ChemistrySelect
·
2024
·Vol. 9
·期 9
·e202303257
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IF 1.9
Rena Simayi,Xiaohui Zhang,Amatjan Sawut,Ziwen Zhu,Tongmeng Wu,Menghao Jiang
Graphical In this paper, the pH-responsive semi-interpenetrating CS/PAA hydrogel was synthesized through UV-initiated free-radical polymerization, enabling the incorporation of chitosan chains into the polyacrylic acid network. Moreover, adjusting the cross linking density of the polymer network and the content of pH-sensitive groups, such as amino and carboxyl groups, by modulating the CS/AA ratio can alter the swelling and pH sensitivity of hydrogels. The hydrogels exhibited not only a strong pH responsiveness, but also pH cycling reversibility, with reversible pH response for the sustained release of Asa in alternating cycles of pH 1.2 and 7.4. Hence, the hydrogels prepared in this study can be more suitable for use in the drug delivery through the human body system. A pH-sensitive semi-interpenetrating network hydrogel was synthesised by free radical polymerization using a one-pot method using chitosan (CS) and alanine (AA) as the raw materials, and then the hydrogel was immersed in a solution of the model drug aspirin (Asa) for loading, and subsequently used for drug sustained-release testing. The effects of the ratio of CS and AA on the internal structure of hydrogels were investigated, and the mechanism of CS/PAA semi-interpenetrating network hydrogels upon drug slow release was explored. The results showed that increasing the composite ratio of PAA resulted in a subsequent increase in the drug loading capacity of CS/PAA hydrogels and the cumulative release of drugs. When the concentration of the drug-loading solution was 200 mg/L, the drug loading and encapsulation efficiency of CS/PAA-1 were 16.23±0.57 (%) and 72.16±3.84 (%), respectively (p < 0.05). The hydrogels showed significant pH-responsive release properties and pH cycling reversibility, with 25.69±1.27 (%) and 77.21±2.68 (%) cumulative drug release over 24 h in the release media of pH 1.2 (simulating gastric fluid) and 7.4 (simulating intestinal fluid), respectively (p < 0.05), and the pH-responsive reversible release of Asa was maintained in alternating cycles in the release media with pH 1.2 and 7.4.
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JOURNAL OF MOLECULAR LIQUIDS
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2024
·
IF 5.3
Zhuoyu Yin,Likang Fu,Hongliang Liu,Na Xiong,Xingmei Wang,Shixing Wang,Yingbi Chen,Chen Wang
Cu(II) has garnered significant attention due to its adverse effects on the environment and human health. To address this issue, researchers developed a magnetic chitosan material (MnFe 2 O 4 -CS) as an adsorbent, exhibiting remarkable properties for effective Cu(II) capture and offering repeatability. MnFe 2 O 4 -CS features abundant nitrogen-containing functional groups that enhance its adsorption performance. Additionally, MnFe 2 O 4 -CS possesses excellent saturation magnetization, enabling easy removal from water. Experimental findings reveal that MnFe 2 O 4 -CS achieves an impressive Cu(II) removal rate of 99.8%. With an adsorption capacity of up to 103.6 mg/g. The fitting results demonstrated that the isothermal process followed the Redlich-Peterson model, indicating a complex adsorption behavior of Cu(II) by MnFe 2 O 4 -CS. The kinetic process followed a pseudo-second-order model, and the thermodynamic parameters prove that the present study is a heat-absorption reaction. The kinetics and thermodynamics prove that the adsorption of Cu(II) by MnFe 2 O 4 -CS is a chemisorption. MnFe 2 O 4 -CS maintains a high removal capacity for Cu(II) in aqueous solutions after six cycles. In summary, MnFe 2 O 4 -CS quickly and efficiently adsorbs Cu(II) ions, showing potential for practical application in heavy metals removal.
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CARBOHYDRATE POLYMERS
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2024
·
IF 10.7
Bowen Shen,Zhaoxu Yan,Yuxian Wang,Liying Zhu,Qianru Zhao,Ling Jiang
A novel strategy that has emerged in recent years involves the use of aerogels for anti-inflammatory treatment, which has been extensively studied for its powerful application prospects in wound healing, diabetic complications, and tissue regeneration. However, the therapeutic efficacy of aerogels alone is compromised due to bacterial infections at the wound site. Therefore, it is necessary to incorporate effective antibacterial systems onto the aerogels to enhance their efficacy against bacterial infections. For instance, the design of cascade reactions targeting specific disease biomarkers for diagnostic and therapeutic purposes holds promise for enhancing treatment efficacy and precision. In this study, we successfully achieved the immobilization of glucose oxidase within an aerogel prepared from nanozymes, demonstrating remarkable catalytic activity and high-temperature stability. The cascade catalytic system comprising nanozymes and glucose oxidase was applied to combat Methicillin-resistant Staphylococcus aureus (MASR) bacterial infections, exhibiting effective biofilm removal capabilities. In therapeutic experiments on ulcerated wounds in diabetic mice, the cascade catalytic system demonstrated outstanding efficacy with excellent biocompatibility. The therapeutic effects were primarily manifested in the rapid clearance of biofilms formed by MASR, achieved by locally depleting glucose in the wound area, thereby promoting the healing process of ulcerated wounds.
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International Journal of Nanomedicine
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2024
·
IF 6.6
Nanan Miao,Tao Jiang,Yuanchao Li,Sihong Xue,Shilei Hao,Chunli Zhou,Yujie Gu,Ran Li,Bo Yu,Xiaoqu Duan,Wenchao Xu,Rupeng Wang,Lei Ran
Background Wound healing is a complex physiological process that can be roughly divided into four stages: hemostasis, inflammation, proliferation, and remodeling. Conventional wound dressings often fail to meet the diverse needs of these healing stages due to their limited functionality. Cryogels, however, possess several attractive properties, such as large, interconnected pores, good mechanical strength, and ease of modification, making them suitable for developing advanced dressings with multiple functions. In this study, we developed a multifunctional cryogel dressing, with biocompatible polysaccharides as the main component, designed to provide a breathable, moist, and antibacterial microenvironment for chronic infected wounds, thereby promoting wound healing.Methods Recombinant keratin 31 (RK31) was combined with chitosan (CS) to produce a CS/RK31 cryogel, referred to as CK. Gallic acid-reduced silver nanoparticles (GA/Ag NPs) were incorporated as the active antibacterial component to create the CS/K31@GA/Ag cryogel, known as CKGA. The cryogel was characterized using scanning electron microscopy (SEM) and a universal testing machine, and its biocompatibility was assessed in vitro. The dynamic hemostatic performance of the cryogel was evaluated with a rat tail amputation bleeding model. Additionally, the antibacterial effects of the cryogel against Staphylococcus aureus and Escherichia coli were tested using agar diffusion assays and turbidimetry. The antioxidant capacity of the CKGA cryogel was also measured in vitro. Finally, the cryogel’s ability to promote wound healing was tested in an SD rat model of infected wounds.Results Characterization results showed that the CKGA cryogel features an interpenetrating porous network structure and exhibits excellent mechanical properties, with a swelling rate of up to 1800%. Both in vitro and in vivo experiments confirmed that the cryogel has good biocompatibility, effectively absorbs exudates, and rapidly stops bleeding. The addition of GA/Ag NPs provided significant antibacterial effects, achieving an inhibition rate of over 99.9% against both S. aureus and E. coli. Furthermore, CKGA cryogels demonstrated a strong scavenging capacity for ROS in a dose-dependent manner. Studies using the SD rat infected wound model showed that the cryogel effectively inhibited bacterial proliferation on wound surfaces, reduced local tissue inflammation, and promoted the healing of infected wounds.Conclusion The multifunctional cryogel, with its rapid hemostatic, antibacterial, and antioxidant properties, as well as its ability to promote cell proliferation, could be widely used as a wound dressing for the healing of bacterial infections.
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Journal of Materials Chemistry A
·
2024
·Vol. 12
·期 7
·4099-4107
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IF 10.7
Yuankun Wang,Defeng Wu
Sufficient water supply and evaporation interfaces are vital for hydrogels as solar evaporators, which require ingenious structural design, from the networks and porous structure inside the bulk to the surface morphology outside the hydrogel. A chitosan based anisotropic hydrogel with well-regulated surface architecture is reported here. The aligned channels formed inside the bulk via directional freezing ensure water supply, and the ionic crosslinking further improves the mechanical stability of the bulk and also reduces the evaporation enthalpy of the seawater inside the channels. The small vessels radially distributed over the pores of the evaporation surface, together with the large-sized pores, act as a reservoir, promoting salt exchange and water evaporation and on the other hand, as drains of concentrated seawater, favoring the accumulation of a salt shell outside the hydrogel. Thus, as-prepared solar evaporator shows desirable performance (3.86 kg m−2 h−1 evaporation rate and 96.7% conversion efficiency under 1 sun irradiation) and superior salt-collection ability. The evaporation rate can maintain well even after 10 desalination cycles (over 3.5 kg m−2 h−1, in 20% brine). This work gives an eco-friendly solution for clean water production by using chitosan-based hydrogel evaporators and proposes a method of regulating evaporation surface architecture for hydrogel-based evaporators.
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ACS Biomaterials Science & Engineering
·
2024
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IF 5.4
Yixiao Chen,Guoqing Li,Yufeng Ge,Su Liu,Jian Weng,Jianjing Lin,Ao Xiong,Hui Zeng,Xinbao Wu,Jun Yang,Fei Yu
In this study, we explore the cartilage defect repair mechanism by phosphocreatine-grafted chitosan hydrogels loaded with berberine-treated ATDC5 cells (CSMP@BBR@ATDC5). Under the optimal concentrations of LPS and BBR ideal conditions, ATDC5 cell toxicity and proliferation were detected with AM/PI and EdU staining. Additionally, qPCR and Western blot were employed to detect the expression of the SIRT1/BMP4 signaling pathway and chondrogenic-related factors in ATDC5 cells. Moreover, BBR-treated ATDC5 was seeded into a phosphocreatine-grafted chitosan hydrogel system. Subsequently, the cartilage defect was established in mice. After 4, 8, and 12 weeks, knee specimens were collected to evaluate the repair of cartilage defects. According to our findings, BBR can increase ATDC5 viability by LPS treatment. Likewise, it upregulates the SIRT1/BMP4 signaling pathway expression and chondrogenic-related factors. Another, it was shown by histological observation that the cartilage defect had been repaired more effectively in the CSMP@BBR@ATDC5 group than in the other groups. Finally, the expressions of chondrogenic-related factors and SIRT1/BMP4 signaling pathway were upregulates in CSMP@BBR@ATDC5 than in other groups. In vitro, BBR protects inflammatory ATDC5 cells and maintains the expression of chondrogenic-related factors. Subsequently, we successfully use CSMP@BBR@ATDC 5 to repair knee cartilage defects in mice.
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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
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2024
·
IF 4.2
Huimin Liao,Jinghong Wang,Feiran Chen,Le Ya,Ningke Fan,Yinghua Shu,Zhenggao Xiao,Zhenyu Wang
The abundance of monoterpenoids and phenolic compounds determines the medicinal quality and anti-insect properties of Agastache rugosa , which can be compromised by biotic stress such as herbivore attacks. The traditional use of chemical pesticides to mitigate herbivore interference is increasingly incompatible with sustainable agriculture. In response, nanotechnology-based biostimulants, which can activate metabolic processes to enhance plant growth and stress resistance, offer a more cost-effective and environmentally-friendly alternative. However, to date, it remains unknown how nano-biostimulants improve the therapeutic value and insect resistance of medicinal plants simultaneously. This study investigates the effect of 0–1000 mg/L of a nano-biostimulant salicylic acid functionalized chitosan nanocomposite (SCN) on the pharmacological and anti-herbivore properties of medicinal plant A. rugosa . Results showed that 100 mg/L SCN significantly inhibited Spodoptera litura growth by 62.9 %, and increased plant shoot and root biomass by 107.2 % and 77.6 %, respectively. Moreover, 100 mg/L SCN significantly upregulated the expression of the key genes ( e.g. , LS , L3OH , and CHS ) involved in monoterpene and phenolic compounds biosynthesis by 1.4–10.1 folds, thus boosting the production of active compounds such as pulegone, β-myrcene, and chlorogenic acid by 1.5–24.4 folds. These enhancements were superior to salicylic acid or chitosan alone. Altogether, our findings promote the sustainable and eco-friendly application of nano-biostimulant in improving the quality of medicinal plants and green pest control in agroecosystems.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yujie Duan,Wei Wang,Ji Jia,Xiaohang Tuo,Yumei Gong,Fengyu Quan
A polyelectrolyte system consisting of sodium alginate (SA) and quaternary ammonium chitosan (QAC) blended with polydopamine-coated copper sulfide particles (CuS@PDA) was chosen to investigate the function of CuS@PDA in the uniform binary blending of anionic and cationic polyelectrolytes in detail. A smart composite fiber SA/QAC/CuS@PDA was prepared via a dry-wet spinning technique. With the addition of CuS@PDA (about 4.3 % in fiber), the as-prepared SA/QAC/ [email protected] fibers ( [email protected] SCFs) showed notably enhanced intensity 359.2 MPa, excellent moisture response, and photothermal conversion performance, with the temperature increasing from 25.9 to 80.7 °C as irradiated under a 980 nm infrared lamp at distance 20 cm away for 120 s. The photothermal performance was maintained after 6 lighting on-and-off cycles. The tensile strength decreased ~23.8 % after 4 cycles, then remained fixed. The diameter increases to ~480 % in wet state but decreases to the original size in dry state for 10 cycles. When the fabric with 90 wt% [email protected] SCFs was used as a water evaporator, the water evaporation rate and efficiency were 1.68 kg·m −2 ·h −1 and 102 % under 1 sun irradiation. This work provides a simple and ecofriendly strategy for fabricating photothermal fabrics by designing and preparing composite fibers.
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PROCESS BIOCHEMISTRY
·
2025
·
IF 4
Ruirui Liu,Qi Li,Huaqiang Cao,Sha Ao,Fanqiong Li,Yan Li,Bin Li,Haiqing Chen,Shilin Liu
In this study, chitosan-stabilized water in water (W/W) emulsions had been fabricated by using polyethylene oxide (PEO) and maltodextrin (MD) to encapsulate Lactobacillus plantarum for high-density culture. Systematic investigations had been conducted to evaluate the effects of chitosan viscosity, concentration, MRS broth concentration, ionic strength, and pH on the stability of the emulsions. The chitosan-stabilized W/W emulsions demonstrated high stability across diverse environmental conditions, exhibiting no phase separation after 7 days storage even at minimal chitosan concentrations of 0.02 wt% (weight percentage, wt%). Notably, the pH-responsive chitosan-stabilized W/W emulsions maintained structural integrity for 30 days at pH 6.0. The semi-permeable characteristics of W/W interfaces enabled efficient nutrient uptake and metabolite exchange, facilitating successful encapsulation and cultivation of Lactobacillus plantarum within the emulsion matrix. Optimal cultivation was achieved using emulsions containing 1.0 wt% MRS broth, yielding a peak viable cell count of 1.09 × 10 9 CFU/mL. These findings demonstrated that chitosan-stabilized W/W emulsions hold significant potential for probiotic protection and the development of microreactors enabling high-density microbial cultivation.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2021
·
IF 5.268
Can Wang,Bingxian Lin,Yunren Qiu
A novel modified polysulfone (PSF) is successfully prepared for hemodialysis by grafting with a well-defined heparin-like polymer, sulfonated dihydroxypropyl chitosan (SDHPCS), which is obtained in proper sequence via alkalization of chitosan, etherification and sulfonation . PSF is modified via chloroacetyl chloride , and then, the chloroacylated polysulfone (CAPSF) with pristine PSF is transformed into CAPSF/PSF blend membrane via the phase inversion, followed introducing amino group into CAPSF on the surface and taking glutaraldehyde as bridge between modified PSF membrane and SDHPCS. The result of 1 H NMR spectrum of prepared CAPSF indicates that the degree of the substitution of chloroacetyl group . The SEM, EDS mapping, FTIR and XPS show that SDHPCS-g-PSF membranes are successfully prepared. The hydrophilicity of the membrane modified by SDHPCS is improved obviously, and the contact angle remarkably reduced from 87 ° to below 45°, exhibiting much better hydrophilicity. The hemocompatibility characterizations including BSA adsorption, Plasma recalcification time (PRT), hemolysis ratio (HR), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) also certificates that SDHPCS-g-PSF possesses lower BSA adsorption and enhanced blood compatibility.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Qun Zheng,Deqiang Qin,Ruifei Wang,Wenjuan Yan,Weihua Zhao,Shigang Shen,Suqing Huang,Dongmei Cheng,Chen Zhao,Zhixiang Zhang
Botanical pesticides are biological pesticides that are environment friendly. However, their instability and short persistence limit their application. In this study, pH sensitive chitosan based rotenone (Rot) nanoparticles (CS/CMCS/Rot-NPs) were prepared using chitosan and carboxymethyl chitosan to take advantage of the acidic nature of the red fire ant midgut. Chitosan based nanoparticles showed photoprotective and slow sustained release effects on Rot and significantly increased the insecticidal activity of Rot against red fire ants. The 24–96hLC 50 of CS/CMCS/Rot-NPs against red fire ants was 3.28–6.84 fold that of Rot. The CS/CMCS/Rot-NPs significantly reduced the venom alkaloid content of red fire ants and their living environment and weakened their survival by increasing their survival cost in the ecological environment. Nanotechnology combined with botanical pesticides can be used as a novel, safe, effective, and ecofriendly method to control red fire ants.
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Biomaterials Science
·
2021
·Vol. 9
·期 9
·3319-3333
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IF 6.843
Mengyu Yao,Qingxia Zou,Wenwu Zou,Zhenze Xie,Zhihao Li,Xiujuan Zhao,Chang Du
The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties is promising for the therapy of bone tumor where large bone defects often occur. In this study, hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds were prepared by the 3D-printing technology. PDA significantly improved the rheological properties of the slurry for molding, mechanical properties, surface relative potential, and water absorption of composite scaffolds. The osteogenic properties of HA/PDA/CMCS composite scaffolds were evaluated by the cell experiment in vitro. The photothermal properties and anti-tumor effects of the scaffolds in vivo were assessed by the tumor model in nude mice. HA/PDA/CMCS composite scaffolds could promote more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) than scaffolds without PDA in vitro and the effect was not hindered by the photothermal process. The PDA-modified composite scaffold had excellent photothermal properties. Cell experiments showed that scaffolds with PDA under irradiation could suppress the tumor effectively. In vivo anti-tumor effects in nude mice indicated that the HA/PDA/CMCS composite scaffold promoted cell apoptosis/necrosis by the direct photothermal effect. Vascular injury was developed subsequently, which lead to the suppression of tumor cell proliferation due to hypoxia-ischemia. HA/PDA/CMCS composite scaffolds with multiple effects have great potential application in bone tumor therapy.
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