Energy Storage Materials
·
2026
·
IF 19.3
Xizhao Wang,Xingshuang Wu,Fenghua Zheng,Lang Zhao,Hongbo Chen,Min Tang,Xinyou He,Wei Xu,Xiangdong Zhu,Zhiming Xiao,Xinghui Liang,Lei Ming,Xing Ou
Alluaudite-type Na 2+2x Fe 2−x (SO 4 ) 3 is considered as a promising cathode for large-scale energy storage due to its high structural stability and cost-effectiveness. However, due to low theoretical specific capacity, NFS still exhibits insufficient overall cost competitiveness, and it also suffers from low intrinsic electrical conductivity. Here, we propose a direct regeneration strategy based on industrial byproducts to prepare a low-cost and high-conductivity Na 2.56 Fe 1.65 Mg 0.05 Mn 0.014 Al 0.006 (SO 4 ) 3 cathode. Compared to traditional synthetic routes for pure compounds, the direct degeneration of industrial byproducts can reduce iron source costs by approximately 83%. In addition, Mg, Mn and Al impurities from industrial byproducts are in situ doped into the polyionic framework, achieving functionalized utilization. Mg/Mn/Al co-doping not only induces strong interactions with oxygen to stabilize the crystal structure, but also decreases Na + migration energy barriers and enhances the electrical conductivity. Na 2.56 Fe 1.65 Mg 0.05 Mn 0.014 Al 0.006 (SO 4 ) 3 exhibits low lattice strain and uniform ion concentration distribution during electrochemical processes, demonstrating excellent rate capability and cycling stability. It shows 100% capacity retention after 1500 cycles at 3 C, and delivers a high discharge capacity of 50.16 mAh g −1 at 30 C. This study provides a scalable route for the valorization of industrial waste and the development of low-cost, high-performance polyanionic cathodes for sodium-ion batteries.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Zhuo Shi,Hongyuan Guo,Xiaoyang Fu,Xiayu Song,Xiu Zhao,Suozhu Wu
Poly(ANI-APBA) composite was prepared by one-step electrochemical deposition. • DA was detected via boronic acid-diol recognition. • An ultra-wide response range (1.00 × 10 −11 M to 1.00 × 10 −4 M) was obtained. • An ultra-low detection limit (2.41 × 10 −12 M) was obtained. • This sensor was simple, stable, accurate, and highly selective. Dopamine is a crucial neurotransmitter, and the misuse of exogenous dopamine may lead to its residues in animal-derived food products, thereby posing potential risks to human health. In this work, an electrochemical sensor was developed for dopamine detection by integrating the highly conductive framework of polyaniline with poly(3-aminophenylboronic acid) having ortho-diol recognition capability. Initially, a poly(aniline- co -3-aminophenylboronic acid) modified electrode was fabricated through the copolymerization of aniline and 3-aminophenylboronic acid. Subsequently, sensitive detection of dopamine was achieved by monitoring the signal of the potassium ferricyanide probe. The results demonstrated that this electrochemical sensor had a wide linear response range (1.00 × 10 −11 M to 1.00 × 10 −4 M) toward dopamine with a detection limit as low as 2.41 × 10 −12 M. The proposed sensor exhibited superb reproducibility, excellent stability, and high selectivity. This study provided a more efficient analytical approach for sensitive determination of dopamine content in pork products. Download: Download high-res image (213KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
Agriculture-Basel
·
2026
·Vol. 16
·期 14
·1567
·
IF 4.5
Qiming Duan,Xiang Li,Kunhong Xie,Aibing Yu,Yuheng Luo,Ping Zheng,Xiangbing Mao,Hui Yan,Jun He
Oxidative stress is a major challenge in weaned piglet production because it impairs intestinal health, nutrient utilization, and growth performance; however, the effects of dietary epigallocatechin-3-gallate (EGCG) on intestinal dysfunction under oxidative stress conditions have not been fully elucidated. This study examined whether dietary EGCG supplementation could improve intestinal function in weaned pigs subjected to Diquat-induced oxidative stress. Thirty-two weaned piglets were allocated to four treatments according to a 2 × 2 factorial arrangement involving dietary EGCG supplementation (0 or 50 mg/kg) and exposure to saline or Diquat (50 mg/kg body weight). Diquat exposure impaired intestinal morphology and antioxidant status and altered the transcription of genes associated with epithelial barrier integrity and redox regulation. Dietary EGCG supplementation partially attenuated these alterations, as reflected by improvements in villus architecture, intestinal antioxidant indices, and the mRNA expression of barrier- and antioxidant-related genes. These findings indicate that dietary EGCG supplementation was associated with improved intestinal function in weaned pigs exposed to oxidative stress. These beneficial effects may be related, at least in part, to changes in redox status, inflammatory responses, epithelial barrier-related gene expression, and selected gut microbial populations. This study supports EGCG as a potential bioactive dietary factor for maintaining intestinal health under oxidative stress conditions.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOTECHNOLOGY
·
2026
·
IF 4
Malik Jan,Kashif Hayat,Israr Khan,Aadil Ahmed Memon,Ibrar Khan
The new metabolite 3-hydroxyphenazine 1-carboxylic acid (3-OH-PCA) was obtained by Aspergillus sclerotiorum ASJ82 whole-cell biocatalysis of phenazine 1-carboxylic acid. Despite the biotechnological perspective, the lack of favorable methods for 3-OH-PCA separation and purification from complex biotransformation media has considerably hampered further experimental studies for large-scale industrial applications because of insufficient amounts of purified compounds. In this context, the present work aimed to develop a simple and proficient technique for the separation and purification of 3-OH-PCA from the crude extraction and culture medium of A. sclerotiorum ASJ82. The static adsorption and desorption characteristics of five macroporous resins were evaluated, namely, HP-20, HZ-818, HZ-801, D001, and D155. Remarkably, compared with the other resins, the HZ-818 resins exhibited notable advantages in the adsorption and desorption of 3-OH-PCA. Additionally, the equilibrium adsorption data of the HZ-818 resins were assessed via the Langmuir and Freundlich isotherm models. The analysis revealed that the experimental data exhibited a favorable fit with the Langmuir isotherm model, providing valuable insights into the adsorption behavior of 3-OH-PCA on the HZ-818 resins. Furthermore, a chromatographic column packed with HZ-818 resins was employed, and dynamic adsorption and desorption experiments were conducted. These tests aimed to establish and optimize the operational parameters required to effectively separate and purify 3-OH-PCA. Under the optimized separation and purification conditions, the average adsorption capacity and desorption ratio of 3-OH-PCA were 21.1 ± 1.2 mg/g dry resin and 88 ± 1.2 %, respectively. After treatment with HZ-818 resin, the 3-OH-PCA content considerably increased. These findings revealed that the purity of 3-OH-PCA was 96.5 ± 2.1 %, whereas the recovery rate was 85.32 ± 1.2 %. The results indicate that the HZ-818 resin has significant potential as an adsorbent for effectively separating and purifying 3-OH-PCA from complex media. Overall, this methodology demonstrates great promise for achieving high yields in the separation and purification of 3-OH-PCA and could be utilized in the large-scale production of 3-OH-PCA purification from A. sclerotiorum ASJ82 extracts in industry, presenting an avenue for further investigation and application.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Foods
·
2026
·Vol. 15
·期 4
·624
·
IF 6
Na Liu,Wenguang Jiang,Huixuan Zhou,Xinyi Hao,Guotian Liu,Wenwu Bao,Xinming Zhou,Tengfei Xu,Yan Xu
Grapevine leafroll-associated virus (GLRaV) is a globally widespread disease that causes substantial economic losses in the wine industry. In severely affected vineyards, GLRaV can reduce grape yield by 20–40%. This study aimed to evaluate the effects of GLRaV infection on polyphenolic and volatile organic compound contents, as well as on the sensory profiles of the resulting wines. A comparative analysis was conducted between GLRaV-3-infected and healthy Cabernet Sauvignon grapes and their corresponding wines. Results show GLRaV-3 significantly alters grape and wine quality. In infected grapes, sugar content decreased while titratable acidity increased. Polyphenol composition was notably altered: phenolic acids and flavonols increased by 22.46% and 15.27%, respectively, whereas flavanols decreased by 17.86%. The levels of aldehydes and C6compounds also rose significantly in the berries. Wines produced from infected grapes showed lower alcohol content and reduced dry extract. Phenolic acids and flavanols were decreased, but total flavonols increased by 12.54%. Among volatile compounds, alcohols, phenols, and fatty acids were elevated, while esters declined by 13.36%. These chemical changes directly influenced sensory attributes. Compared with wines from healthy grapes, those from infected grapes exhibited improved tannin texture and longer aftertaste. However, they were inferior in color intensity, aroma intensity, body fullness, and varietal typicity.
✓ 已验证
DOI
PubMed
高影响因子
Reaction Chemistry & Engineering
·
2026
·
IF 2.9
Letao Guo,Mei Yang,Lixia Yang,Mei Han,Wenna Tang,Guangwen Chen
Lithium diisopropylamide (LDA)-mediated aldol condensation is a fundamental method for the synthesis of β-hydroxy esters. This strategy was applied in our previous synthesis of the general cap structure of Chidamide (3-(3-pyridyl)acrylic acid) using tert-butyl acetate (TBA) and 3-pyridine aldehyde, where the steric hindrance of the tert-butyl group effectively suppresses enolate self-condensation. However, this steric advantage also limits subsequent functionalization. In contrast, ethyl acetate (EA) offers greater synthetic flexibility due to the favorable leaving ability of the ethoxy group, but suffers from pronounced competing enolate consumption under batch conditions. Herein, we systematically investigated the limitations of batch LDA-mediated aldol condensation between EA and 3-pyridine aldehyde and developed a continuous-flow strategy to overcome these challenges. Under batch conditions at -60 oC, the major competing pathways involving ester enolates and 3-pyridine aldehyde were identified, and a comprehensive side reaction network was proposed. Based on this analysis, the use of a sufficient excess of LDA was found to be critical for improving product yield by suppressing proton transfer to ester enolates and ensuring sufficient deprotonation of EA. However, this strategy becomes ineffective at elevated temperatures, as evidenced by the decrease in yield from 90.1% at -60 oC to 45.8% at -20 oC, with 2.0 equiv of LDA. Then, a continuous-flow system was implemented to maximize LDA participation in EA deprotonation and suppresses enolate self-condensation and decomposition via precise residence time control. Product yields exceeding 90% were achieved at -20 oC for representative aldehydes using 1.2 equiv of LDA, together with good scalability.
✓ 已验证
DOI
高影响因子
ACS Nano
·
2026
·
IF 17.3
Xinhao Li,Weikang Hu,Yao Huang,Yanmei Ma,Zuokun Yin,Tong Wang,Chengzhi Hu
Unraveling the precise kinetics of the intrinsic apoptotic pathway requires resolution of the temporal lag between mitochondrial permeabilization and downstream proteolytic execution. However, dissecting these distinct molecular events within the crowded cytosolic environment of a single live cell remains limited by the lack of nonperturbative, multiplexed sensing tools. Here, we report a dual-channel nanoprobe capable of label-free, simultaneous monitoring of Cytochrome c (Cyt c) translocation and Caspase-3 activation. The nanoprobe features physically isolated nanochannels allowing for orthogonal functionalization: one channel acts as an aptamer-based sensor for Cyt c, while the second functions via the enzymatic cleavage of a specific peptide substrate by Caspase-3. This design enables the synchronous transduction of protein binding and enzymatic activity into independent current signals. The probe exhibited high sensitivity, selectivity, and stability in complex biological fluids. We applied this platform to monitor the dynamics of Cyt c and caspase-3 in breast cancer cells, revealing significant heterogeneity in apoptosis and a spatiotemporal delay between Cyt c release and caspase-3 activation, consistent with the intrinsic apoptosis pathway. This dual-detection methodology provides a minimally invasive approach with high spatial and temporal resolution for probing apoptotic signaling at the single-cell level and enables quantitative assessment of heterogeneous cellular responses to apoptotic stimuli.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2026
·
IF 5.7
Manman Yuan,Jing Ye,Xiangqiao Sun,Zhiwu Tong,Tingting Wang,Renxiang Tan,Xingxin Wu
Acaudiolide ameliorates liver fibrosis in mice • Acaudiolide inhibits TGF-β1/SMAD signaling in HSCs • Acaudiolide inhibits the nuclear translocation of p-SMAD2/3 • Acaudiolide weakens the interaction between SMAD4 and p-SMAD2/3 • SMAD4 is a candidate covalent target of acaudiolide Hepatic stellate cell (HSC) activation is a central driver of fibrosis progression in metabolic dysfunction-associated steatohepatitis (MASH), yet effective antifibrotic pharmacotherapies remain limited. Here, we identify acaudiolide, a sulfur-bridged symmetric dimeric macrodiolide isolated from the fungus Acaulium sp. H-JQSF, as a natural-product lead that suppresses HSC activation and experimental liver fibrosis. In a Western diet (WD)/CCl 4 murine model of MASH, acaudiolide reduced collagen deposition, alpha-smooth muscle actin (α-SMA) expression and fibrogenic gene expression. Transcriptomic profiling of HSCs showed that acaudiolide antagonized transforming growth factor-β1 (TGF-β1)-driven profibrotic programs. Mechanistically, acaudiolide did not measurably alter SMAD2/3 phosphorylation but markedly reduced the nuclear accumulation of phosphorylated SMAD2/3 (p-SMAD2/3). Integration of Connectivity Map (CMap) analysis with isotopic tandem orthogonal proteolysis-activity-based protein profiling (isoTOP-ABPP) chemical proteomics nominated SMAD4 as a candidate covalent target of acaudiolide. Covalent docking suggested Cys363 as a potential engagement site, and co-immunoprecipitation showed that acaudiolide weakened the association of SMAD4 with p-SMAD2/3. These findings support a model in which acaudiolide interferes with SMAD complex assembly, thereby attenuating TGF-β-dependent profibrotic transcription and HSC activation. Collectively, our data nominate acaudiolide as a preclinical antifibrotic lead and SMAD4 as a potentially tractable downstream node for pharmacological modulation of TGF-β signaling in MASH-related fibrosis. Download: Download high-res image (386KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Jiaozhong Cai,Jiacheng Li,Jiushuai Deng,Bozeng Wu,Ni Xiao,Junnan Chen,Wei Weng,Xiaopeng Chi,Wen Tan,Guangsheng Zeng,Shuiping Zhong
Selective depression of chalcopyrite while preserving molybdenite floatability remains challenging. Conventional sulfur-containing depressants may oxidize readily, require high dosages, or depend on strong alkalinity, prompting the development of new selective reagents. Sodium 3-mercapto-1-propanesulfonate (MPS), containing thiol and sulfonate groups, was introduced as a selective chalcopyrite depressant. At pH 7 and 1.5 × 10 −5 mol L −1 MPS, the maximum recovery difference in single-mineral flotation reached 87.6 percentage points. In artificial mixed-mineral flotation, Cu recovery decreased to 7.28%, whereas Mo recovery remained at 91.16%, increasing the separation index from 1.28 to 11.49. Contact angle, SEM–EDS, and FTIR analyses indicated preferential retention of MPS-related species on chalcopyrite, together with interaction between thiol S and surface Cu sites and enhanced surface hydrophilicity associated with the sulfonate group. Under the electrochemical test conditions, MPS attenuated the anodic response and reduced the corrosion current density of chalcopyrite by approximately 40%, with little effect on molybdenite. DFT calculations further identified the Cu site on chalcopyrite (112) as more favorable for MPS adsorption than the Fe site (−100.96 versus −86.02 kJ mol −1 ), whereas the modelled adsorption configuration on molybdenite (001) was energetically unfavorable (+47.61 kJ mol −1 ). This study elucidates a selective depression mechanism involving preferential adsorption, increased surface hydrophilicity, and altered chalcopyrite redox behavior, while demonstrating the potential of MPS for near-neutral Cu Mo flotation separation. Download: Download high-res image (142KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
Surfaces and Interfaces
·
2026
·
IF 6
Hui Zhou,Bingxin Zhu,Xiang Li,Baolei Liu,Zhigang Liu,Shihua Yu
To recover the high value-added pharmaceutical intermediate tenofovir from wastewater efficiently and conveniently, a tailored magnetic composites of Fe 3 O 4 @SiO 2 @La(OH) 3 have been prepared via solvothermal and in-situ reduction methods. It exhibits the ability to remove tenofovir with high efficiency and easily separated from matrix. Batch sorption experiments demonstrated that Fe 3 O 4 @SiO 2 @La(OH) 3 can remove tenofovir with the maximum adsorption capacity of 64.53 mg/g, the largest removal of 93.07%, and fast equilibrium time of 5 min. The kinetics of tenofovir adsorption on the magnetic composite is in line with the pseudo-second-order model, while the isotherm is fitted well by the Langmuir model, and thermodynamic parameters represent that adsorption process is spontaneous and endothermic. Moreover, the saturated Fe 3 O 4 @SiO 2 @La(OH) 3 have been desorbed by mechanical stirring with the high desorption rate of 93.02%, and the adsorption capacity maintaining 47.72 mg/g after five cycles. Importantly, the composites can be used for tenofovir removal from crude extracts of pharmaceutical wastewater, with an adsorption capacity of 51.61mg/g in 5 min. Finally, the adsorption mechanisms are explored by pH experimental evidence and XPS analysis, which show that mainly involve electrostatic attraction and the inner-sphere complexation between La(OH) 3 and phosphate groups of tenofovir via ligand exchange. All the results prove that the proposed tenofovir recovery technique, providing new ideas for the recovery of high value-added substances and waste resources rationalization of the application of development. A magnetic Fe 3 O 4 @SiO 2 @La(OH) 3 was synthesized and realized the recovery of tenofovir with high economic value in pharmaceutical wastewater crude extracts. Download: Download high-res image (249KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
Light-Science & Applications
·
2026
·Vol. 15
·期 1
·135
·
IF 24
Maimaitizi Hujiabudula,Ågren Hans,Chen Guanying
The development of pure-blue perovskite light-emitting diodes (PeLEDs) still lags behind that of green and red-emitting PeLEDs. Mixed halide (Br/Cl) perovskite nanocrystals (PeNCs) are commonly employed for blue emission but suffer from halide vacancies and ion migration. Here, we present a passivation strategy using the multifunctional fluorinated phosphonic acid molecule (1H,1H,2H,2H-heptadecafluorodec-1-yl)phosphonic acid (HFPA), which possesses active functional groups that improve the stability and electroluminescence performance of CsPb(Br/Cl) 3 NCs. The HFPA molecule is shown to interact with uncoordinated Pb 2+ on the PeNC surface through the phosphonate groups, concurrently establishing hydrogen bonds with adjacent halide ions. Moreover, the presence of fluorine atoms promotes ionic bond formation with the halide octahedra, thereby stabilizing the octahedral structure. The fabricated PeNC-LEDs exhibited a spectrally stable pure-blue emission peak at 467 nm, achieving a significantly improved external quantum efficiency (14.8%, 9-fold higher), maximum luminance (1052 cd·m -2 , 10-fold higher), and half-life (342 s, 13-fold higher) compared to the device fabricated with unmodified CsPb(Br/Cl) 3 NCs. Furthermore, the effective passivation of surface vacancies and stabilization of halogen ions by the HFPA molecules successfully suppressed ion migration in the PeNC-LEDs, thereby significantly enhancing the stability of the device.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Ting Zhao,Hang Liu,Gacao Dou,Dongting Zhang,Junqiang Qiao,Juan Yang,Pengjun Ma,Cuiying Lu,Hongxia Li,Hongruo Ma,Kunjie Wang,Bingjun Yang
The nanostructured process effectively boosts the rate capability of Fe 2 (MoO 4 ) 3 . • The FMO-4.25 maintains a high capacity of 74.5 mAh g −1 at 100C. • Even at −20 °C, it retains 65 mAh·g −1 at 1C after 500 cycles. • In-situ EIS tracked interface kinetics evolution and CEI formation. Fe 2 (MoO 4 ) 3 (FMO), a promising polyanionic cathode material for sodium-ion batteries (SIBs), offers a stable three-dimensional framework, high operating voltage, and exceptional thermal stability, positioning it as a suitable candidate for large-scale energy storage systems. However, its practical implementation is still hindered by sluggish reaction kinetics. In this study, we address the issues of low electronic conductivity and slow Na + migration in FMO cathode material by an electrospinning-based nano-Synthesis strategy. By precisely regulating the pH of the precursor solution and optimizing the sintering process, the as-prepared FMO-4.25 electrode delivers a high specific capacity of 83.4 mAh·g −1 at 2C after 100 cycles and maintains a discharge capacity of 74.5 mAh·g −1 even at an ultrahigh rate of 100C. Moreover, it exhibits remarkable rate capability and long-term cycling stability even under low-temperature conditions. The electrochemical analysis reveals that the nano structuring of the FMO-4.25 electrode effectively enhances the kinetics of ion diffusion and electron transfer. Furtherover, the nanostructure effectively suppresses volume strain during Na + (de)intercalation, promotes the formation of a stable cathode-electrolyte interphase (CEI), and preserves the integrity of the interfacial and conductive networks, thereby synergistically improving the structural stability of the material. This work provides new insights into the controlled synthesis and mechanistic understanding of high-performance iron molybdate-based cathode materials, offering a valuable reference for advancing the practical application of SIBs in high-power and low-temperature environments. Download: Download high-res image (88KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）