Nature Communications
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2022
·Vol. 13
·期 1
·1-10
·
IF 17.694
Yang Mingke,Wang Huishan,Zuo Julian Y.,Deng Chun,Liu Bei,Chai Liya,Li Kun,Xiao Han,Xiao Peng,Wang Xiaohui,Chen Wan,Peng Xiaowan,Han Yu,Huang Zixuan,Dong Baocan,Sun Changyu,Chen Guangjin
n-butane and isobutane are important petrochemical raw materials. Their separation is challenging because of their similar properties, including boiling point. Here, we report a zeolitic imidazolate framework-8 (ZIF-8)/N,N-Dimethylpropyleneurea (DMPU)-water slurry as sorption material to separate butane mixtures. The isobutane/n-butane selectivity of ZIF-8/DMPU-water slurries is as high as 890 with high kinetic performance, which transcends the upper limit of various separation materials or membranes reported in the literature. More encouragingly, a continuous pilot separation device was established, and the test results show that the purity and recovery ratio of isobutane product are 99.46 mol% and 87%, respectively, which are superior to the corresponding performance (98.56 mol% and 54%) of the industrial distillation tower. To the best of our knowledge, the use of metal-organic frameworks (MOFs) for gas separation in pilot scale remains underexplored, and thus this work provides a step forward to the commercial application of MOFs in gas separation.
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Nano-Micro Letters
·
2022
·Vol. 14
·期 1
·1-20
·
IF 23.655
Song Limeng,Zhang Fan,Chen Yongqiang,Guan Li,Zhu Yanqiu,Chen Mao,Wang Hailong,Putra Budi Riza,Zhang Rui,Fan Bingbing
Traditional ceramic materials are generally brittle and not flexible with high production costs, which seriously hinders their practical applications. Multifunctional nanofiber ceramic aerogels are highly desirable for applications in extreme environments, however, the integration of multiple functions in their preparation is extremely challenging. To tackle these challenges, we fabricated a multifunctional SiC@SiO 2 nanofiber aerogel (SiC@SiO 2 NFA) with a three-dimensional (3D) porous cross-linked structure through a simple chemical vapor deposition method and subsequent heat-treatment process. The as-prepared SiC@SiO 2 NFA exhibits an ultralow density (~ 11 mg cm − 3 ), ultra-elastic, fatigue-resistant and refractory performance, high temperature thermal stability, thermal insulation properties, and significant strain-dependent piezoresistive sensing behavior. Furthermore, the SiC@SiO 2 NFA shows a superior electromagnetic wave absorption performance with a minimum refection loss ( RL min ) value of − 50.36 dB and a maximum effective absorption bandwidth ( EAB max ) of 8.6 GHz. The successful preparation of this multifunctional aerogel material provides a promising prospect for the design and fabrication of the cutting-edge ceramic materials.
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PHARMACEUTICAL RESEARCH
·
2022
·Vol. 39
·期 9
·2263-2276
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IF 4.58
He Xiaoshuang,Wei Yuanfeng,Wang Shiru,Zhang Jianjun,Gao Yuan,Qian Shuai,Pang Zunting,Heng Weili
Honokiol (HK), a BCS class II drug with a wide range of pharmacological activities, has poor solubility and low oral bioavailability, severely limiting its clinical application. In the current study, incorporating a water-soluble meglumine (MEG) into the crystal lattice of HK molecule was performed to improve its physicochemical properties. The binary mixture of HK and MEG was obtained by anti-solvent method and characterized by TGA, DSC, FTIR, and PXRD. The SCXRD analysis showed that two HK − molecules and two MEG + molecules were coupled in each unit cell via the ionic interaction along with intermolecular hydrogen bonds, suggesting the formation of a salt, which was further confirmed by the XPS measurements. However, the ∆pK a value between HK and MEG was found to be less than 1, which did not follow the oft-quoted ∆pK a rule for salt formation. After salification with MEG, the solubility and dissolution rate of HK exhibited 3.50 and 25.33 times improvement than crystalline HK, respectively. Simultaneously, the powder flowability, tabletability and stability of HK-MEG salt was also significantly enhanced, and the salt was not more hygroscopic, and that salt formation did not compromise processability in that regard. Further, in vivo pharmacokinetic study showed that C max and AUC 0-t of HK-MEG salt were enhanced by 2.92-fold and 2.01-fold compared to those of HK, respectively, indicating a considerable improvement in HK oral bioavailability.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2022
·Vol. 33
·期 23
·18758-18767
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IF 2.779
Yang Akang,Zhang Lun,Xu Yinyan,Wang Qian,Lyu Mei,Lu Hongbo,Zhu Jun
Cs 2 AgBiBr 6 is a lead-free perovskite that shows great potential to solve the toxicity and instability of organic–inorganic lead perovskite. However, because of the poor interface contact and inferior film quality, the open-circuit voltage and the power conversion efficiency of the solar cells are inhibited. Herein, the Cs 2 AgBiBr 6 film quality is improved by adding formamidinium acetate into the precursor solution. With additive regulation, the grain size increases and the film surface is more smooth. The crystal structure remains unchanged, and the defect density decreases. Correspondingly, the average power conversion efficiency of the target device increases more than 30% than the control device. The best efficiency approaches 2.09%, and the open-circuit voltage is surprisingly high at 1.23 V, the highest value reported for Cs 2 AgBiBr 6 solar cells. Moreover, the device remains more than 90% of its initial efficiency after 40 days of storage under environmental conditions, showing excellent stability. This work is therefore helpful for enhancing the efficiency and stability of inorganic lead-free perovskite solar cells toward future commercialization.
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CHINESE JOURNAL OF POLYMER SCIENCE
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2022
·Vol. 40
·期 11
·1380-1388
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IF 3.815
Gao Meng-Hang,Feng Wen,Qi Xiao-Dong,Wang Yong
Developing thermal management fabrics with good energy storage and multistimuli responsive properties is important for regulating the body temperature in complex environment. Herein, the intelligent nonwoven membranes were fabricated via a coaxial electrospinning method, resulting in a core-sheath structure with poly(ethylene glycol) (PEG) as core and polyurethane (PU) as sheath. Additionally, polypyrrole (PPy) with good light absorption ability and electrical conductivity was deposited onto the surface of the PU@PEG electrospun fibers via electrochemical polymerization. The PPy layer enabled the membranes to respond quickly to sunlight and electrical stimuli. The membranes could heat up to 86 °C under simulated sunlight within 200 s or produce remarkable electrothermal effect under a low voltage input of only 1 V, exhibiting efficient energy conversion and storage performances. The photothermal and electrothermal conversion effect could be easily adjusted by controlling the polymerization time of PPy. Therefore, the multifunctional membranes with high latent heat, good mechanical properties as well as excellent photothermal/electrothermal conversion ability are promising in personal thermal management applications.
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Microsystems & Nanoengineering
·
2022
·Vol. 8
·期 1
·1-10
·
IF 8.006
Sun Hao,Fang Xudong,Fang Ziyan,Zhao Libo,Tian Bian,Verma Prateek,Maeda Ryutaro,Jiang Zhuangde
Flexible strain sensors are promising candidates for intelligent wearable devices. Among previous studies, although crack-based sensors have attracted a lot of attention due to their ultrahigh sensitivity, large strain usually causes fractures in the conductive paths. Because of the unstable crack structure, the tradeoff between sensitivity and workable strain range is still a challenge. As carbon nanotubes (CNTs) and silver nanowires (AgNWs) can form a strong interface with the thermoplastic substrate and strengthen the conductive network by capillary force during water evaporation, CNTs and AgNWs were deposited on electrospun TPU fiber mats via vacuum-assisted filtration in this work. The prestretching treatment constructed a microcrack structure that endowed the sensor with the combined characteristics of a wide working range (0~171% strain), ultrahigh sensitivity (a gauge factor of 691 within 0~102% strain, ~2 × 10 4 within 102~135% strain, and > 11 × 10 4 within 135~171% strain), a fast response time (~65 ms), small hysteresis, and superior durability ( > 2000 cycles). Subsequently, the sensing mechanism of the sensor was studied. Distributed microcrack propagation based on the “island-bridge” structure was explained in detail, and its influence on the strain-sensing behavior of the sensor was analyzed. Finally, the sensor was assembled to monitor various vibration signals and human motions, demonstrating its potential applications in the fields of electronic skin and human health monitoring.
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Applied Nanoscience
·
2022
·Vol. 12
·期 12
·3995-4004
·
IF 3.869
Bao Li-hong,Wen Yu-xin,Ling Jia-wen,Guan Fang-lan,Nie Jin-mei,Zhang Mei
In this study, titanium dioxide (TiO 2 ) and graphene oxide (GO) were used to make a titanium dioxide/reduced graphene oxide (TG) composite under hydrothermal condition, and the TG composite was subsequently dye-sensitization (DTG). TEM, XRD, Raman, XPS, and UV–vis DRS spectroscopy were used to examine the structure and morphology of DTG, and the results revealed that the grafting rate of dye molecules on TG was approximately 20.4% and the band-gap value for TiO 2 , TG and DTG were 3.21, 3.03, 2.57 eV, respectively. The photocatalytic performances of DTG, TG, and TiO 2 were investigated under the illumination of a xenon lamp, and it was discovered that the final removal rates of MB by TiO 2 and TG were only 21.53% and 50.37%, but DTG can remove 97.67% of MB, the COD value of the effluent decreased by 88.24%. Furthermore, the elimination rate of MB maintained over 90% after 5 cycles of photocatalytic tests, indicating that DTG had good endurance.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2022
·Vol. 33
·期 30
·23566-23579
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IF 2.779
Guo Qiwen,Liu Siyuan,Men Xinpeng,Chen Zhe,Yao Lei,Wang Geming,Zhao Hongyang,Lin Zhidong,Wu Qian
In this paper, an ultra-sensitive glassy carbon electrode modified with β-cyclodextrin and graphene oxide (β-CD-GO/GCE) has been prepared for the detection of biomolecules [ascorbic acid (AA), dopamine (DA) and uric acid (UA)] in aqueous solution at μM level. The three biomolecules (AA, DA and UA) can be simultaneously detected by the modified electrodes, and the electrical signals corresponding to various biomolecules can be identified clearly in cyclic voltammetry and differential pulse voltammetry curves. The simultaneous detection limits of AA, DA, UA were 4.58, 1.56, 1.27 μM, respectively. This ultra-sensitivity should be attributed to the formation of host–guest complexes between β-CD and the biomolecules. Furthermore, the anti-interference experiments indicated the β-CD-GO/GCE exhibited satisfactory selective recognition performance.
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Signal Transduction and Targeted Therapy
·
2022
·Vol. 7
·期 1
·1-17
·
IF 38.104
Zeng Hao,Pan Ting,Zhan Meiling,Hailiwu Renaguli,Liu Baolin,Yang Hua,Li Ping
Endothelial-to-mesenchymal transition (EndoMT), the process wherein endothelial cells lose endothelial identity and adopt mesenchymal-like phenotypes, constitutes a critical contributor to cardiac fibrosis. The phenotypic plasticity of endothelial cells can be intricately shaped by alteration of metabolic pathways, but how endothelial cells adjust cellular metabolism to drive EndoMT is incompletely understood. Here, we identified 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) as a critical driver of EndoMT via triggering abnormal glycolysis and compromising mitochondrial respiration. Pharmacological suppression of PFKFB3 with salvianolic acid C (SAC), a phenolic compound derived from Salvia miltiorrhiza , attenuates EndoMT and fibrotic response. PFKFB3-haplodeficiency recapitulates the anti-EndoMT effect of SAC while PFKFB3-overexpression augments the magnitude of EndoMT and exacerbates cardiac fibrosis. Mechanistically, PFKFB3-driven glycolysis compromises cytoplasmic nicotinamide adenine dinucleotide phosphate (reduced form, NADPH) production via hijacking glucose flux from pentose phosphate pathway. Efflux of mitochondrial NADPH through isocitrate/α-ketoglutarate shuttle replenishes cytoplasmic NADPH pool but meanwhile impairs mitochondrial respiration by hampering mitochondrial iron-sulfur cluster biosynthesis. SAC disrupts PFKFB3 stability by accelerating its degradation and thus maintains metabolic homeostasis in endothelial cells, underlying its anti-EndoMT effects. These findings for the first time identify the critical role of PFKFB3 in triggering EndoMT by driving abnormal glycolysis in endothelial cells, and also highlight the therapeutic potential for pharmacological intervention of PFKFB3 (with SAC or other PFKFB3 inhibitors) to combat EndoMT-associated fibrotic responses via metabolic regulation.
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MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 9
·1-10
·
IF 6.408
Wang Yuexin,Chen Rui,Shen Bo,Li Cai,Chen Junman,Wang Yanshuang,Tian Shen,Li Xuemiao,Luo Nini,Liu Rui,Ding Shijia,Zhu Chuanlong,Xia Qianfeng
A multifunctional catalytic nanomaterial (Co-MOF@AuNP@ABEI) composed of cobalt-doped metal–organic frameworks (Co-MOF), gold nanoparticles (AuNP), and N -(4-aminobutyl)- N -(ethylisoluminol) (ABEI) is reported. Co-MOF@AuNP@ABEI exhibits high synergistic and zero-distance catalytic properties, which are beneficial to the improvement of the detection sensitivity of an electrochemiluminescent (ECL) biosensor. After coupling with the ECL system and 3D magnetic walking nanomachine amplification strategy, the Co-MOF@AuNP@ABEI can achieve an ultrasensitive ECL assay of Burkholderia pseudomallei with the limit of detection (LOD) of 60.3 aM, which is 2 and 4 orders of magnitude lower than individual ECL system without the nanomachine (4.97 fM) and individual walking nanomachine (340 fM), and superior to the pathogenic bacteria analyses in the previous report. Moreover, the LOD of the proposed ECL detection system for the determination of B. pseudomallei in serum sample was as low as 9.0 CFU mL −1 . The relative standard deviations (RSD) of ECL intensity for the detection of five B. pseudomallei -spiked serum samples were 4.02%, 0.84%, 0.84%, 1.55%, and 0.21%, respectively. The recoveries of the ECL biosensor for the detection of B. pseudomallei DNA-spiked serum samples were 93.63 ~ 107.83%. Therefore, this work demonstrated that the developed multifunctional catalytic nanomaterial with synergistic and zero-distance catalytic properties can be used as excellent ECL signal reporter to improve the detection sensitivity of ECL biosensor. Graphical abstract
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MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 9
·1-9
·
IF 6.408
Yang Fei,Wu Xiaohong,Li Chen,Chen Yuxiao,Liu Shu,Zhang Cuiling,Xian Yuezhong
A new coordination polymer (Ce-Fe-GMP) with excellent catalytic activity was prepared by a facile route, which was further applied to the detection of F − with high sensitivity and selectivity. The simple doping of Fe 3+ into the coordination network can easily modulate the mixing ratio of Ce 3+ and Ce 4+ in the presence of H 2 O 2 , which can extremely improve the catalytic ability of Ce-Fe-GMP. Based on the synergistic effect, the Ce-Fe-GMP with dual-active sites shows better peroxidase activity than that of Ce-GMP. In addition, we found that F − can inhibit the peroxidase activity of Ce-Fe-GMP because of the coordination structure fragmentation and the regulation of Ce 3+ /Ce 4+ ratio. Therefore, different concentrations of F − can be detected by the colorimetric reaction based on this mechanism. The absorption at 652 nm displays a good linear relationship versus the concentration of F − over the range 2.0 to 100.0 μM. Furthermore, F − in real mineral-mixed samples can be measured with satisfactory results. The colorimetric strategy based on the peroxidase activity of Ce-Fe-GMP is simple and low-cost, which shows the potential applications in the field of on-site environment measurement. Graphical abstract
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POLYMER BULLETIN
·
2022
·Vol. 80
·期 7
·7927-7947
·
IF 2.843
Wang Qian,Zhu Sining,Xi Chen,Zhang Fan
A novel crosslinked hyperbranched polyamide-amines adsorbent (CHAP-SH) with sulfhydryl functional groups was synthesized by modifying thiourea and its selective adsorption properties for Cu (II) were studied. The adsorption of coexisting ions showed that the CHAP-SH had high adsorption capacity and selectivity for Cu (II). The adsorption characteristics and mechanism of the CHAP-SH for Cu (II) were systematically investigated. The results of shake flask adsorption experiments indicated that the adsorption procedure was well adapted to the Langmuir isotherm and pseudo-second-order kinetics models, and the maximum adsorption capacity of Cu (II) was 158.48 mg/g at pH = 5.0 and 45 ℃. The adsorption mechanism of the CHAP-SH for Cu (II) was mainly the synergistic interaction with –NH, –COO − , and –SH functional groups. After seven adsorption/desorption cycles, it could still maintain a high removal rate, which provided great potential for the development of multiple novel and reusable immobilized functional materials to efficiently isolate the Cu (II) ions.
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