MOLECULES
·
2024
·Vol. 29
·期 3
·715
·
IF 4.2
Zhe Li,Xiaosui Luo,Qiong Li,Zhengji Jin,Abid Naeem,Weifeng Zhu,Lihua Chen,Yi Feng,Liangshan Ming
Porous materials are widely used as an effective strategy for the solubilization of insoluble drugs. In order to improve the solubility and bioavailability of low water-solubility drugs, it is necessary to prepare porous materials. Mannitol is one of the most popular excipients in food and drug formulations. In this study, porous mannitol was investigated as a drug carrier for low water solubility drugs. Its fabrication, drug loading, and drug release mechanisms were investigated. Porous mannitol was fabricated using the co-spray–antisolvent process and utilizing polyvinylpyrrolidone K30 (PVP K30) as the template agent. Porous mannitol particles were prepared by changing the proportion of the template agent, spraying the particles with mannitol, and eluting with ethanol in order to regulate their pore structure. In subsequent studies, porous mannitol morphology and characteristics were determined systematically. Furthermore, curcumin and ibuprofen, two poorly water-soluble drugs, were loaded into porous mannitol, and their release profiles were analyzed. The results of the study indicated that porous mannitol can be prepared using PVP K30 as a template and that the amount of template agent can be adjusted in order to control the structure of the porous mannitol. When the template agent was added in amounts of 1%, 3%, and 5%, the mannitol pore size increased by 167.80%, 95.16%, and 163.98%, respectively, compared to raw mannitol. Molecular docking revealed that mannitol and drugs are adsorbents and adhere to each other by force interaction. The cumulative dissolution of curcumin and ibuprofen-loaded porous mannitol reached 69% and 70%, respectively. The release mechanism of curcumin and ibuprofen from drug-loaded mannitol was suitable for the Korsmeyer–Peppas kinetic model. In summary, the co-spray–antisolvent method proved effective in fabricating porous materials rapidly, and porous mannitol had a remarkable effect on drug solubilization. The results obtained are conducive to the development of porous materials.
研究领域:
药剂学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Qiaoshan Chen,Yueling Chen,Mingfei Yu,Bin Xu,Houyi Wu,Liuyi Li,Jinhong Bi
A metal–insulator-semiconductor (MIS) ternary photo-system was intricately crafted through precise amalgamation polyvinylpyrrolidone (PVP)-capped metal Cu with typical covalent triazine framework CTF-1 via electrostatic self-assembly. The 2 % Cu-PVP-CTF exhibited an impressive CH 4 yield of 80.7 μmol·g −1 ·h −1 with selectivity of 96.8 % under visible light, representing a 2.3-fold and 112-fold improvement over Schottky-type Cu-CTF and pristine CTF-1, respectively. In-situ XPS and VASP-diff calculations unfolded that the ultrathin PVP insulating layer significantly expedited interfacial charges tunneling, corroborated by smaller lifetime τ 2 determined via femtosecond transient absorption spectroscopy. The intermediates of paramount importance in CO 2 reduction like *COOH and *HCHO were meticulously monitored by in-situ Fourier infrared spectroscopy. DFT calculations elucidated that Cu-PVP-CTF was notably more adept at facillitating the rate-determining step (*COOH → *CO) to produce CH 4 than Cu-CTF. This work tamps the groundwork for conceptional roadmap in designing novel MIS photo-system for CO 2 conversion.
研究领域:
材料科学
·
催化化学
·
能源转换
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产品关联
DOI
高影响因子
Materials Today Bio
·
2023
·
IF 8.2
Chuan Xie,Qinqin Xiong,Yuanzhi Wei,Xin Li,Jiajun Hu,Min He,Shinan Wei,Jia Yu,Sha Cheng,Mashaal Ahmad,Yufei Liu,Sihai Luo,Xi Zeng,Jie Yu,Heng Luo
Sustained drug release has attracted increasing interest in targeted drug therapy. However, existing methods of drug therapy suffer drug action time, large fluctuations in the effective concentration of the drug, and the risk of side effects. Here, a biodegradable composite of polybutylene adipate co-terephthalate/polyvinylpyrrolidone (PBAT/PVP) consisting of electrospun hollow microspheres as sustained-released drug carriers is presented. The as-prepared PBAT/PVP composites show faster degradation rate and drug (Erlotinib) release than that of PBAT. Furthermore, PBAT/PVP composites loaded with Erlotinib provide sustained release effect, thus achieving a better efficacy than that after the direct injection of erlotinib due to the fact that the composites allow a high drug concentration in the tumor for a longer period. Hence, this work provides a potential effective solution for clinical drug therapy and tissue engineering using drug microspheres with a sustained release.
研究领域:
药剂学
·
材料科学
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2022
·Vol. 33
·期 17
·14228-14239
·
IF 2.779
Liu Jieling,Yang Jiaji,An Shuyue,Wen Meiqi,Wang Xian,Gong Rongzhou,Nie Yan
Metal-organic framework (MOF) crystals have promising applications in a number of different fields, but the growth of MOF crystals with controllable morphology and high uniformity remains a major challenge. By taking the advantage of the synergistic effects of water molecules in the mixed solvent and polyvinylpyrrolidone (PVP) surfactants, this work demonstrates an approach for the preparation of NH 2 -MIL-88B(Fe) MOF crystals with both highly customizable size and aspect ratios and high uniformity. The effects of the concentration of water in the mixed solvent and the amount of PVP surfactants on the morphology and size of the MOF crystals were investigated. The morphology and crystalline properties were characterized by scanning electron microscopy and X-ray diffraction techniques. The data showed that through controlling the concentration of water in the solvent and the amount of the PVP surfactant, the size of the MOF crystals can be tuned rather widely, over 344–5.14 μm, while the aspect ratio of the crystals can be varied widely over 1.0–7.1. Possible mechanisms for such high tunability were discussed. As an example of potential applications, the complex permeability and permittivity of MOF-derived composites (25 wt%) were measured over a wide frequency range of 2–18 GHz. The parameters were then used to evaluate the potential for electromagnetic wave absorption. The results indicate that the composite with a thickness of only 1.2 mm exhibits a “− 10 dB” absorption bandwidth of 4.1 GHz and a minimum reflection of − 20 dB. Such bandwidth and reflection properties provide inspiration for future design of lightweight, broadband electromagnetic wave absorbers from the perspective of fine morphology control.
研究领域:
材料科学
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化学工程
·
电磁学
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DOI
高影响因子
JOURNAL OF PHARMACEUTICAL SCIENCES
·
2021
·
IF 3.534
Yiru Wang,Yudan Fang,Feng Zhou,Qi Liang,Yueyi Deng
HPMCAS-HF, HPMCAS-MF and HPMCAS-LF were used as carriers to prepare the amorphous solid dispersions (ASDs) of quercetin (Que) by co-precipitation. The Que ASD based on PVP K30 was prepared by solvent evaporation method. The ability of polymer to inhibit Que crystallization was evaluated. The study found the order of the ability of polymer to inhibit Que nucleation to be: HF > MF > LF > K30, and that to maintain Que supersaturation to be: HF > K30 > MF > LF. The prepared solid dispersions were characterized by IR, DSC and PXRD. Although HF was the most effective crystallization inhibitor, the release of the Que/HF ASD was poor and assigned to the carrier-controlled dissolution for the strong interactions between Que and HF. The Que/MF ASD exhibited better dissolution behavior compared to the Que/K30 ASD. The dissolution behavior of the Que ASD depended on the polymer-Que interactions and the ability of crystallization inhibition of the polymer.
研究领域:
药剂学
·
药物传递系统
·
生物医学工程
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2015
·Vol. 40
·期 1
·589-595
·
IF 3.086
Hui Yang,Yuan Xie,Guisong Hao,Weiwei Cai,Xingzhong Guo
Porous alumina (Al2O3) microspheres with incontinuous multicavities have been successfully prepared via an oil-in-water (O/W) emulsion method accompanied by a sol–gel process in the presence of polyvinylpyrrolidone (PVP), sorbitan monooleate (Span 80) and ethyl acetoacetate (EAA). The introduction of PVP as a phase separation inducer into the oil phase of the O/W emulsion leads to the formation of incontinuous multicavities inside the microspheres, and the size of the cavities enlarges with the increase of the amount of PVP, while has no significant influence on the surface morphology and particle size distribution of the microspheres. EAA works as a chelating agent to ensure a spherical shape, and Span 80 acts as a stabilizer to preserve a smooth surface. An appropriate amount of PVP, EAA and Span 80 allow the formation of porous alumina microspheres with incontinuous multicavities. A preliminary mechanism based on phase separation for the structural evolution of alumina porous microspheres with multicavities is suggested. The spheres after heat treatment experience a phase transformation process in the following sequence: amorphous → γ-Al2O3 → α-Al2O3.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
Microsystems & Nanoengineering
·
2021
·Vol. 7
·期 1
·1-12
·
IF 7.127
Qin Ruzhan,Hu Mingjun,Li Xin,Liang Te,Tan Haoyi,Liu Jinzhang,Shan Guangcun
The development of flexible capacitive pressure sensors has wide application prospects in the fields of electronic skin and intelligent wearable electronic devices, but it is still a great challenge to fabricate capacitive sensors with high sensitivity. Few reports have considered the use of interdigital electrode structures to improve the sensitivity of capacitive pressure sensors. In this work, a new strategy for the fabrication of a high-performance capacitive flexible pressure sensor based on MXene/polyvinylpyrrolidone (PVP) by an interdigital electrode is reported. By increasing the number of interdigital electrodes and selecting the appropriate dielectric layer, the sensitivity of the capacitive sensor can be improved. The capacitive sensor based on MXene/PVP here has a high sensitivity (~1.25 kPa −1 ), low detection limit (~0.6 Pa), wide sensing range (up to 294 kPa), fast response and recovery times (~30/15 ms) and mechanical stability of 10000 cycles. The presented sensor here can be used for various pressure detection applications, such as finger pressing, wrist pulse measuring, breathing, swallowing and speech recognition. This work provides a new method of using interdigital electrodes to fabricate a highly sensitive capacitive sensor with very promising application prospects in flexible sensors and wearable electronics.
研究领域:
材料科学
·
传感器技术
·
柔性电子
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产品关联
DOI
PubMed
高影响因子
Materials Research Express
·
2020
·Vol. 7
·期 2
·025027
·
IF 1.929
Hong Zhao,Diandian Liu,Shujuan Xu,Yao Chen,Fujun Yin,Tao Yang,Mingyan Wang,Hua Deng,Wei Zhang,Weiwei Liu,Xiaohong Liu
Active electrocatalysts are the key to water splitting for hydrogen production through the electrolysis. In this paper, 50 nm silver nanoplates were used as templates for synthesis of Au–Ag island-shaped nanoplates by controlling the surface chemistry. The guiding mechanism of polyvinylpyrrolidone (PVP, Mw = 40 000) to Au–Ag island-shaped nanoplates crystal was also further investigated. It is found that the surface energy of Ag nanoplates between (100) and (111) crystal planes can be regulated by varying the amount of PVP in the system. Then a uniform Au-Ag triangular island nanostructure was obtained. Compared with the Ag nanoplates catalysts, the Au–Ag island nanoplates catalysts show the superior catalytic performances in hydrogen evolution electrocatalysis (HER). These results demonstrate a new surface chemistry modification by PVP and a galvanic displacement reaction for designing the active electrocatalysts. More importantly, the Au–Ag island-shaped nanoplates show an unconventional growth mode of preserving the original Ag nano-triangular crystal structure. The enhanced performance in electrocatalysis can be mainly attributed to Au–Ag alloy structure, which allows the appearance of synergistic effects. The present work demonstrates the crucial roles of surface chemistry in catalysts synthesis, which may guide the design of active bimetallic catalysts.
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Qiangqiang Wang,Xuanyu Zhang,Lei Qian,Chaoyu Xiang
Perovskite quantum dot light-emitting diodes (QLEDs) are potential candidates for next-generation displays due to their high color purity and wide color gamut. Due to the strong electron-accepting ability of poly[bis(4-phenyl) (2,4,6-trimethylphenyl) amine] (PTAA), quantum dot (QD) films are prone to be charged, which leads to the imbalance of charge injection and the increase of nonradiative recombination, ultimately affecting the performance of the QLEDs. Here, we compared and studied two polymers, poly(methyl methacrylate) (PMMA) and poly(vinyl pyrrolidone) (PVP), as the hole interface buffer layers of QD films, which effectively reduced the defect density, suppressed nonradiative recombination, and greatly improved the efficiency and stability of QLEDs. The devices with PMMA achieved a maximum external quantum efficiency of 20.71%.
研究领域:
材料科学
·
光学工程
·
电子工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Yong Qian,Chenling Huang,Rong Chen,Shizhen Dai,Chunyan Wang
A composite of well dispersed MnO 2 nanoparticles adhered on multi-walled carbon nanotubes (MnO 2 @MWNT) is obtained through facile hydrothermal process and followed by high temperature annealing. The nanoscale MnO 2 particles were homogeneously distributed on the surface of MWNTs under polyvinyl pyrrolidone (PVP)-assisted reaction. The MnO 2 @MWNT composite (34.43 wt. % MnO 2 ) displays a high specific capacitance of 285.12 F/g at a current density of 1 A/g in 1 M Na 2 SO 4 electrolyte. The electrode exhibits good cycling stability, which the specific capacitance retention retains up to 90.17% after 1000 cycles at 1 A/g.
研究领域:
材料科学
·
能源存储与转换
✓ 已验证
DOI
高影响因子
FUEL
·
2025
·
IF 7.5
Yang Zheng,Wei Su,Hualong Zhou,Jiaqing Wang,Wenbo Zhang,Yi Xing
To address the problems of difficult degradation of Chlorinated volatile organic compounds (CVOCs) and easy deactivation of catalysts by chlorine poisoning, o-Dichlorobenzene ( o- DCB) was used as a model pollutant, and a shape size-tunable CeCoOx catalyst was designed by Prussian blue analogue (PBA) derivatization, and the nucleation rate of the precursor was controlled by regulating the amount of Polyvinyl pyrrolidone (PVP) added (0–15 g), so that the CC-PVP y catalysts with hexagonal bipyramidal to lamellar gradient structures were successfully prepared, and their structure-efficacy relationship and mechanism were systematically elucidated. The results showed that the appropriate amount of PVP could optimize the crystallinity and size uniformity of the precursor, and the resulting CC-PVP 1 catalyst showed a complete hexagonal bipyramidal structure with maximum specific surface area and pore volume, and the surface was enriched with highly active Co 3+ species and adsorbed oxygen. Mechanistic studies have shown that chlorine poisoning mainly occurs through Cl - occupying the oxygen vacancies, leading to a decrease in the crystallinity of the catalyst, a collapse of the pore structure, a weakening of the redox capacity and a decrease in the number of acid sites. CC-PVP 1 significantly delayed the deactivation by reducing the amount of Cl deposited on the catalyst surface due to its high structural integrity. This study deepens the understanding of the catalytic combustion mechanism of CVOCs and provides a feasible strategy for the development of efficient chlorine-resistant catalysts.
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DOI
高影响因子
Soft Matter
·
2019
·Vol. 16
·期 1
·132-141
·
IF 3.399
Yangjie Xu,Jiulong Zhao,Zhilun Zhang,Jing Zhang,Mingxian Huang,Shige Wang,Pei Xie
In this study, sodium alginate (ALG)/poly dopamine (PDA)–polyvinylpyrrolidone (PVP) nanocomposites was synthesized via a one-step electrostatic spraying method. The spinning solution of ALG and dopamine was electrostatically sprayed into an alkaline solution of PVP, calcium chloride and tris buffer (pH = 8.5), in which the gelation of ALG and the polymerization of dopamine could be simultaneously triggered. PDA hence produced possesses a high photothermal conversion efficiency, while the PVP that was facilely conjugated onto the surface of nanocomposites improves the colloidal stability and compatibility of the material. Moreover, the ALG renders the nanocomposite excellent drug (doxorubicine, DOX) loading capacity. Promisingly, the temperature increment during the PTT process could promote the DOX release, thus enhancing its therapeutic effect. The in vitro/in vivo biosafety and tumor treatment experiments further corroborate that the ALG/PDA–PVP nanocomposites have remarkable biocompatibility and synergism for tumor hyperthermia and chemotherapy. Consequently, such a one-step electrospray strategy provides a new way for designing nanomaterials and is expected to significantly promote the development of organic photothermal therapeutic agents with excellent bio-compatibility.
研究领域:
生物医学工程
·
纳米医学
·
癌症治疗
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）