Small
·
2026
·
IF 11.8
Nana Song,Hezhen Shang,Jie Shao,Pengyu Zhao,Rui Wang,Qiang Bai,Zhiyang Zhang,Ning Sui,Lingxin Chen,Xiaokun Wang
Routine screening and longitudinal surveillance of hepatocellular carcinoma (HCC) require sensitive, on-site analytical methods. Lateral flow immunoassays (LFAs) enable large-scale screening but lack intrinsic signal amplification. Although nanozymes can enhance LFA readouts, their amplification remains constrained by inefficient hydrogen peroxide (H 2 O 2 ) activation. Herein, an electronically coupled Au/PtIr trimetallic nanozyme (Au/PtIr NPs) is constructed by decorating Au nanoparticle (Au NP) surfaces with island-like PtIr alloy nanodomains. This architecture forms spatially adjacent dual-site adsorption interfaces with heterogeneous electronic properties. Alloy-induced interfacial electronic modulation synergistically optimizes H 2 O 2 adsorption and facilitates its homolytic O─O bond, selectively enhancing •OH generation and accelerating peroxidase-like (POD-like) catalytic kinetics. Integrated into an LFA platform, Au/PtIr NPs enable sensitive and reliable detection of α-fetoprotein (AFP) in clinical samples, with a linear response from 0.2–1000 ng mL −1 and a limit of detection (LOD) of 57.7 pg mL −1 , which is 390-fold lower than that of conventional Au NP-based LFAs. The assay shows good agreement with clinical reference methods. The electronically regulated Au/PtIr interface maintains reliable amplification in complex biological matrices. Coupled with a simplified readout workflow, it enables minimally instrumented point-of-care detection. This electronic-interface engineering approach provides a generalizable route to catalytic signal amplification for LFA-based diagnostics.
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Molecular Catalysis
·
2025
·
IF 4.9
Min Yang,Shuang Sheng,Ziyi Wan,Yaoyao Xu,Rui Qi,Xiaofeng Luo,Weiyu Pan,Kunshan Yang,Ziqing Zhang,Guowei Deng
Hydrogen evolution reaction (HER) is a key step in the production of hydrogen (H 2 ) by overall water splitting, which is of great significance for the storage and conversion of renewable energy. Nevertheless, the elevated excess potential and insufficient stability of catalysts constrain their industrial applicability. Due to the poor catalytic activity of NiWO 4 in alkaline solution, this study investigated the effect of IB metal (IB=Au, Ag, Cu) ion doping and its interaction with different concentrations of IB x /NiWO 4 ( X = 1,2,3,4 mmol) on catalytic activity to achieve stable H 2 in alkaline media. In 1.0 M KOH solution, the current density is 10 mA cm −2 , the Au 3 /NiWO 4 exhibits a low overpotential is 86.11 mV, the slope of Tafel is 115.16 mV dec −1 , and the overpotential of Ag 3 /NiWO 4 is 168.41 mV, with a Tafel slope of 64.32 mV dec −1 , the catalyst also showed long term stability for 150 h, the Au 3 /NiWO 4 NF‖Au 3 /NiWO 4 NF catalysts achieved a low voltage of 1.45 V at 10 mA cm −2 current density for 100 h. The synergistic interactions of bimetals present a novel approach for enhancing catalyst design and optimizing performance.
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Nanoscale
·
2025
·
IF 5.1
Hong Wang,Xin Yang,Tong Zhu,Xiao Su,Liang Xiao,Qianqian Yu,Pingan Liu,LinGe Wang
The integration of electromagnetic wave absorption, antibacterial functionality, and environmental remediation into a single composite material remains a formidable challenge due to conflicting material property requirements. To address this, we fabricate plasmonic MXene/Au@Ag core–shell nanocomposites via in situ reduction, leveraging the synergistic effects of bimetallic architecture and MXene's tunable surface chemistry. The Au@Ag core–shell nanoparticles enhance interfacial polarization and plasmonic resonance, enabling ultra-broadband absorption (7.6 GHz effective absorption bandwidth) with a minimum reflection loss of −42.93 dB at 2.8 mm thickness, alongside a 42.9 dB m2 radar cross-section reduction. Concurrently, the composite exhibits >95% antibacterial efficiency via Ag+ release and light-triggered ROS generation, alongside >90% adsorption capacity for organic pollutants through MXene's functionalized surface. By unifying electromagnetic stealth, antimicrobial action, and environmental remediation, this work establishes a versatile platform for next-generation composites in aerospace, biomedical, and environmental engineering.
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高影响因子
BIOMEDICAL MICRODEVICES
·
2025
·Vol. 27
·期 4
·1-12
·
IF 3.3
Zhang Jingfei,Nan Xuanxu,Yang Li,Cui Yue
The Lateral flow immunoassay (LFIA) has been widely used in environmental monitoring and disease diagnosis due to its advantages of low cost, simple operation, and convenience. However, its accuracy and sensitivity remain major challenges to be addressed. D-dimer is an important biomarker for thrombotic diseases. In this work, we show for the first time a core–shell Au@Ag nanoparticle (NP) labeled colorimetrically enhanced LFIA for D-dimer detection. The superior performance of Au@Ag LFIA stems from the silver shell's enhancement of plasmon resonance, which boosts optical signals to yield brighter scattering and superior visual contrast. Compared with conventional AuNPs, Au@AgNPs significantly improve sensitivity, leading to more accurate results. The detection limit for D-dimer was improved by approximately tenfold, reaching 1 ng/mL, due to the improved cross-coupling efficiency of Au@AgNPs compared with AuNPs. We anticipate that, with further development and validation, this enhanced LFIA could become a valuable tool in a wide range of clinical diagnostic applications.
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ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Yuting Zhang,Ze Zhang,Hehua Zhang,Xin Xu,Tong Shen,Xiaohui An,Hongzhi Pan,Dong Chang
Circulating tumor cells (CTCs), as a critical biomarker for early diagnosis and real-time monitoring of tumor progression, play a significant role in early cancer diagnosis, treatment monitoring, and prognosis evaluation. However, existing CTCs detection methods are limited by low purity, long processing time, high cost, and insufficient specificity, making them inadequate for clinical needs. This study developed an ultrasensitive and visually detectable CTCs sensing platform. The platform integrates nucleic acid aptamer-functionalized dopamine-coated magnetic nanoparticles as capture probes for the specific isolation and enrichment of CTCs, and MXenes@MnCoZDH@Au NPs as signal-amplifying nanoprobes with exceptional peroxidase-like activity. The colorimetric sensing mechanism relies on the linear increase in absorbance with CTCs concentration, enabling quantitative detection. Under optimized experimental conditions, the sensor demonstrated a broad detection range of 10 to 10 6 cells/mL and an ultra-low 2 cells/mL detection limit. Compared to traditional methods, this detection approach exhibited high specificity, sensitivity, and reproducibility, highlighting its potential for clinical translation. This innovative method provides a reliable and practical tool for liquid biopsy-based cancer diagnostics, offering significant advancements in precision medicine.
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International Journal of Electrochemical Science
·
2025
·
IF 2.4
Yan Hu,Tao Jiang
The developed wearable electrochemical sensing platform demonstrates significant potential for continuous monitoring of cortisol in human sweat, a key biomarker for evaluating stress and fatigue levels in athletic performance. Utilizing a novel Au-decorated nanocomposite functionalized with β-cyclodextrin-assisted molecular recognition sites, this study outlines a systematic fabrication process where SiC nanoparticles are first oxidized and subsequently decorated with gold nanoparticles, achieving an average Au particle diameter of 5.3 ± 1.2 nm to enhance conductivity and electron transfer kinetics. The incorporation of dual amine-terminated β-cyclodextrin not only improves molecular recognition but also facilitates selective cortisol capture, as evidenced by sensitivity improvements to approximately 1.85 μF per ng/mL over a linear range of 5–45 ng/mL and a limit of detection as low as 2.8 ng/mL. Comprehensive electrochemical evaluations, including cyclic voltammetry, confirm the sensor’s ability to reliably distinguish cortisol from potential interferents, yielding selectivity coefficients between 18.3 and 31.0, with reproducibility demonstrated by relative standard deviations below 4.8 %. Real sweat sample analyses using a standard addition method provided a robust calibration curve (R² = 0.993), confirming effective quantification in complex biological matrices typical of athletic environments. Furthermore, the sensor exhibited excellent mechanical resilience, with a capacitance reduction of only 4 % after 20 bending cycles, and maintained stable performance over 30 days, indicating long-term durability suitable for wearable sports applications. This innovative approach integrates material design, surface chemistry, and device engineering to enable rapid, accurate, and noninvasive monitoring of athlete stress levels, offering a promising avenue for real-time physiological tracking during training and competitive performance.
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BIOSENSORS & BIOELECTRONICS
·
2017
·
IF 7.78
Chao Liu,Jing Dong,Geoffrey I.N. Waterhouse,Ziqiang Cheng,Shiyun Ai
A sensitive sandwich-type electrochemical immunosensor was developed for the detection of avian leukosis virus subgroup J (ALV-J), which benefitted from multiple signal amplification involving graphene-perylene-3,4,9,10-tetracarboxylic acid nanocomposites (GR-PTCA), nanocellulose-Au NP composites (NC-Au) and the alkaline phosphatase (ALP) catalytic reaction . GR-PTCA nanocomposites on glassy carbon electrodes served as the immunosensor platform. Due to their excellent electrical conductivity and abundant polycarboxylic sites, the GR-PTCA nanocomposites allowed fast electron transfer and good immobilization of primary antibodies, thereby affording a strong immunosensor signal in the presence of ALV-J. The detected signal could be further amplified by the introduction of NC-Au composites as a carrier of secondary antibodies (Ab 2 ) and by harnessing the catalytic properties of Au and ALP. Under optimized testing conditions, the electrochemical immunosensor displayed excellent analytical performance for the detection of ALV-J, showing a linear current response from 10 2.08 to 10 4.0 TCID 50 /mL (TCID 50 : 50% tissue culture infective dose) with a low detection limit of 10 1.98 TCID 50 /mL (S/N = 3). In addition to high sensitivity, the immunosensor showed very good selectivity, reproducibility and operational stability, demonstrating potential application for the quantitative detection of ALV-J in clinical diagnosis.
研究领域:
免疫学
·
生物传感器
·
分子诊断
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兽医病毒学
·
纳米医学
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高影响因子
BIOSENSORS & BIOELECTRONICS
·
2015
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IF 6.409
Cui Ye,Min-Qiang Wang,Xia Zhong,Shihong Chen,Yaqin Chai,Ruo Yuan
One-dimensional Pd–Au nanowires (Pd–Au NWs) were prepared and applied to fabricate an electrochemiluminescence (ECL) biosensor for the detection of acetylcholinesterase (AChE) activity. Compared with single-component of Pd or Au, the bimetallic nanocomposite of Pd–Au NWs offers a larger surface area for the immobilization of enzyme, and displays superior electrocatalytic activity and efficient electron transport capacity. In the presence of AChE and choline oxidase (ChOx), acetylcholine (ATCl) is hydrolyzed by AChE to generate thiocholine, then thiocholine is catalyzed by ChOx to produce H 2 O 2 in situ , which serves as the coreactant to effectively enhance the ECL intensity in luminol-ECL system. The detection principle is based on the inhibited AChE and reactivated AChE as dual biomarkers, in which AChE was inhibited by organophosphorus (OP) agents, and then reactivated by obidoxime. Such dual biomarkers method can achieve credible evaluation for AChE activity via providing AChE activity before and after reactivation. The liner range for AChE activity detection was from 0.025 U L −1 to 25 KU L −1 with a low detection limit down to 0.0083 U L −1 .
研究领域:
分析化学
·
生物传感器
·
纳米材料
·
酶活性检测
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高影响因子
Science China-Materials
·
2017
·Vol. 60
·期 11
·1129-1144
·
IF 3.956
Yang Yanjun,Jiang Xinyu,Chao Jie,Song Chunyuan,Liu Bing,Zhu Dan,Sun Youzhi,Yang Boyue,Zhang Qiaowei,Chen Ye,Wang Lianhui
Magnetic core gold shell nanostructures which integrate both SERS activity and superparamagnetism are widely utilized in SERS-based detection as SERS substrates, sample separation and preconcentration operators, as well as external magnetic field controlled directional carrier. However, most of the reported gold shells coated on the magnetic cores had smooth surfaces rather than branched nanostructures with enhanced SERS activity. Here, a novel type of Fe 3 O 4 -Au core-shell nanoparticles with branched gold shell was prepared by a seed-mediated method together with the shape induction agent AgNO 3 , and their growth process and mechanism, properties, as well as morphologically controlled synthesis were also investigated. The branched gold coated magnetic nanoparticles (B-GMNPs) with improved SERS performance were further utilized to build superparamagnetic and SERS-active capturers by assembling tetrahedral DNA onto their surfaces for sandwich-structured detection of cancer-related biomarker miRNA-21. The experimental results indicate that highly sensitive and specific detections can be obtained by the proposed SERS sensing system including B-GMNPs and tetrahedral DNA, and the limit of detection (LOD) of miRNA-21 in serum is 623 amol L −1 . These B-GMNPs can be used as good SERS substrates with the functions of external magnetic field controlled sample separation and directional enrichment for effective SERS-based biochemical sensing and detections.
研究领域:
纳米材料
·
生物分析化学
·
癌症诊断
·
表面增强拉曼光谱
·
生物传感器
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高影响因子
ACS Applied Materials & Interfaces
·
2013
·
IF 5.008
Ningyan Cheng,Jingqi Tian,Qian Liu,Chenjiao Ge,Abdullah H. Qusti,Abdullah M. Asiri,Abdulrahman O. Al-Youbi,Xuping Sun
Au nanoparticles (AuNPs) were loaded on graphitic carbon nitride (g-C3N4) nanosheets prepared by ultrasonication-assisted liquid exfoliation of bulk g-C3N4 via green photoreduction of Au(III) under visible light irradiation using g-C3N4 as an effective photocatalyst. The nanohybrids show superior photocatalytic activities for the decomposition of methyl orange under visible-light irradiation to bulk g-C3N4, g-C3N4 nanosheets, and AuNP/bulk g-C3N4 hybrids.
研究领域:
材料科学
·
环境催化
·
纳米技术
·
光催化
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.1
Fan Wu,Junyao Li,Ning Gu,Wenxin Huang,Datong Wu,Wenrong Cai,Zheng-Zhi Yin,Yong Kong
Since d -glucose (D-Glu) plays significant roles in energy generation and metabolite production while l -glucose (L-Glu) cannot be metabolized, discrimination and detection of Glu enantiomers is of great importance for people's daily life. Herein, chiral Au/Co 3 O 4 nanoclusters are synthesized by using L-cysteine (L-Cys) as the chiral inducer and Au 3+ as the self-assembly inducer. The introduction of Au can also enhance the conductivity of the chiral Au/Co 3 O 4 . The resulting L-Au/Co 3 O 4 nanoclusters show higher affinity toward L-Glu due to the consistent chirality of L-Au/Co 3 O 4 nanoclusters and L-Glu, which can be used for the electrochemical discrimination and detection of Glu enantiomers. Accordingly, the D-Au/Co 3 O 4 nanoclusters synthesized by using D-Cys as the chiral inducer show higher affinity toward D-Glu, and thus they can also be used for the electrochemical discrimination and detection of Glu enantiomers. The chiral Au/Co 3 O 4 exhibits high selectivity, reproducibility and stability when used for the discrimination of Glu enantiomers. Although the linear range is relatively narrow (0.05–1.5 mM), both chiral discrimination and electrochemical detection can be achieved by the proposed dual-functional sensor, which is quite different from the common Glu sensors.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2026
·Vol. 27
·期 2
·705
·
IF 4.9
Di Chen,Aoyun Meng,Zhen Li,Jinfeng Zhang
Designing and constructing heterojunctions has emerged as a pivotal strategy for improving the photocatalytic efficiency of semiconductors. In this study, we report the controlled synthesis of an Au/Zn3In2S6Schottky junction through a combination of hydrothermal and in situ photodeposition methods. The structural, morphological, and photoelectrochemical properties of the catalyst were meticulously characterized using a suite of techniques including X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), diffuse reflectance spectroscopy (DRS), X-ray photoelectron spectroscopy (XPS), photoelectrochemical (PEC) measurements, and electron spin resonance (ESR) spectroscopy. The optimized 3% Au/Zn3In2S6composite exhibited a remarkable enhancement in both photocatalytic activity and stability, achieving a 90.4% removal of bisphenol A (BPA) under UV–visible light irradiation within 100 min. The corresponding first-order reaction rate constant was approximately 1.366 h−1, nearly 4.37 times greater than that of the pristine Zn3In2S6. This substantial improvement can be attributed to several key factors, including increased BPA adsorption, enhanced light absorption, and the efficient charge separation facilitated by the Au/Zn3In2S6heterojunction. Photogenerated holes, superoxide radicals, and hydroxyl radicals were identified as the primary reactive species responsible for the BPA degradation. This work highlights the potential of metal-modified semiconductors for advanced photocatalytic applications, offering insights into the design of highly efficient materials for environmental remediation.
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