MOLECULES
·
2019
·Vol. 24
·期 17
·3039
·
IF 3.06
Yijie Mao,Yu Zhang,Wei Hu,Weiwei Ye
Histamine can be formed by enzymatic decarbonylation of histidine, which is an important indicator of seafood quality. A rapid and sensitive assay method is necessary for histamine monitoring. A fluorescence resonance energy transfer (FRET) assay system based on a carbon dot (CD)-modified nanoporous alumina membrane and Fe3O4@Au magnet nanocomposites has been developed for histamine detection in mackerel fish. CDs immobilized on nanoporous alumina membranes were used as donors, which provided a fluorescence sensing substrate for histamine detection. Fe3O4@Au magnet nanocomposites can not only act as acceptors, but also concentrate histamine from fish samples to increase detection sensitivity. Histamine was detected by the fluorescence signal changes of CDs capturing histamine by an immune reaction. The fluorescence signals of CDs were quenched by Fe3O4@Au magnet nanocomposites via the FRET mechanism. With an increase of histamine, the fluorescence intensity decreased. By recording fluorescence spectra and calculating intensity change, histamine concentration can be determined with a limit of detection (LOD) of 70 pM. This assay system can be successfully applied for histamine determination in mackerel fish to monitor the fish spoilage process in different storage conditions. It shows the potential applications of CDs-modified nanoporous alumina membranes and Fe3O4@Au magnet nanocomposites-based biosensors in the food safety area.Keywords:fluorescence resonance energy transfer;CDs;nanoporous alumina membrane;food safety
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ACS Nano
·
2025
·
IF 16
Yao Yao,Yue Zhao,Huijuan Zhang,Wenting Pan,Wei Liang,Yijian Jiang,Xinlong Yan,Yinzhou Yan
The development of surface-enhanced Raman spectroscopy (SERS) as an ultrasensitive fingerprint analysis technique in precision medicine requires high-performance SERS substrates with controllable nanostructure (hot-spot) distribution, simple fabrication, superior stability, biocompatibility, and extraordinary optical responses. Unfortunately, fabrication of arbitrary nanostructures with high homogeneity on a large scale for SERS is still challenging. Herein, we report an ultrafast laser parallel fabrication protocol for Au/2D-transition-metal dichalcogenide hybrid SERS biosensors. The leveraged photonic nanojets (PNJs) are generated by a micron-sized microsphere monolayer to simultaneously trigger localized phase transition in 2H-MoTe2, achieving a 1T′-MoTe2 nanopattern array with a density of 1 million per mm2 by a single laser shot. The Au nanoparticle clusters (AuNCs) are subsequently grown in situ from the 1T′ regions, creating a AuNCs on 1T′/2H-MoTe2 (AuNCs@1T’/2H-MoTe2) hybrid SERS substrate. The fabricated feature diameter and overlay accuracy of the patterned AuNCs are 210.1 ± 3.4 and 9.2 ± 1.7 nm, respectively. To eliminate background noise, we designed dimer-AuNCs@1T′/2H-MoTe2 (dAuNCs@1T′/2H-MoTe2), achieving a detection limit of 10–13 M with an enhancement factor of 4.9 × 108 for the methylene blue (MB) analyte. The strong localized surface plasmon resonances in the dAuNCs as well as efficient charge transfers between Au, 2H-MoTe2, and MB contribute to the majority of Raman enhancement. The multiscale dAuNCs@1T′/2H-MoTe2 array provides a powerful SERSome (comprising multiple SERS spectra) platform for therapeutic drug monitoring, by which we successfully identified the metabolic behaviors of living gastric adenocarcinoma cells administered with two drugs, i.e., capecitabine, oxaliplatin, and their combination. The present work establishes opportunities for creating a highly ordered nanopattern array for ultrasensitive SERSome analysis of cell metabolism in cancer therapy.
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MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 2
·1-10
·
IF 5.833
Pei Yujiao,Ge Yonghao,Zhang Xiaoru,Li Ying
A cathodic photoelectrochemical sensor has been developed for the determination of exosomes, based on a dual-signal reduction strategy. A heterostructure of NiO/BiOI/Au NP/CdSe was synthesized as a photoelectrochemical sensing interface, which is able to suppress the recombination of electron-hole pairs and produce a higher photocurrent. The obtained materials were characterized, and the mechanism for the generation of the cathodic photocurrent was proposed. CdSe QDs (quantum dots) modified with DNA 2 were assembled on the electrode through the hybridization with EpCAM aptamer on the surface of ITO/NiO/BiOI/Au NP. The introduction of CdSe QDs to the electrode increases the photocurrent.The recognition of exosomes with aptamer DNA led to the separation of CdSe QDs from the electrode, which in turn caused the decrease of photocurrents. Meanwhile, the big volume of exosomes hinders the electron transfer between the electrode and electrolyte. Due to the dual reduction effect, a sensitive PEC sensor was obtained with a detection limit of 1.2 × 10 2 particles/μL exosomes ( λ ex = 430 nm, bias voltage = − 0.1 V). The cathodic photoelectrochemical sensor showed good selectivity, performed well in a complex biological environment and could be used to distinguishbreast cancer patients from healthy individuals. Graphical abstract
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Zhenjun Liu,Tianpei Yang,Yi Shen
The glycerol electrochemical oxidation (GEOR) represents a sustainable strategy for converting abundant biomass-derived feedstocks into high value-added chemicals. Herein, we prepared a series of Pt/Au/Ti catalysts via electrodepositing Pt nanoparticles (NPs) onto Au-sputtered Ti substrates (Au/Ti). The atomic Pt/Au ratio on the surface was engineered through pulse-deposition cycles. The structures of the catalysts were characterized by scanning electron microscopy, atomic force microscopy and X-ray diffraction, confirming that Pt NPs were uniformly deposited on the Au/Ti surface. Electrochemical evaluations demonstrated that the 10Pt/Au/Ti catalyst has superior GEOR performance in 1 M KOH solutions, achieving a peak current density of 13.16 mA cm −2 . Operando electrochemical impedance spectroscopy revealed that Au and Pt worked synergistically to promote the adsorption of adsorbed hydroxyl species ( OH ad ) and glycerol, thereby improving GEOR activity. Product analysis revealed that the 10Pt/Au/Ti catalyst yielded the highest glyceric acid selectivity of 93.6% at 0.9 V vs. RHE under alkaline conditions. This study provides an efficient strategy for the highly selective conversion of glycerol into high value-added C 3 products.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Hanyue Jiang,Juan Lu,Wenzhuo Wang,Pengfei Han,Guangping Ma,Tengying Ma,Li Tian,Jing Wang
In this study, a porous bimetallic oxide Cu 4 RuO 5 with a high specific surface area was prepared via electrospinning followed by high-temperature calcination. This oxide exhibited a significant electrochemiluminescence (ECL) signal when reacting with S 2 O 8 2− . Utilizing this bimetallic oxide as an ECL material, we constructed a simple solid-state ECL sensor, in conjunction with Au NPs@SiO 2 , for the sensitive detection of tilmicosin in milk. The sensor was constructed using a layered modification approach. Initially, the bimetallic oxide Cu 4 RuO 5 was modified onto the electrode surface. Cu 4 RuO 5 not only serves as a luminescent reagent but also promotes electron transfer within the system due to its large specific surface area and porosity, achieving amplification of the first-stage ECL signal. Subsequently, Au NPs@SiO 2 was modified onto the oxide surface. The SiO 2 shell effectively shields the system from complex matrix interferences while providing a large specific surface area for the immobilization of Au NPs. The Au NPs further accelerate electron transfer, thereby achieving amplification of the second-stage signal. Based on this two-step amplification strategy, the constructed ECL sensor exhibits a linear response range for tilmicosin from 1.0 × 10 −13 to 1.0× 10 −6 mol L −1 , yielding a detection limit of 2.01 × 10 −14 mol L −1 (3σ/m). This sensor combines high sensitivity, good selectivity, and excellent stability, providing a novel method for the rapid determination of antibiotic residues in food, successfully implemented to enable rapid determination of tilmicosin in milk matrices.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Cunwei Wang,Man Peng,Xishun Peng,Haili Zhang,Caizhen Zu,Zhangwei Tan,Yuxue He,Zhongchen Bai
This study presents a surface-enhanced Raman scattering (SERS) sensing platform based on a MoS 2 /Au@Ag heterojunction for specifically detecting the residues of thiram pesticide. A Nano-MoS 2 film was firstly prepared by depositing MoS 2 nanosheets on the surface of a stainless steel sheet. Subsequently, Au nanoparticles and Ag nanoparticles were deposited on the surface of MoS 2 film to form a MoS 2 /Au@Ag heterojunction for SERS application. This well-performing SERS substrate was originated from the synergistic effect of electromagnetic (EM) enhancement and chemical (CM) enhancement to boost its SERS signal. Here, the CM contribution could be up to 41.8 % in the process of optimizing interfacial charge transfer (CT) pathways in MoS 2 /Au@Ag heterojunction. Thus, the SERS sensor based on MoS 2 /Au@Ag film showed an excellent signal homogeneity (RSD = 4.36 %) and an ultrahigh sensitivity to thiram molecules with a limit of detection (LOD) as low as 0.32 nM. Moreover, it could also recognize the thiram residues at 10 nM level in citrus peels, with a recovery rate of 91.0–109.0 %. The SERS sensor we developed in this study has a high sensitivity, excellent reproducibility, and long-term stability, which could be widely applied for the food safety monitoring
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Scientific Reports
·
2017
·Vol. 7
·期 1
·1-8
·
IF 4.259
Chen Xu,Zhou Donglei,Xu Wen,Zhu Jinyang,Pan Gencai,Yin Ze,Wang He,Zhu Yongsheng,Shaobo Cui,Song Hongwei
Localized electric filed enhancement by surface plasmon resonance (SPR) of noble metal nanoparticles is an effective method to amplify the upconversion luminescence (UCL) strength of upconversion nanoparticles (UCNPs), whereas the highly effective UCL enhancement of UCNPs in colloids has not been realized until now. Here, we designed and fabricated the colloidal Au-Ag nanocage@NaYF 4 @NaYF 4 :Yb,Er core-shell hybrid with different intermediate thickness (NaYF 4 ) and tunable SPR peaks from visible wavelength region to NIR region. After the optimization of the intermediate spacer thickness (~7.5 nm) of NaYF 4 NPs and the SPR peak (~950 nm) of noble metal nanoparticles, an optimum enhancement as high as ~25 folds was obtained. Systematic investigation indicates that UCL enhancement mainly originates from the influence of the intermediate spacer and the coupling of Au-Ag nanocages with the excitation electromagnetic field of the UCNPs. Our findings may provide a new thinking on designing highly effective metal@UCNPs core-shell hybrid in colloids.
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ELECTROANALYSIS
·
2024
·Vol. 36
·期 10
·e202400028
·
IF 2.7
Suning Man,Junying Zheng,Yi Zhang,Lei Huang,Xiaoping Wu
Given the high solubility and mobility of hexavalent chromium in the environment and edible plants, the development of a suitable method for the screening and quantification of Cr(VI) is highly desirable. Herein, a selective and sensitive sensing method for detecting Cr(VI) in food grains was established, using an electrodeposited gold-palladium bimetallic nanoparticles (BNPs) based electrochemical sensor and a microwave digestion procedure for chromium dissolution. The sensor interface was characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and cyclic voltammetry. The results indicate that the fabricated sensor has a larger active surface area and an enhanced electrocatalytic effect compared to the monometallic modification, leading to a significant increase in the electrochemical reduction current of Cr(VI) as a consequence of synergistic effects. Using square wave anodic stripping voltammetry, the sensor demonstrates a wide linear range (5–3000 μg L −1 ) and a low detection limit of 2.7 μg L −1 for Cr(VI), as well as considerable repeatability and stability. Satisfactory selectivity towards Cr(VI) was also demonstrated, even in the presence of 500-fold Cr(III) and 100-fold common heavy metal ions like Cd(II), Pb(II), and Hg(II). The proposed sensing method offers a promising alternative for rapidly identifying toxic Cr(VI) in water and food grains.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Sen Sun,Yan Wang,Li'na Wang,Tong Guo,Xiaorong Yuan,Dongxia Zhang,Zhonghua Xue,Xibin Zhou,Xiaoquan Lu
Here, a unique triple-layered core-shell structure (Au@N-CQDs@Pt) with an Au metal core, nitrogen-doped carbon quantum dots interlayer, and metal Pt outside shell was obtained by chemical reduction of HAuCl 4 and H 2 PtCl 6 in the presence of N-CQDs. The remarkable advantage of the method reported here is no any stabilizer or surfactant agent involved. The results of transmission electron microscopy (TEM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX) spectroscopy, X-ray photoelectron spectroscopy (XPS) reveal that the as-prepared nanocomposites exhibit the nanostructured dendritic Pt and the quantity of Pt shell can be easily changed through controlling the synthesis time. Specifically, Au@N-CQDs@Pt displays excellent catalytic activity toward methanol oxidation reaction in alkaline condition than Au-Pt without N-CQDs, which indicate the useful application of CQDs in designing new catalysts to be used in direct methanol fuel cells.
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Materials Science & Engineering C-Materials for Biological Applications
·
2015
·
IF 3.088
Zhuo Guo,Ze-yu Wang,Hui-hua Wang,Guo-qing Huang,Meng-meng Li
A sensitive electrochemical sensor has been fabricated to detect Isoniazid (INZ) using reduced graphene oxide (RGO) and Au nanocomposites (RGO–Au). RGO–Au nanocomposites were synthesized by a solution-based approach of chemical co-reduction of Au(III) and graphene oxide (GO), and were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, and Fourier transform infrared (FT-IR). The Au nanoparticles separate the RGO sheets in the precipitate and prevent RGO sheets from aggregation upon π–π stacking interactions. RGO–Au nanocomposites were used to modify the glassy carbon electrode (GCE). The electrochemical properties of RGO–Au/GCE were investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), and the RGO–Au/GCE exhibited remarkably strong electrocatalytic activities towards INZ. Under the optimized conditions, there was linear relationships between the peak currents and the concentrations in the range of 1.0 × 10 − 7 M to 1.0 × 10 − 3 M for INZ, with the limit of detection (LOD) (based on S/N = 3) of 1.0 × 10 − 8 M for INZ.
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ACS Applied Energy Materials
·
2019
·
IF 0
Mangwei Cui,Yan Xiao,Litao Kang,Wei Du,Yanfeng Gao,Xueqin Sun,Yanli Zhou,Xiangming Li,Hongfei Li,Fuyi Jiang,Chunyi Zhi
As a promising anode for aqueous batteries, Zn metal shows a number of attractive advantages such as low cost, low redox potential, high capacity, and environmental benignity. Nevertheless, the quick growth of dendrites/protrusions on the “hostless” Zn anodes not only enlarges batteries’ internal resistance but also causes sudden shorting failure by piercing separators. Herein, we report a novel heterogeneous seed method to guide the morphology evolution of plated Zn. The heterogeneous seeds are sputtering-deposited quasi-isolated nano-Au particles (Au-NPs) that enable a uniform and stable Zn-plating/stripping process on the anodes. Tested on Zn|Zn symmetric cells, the Au-nanoparticle (NP) decorated Zn anodes (NA-Zn) demonstrate much better cycling stability than the bare ones (92 vs 2000 h). In NA-Zn|CNT/MnO2 batteries, this heterogeneous seed prolongs the lifetime of the device from ∼480 cycles up to 2000 cycles. This work offers a facile and promising Zn dendrite/protrusion suppressing route for the achievement of long-life Zn-ion batteries.
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Journal of the Taiwan Institute of Chemical Engineers
·
2017
·
IF 4.217
Likang Fu,Libo Zhang,Shixing Wang,Bing Zhang,Jinhui Peng
A new adsorbent was synthesized via functionalizing nano-silica with poly(methacryloxyethyltrimethyl ammonium chloride) (PDMC) for selective recovery of Au(III) from aqueous solutions. The adsorbent was characterized by FT-IR, TGA, XPS and TEM. A batch adsorption experiment was conducted to evaluate the adsorption capacity, reusability and selectivity. The maximum adsorption capacity of Au(III) was 127.3 mg/g at room temperature and the optimum pH 3.0. The adsorption equilibrium was achieved within 20 min. The adsorption process followed preferably the pseudo-second order kinetics and the Langmuir isotherm model. Ion exchange between gold ions and amines/chlorine groups played an important role in the adsorption process. The adsorption desorption cycles indicated that the adsorbent had a stable adsorption performance and retained high adsorption efficiency. Moreover, the adsorbent can selectively adsorb Au(III) from coexisting ions in aqueous solution. Therefore, nano-silica modified with PDMC could be of great potential in recovering Au(III) from industrial effluents and waste e-products.
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