-representing 330-, 946-, and 476-fold improvements over conventional colorimetric LFIA (CM-LFIA), respectively, with recovery rates of 83.2-118.1% and reproducibility (CV < 13%) in complex milk matrices. ML-based multi-peak analysis reduced quantification error from 21-fold to 13-fold overestimation, compared to single-peak calibration. Overall, this ML-integrated SERS-LFIA delivers unprecedented sensitivity, accuracy, and field-deployability for quinolone residue monitoring in dairy products.
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ACS Omega
·
2026
·
IF 5.2
Xuan Liu,Liangliang Chang,Aiguo He,Zengzhe Xi,Chunsheng Zhou,Baoyue Cao
The persistence of fluoroquinolone antibiotics like OFL in aquatic environments poses a significant ecological and public health risk due to their poor biodegradability and potential to induce antibiotic resistance. This study reports the fabrication of free-standing, flexible nanofibrous films via electrospinning, incorporating optimal BGFZ9 nanoparticles into a P(VDF-HFP) matrix (denoted as P(VDF-HFP)@BGFZ9). Comprehensive characterization reveals that the BGFZ9 nanoparticles act as effective heterogeneous nucleating agents, significantly promoting the formation of piezoelectric β-phase in P(VDF-HFP) and enhancing the ferroelectric polarization of the composite through interfacial coupling. Under ultrasonic excitation, the composite film exhibits remarkable piezocatalytic performance for OFL degradation, following pseudo-first-order kinetics. The film with an optimal 10% BGFZ9 loading achieves a reaction rate constant of 0.684 min–1·g–1 under piezocatalysis, which is approximately 1.22 times higher than that of the pure polymer film. A synergistic piezophotocatalytic effect is observed under combined ultrasonic and light irradiation, leading to an OFL removal efficiency of 85.71% within 3 h and a further increased rate constant of 1.043 min–1·g–1. Radical scavenger experiments and EPR spectroscopy identify superoxide radicals •O2– and h+ as the primary reactive species responsible for the degradation. The composite film demonstrates excellent cycling stability, retaining 94.4% of its initial activity after five consecutive runs, alongside robust structural integrity. This work provides a novel strategy for developing efficient, stable, and easily recyclable flexible piezocatalytic materials for antibiotic wastewater remediation.
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