Journal of Translational Medicine
·
2024
·Vol. 22
·期 1
·1-19
·
IF 6.1
Qin Qian,Shan Zhiyan,Xing Lei,Jiang Yutong,Li Mengyue,Fan Linlin,Zeng Xin,Ma Xinrui,Zheng Danyang,Wang Han,Wang Hui,Liu Hao,Liang Shengjun,Wu Lijie,Liang Shuang
Autism spectrum disorder (ASD) is a multifaceted neurodevelopmental disorder predominant in childhood. Despite existing treatments, the benefits are still limited. This study explored the effectiveness of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) loaded with miR-137 in enhancing autism-like behaviors and mitigating neuroinflammation. Utilizing BTBR mice as an autism model, the study demonstrated that intranasal administration of MSC-miR137-EVs ameliorates autism-like behaviors and inhibits pro-inflammatory factors via the TLR4/NF-κB pathway. In vitro evaluation of LPS-activated BV2 cells revealed that MSC-miR137-EVs target the TLR4/NF-κB pathway through miR-137 inhibits proinflammatory M1 microglia. Moreover, bioinformatics analysis identified that MSC-EVs are rich in miR-146a-5p, which targets the TRAF6/NF-κB signaling pathway. In summary, the findings suggest that the integration of MSC-EVs with miR-137 may be a promising therapeutic strategy for ASD, which is worthy of clinical adoption.
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JOURNAL OF POLYMER RESEARCH
·
2024
·Vol. 31
·期 5
·1-12
·
IF 2.6
Wang Kui,Huang Weijiang,Tu Chunyun,Tian Qin,Fu Qiuping,Yan Wei
High flame retardancy, satisfactory mechanical properties are crucial for polymeric composites employed in fields with safety requirements. Inorganic fillers can effectively regulate the structure and composition of polymeric materials and have become an effective strategy for fabricating high-performance polymeric composites. Herein, aluminum phosphate–coated sepiolite (Sep@AlPO 4 ) fillers are fabricated as a multifunctional additive to modify polyethylene oxide (PEO), PEO nanocomposites were prepared via incorporation of Sep@AlPO 4 and phenethyl-bridged 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) derivative (DiDOPO) in the PEO matrix, and the synergistic effects between Sep and AlPO 4 are discussed. The results reveal that Sep@AlPO 4 could simultaneously enhance the flame retardancy and strengthen the mechanical properties of PEO/DiDOPO. Additionally, Sep@AlPO 4 could increase the viscosity, storage modulus, and loss modulus of the composites. This study provides an effective strategy for fabricating enhanced flame retardants to improve the performance of polymers.
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CELLULOSE
·
2024
·Vol. 31
·期 9
·5779-5794
·
IF 4.9
Wang Weiqi,Wang Fan,Wang Yuqing,Zhang Lili,Okamoto Yoshio,Shen Jun
Four cellulose derivatives bearing benzothienyl or carbazolyl fluorophore pendants were successfully synthesized through carbamoylation followed by Steglich esterification or only esterification process, respectively. The enantioselective fluorescent sensing properties of the obtained derivatives were then evaluated using eight chiral substrates, including chiral aromatic amines and chiral amino alcohol-based drug intermediates. The four bulky host macromolecules exhibited good enantioselective fluorescence response to most of the tested guests with high enantioselectivity and sensitivity. Especially, a high enantiomeric fluorescence difference ratio ( ef = 37.16) was achieved on cellulose tris(2-benzothienylformate) ( Cel - 3 ) for the α-methylbenzylamine ( Q2 ), an important chiral agricultural drug intermediate. Worthy to be mentioned, an interesting opposite fluorescence response and a dual fluorescence enhancement pattern were also observed on the benzothienyl derivative Cel - 3 for the enantiomer pairs of 1-(4-methoxyphenyl) ethylamine ( Q3 ) and phenylglycinol ( Q6 ), a critical intermediate for chiral drug as an antilipemic agent in high demand, respectively. It indicated that the bulky Cel - 3 possessed excellent enantioselective fluorescent sensing properties to the chiral aromatic amine and amino alcohols, revealing good potential as efficient chiral fluorescent sensors. It was speculated that a beneficial chiral domain may be constructed by the appropriate arrangement of bulky conjugated benzothienyl or carbazolyl pendants on the phenylcarbamates or esters surrounding the helical backbone of cellulose, which was crucial for the efficient chiral fluorescent sensing performance. The introduction of bulky fluorophore pendants on the cellulose phenylcarbamates or esters presents an efficient strategy to produce effective chiral fluorescent recognition materials. Graphical Abstract
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Advanced Composites and Hybrid Materials
·
2024
·Vol. 8
·期 1
·1-15
·
IF 23.2
Chen Sisi,Liu Xin,Miao Yaping,Ge Shengbo,Li Shi-xiong,Liu Lin,Hou Lin,Rezakazemi Mashallah,Aminabhavi Tejraj M.,Fan Wei
With the rapid development of smart wearable devices, there is an increasing demand for materials that exhibit high strain, fatigue resistance, flexibility, and durability. Polyurethane (PU) fibers have gained attention due to their flexible molecular structure and adjustable formulations. However, the fatigue and aging resistance of traditional PU fibers are relatively weak, limiting their potential applications. To address this issue, this study presents a method for preparing PU-CNC self-healing composite fibers by incorporating environmentally friendly cellulose nanocrystals (CNC). It was found that the PU molecular chains create hydrogen bonds with the hydroxyl groups in the surface of CNC, forming a dynamic network with physical crosslinking that enhances the tensile strength and elongation, the self-healing ability, and the fatigue and aging resistance of PU-CNC composite fibers. Moreover, after fatigue and aging resistance tests, the mechanical characteristics of PU-CNC composite fibers are almost unchanged. When compared to PU fibers without CNC, the elongation at break and tensile strength of PU-1% CNC composite fibers increased by 33.92% and 17.93%, respectively. After the scratch test, the cracks on the surface of the self-healing of PU-1% CNC composite fibers disappeared, and the elongation at break and tensile strength increased by 57.18% and 128.02%, respectively. The flexibility and adaptability of this composite fiber provide a broad application prospect for the integration of flexible sensors and smart wearable devices, contributing to enhanced safety and durability in future smart devices.
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JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 34
·16129-16140
·
IF 3.5
Wang Youwei,Wang Xiushan,Xu Huan,Wu Ang,Chen Ying,Li Guiqiang,Dong Chuanxin,Li Yahui,Mei Chao,Li Shuailin,Zhang Hehu
To address solubility, plasticizer leakage, and ionic carrier issues in PVC-based solid ion-selective electrodes, a novel plasticizer-free photocurable solid Ca 2+ -selective electrode (GC/PANI/CPANI/Ca 2+ (PBA)-ISE) was developed using a novel electrode structure. A new Ca 2+ -sensitive membrane based on poly(butyl acrylate) (PBA) was synthesized by ultraviolet polymerization, with conductive polyaniline (PANI) as the solid contact layer and a copolymer of aniline and 2,5-dimethoxyaniline (CPANI) as the coating. All potential electrochemical tests were carried out on the prepared Ca 2+ -selective electrode. The response slope of the electrode was 28.33 mV decade −1 , the detection limit was 6.9 × 10 −6 M, the stable linear range was 1 × 10 −6 to 1 × 10 −2 M, and it had a good Nernst response. The chronopotentiometric analysis and water layer tests showed that the potential drift of GC/PANI/CPANI/Ca 2+ (PBA)-ISE was as low as 0.0125 mV s −1 and 1.247 mV h −1 . In addition, the interference tests of environmental factors were carried out. When the electrode was in different interference light and gas environments, the potential changes of 1.6 × 10 −4 mV s −1 and 1.2 × 10 −3 mV s −1 were observed. Compared with previous reports and commercial electrodes, the prepared GC/PANI/CPANI/Ca 2+ (PBA)-ISE showed good electrochemical performance, and the recovery rate in Ca 2+ test solutions was higher (97.2–99.9%). This study provided theoretical insights to address solubility, plasticizer leakage, and ion carrier leakage issues in solid-state contact ion-selective electrodes. At the same time, this study provided a new structure and preparation method for the preparation of all-solid-state Ca 2+ -selective electrode. Graphical abstract
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RARE METALS
·
2025
·
IF 11
Li Xiang,Li Gui-Dong,Chen Ye,Tian Meng-Kui
Lithium iron phosphate (LiFePO 4 , LFP) batteries have shown extensive adoption in power applications in recent years for their reliable safety, high theoretical capability and low cost. Nevertheless, the finite lifespan of these batteries necessitates the future processing of a significant number of spent LFP batteries, underscoring the urgent need for the development of both efficient and eco-friendly recycling methods. This study combines the advantages of wet leaching and direct regeneration methods, leveraging citric acid’s multifaceted role to streamline the combined leaching and hydrothermal processes. Results indicate that citric acid efficiently leaches all elements from spent LFP batteries. Furthermore, through its unique structure, it enhances hydrothermal regeneration by stabilizing metal ions and controlling crystal growth, and also acts as a carbon source for the surface carbon coating of regenerated LFP (R-LFP). The R-LFP shows outstanding electrochemical stability, achieving a discharge capacity of 155.1 mAh·g −1 at 0.1C, with a capacity retention rate of 93.2% after 300 cycles at 1C. Furthermore, economic and environmental analyses demonstrate this method’s superior cost-effectiveness and sustainability. Therefore, the method proposed in this study is efficient, simple and avoids the complex process of element separation, innovatively using a single reagent to achieve closed-loop recycling of LFP batteries, providing a novel and effective solution for the resource sustainability application. Graphical abstract
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 5
·1-10
·
IF 5.3
Yang Xiao,Li Chunguang,Xia Jianfei,Zhang Feifei,Wang Zonghua
A three-dimensional (3D) self-assembled AuNPs/Ti 3 C 2 MXene hydrogel (AuNPs/Ti 3 C 2 MXH) nanocomposite was prepared for the fabrication of a novel microRNA-122 electrochemical biosensor. The 3D hydrogel structure was gelated from two-dimensional MXene nanosheets with the assistance of graphite oxide and ethylenediamine. MXene hydrogels supported the in situ formation of Au nanoparticles (AuNPs) that predominantly exploring the (111) facet, and these AuNPs are utilized as carriers for hairpin DNA (hpDNA) probes, facilitating DNA hybridization. MXene acted as both a reductant and stabilizer, significantly improving the electrochemical signal. In addition, the conjugation of PAMAM dendrimer-encapsulated AuNPs and H-DNA worked as an ideal bridge to connect targets and efficient electrochemical tags, providing a high amplification efficiency for the sensing of microRNA-122. A linear relationship between the peak currents and the logarithm of the concentrations of microRNA-122 from 1.0 × 10 −2 to 1.0 × 10 2 fM (I = 1.642 + 0.312 lg c , R 2 = 0.9891), is obtained. The detection limit is 0.8 × 10 −2 fM (S/N = 3). The average recovery for human serum detection ranged from 97.32 to 101.4% (RSD < 5%). Graphical Abstract
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RARE METALS
·
2025
·
IF 11
Qi Liu-Jie,Zhang Zhao-Qi,Iqbal Mujahid,Wang Fei,Li Jing-An,Guan Shao-Kang
Drug-eluting magnesium (Mg) alloy stents have a slower degradation rate and lower restenosis rate compared with uncoated stents, demonstrating good clinical efficacy. However, the release of anti-hyperplasia drugs from coatings delays endothelial tissue repair, thus leading to late stent thrombosis. To address these issues, a dual self-healed coating with various biological properties was fabricated on magnesium fluoride/polydopamine (MgF 2 /PDA)-treated Mg alloys by spraying-assisted layer-by-layer (LBL) self-assembly of chitosan (CS), gallic acid (GA), and 3-aminobenzeneboronic acid-modified hyaluronic acid (HA-ABBA). The LBL coating, approximately 1.50 μm thick, exhibited a uniform morphology with good adhesion strength (~ 1065 mN). The annual corrosion rate ( P i ) of LBL samples was ~ 1400 times slower than that of the Mg substrate, due to the physical barrier function provided by MgF 2 /PDA layers and the dual self-healed ability of LBL layers. The rapid self-healing ability (with a healing period of ~ 4 h under dynamic/static conditions) resulted from the synergistic interplay between the recombination of diverse chemical bonds within the LBL coating and the coordination of LBL-released GA with Mg 2+ , as corroborated by computer simulations. Compared with the drug-eluting coatings, the LBL sample demonstrated substantial advantages in anti-oxidation, anti-denaturation of fibrinogen, anti-platelet adhesion, anti-inflammation, anti-hyperplasia, and promoted-endothelialization. These benefits effectively address the limitations associated with drug-eluting coatings. Graphical abstract
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TRANSITION METAL CHEMISTRY
·
2025
·
IF 1.7
Zhang Zhichao,Zhang Jianbo,Li Kangzheng,Tang Binglin,Wang Xiaohui,Tan Ling,Hu Yijie,Luo Qingcheng,Yin Zhe,Yu Guoping,Lv Bo
Natural mineral composite catalysts have attracted much attention due to their great potential in the fields of water treatment, air purification and energy conversion. In this study, porous TiO 2 materials were synthesized from ilmenite by a two-stage calcination and acid leaching process, and porous TiO 2 /CdS composites were prepared by a hydrothermal method. The results of photocatalytic experiments indicate that the porous TiO 2 /CdS composite (PTC-2) with a Ti/Cd molar ratio of 1:1 exhibits the highest photocatalytic activity, with the degradation rate of methylene blue achieving a maximum value of 96.6% at 80 min. Moreover, the composite maintains a degradation efficiency of 88.5% after five cycles. The findings demonstrate that the TiO 2 /CdS heterojunction significantly enhances the photocatalyst's absorption of visible light while facilitating the effective separation and transfer of photogenerated electron–hole (e − /h + ) pairs. The porous architecture of the composite facilitates superior electron transport pathways and effectively mitigates e − /h + recombination. Furthermore, a mechanism for the photocatalytic degradation of organic dyes using porous TiO 2 /CdS composites is proposed, wherein photogenerated superoxide radicals ( · O 2 − ) and hydroxyl radicals ( · OH) serve as the primary reactive species. This study explores the cost-effective synthesis of TiO 2 /CdS heterojunctions and makes a significant contribution to the advancement and utilization of natural minerals for pollution degradation.
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Biology Direct
·
2024
·Vol. 19
·期 1
·1-14
·
IF 5.7
Sun Tong,Yang Zhiguang
Six-transmembrane epithelial antigen of prostate 3 (STEAP3) is associated with the progression of several human malignancies. However, its role in lung squamous cell carcinoma (LUSC) remains unclear. We measured STEAP3 expression in LUSC cell lines and tissues. LUSC cells with stable STEAP3 overexpression and knockdown were obtained through G418 selection. Multiple assays were used to evaluate the malignant phenotypes of LUSC cells and the activation of the β-catenin signaling. The potential transcriptional regulatory factors of STEAP3 were predicted using the JASPAR database, and the correlation between transcription factor AP-2 gamma (TFAP2C) and STEAP3 was analyzed through the GEPIA database. The study evaluated the regulatory relationship between a potential transcription factor and STEAP3 through ChIP and luciferase reporter assays. Additionally, rescue assays were utilized to ascertain whether TFAP2C serves as the upstream regulatory factor of STEAP3, contributing to LUSC progression. Finally, tumor growth and metastasis were evaluated in vivo. STEAP3 expression was notably higher in LUSC, and its overexpression was linked to a poor prognosis. Moreover, STEAP3 overexpression activated the β-catenin pathway, thereby accelerating cell proliferation and metastasis. Conversely, STEAP3 knockdown had an anti-tumor effect in LUSC. Additionally, TFAP2C bound directly to the STEAP3 promoter and positively regulate its expression in LUSC. The anti-tumor effects of TFAP2C knockdown were partially reversed by STEAP3 overexpression. The study indicates that the TFAP2C/STEAP3 axis may be a therapeutic target for LUSC treatment. This enhances our understanding of lung carcinogenesis.
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JOURNAL OF POLYMER RESEARCH
·
2024
·Vol. 32
·期 1
·1-13
·
IF 2.6
Zhang Xian,Jiang Shuai,Guo Jianming,Xin Zhong
The stretchable, biodegradable, thermos-responsive, biocompatible and novel poly(1,3-propylene sebacate)-co-poly(glycerol sebacate) polyurethanes (PPGSU), based on poly(glycerol sebacate) (PGS) and poly(1,3-propylene sebacate) (PPS), were synthesized using simple solvent-based two-step method. The comprehensively properties of PPGSU, including the chemical structure, crystalline structure, thermal stability, mechanical performance, water absorption, degradation behavior, drug release behavior, temperature-responsive shape memory effect, as well as biocompatibility were investigated in detail. The impact of the different ratio of PPS and PGS on the properties of final PPGSU product was also studied. The introduction of PPS in the poly(glycerol sebacate urethance) (PGSU) system could increase the glass transition temperature ( T g ) and stretchability. The PPGSU polymers showed adjustable tensile strength ranging from 0.5 MPa to 1.3 MPa, as well as the degradable rate and shape memory effect. Furthermore, these elastomers exhibited promising in vitro biocompatibility with adult mouse fibroblasts L929 cells, indicative of their potential for medical applications. Additionally, the possible potential application of biodegradable PPGSU elastomers in the field of drug delivery were examined. Overall, this research offers new perspectives on the development of biomaterials with tailored properties for medical applications.
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JOURNAL OF FLUORESCENCE
·
2025
·
IF 3.1
Han Bo-Ming,Zhang Hao-Rui,Gao Wen-Jie,He Xi-Wen,Li Wen-You,Zhang Yu-Kui
In this work, a dual-emission material based on lanthanide metals was synthesized and used as a ratio fluorescence sensor to respond to Hg 2+ and H 2 O 2 , respectively. Tb-BDC-NH 2 as a bimetal MOFs had double ligands and exhibited double fluorescence emission peaks at 550 nm and 450 nm. The two emission peaks of Tb-BDC-NH 2 can be quenched by Hg 2+ and H 2 O 2 respectively, forming a built-in calibration signal for ratio fluorescence detection. Based on the different detection conditions of the Hg 2+ and H 2 O 2 , the simultaneous detection of the two detection substances can be achieved with simple operation. This detection system had good stability and anti-interference ability. Under optimal conditions, the detection limit for Hg 2+ detection was 0.2 µM. Meanwhile, for the detection of H 2 O 2 , the detection limit was 11 µM and large linear ranges were obtained. Through actual sample testing, it had been proven that the ratio fluorescence sensor based on Tb-BDC-NH 2 had good application prospects. And the work also provided a new idea for double substances detection.
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