ANALYTICAL SCIENCES
·
2026
·
IF 2
Cheng Shipei,Liang Jinhua,Huang Guidan,Ye Hongying,Yang Mengdan,Lin Bingjian,Nie Jinfang,Zhu Wenyuan,Zhang Yun
A novel colorimetric sensing platform was developed for rapid detection of L-cysteine (L-Cys) in human serum and milk samples, utilizing L-glutamic acid-coated Fe 3 O 4 quantum dots (Glu-Fe 3 O 4 QDs) with enhanced peroxidase-like activity. The Glu-Fe 3 O 4 QDs were synthesized via a two-step hydrothermal method, where L-glutamic acid modification significantly improved both catalytic performance and stability compared to unmodified Fe 3 O 4 nanoparticles. Characterization by TEM, XPS, and FTIR confirmed the ultrasmall size (2.57 ± 0.78 nm) and successful surface functionalization with carboxyl/amino groups. The nanozymes catalyzed the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of H 2 O 2 , generating a blue color change measurable at 652 nm. L-Cys suppressed this reaction by competitively consuming hydroxyl radicals, enabling quantitative detection with a linear range of 5–50 µM (R 2 = 0.997) and a low detection limit of 0.73 µM. The method exhibited high selectivity against interfering amino acids and ions, and achieved recoveries of 96.99–107.59% in spiked serum and milk samples with RSDs < 3.86%. This work provides a simple, cost-effective tool for monitoring L-Cys in complex biological matrices, with potential applications in food safety and clinical diagnostics. Graphical abstract The alternative text for this image may have been generated using AI. Ultrasmall L-glutamic acid-coated Fe3O4 quantum dots (Glu-Fe3O4 QDs) were synthesized, exhibiting enhanced peroxidase-like activity that catalyzes TMB-H2O2 chromogenic reaction. The system enables rapid colorimetric detection of L-cysteine in human serum and milk with high selectivity and a detection limit of 0.73 μM
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Tonggong Liu,Wenjuan Liu,Ziyuan Peng,Jie Wen,Shengjie Wu,Xiaona Zhao,Jingzhe Wang,Dayong Gu
Viral myocarditis (VMC), caused by pathogens such as coxsackievirus B3 (CVB3), leads to severe cardiac injury and currently lacks specific therapeutic options. Here, we report a biomimetic antiviral strategy based on receptor engineering and intracellular gelation. By combining genetic and protein engineering, we generated a high-affinity Coxsackievirus and adenovirus receptor mutant (Mut-1_CAR) that markedly enhances the binding of host cardiomyocytes to CVB3. Using photochemical crosslinking, these engineered cells were converted into structurally stable, function-retaining gelated cells (PMs). PMs efficiently adsorb and neutralize virus particles, significantly reducing CVB3 plaque formation in vitro. In a murine model of viral myocarditis, PMs demonstrated excellent in vivo safety and biocompatibility while effectively lowering viral load and mitigating myocardial injury. This study establishes a "receptor enhancement + function fixation" approach for non-immune-dependent viral neutralization, providing a conceptual and technical foundation for the development of novel cell-based biomimetic antiviral therapies.
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COLLOID AND POLYMER SCIENCE
·
2026
·
IF 2.9
Zhou Lu,Yu Xiaozhou,Lyu Shuxiang,Liao Xiaoyuan,Li Zhen,Yao Yue,Zhang Haoling
A novel small-caliber vascular prosthesis prototype (SCVPs) with antibacterial application is proposed based on the controlled delivery of heparin from ZIF@polymer monolith. The traditional powdery small-caliber vascular prosthesis material has the disadvantages of difficult separation and easy agglomeration, which limits its applications. Heparin (HP)-loaded porous ZIF-8/Polymer (PEG, PVA, and PVP) monoliths were fabricated using a freeze-casting method in liquid nitrogen (− 196 ℃) for controlled heparin release and sterilization. The incorporation of ZIF-8/Polymer significantly improved the antibacterial performance of the samples, prolonged the slow-release time of heparin sodium, and also resulted in better mechanical properties. The samples synthesized at a heparin sodium concentration of 0.36 mg·mL −1 exhibited good sustained release of heparin sodium when used as artificial antigenic matrix. Among these materials, the cured HP@ZIF-8 sample had a retarded release time of up to 15 h, with a cumulative release of 223.56 μg at 24 h. With PVA as the optimal polymer, heavy metal ions from the cured HP@ZIF-8 material can cause severe toxic damage to the internal structure of bacteria, interfere with bacterial metabolism, and thus show obvious antibacterial effects.
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MOLECULAR AND CELLULAR BIOCHEMISTRY
·
2026
·
IF 4.7
Li Sijie,Huang Huanhuan,Feng Jiahui,Gu Qiang,Sun Daquan
Hepatocellular carcinoma (HCC) ranks among the most lethal cancers, and its dismal prognosis underscores the urgent need to elucidate the underlying carcinogenic mechanisms. Endoplasmic reticulum lipid rafts associated protein 2 (ERLIN2), an endoplasmic reticulum protein, has been implicated in various malignant tumors. However, its functional role in HCC remains poorly understood. Here, we found elevated ERLIN2 expression and N-glycosylation modification at asparagine 106 (N106) in HCC. We identify site-specific N-glycosylation as a crucial advantage of ERLIN2 that may result in aberrant cancer cell growth. Overexpression of either N-glycosylated ERLIN2 (wild-type, WT) or an asparagine-to-glutamine mutant (N106Q) in HCC cell lines indicated that N106 N-glycosylation of ERLIN2 acts as an important advantage in the tumorigenesis and triggers aberrant cell proliferation, migration, and invasion. Furthermore, we found that E3 ubiquitin ligase membrane-associated ring-CH-type finger protein 6 (MARCHF6) can mediate the ubiquitination degradation of ERLIN2, and this effect is more significant after the N-glycosylation at the N106 site is inhibited. In addition, excessive N-glycosylation at this site enhanced the interaction between ERLIN2 and cyclin B1 (CCNB1), leading to dysregulated CCNB1 expression and further accelerating the progression of HCC. Comprehensive studies confirm that N-glycosylation is a significant post-translational modification of ERLIN2 in HCC, and elucidating this mechanism may pave the way for the development of novel therapeutic strategies in the future.
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Nano-Micro Letters
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2026
·Vol. 18
·期 1
·128
·
IF 36.3
Wang Wenqiang,Luo Zebang,Yu Xingge,Yin Xiaojia,Xiang Li,Pan Anlian
Breathable and Stretchable 3D Electronics Electrospun SEBS nanofiber mats combined with sub-50 μm liquid metal patterning yield ultrahigh permeability (5.09 mL cm −2 min −1 , 2520 g m −2 day −1 ) and mechanical robustness (750% strain), ensuring zero skin irritation after 1 week.
Stable Vertical Interconnects Strain isolators (SIL) decouple substrate deformation from vertical interconnects, maintaining conductivity under 750% strain and >32,500 cycles, surpassing conventional multilayer systems (<250% strain).
Gesture Recognition Assistive Glove A wireless glove integrating 5 strain sensors, a three-axis accelerometer, and CNN-based learning (98% accuracy) enables real-time robotic hand control, with direct relevance to rehabilitation, prosthetics, and human–robot collaboration.
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JOURNAL OF MATERIALS SCIENCE
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2026
·
IF 3.9
Feng Mingyue,Li Chixuan,Li Furu,Zhang Chengqian,Ren Yan
Although perovskite crystals exhibit defect tolerance, the presence of crystal defects may still compromise their photodetection performance. In this paper, we study the solution growth of high-quality δ-CsPbI 3 single-crystalline fibers (SCFs), and highlight the impact of crystal quality on the enhancement of the photodetector performances. To achieve high-quality δ-CsPbI 3 SCFs, a seeded growth of δ-CsPbI 3 SCFs is carried out using an optimized HI-DMF growth protocol. In this protocol, fiber seeds picked in HI aqueous solution are seeded to grow in DMF solution. As a result, high-quality flexible δ-CsPbI 3 SCFs with a large length-to-width ratio are obtained. The photodetector fabricated with the high-quality SCF in an Ag/CsPbI 3 /Ag architecture exhibits a low dark current, excellent device stability, a higher signal-to-noise ratio and a ninefold enhancement in photo-responsivity compared with the detector made using defective crystal. These findings establish a critical link between crystal perfection and advanced photodetector functionality, offering new avenues for high-performance X-ray detection technologies. Graphical abstract
CsPbI 3 single-crystalline fibers prepared by seeded growth exhibit high crystal quality, excellent flexibility and enhanced photodetection performance.
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Microsystems & Nanoengineering
·
2026
·Vol. 12
·期 1
·1
·
IF 9.9
Lin Zhanhong,Zhang Dongxing,Ding Wangwang,Feng Junyu,Yu Linghao,Wang Zilai,Zhang Naibo,Guo Qiuquan,Yang Jun
This paper proposes a novel 3D printing technology for fabricating high-performance volumetric electronic circuits. It introduces a particle-free conductive system based on a nontoxic reductant-functionalized polymer coating, offering a microscopic localized enhancement technique. By in-situ reducing silver onto custom-designed substrates, highly conductive and controllable coatings are formed, allowing frequency selective surfaces (FSS) to be extended from planar to spatial volumes (3DFSS). As a result, more desirable FSS characteristics can be achieved, such as significantly stable filtering performance for different incident angles and polarization modes of electromagnetic waves regardless of obliquity, compared to corresponding 2DFSS. The proposed FSS achieves a bandwidth of 4.4–7.8 GHz (fractional bandwidth of 54.8%) with a reflection coefficient below −10 dB. Design guidelines based on the equivalent circuit model (ECM) illustrate the transition from this 3DSS to a filter response. The designed array FSS boasts excellent structural compactness and mechanical robustness, enabling seamless integration with building materials. It provides electromagnetic signal modulation across scales, offering a technological solution for electromagnetic compatibility and signal transmission quality issues in miniaturized communication systems.
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International Journal of Minerals Metallurgy and Materials
·
2022
·Vol. 29
·期 4
·662-670
·
IF 3.85
Liu Zhenxing,Deng Fangjie,Zhou Yuan,Liang Yanjie,Peng Cong,Peng Bing,Zhao Feiping,Yang Zhihui,Chai Liyuan
Cubic boron arsenide (BAs) has attracted great attention due to its high thermal conductivity, however, its controllable, stable, and ideal preparation remains challenging. Herein, we investigated the effect of iodine-containing transport agents I 2 and boron triiodide (BI 3 ) on BAs synthesized and grown through chemical vapor transport. Results show that similar to the commonly used I 2 , BI 3 accelerates the synthesis and improves the mass fraction of BAs from ∼12% to over 90% at 820°C and 1.5 MPa, a value beyond the promoting effect of only increasing temperature and pressure. Both agents enhance the quality of BAs crystals by reducing the full width at half maximum by up to 10%–20%. I 2 agglomerates the grown crystals with twin defects (∼50 nm wide), and BI 3 improves the crystal anisotropy and element uniformity of BAs crystals with narrow twins (∼15 nm wide) and increases the stoichiometry ratio (∼0.990) to almost 1. Owing to the boron interstitials from the excessive boron supply, the spacing of layers in {111} increases to 0.286 nm in the presence of I 2 . Owing to its coordinated effect, BI 3 only slightly influences the layer spacing at 0.275 nm, which is close to the theoretical value of 0.276 nm. In the chemical vapor transport, the anisotropic crystals with flat surfaces exhibit single-crystal characteristics under the action of BI 3 . Different from that of I 2 , the coordinated effect of BI 3 can promote the efficient preparation of high-quality BAs crystal seeds and facilitate the advanced application of BAs.
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BIOGERONTOLOGY
·
2026
·Vol. 27
·期 2
·72
·
IF 5.3
Zhang Xiaoli,Wang Chengniu,Chen Weiguan
Aging is a major risk factor for the onset and progression of many neurodegenerative diseases. Inflammation is the body’s natural defense mechanism against harmful stimuli . A growing body of research has highlighted the intricate relationship between aging and inflammation, with chronic low - grade inflammation, often referred to as “inflammaging,” being a hallmark of the aging process. Cycloneolitsol (CL) is a C-32 cycloartane-type triterpene from Taxodium ascendens which has been reported to possess the anticancer, neuroprotection and antibacterial activities. Its specific role and the underlying molecular mechanisms in modulating the aging process remain unclear. Our study aimed to explore the possible anti-aging effect and mechanisms of CL. Network pharmacology predicted core targets and several potential pathways, which are associated with the anti-aging effect of CL. RAW264.7 macrophages and Caenorhabditis elegans were selected for evaluating its anti-aging and anti-inflammation activity. The results showed that CL exerted obvious anti-inflammatory effects against LPS-induced M1-type polarization of RAW264.7 cells via NF-κB signaling pathway. In C. elegans , CL improved Biological Characteristics and prolonged the lifespan without reproductive toxicity. Furthermore, experiments on different mutant C. elegans strains and the nuclear translocation of SKN-1 confirmed that CL activates autophagy and enhances the antioxidant stress response ability through the SEK-1/PMK-1/SKN-1 signaling pathway. This study provides novel insights into the biological activities of CL, highlighting its potential as a natural product for treating inflammation-related diseases and delay aging.
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CATALYSIS LETTERS
·
2026
·Vol. 156
·期 4
·101
·
IF 2.5
Zou Congyang,Liu Ruijie,Yang Mingjie,Tian Jie,Wang Yujie
Exploring stable and efficient photocatalysts to promote the photo-oxidative degradation of volatile organic compounds (VOCs) is essential for air pollution control. In this study, MIL-101(Fe) modified with silver nanoparticles (Ag NPs) was synthesized via a simple solvothermal method. Under visible light irradiation for 90 min, the optimal catalyst MF/Ag-5% composite achieved a styrene conversion rate of 91.8%, with a corresponding kinetic rate constant of 0.022 min⁻ 1 . Moreover, the catalyst retained its photocatalytic activity over four consecutive cycles. The results indicate that the incorporated Ag NPs effectively extract photogenerated electrons from MIL-101(Fe), thereby promoting efficient charge carrier separation. Additionally, the localized surface plasmon resonance (SPR) effect of Ag NPs extends the light absorption range of MIL-101(Fe), facilitating the generation of reactive species such as hydroxyl radicals (·OH) and superoxide anion radicals (·O₂⁻). This work offers a novel approach for designing highly efficient and stable photocatalysts for air purification applications.
Section
Graphical
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CELLULAR AND MOLECULAR LIFE SCIENCES
·
2026
·
IF 6.5
Huang Yafei,Liu Hong,Tong Chao,Wang Zhimin,Xu Miaomiao,Dong Mengqi,Rao Rongjia,Wang Xianqiang,Feng Wei,Hu Zhan,Xu Fei,Zhao Wei,Wang Li,Hu Shengshou,Zhou Bingying
Drug-induced mitochondrial toxicity is a major contributing factor to cardiotoxicity, which can cause drug attrition and adverse cardiac events. To assess the toxicity of anti-inflammatory agents, we used adult human primary cardiomyocytes (hPCMs) to screen 18 clinically available anti-inflammatory drugs in a high-content manner, and revealed widespread mitochondrial dysfunction without affecting cell viability. Nabumetone, a representative nonsteroidal anti-inflammatory drug with profound mitochondrial toxicity, induced mitochondrial fission, inhibited mitophagy, and impaired both electrophysiological and metabolic functions in adult hPCMs. Mechanistically, we uncovered that nabumetone (Nab) exerted its toxic effects through the prostaglandin E2- E-type prostanoid receptor 4 (PGE 2 -EP 4 ) pathway, which was essential for its anti-inflammatory functions. To find an alternative route to ameliorate mitochondrial damage, we identified SIRT3 as a downstream target of nabumetone. Its mRNA, protein, and activity levels were significantly reduced upon nabumetone treatment. SIRT3 activator honokiol exhibited protective potential against NSAID-induced mitochondrial toxicity both in hPCMs and in nabumetone-treated mice. Finally, through screening mitochondrial liability in various common cardiomyocyte models, we identified mitochondrial abundance as an important determinant of the sensitivity of cells towards mitochondrial toxicants. Our study demonstrates the vast presence of mitochondrial dysfunction in human adult cardiomyocytes imposed by clinically used anti-inflammatory drugs, and identified both toxicity and protective pathways that may serve future therapeutic purposes.
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JOURNAL OF CHEMICAL SCIENCES
·
2026
·Vol. 138
·期 1
·15
·
IF 1.8
Wang Kun-Peng,Liu Jie,Chen Xi,Wu Gui-Lin,Zhang Er-Ji,Deng Tian-Song
Gold nanorods, as a type of anisotropic nanoparticles, require uniformity for their properties and applications. Here, we demonstrate the successful preparation of well-dispersed and uniformly shaped GNRs through a two-step seed-mediated growth method by separating the symmetry breaking of seeds from subsequent growth. We determined that adding the first growth solution (Solution A) into the second growth solution (Solution B) after 30 min was optimal, and monitored the growth progress by recording the growth status every 30 min, observing that the growth of Solution A (150 min) and Solution B (210 min) essentially ceased. Furthermore, by adjusting the seed quantity, silver ion content, and pH value of the growth solution in each step, we could tune the wavelength of the localized surface plasmon resonance (LSPR) peak within the range of 668 to 1020 nm. Additionally, the trend of overall electric field intensity variations were determined through finite difference time domain (FDTD) simulations. We believe that this approach will further facilitate practical applications of GNRs research, as these applications rely on the high uniformity of GNRs. Graphical abstract Synopsis .
We demonstrate the preparation of uniformly shaped gold nanorods through a two-step seed-mediated growth method by separating
the symmetry breaking of seeds from subsequent growth. By adjusting the seed quantity, Ag + content, and pH value of the growth
solution, we could tune the LSPR from 668 to 1020 nm.
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