INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Kanjun Sun,Xiuting Shi,Xuan Xie,Wenbo Hou,Xiangbing Wang,Hui Peng,Guofu Ma
The flexible energy storage devices are more challenging because they not only need to perform well in terms of electrochemical properties, but also need to exhibit wide temperature domain and good mechanical properties. Herein, we prepare a novel wide temperature flexible polyacrylamide (PAM)/carboxymethyl chitosan (CMCS)/polyethylene glycol (PEG)‑sulfuric acid (H 2 SO 4 ) hydrogel electrolyte (PAM/CMCS/PEG-H 2 SO 4 ) by one-step free radical polymerization method using PAM as the polymer matrix, CMCS as blend material and PEG as functional additive. Among them, CMCS contains numerous -OH and -NH 2 groups, which can cross-link PAM and PEG to form network and bond with water molecules, making the hydrogel has excellent performance. The optimized PAM/CMCS/PEG-H 2 SO 4 hydrogel has a tensile strain about 800 % and high conductivity in the temperature ranges from −10 to 90 °C. The flexible supercapacitor assembled with commercial AC as electrode, PAM/CMCS/PEG-H 2 SO 4 hydrogel as electrolyte exhibits good cycle life with capacitance retention rate of 83.3 % after 5000 charge/discharge cycles. In addition, the device exhibits excellent electrochemical performance under wide temperature domain and various bending angles.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Yajie Zhong,Libin Dong,Jiao Li,Farzad Seidi,Guofu Li,Huining Xiao
Chronic wounds, particularly those with non-healing ulcers, show high levels of oxidant stress, such as excessive reactive oxygen species (ROS), which delays the healing process. Bacterial infections in wounds increase the need for antibiotics, which brings up serious concerns regarding antibiotic resistance. The innovative antibiotic-free strategies to endow the hydrogels with antibacterial and antioxidant features including the grafting of ROS-scavenging moieties onto the hydrogel structure are in high demand for wound management. Herein, an antibacterial and antioxidant hydrogel with rapid self-healing performance was fabricated via the dynamic borate ester cross-linkages between catechol-grafted chitosan (CS-CA) and polyvinyl alcohol in the presence of borax with the incorporation of ellagic acid (EA). Benefiting from the catechol groups from EA and CS-CA, the resulting hydrogel exhibited desirable adhesive property, excellent antioxidant and intensified antibacterial dual functions. Furthermore, the hydrogel demonstrated remarkable biocompatibility and pH-responsive behavior for the controlled release of EA, attributed to the reversible characteristics of borate ester linkages. Notably, these multifunctional hydrogels exhibited substantial regenerative capabilities in wound healing, as evidenced by in vivo assessments conducted on a full-thickness skin defect model, highlighting their considerable potential as wound dressings for effective wound management.
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THIN SOLID FILMS
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2024
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IF 2
Tran Dung Hoang,Thuy Chinh Nguyen,Thanh Tung Doan,Thanh Dung Ngo,Thi Yen Nguyen,Ba Thanh Ngo,Thanh Thuy Tran,Trong Lu Le
Polyvinyl alcohol (PVA) is a widely used polymer in the electrospinning technique. It is water-soluble, which limits the application of electrospun PVA matrix. In this study, chitosan (CS) and biosynthesized TiO 2 @Ag nanoparticles were incorporated into PVA to enhance its antibacterial properties and photocatalysis. The PVA/CS/TiO 2 @Ag nanofiber mat was prepared using the electrospinning method with a voltage of 20 kV, a needle-collector distance of 15 cm, and a flow rate of 0.5 mL. h − 1 . The concentrations of the PVA and CS solutions were 10% and 2%, respectively. The TiO 2 @Ag nanoparticles were synthesized using AgNO 3 solution, TiO 2 nanoparticles as precursors, and Cleistocalyx operculatus leaf extract as a reducing agent. The morphology and structure of the PVA/CS/TiO 2 @Ag nanofiber mat were analyzed using scanning electron microscopy and infrared spectroscopy. The PVA/CS/TiO 2 @Ag nanofibers exhibited an average fibril diameter of 116.4 nm. Additionally, the antibacterial activity against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ), as well as the photocatalytic properties of these mats, were assessed. The results indicated that the addition of CS and TiO 2 @Ag led to changes in the hydrophilic properties and antibacterial efficacy of PVA. The inhibition zones of the PVA/CS/TiO 2 @Ag nanofiber mat against E. coli and S. aureus were measured at 5 and 4 mm, respectively. The water contact angle of PVA/CS/TiO 2 @Ag nanofiber mat showed a significant increase. The PVA/CS/TiO 2 @Ag nanofibers were able to degrade 94.56 ± 0.57% and 98.17 ± 0.11% of methylene blue dye under sunlight irradiation after 10 and 20 min of exposure, respectively. These findings suggest that the PVA/CS/TiO 2 @Ag nanofiber mat has the potential for applications in the textile industry or medicinal field as antibacterial and photocatalytic coatings.
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CARBOHYDRATE RESEARCH
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2024
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IF 2.4
Lin Wang,Meihua Xin,Mingchun Li,Tao Zhang,Yu Pang,Yangfan Mao
N -(4- N ′-pyridine-benzylcarbonyl chloride) chitosan (CBPyC), N - p -biguanidine benzoyl chitosan (CSBG), and N -( p -biguanidine -1-pyridine-4-benzylcarbonyl chloride) chitosan (CSQPG) were synthesized. The structures of prepared chitosan derivatives were characterized using nuclear magnetic resonance spectroscopy (NMR) and ultraviolet–visible (UV–vis) spectroscopy, and the degree of substitution was determined through elemental analysis (EA) and evaluated on the basis of the integral values in 1 H NMR. The antibacterial activities of chitosan derivatives against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) were investigated in vitro using antibacterial rate, minimal inhibitory concentration and minimum bacterial concentration assays. The antibiofilm activity was also assessed using the crystal violet assay. CSQPC exhibited higher antibacterial and antibiofilm activities against E. coli and S. aureus compared to CBPyC and CSBG. The antibacterial rate of CSQPG against E. coli and S. aureus at a concentration of 0.5 mg/mL was 43.3% and 100%, respectively. The biofilm inhibition rate of CSQPG at 0.5 MIC against E. coli and S. aureus was 56.5% and 69.1%, respectively. At a concentration of 2.5 mg/mL, the biofilm removal rates of E. coli and S. aureus were 72.9% and 90.1%, respectively. The antibacterial and antibiofilm activities of CSQPG were better than CSBG and CBPyC, and the combination of guanidine and quaternary ammonium further improved the positive charge density of chitosan and enhanced its antibacterial activity.
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Scientific Reports
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2024
·Vol. 14
·期 1
·1-12
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IF 3.8
Yang Bing,Liu Baoliang,Gao Yuanyuan,Wei Junjie,Li Gang,Zhang Hui,Wang Linlin,Hou Zhaosheng
This study developed a kind of PEG-crosslinked O-carboxymethyl chitosan (O-CMC–PEG) with various PEG content for food packaging. The crosslinking agent of isocyanate-terminated PEG was firstly synthesized by a simple condensation reaction between PEG and excess diisocyanate, then the crosslink between O-carboxymethyl chitosan (O-CMC) and crosslinking agent occurred under mild conditions to produce O-CMC–PEG with a crosslinked structure linked by urea bonds. FT-IR and 1 H NMR techniques were utilized to confirm the chemical structures of the crosslinking agent and O-CMC–PEGs. Extensive research was conducted to investigate the impact of the PEG content (or crosslinking degree) on the physicochemical characteristics of the casted O-CMC–PEG films. The results illuminated that crosslinking and components compatibility could improve their tensile features and water vapor barrier performance, while high PEG content played the inverse effects due to the microphase separation between PEG and O-CMC segments. The in vitro degradation rate and water sensitivity primarily depended on the crosslinking degree in comparison with the PEG content. Furthermore, caused by the remaining –NH 2 groups of O-CMC, the films demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus . When the PEG content was 6% (medium crosslinking degree), the prepared O-CMC–PEG −6% film possessed optimal tensile features, high water resistance, appropriate degradation rate, low water vapor transmission rate and fine broad-spectrum antibacterial capacity, manifesting a great potential for application in food packaging to extend the shelf life.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Zhao Wei,Zoe Gunter,Zhe Qiang,Jie Ren
Chitosan (CS), a versatile biopolymer known for its diverse bioactivity, is commonly used as a coating or finishing agent to enhance fabric performance and broaden their applications. However, conventional methods for introducing CS coating layer on the fabrics often relies on using composition to control their functionality, limiting the ability to tailor properties for specific needs. In this study, we introduce an innovative coating platform utilizing drying, ionic gelation, or a combination of both to control the morphology and amino-protonation degree of CS. This approach allows the development of three distinct functional CS coatings from the same material composition. The method is effectively applied to cotton and polylactic acid (PLA)-based non-woven fabrics, preserving the permeability, breathability, and mechanical properties of the substrates. By varying processing conditions, it is found that CS coatings can impart distinct functions to the fabrics upon their morphology, such as attaining high degree of hydrophobicity (with a water contact angle reaching 129°), broad-spectrum antibacterial activity (>99.99 %) for the sample prepared by combined drying and ionic gelation methods. Additionally, our CS-coated fabrics can exhibit good biocompatibility, as demonstrated by cytocompatibility and histocompatibility evaluations, while excellent anti-adhesive properties and healing performance in infected wound models in rats can be obtained with the presence of CS microsphere. Our methods are straightforward and potentially scalable, enabling modular control over the functionality of CS-coated fabrics to meet diverse requirements. This work offers a promising strategy for modifying fabric properties with CS coatings, making it suitable for various applications such as facial masks, dressings, and antibacterial textiles.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Yu Fu,Shijie Zhao,Boqiang Zhang,Ye Tian,Dong Wang,Xinxing Ban,Yuelong Ma,Lin Jiang,Zhenshuai Wan,Zunghang Wei
Flexible nanofiber membranes are compelling materials for the development of functional multi-mode sensors; however, their essential features such as high cross-sensitivity, reliable stability and signal discrimination capability have rarely been realized simultaneously in one sensor. Here, a novel multi-mode sensor with a nanofiber membrane structure based on multiple interpenetrating networks of bidisperse magnetic particles, sodium alginate (SA), chitosan (CHI) in conjunction with polyethylene oxide hydrogels was prepared in a controllable electrospinning technology. Specifically, the morphology distributions of nanofibers could be regulated by the crosslinking degree of the interpenetrating networks and the spinning process parameters. The incorporation of SA and CHI endowed the sensor with desirable flexibility, ideal biocompatibility and skin-friendly property. Besides, the assembled sensors not only displayed preferable magnetic sensitivity of 0.34 T −1 and reliable stability, but also exhibited favorable cross-sensitivity, quick response time, and long-term durability for over 5000 cycles under various mechanical stimuli. Importantly, the multi-mode stimuli could be discriminated via producing opposite electrical signals. Furthermore, based on the signal distinguishability of the sensor, a wearable Morse code translation system assisted by the machine learning algorithm was demonstrated, enabling a high recognizing accuracy (>99.1 %) for input letters and numbers information. Due to the excellent multifunctional sensing characteristics, we believe that the sensor will have a high potential in wearable soft electronics and human-machine interactions.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Xu-Mei Zhang,Man Zhang,Ning-Ning Xu,Shu-Juan Zheng,Ni Cheng
Chronic cutaneous wounds present a significant challenge for healthcare providers globally, with the risk of bacterial infections emerging as a particularly concerning issue. There is an increasing need to employ a combination of diverse antibacterial strategies to address infections comprehensively in chronic wounds. This study introduces a highly efficient antibacterial platform that encapsulates the NO precursor (BNN6) into β-cyclodextrin-modified hemin-bearing polydopamine nanoparticles called NO/CHPDA. These nanoparticles are seamlessly integrated into a hydrogel composite comprised of L-arginine grafted chitosan (Arg-CS) and oxide dextrans (oDex). The amalgamation of photothermal therapy (PTT), chemodynamic therapy (CDT), and nitric oxide (NO) antibacterial strategies within the NO/CHPDA@Arg-CS/oDex nanocomposite hydrogel demonstrates a synergistic and highly effective capacity to eradicate bacteria and accelerate the wound healing process in vivo . Remarkably, this nanocomposite hydrogel maintains excellent biocompatibility and induces minimal side effects. The resulting nanocomposite hydrogel represents a promising therapeutic solution for treating bacterial infections in wound healing applications.
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FOOD HYDROCOLLOIDS
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2025
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IF 12.4
Fuyuan Ding,Lin Fu,Xiaowei Huang,Jiyong Shi,Megan Povey,Xiaobo Zou
Self-healing hydrogels prepared with biopolymers have been widely applied in various engineering fields. In this study, the carboxymethyl chitosan (CMC) hydrogels were fabricated through crosslinking with oxidized alginate (ADA), which can be applied in smart food packaging fields. The concentration of oxidized alginate has greatest impact on the physicochemical properties of the hydrogels. Due to the dynamic properties of Schiff base linkages and hydrogen bonds, the hydrogel demonstrated self-healing. Higher concentrations of oxidized alginate result in weaker self-healing ability of the hydrogels. The self-healing properties endowed the hydrogel with 3D printable capacity. The anthocyanin (An) in the hydrogel exhibited a color change when exposed to acidic and basic gases, making the hydrogel potentially useful for smart indicators. These intelligent indicators can be used to detect the freshness of chicken, pork and fish. In addition, the hydrogel showed excellent biodegradable properties and can be degraded in lake, soil and simulated seawater. The self-healing, biodegradable and pH sensitive hydrogels has the potential to be applied in smart food packaging.
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Liming Chang,Yanai Chen,Min Zhou,Yuanwei Gao,Yong Wang,Wenjuan Li,Zhe Cui,Chengyan Zhou,Yingna He,Jianglei Qin
Bleeding and bacterial infection are common problems associated with wound treatment, while effective blood clotting and vessel regeneration promotion are the primary considerations to design the wound dressing materials. This research presents a chitosan-based hydrogel with grafted quaternary ammonium and polyphosphate (QCSP hydrogel) as the antibacterial hemostatic dressing to achieve burn wound treatment. The tissue adhesion of the hydrogel sealed the blood flow and the polyphosphate grafted to the chitosan promoted the activation of coagulation factor V to enhance the hemostasis. At the same time, the grafted quaternary ammonium enhanced the antibacterial ability of the biodegradable hydrogel wound dressing. In addition, the polydopamine as a photothermal agent was composited into the hydrogel to enhance the antibacterial and reactive oxygen scavenging performance. The in vivo hemostasis experiment proved the polyphosphate enhanced the coagulation property. Moreover, this photothermal property of the composite hydrogel enhanced the burn wound repairing rate combined with the NIR stimulus. As a result, this hydrogel could have potential application in clinic as dressing material for hemostasis and infection prone would repairing.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Gang Wu,Wei Su,Lini Huo,Qing Guo,Jianhua Wei,Haiyi Zhong,Peiyuan Li
Developing bifunctional innovative food packaging for maintaining and monitoring food freshness is crucial for food safety. Here, we prepared tannic acid cinnamaldehyde nanoemulsions through self-assembly and ionic cross-linking between the natural emulsifiers tannic acid and cinnamaldehyde, and were incorporated into chitosan as a protective outer layer. Sodium alginate anchored with alizarin was employed as the sensing inner layer. A pH-sensitive bilayer film integrating real-time monitoring and maintenance of food fresh food freshness was designed using layer-by-layer assembly (LBL) technology. The prepared bilayer film exhibited 100 % UV protection, >99 % antimicrobial effect, and 94.86 % and 97.91 % clearance rates for DPPH and ABTS free radicals, respectively. In addition, the bilayer film exhibited high biosafety and sensitive, reversible, and rapid response to pH/NH 3 . Shrimp preservation experiments showed that the smart bilayer film could effectively slow down the growth of microorganisms on the surface of shrimp, extend the freshness period of shrimp, and could monitor the freshness of shrimp in real-time through color changes. In conclusion, the prepared SL-CCT bilayer film has excellent potential for food preservation and freshness monitoring, providing a new perspective for design and development of multifunctional smart food packaging films.
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APPLIED CLAY SCIENCE
·
2024
·
IF 5.3
Jinmiao Chen,Yuxi Mo,Xiangyan Zhang,Shaohua Zhang,Aihua Cui,Xueqin Wang,Jiwei Li
In this study, chitosan/polyethylene oxide fibrous membranes (CS/PEO) with varying halloysite nanotubes (HNTs) contents were prepared by solution-blow spinning. The HNTs-CS/PEO membranes with a 12 wt% HNTs content exhibited excellent hydrophilicity, air permeability, and flexibility. The in vitro hemostasis time of the 12 % HNTs-CS/PEO was 217 s, and it was observed to form a stable thrombus. Moreover, the antibacterial efficacy of 12 % HNTs-CS/PEO against Escherichia coli and Staphylococcus aureus was 90.05 % and 69.86 %, respectively. Furthermore, the in vitro cytotoxicity study demonstrated the nontoxic nature of the 12 % HNTs-CS/PEO. The solution-blow spinning HNTs-CS/PEO fibrous membrane can potentially prevent the risk of distal thrombosis caused by separating individual HNTs and offer the advantages of a simple preparation and application process. This study presents a novel first-aid hemostatic dressing and offers a novel approach to loading inorganic nanoparticles onto fibers.
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