PHARMACOLOGICAL RESEARCH
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2022
·
IF 10.334
Yuhang Li,Yitian Li,Sennan Xu,Yue Chen,Pan Zhou,Ting Hu,Hua Li,Ying Liu,Yaping Xu,Jie Ren,Yan Qiu,Canzhong Lu
Psoriasis is an incurable autoimmune disease that affects 2–3% of the world’s population. Limited understanding of its pathogenesis hinders the development of therapies for the disease. Herein, we reported that N-acylethanolamine acid amidase (NAAA), a cysteine enzyme that catalyzes the hydrolysis of fatty acid ethanolamides (FAEs), was upregulated in psoriasis patients and imiquimod (IMQ)-induced mouse model of psoriasis. The upregulated NAAA contributes to the progression of psoriasis via enhancing dendritic cell (DCs) maturation. Transgenic expression of NAAA in mice accelerated the development of psoriasis, whereas genetic ablation of NAAA or local administration of NAAA inhibitor F96 ameliorated psoriasis. NAAA expressed in dendritic cells (DCs), but not in macrophages, T cells, or keratinocytes plays a critical role in psoriasis development. In addition, the results showed that NAAA degrades palmitoylethanolamide (PEA) and reduces PEA-PPARα-mediated dissociation of NF-κB p65 from Sirtuin 1 (SIRT1), subsequently, repressing the acetylation of p65 and down-regulating IL10 production. The decreased IL10 then leads to the maturation of DCs, thus promoting the development of psoriasis. These results provide new insights into the pathophysiological mechanism of psoriasis and identify NAAA as a novel target for the treatment of psoriasis.
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高影响因子
ACS Omega
·
2022
·
IF 4.132
Tianxiang Jin,Jingwei Su,Qingyun Luo,Wei Zhu,Haizhen Lai,Dejuan Huang,Chunyan Wang
Biomass-derived activated carbon is a widely used electrode material for supercapacitors. One of the keys to preparing high-performance activated carbon is the selection of appropriate precursors. Daylily is a common edible herb and is widely planted in Asia. It is rich in nitrogen and phosphorus, so it can be used as a precursor of heteroatom-doped activated carbon. Herein, a daylily-derived porous carbon with a large specific surface area and high content of heteroatoms has been successfully prepared by a simple carbonization method. The as-prepared carbon materials showed a remarkable specific capacitance of 299.1 F/g at 0.5 A/g and excellent cycling stability of 99.6% after 4000 cycles at a current density of 1 A/g. Moreover, the assembled symmetric supercapacitor showed a high energy density of 21.6 Wh/kg at a power density of 598.2 W/kg in 6 M KOH electrolyte. These results demonstrate that the daylily-derived porous carbon is an excellent material for high-performance supercapacitors.
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高影响因子
DALTON TRANSACTIONS
·
2022
·Vol. 51
·期 26
·10160-10168
·
IF 4.569
Li Luo,Siran Xu,Xin Yu,Zhe Wang,Wenjing Li,Yeshuang Du,Min Ruan,Qi Wu
Developing low-cost, high-performance and corrosion-resistant catalysts for water splitting is anticipated, but it will also be a big challenge. In this study, nanowall-like N-Ni5P4/Ni2P/NF (N-NiP/NF) was synthesized by a simple two-step method involving hydrothermal treatment and phosphorylation. The catalyst has good catalytic activity for the OER, and only 160 mV is required to achieve a current density of 10 mA cm−2 in 1 M KOH, which is even better than RuO2, with good corrosion resistance. In addition, N-Co2P/Ni2P/NF (N-CoP/NF) was synthesized by the same method with good electrocatalytic properties and good conductivity towards the HER. N-NiP/NF was used as the anode and N-CoP/NF was used as the cathode to form the N-NiP//N-CoP double electrode system, which showed excellent electrolytic performance for water splitting, requiring only 1.48 V to reach 10 mA cm−2. This is mainly due to the strong electronegativity of N that makes the N doping induce the electron transfer process, which results in a high catalytic activity of the adjacent transition metal atoms and thus promotes the electrolysis of water, as well as the unique vertical nanowall-like structure, which gives the material a large surface area and accessibility to active sites, facilitating the adsorption of water molecules and catalytic reactions. In addition, the unique structure favors the diffusion of water molecules and the release of gaseous products, ensuring close contact between the catalyst and the electroactive material. This simple non-metallic N doping strategy provides a new way to produce efficient non-precious metal catalysts.
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高影响因子
CHEMICAL PAPERS
·
2022
·Vol. 76
·期 9
·5819-5825
·
IF 2.146
Lin Yuan,Li Xin Kang,Yan Jia Ying,Lei Ying Lin,Chen Jing,Li Bao Qiong
A sample and effective approach for quantitative determination of the prohibited component named psoralen in cosmetics was proposed on the basis of emission-excitation fluorescence matrix (EEFM) coupled with N-PLS method. The standard samples were divided into the calibration set and prediction set; the N-PLS model was established on the calibration set and the predictive ability of the established model was validated by prediction set. In this regard, some statistical parameters and figures of merit, such as correlation coefficient of calibration ( \(R_{{\text{c}}}^{2}\) ) and prediction ( \(R_{{\text{p}}}^{2}\) ), root mean square error of calibration ( RMSEC ) and prediction ( RMSEP ), and recovery were investigated to evaluate the performance of proposed method. The N-PLS model developed on the EEFM showed \(R_{c}^{2}\) and \(R_{{\text{p}}}^{2}\) of 0.9951 and 0.9982, respectively, and showed RMSEC and RMSEP of 1.5636 and 2.7618, respectively, demonstrating the established model has good linearity and predictive ability. Moreover, the recovery rates in the range of 105.40–123.61% demonstrated that the proposed strategy has good accuracy. Finally, the established model applied to the real cosmetic samples showed that the psoralen was not detected, and the obtained results were in accordance with those of the validated gas chromatography method. The satisfactory results indicated that EEFM combined with the N-PLS method can be employed as a reliable tool for quality monitoring of cosmetic products.
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ACS Applied Nano Materials
·
2022
·
IF 6.14
Jiang Zhao,Shumeng Wang,Lijuan Gao,Da Zhang,Yanyan Guo,Rongqing Xu
As an energy storage component of wearable electronics, planar micro-supercapacitors (MSCs) hold great advantages in terms of flexibility, miniaturization, and integration. However, the preparation process of MSCs is rather cumbersome. A simple, fast, and efficient technique for preparing MSCs is still of strong desirability. Herein, a fast and efficient laser direct writing technique is proposed to in situ fabricate NiO nanoparticles anchored on N-doped laser-induced graphene (NiO/NLIG) composite electrodes on account of the formation principle of the polyimide (PI) film, which are subsequently assembled into high-performance flexible planar MSCs. The as-assembled NiO/NLIG MSCs can achieve a remarkable areal specific capacitance of 25.11 mF cm–2, a superior energy density of 1.88 mW h cm–2 at a high power density of 0.02 mW cm–2, excellent bendability, and good cycling performance. Furthermore, due to advantages of consistency and stability of laser direct writing, the proposed high-performance planar NiO/NLIG MSCs with consistency and stability can be easily modularized and integrated to provide customized requirements and are the most promising crucial micro-power energy storage components for flexible integrated electronics.
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Materials
·
2022
·Vol. 15
·期 15
·5331
·
IF 3.748
Min Sun,Pengyu Zhang,Qingmin Li,Guowu Tang,Ting Zhang,Dongdan Chen,Qi Qian
N-type bismuth telluride (Bi2Te3) based thermoelectric (TE) fibers were fabricated by thermal drawing and Bridgman annealing, and the influence of Bridgman annealing on the TE properties of n-type Bi2Te3-based TE fibers was studied. The Bridgman annealing enhanced the electrical conductivity and Seebeck coefficient because of increasing crystalline orientation and decreasing detrimental elemental enrichment. The TE performance of n-type Bi2Te3-based TE fibers was improved significantly by enhancing the power factor. Hence the power factor increased from 0.14 to 0.93 mW/mK2, and the figure-of-merit value is from 0.11 to 0.43 at ~300 K, respectively.Keywords:n-type Bi2Te3;thermoelectric fibers;thermal drawing;Bridgman annealing
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 35
·16752-16763
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IF 3.925
Kai Guo,Aizeng Ma,Zijian Wang,Jinzhi Li,Bingfeng Wu,Tong Liu,Dadong Li
The design of various hierarchical structures and morphologies of ZSM-22 zeolite catalysts is attempted through a post-treatment using different concentrations of NaOH and subsequently treating with HCl solution including fluosilicic acid (H2SiF6) and then loading Pt on their surfaces. The effects of samples on textural characters, acidity, as well as n-heptane catalytic hydroisomerization evaluation were examined. The formation process of the hierarchical structures was further investigated. Test and evaluation results indicated that samples treated with 0–0.5 M NaOH and subsequently treated with 6.0 M HCl and 0.1 M H2SiF6 were much more controllable and reasonable due to the better structure-activity relationship of the catalyst by changing crystal morphologies and introducing hierarchical structures. Indeed, PZH-0.3 exhibited 81.1% of the highest n-heptane conversion and 76.4% of total i-heptane yield in the n-heptane catalytic hydroisomerization process at 260 °C, PZH-0.5 displayed 13.6% of the maximum multi-branched i-heptane yield, which was above 104.1% in comparison with PZ-0 at 320 °C. Moreover, PZH-0.3 presented the highest n-butane yield, which possessed a proportion of 65.9% in the butane component of cracking products at 340 °C and improved an average of 16% and 22 times when utilizing PZ-0 and Pt/ZSM-5 catalysts. Additionally, the mechanism of the reaction process is briefly depicted according to the distribution of the reaction products. The regulation of zeolite both on crystal morphologies and pore hierarchy has obvious advantages in the hydroisomerization process, which can improve the composition of multi-branched isomers with high octane number effectively as well as supply raw materials for the chemical industry.
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Frontiers of Optoelectronics
·
2022
·Vol. 15
·期 1
·1-9
·
IF 0
Zhou Xingwei,Zhang Wei,Zhang Zunhao,Wang Zizhun,Zou Xu,Li Dabing,Zheng Weitao
The oriented two-dimensional porous nitrogen-doped carbon embedded with CoS 2 and MoS 2 nanosheets is a highly efficient bifunctional electrocatalyst. The hierarchical structure ensures fast mass transfer capacity in improving the electrocatalytic activity. And the greatly increased specific surface area is beneficial to expose more electrocatalytically active atoms. For oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) tests in 1 mol/L KOH solution, only 194 and 140 mV overpotential are required to achieve a current density of 10 mA/cm 2 , respectively. Our research provides an effective strategy for synergizing the individual components in nanostructures for a wide range of electrocatalytic reactions. Graphical Abstract
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SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Weiyi Bu,Yan Zhang,Qixuan Qin,Yuliang Li,Zhijie Zhou,Changhua Hu,Xiaohong Chuai,Tianshuang Wang,Peng Sun,Geyu Lu
In our work, CdS nanocrystals were simply prepared via coprecipitation method and subsequent annealing process (300, 400, 500 °C). X-ray powder diffraction (XRD) and the transmission electron microscope (TEM) etc. methods were used to analyze structure morphologies of the samples. The unannealed CdS nanocrystal is cubic, its phase evolution depends on annealing temperature. At 300 °C, its cubic phase was remained. Annealing at 400 °C makes small amount of hexagonal phase produced and cubic/hexagonal homojunctions were formed. Thorough phase transition to hexagonal phase was completed at 500 °C. The sensing properties based on the synthesized CdS nanocrystals with different phase structures were measured. The CdS-400 based sensor had the highest sensitivity to n-propanol, which was 41 at the optimum temperature of 225 °C. The response time was less than 1 s and the best selectivity was also obtained. The greatly enhanced gas sensing performance may be attributed to cubic/hexagonal CdS homojunction.
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ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Li Fu,Xiancheng Liu,Ying Zeng,Qingqing Zhang,Bin Zhang,Xuwen Gao,Guizheng Zou
The electrochemiluminescence (ECL) bioassay is prominently carried out with the involvement of the coreactant. To remove the detrimental effects of the coreactant on the ECL of luminophores, herein, a promising ECL immunoassay strategy with biocompatible nanoparticles as the luminophore is proposed, which involves directly and electrochemically oxidizing the luminophore methionine-capped Au (Met@Au) nanocrystals (NCs) without the participation of any coreactant. Met@Au NCs are a kind of n-type nanoparticles, and they can be electrochemically injected with valence band (VB) holes around +0.80 and +1.10 V (vs Ag/AgCl). The electrochemically injected exogenous VB hole can recombine with the endogenous conduction band electron of Met@Au NCs and eventually bring out two coreactant-free and near-infrared ECL processes around 0.80 V (ECL-1) and 1.10 V (ECL-2). The intensity of coreactant-free ECL is primarily determined by the electrochemical oxidation-induced hole-injection process. ECL-2 is considerably stronger than ECL-1 and can be exploited for determining the carcinoembryonic antigen (CEA) in a sandwich immunoassay procedure with a linear range from 0.1 to 50 pg/mL as well as a limit of detection of 0.03 pg/mL (S/N = 3).
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高影响因子
Chemosensors
·
2022
·Vol. 10
·期 8
·334
·
IF 4.229
Shangxin Guo,Jing Lan,Bo Liu,Baixiu Zheng,Xingchu Gong,Xiaohui Fan
The carbon quantum dot (CQD) paper-based analytical device (PAD) has drawn great attention and is being intensively explored. However, the construction of a continuous flow CQD synthesis device remains challenging. In this work, a continuous flow reaction apparatus was constructed to synthesize nitrogen-doped CQDs using a mixed-solvent system of tetraethylene glycol and water. The optical properties of the CQDs were characterized. The CQDs were found to be quenched by phenolics such as chlorogenic acid, salvianolic acid B, and rutin. The CQD PAD was prepared for the determination of the total phenolic content of honeysuckle extracts. A smartphone was used to test the analytical performance of the CQD PAD. The results demonstrated that the degree of fluorescence quenching of the CQDs showed a linear relationship with the concentration of the added chlorogenic acid solution. This method was compared with the total phenolic assay in the Chinese Pharmacopoeia, and the statistical test showed no significant difference between their results. With aqueous tetraethylene glycol as the solvent for the synthesis, the continuous flow reactor for CQD preparation could be easily set up. The CQD PAD is convenient, cheap, and expected to be used for the rapid quality detection of traditional Chinese medicines.Keywords:Chinese medicine quality;carbon quantum dots;PAD;total phenolic content;continuous flow synthesis;tetraethylene glycol
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2022
·
IF 24.319
Xinxin Han,Bingjie Lu,Xin Huang,Cheng Liu,Shixia Chen,Jingwen Chen,Zheling Zeng,Shuguang Deng,Jun Wang
S-scheme photocatalysts are more efficient than the conventional type-II configuration, but the CO 2 reduction performances are still unsatisfactory. Herein, we firstly report the layered double hydroxide (LDH) based S-scheme heterostructure photocatalyst (NiIn LDH/In 2 S 3 ) with n-type NiIn LDH and p-type In 2 S 3 . The built-in internal electric field directs the photogenerated electrons flow from the conductive band of In 2 S 3 to the valance band of NiIn LDH, which is confirmed by operando and theoretical experiments. The CO 2 photoreduction intermediates are monitored by in-situ Raman spectra, and the density functional calculations disclose the reduced energy barrier for CO desorption on the heterojunction. Therefore, without cocatalysts or sacrificial agents, the NiIn LDH/In 2 S 3 heterojunction delivers a high CO yield rate of 29.43 μmol g −1 h −1 under visible light irradiation, ca. 3.5 and 4.3 times higher than the single counterpart NiIn LDH and In 2 S 3 . Notably, this value is the highest among S-scheme CO 2 photocatalysts and surpasses most top-ranking benchmarks.
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危险品化学品经营许可证（带存储）