ELECTROCHIMICA ACTA
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2026
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IF 5.6
Xiaolei Shi,Zhuannian Liu,Yifei Wang,Benlong Wei
The K-CP/MnO 2 composite was prepared by loading manganese dioxide (MnO 2 ) nanosheets onto potassium hydroxide (KOH) activated carbonized polyaniline (K-CP) via low-temperature hydrothermal reaction. The composite demonstrated high efficiency in removing Pb 2+ and Zn 2+ in the hybrid capacitive deionization (HCDI) technology. K-CP/MnO 2 presents a core-shell structure with conductive K-CP as the core and electrochemically active MnO 2 constructed by porous nanosheets as the shell. The disordered entanglement of K-CP and MnO 2 nanoflakes significantly increases the interlayer spacing, optimizes the pore distribution, creates favorable conditions for charge and ion transport, and realizes the synergistic effect of electric double layer (EDL) adsorption and Faradaic reactions. The specific capacitance (SC) of K-CP/MnO 2 at 5 mV s −1 is 112.03 F g −1 , which is nearly 3.76 times that of CP (29.82 F g −1 ). At a voltage of 1.2 V (100 mg L −1 ), the electrosorption capacity (SAC) of the K-CP/MnO 2 electrode for Pb 2+ and Zn 2+ is 124.66 and 96.86 mg g −1 , respectively. After 15 adsorption/desorption cycles in the HCDI device, the adsorption capacity for Pb 2+ and Zn 2+ is retained at 86.81% and 82.59%, respectively. The experiments indicate that the removal of Pb 2+ primarily occurs through electrosorption, redox reactions, and surface complexation, while Zn 2+ is inserted into the channel provided by MnO 2 and participates in the solid phase reaction. The K-CP/MnO 2 composite prepared in this study offers a novel approach for designing high-performance HCDI electrodes and achieving the selective removal of heavy metals.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.1
Rongkun Zhu,Mengting Cai,Qiuyu Liao,Xiaobin Meng,Hong Yu,Huanghui Zeng,Zhuomiao Lin,Guicui Zhang
In this study, graphene quantum dots (GQDs) with a high density of carboxyl groups were synthesized via a thermal dissolution method. The surface carboxyl groups of the GQDs were then conjugated with the amino groups of dopamine (DA) through an amidation reaction, yielding a novel fluorescent prob.(GQDs@DA), which features catechol groups. Leveraging the distinctive catechol moiety of vancomycin (VAN) as a functional handle, we employed GQDs@DA and a sol-gel process to construct molecularly imprinted polymers (MIPs@GQDs@DA) on a SiO₂ matrix. This resulted in the formation of highly selective recognition cavities complementary to the VAN template molecule in the final MIPs@GQDs@DA probe.When we used excitation light with a wavelength of 360 nm to excite the composite material, MIPs@GQDs@DA emits a stable fluorescence peak at 460 nm. Vancomycin can sensitively and rapidly bind to MIPs@GQDs@DA, thereby quenching the fluorescence generated at 460 nm. Calculations revealed that the quenched fluorescence intensity at 460 nm exhibits a good linear relationship with the concentration of vancomycin, within a linear range of 0–80 μg/mL, and a detection limit of 0.83 μg/mL (S/N = 3). This probe was applied to detect vancomycin in real human serum samples, and the experimental results were consistent with the expected outcomes.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.5
Mingxiao Feng,Zhenjie Chen,Qian Yu,Chunyan Yan,Dawei Zhang
Pinellia ternata (Thunb.) Breit. has been used in China for more than two thousand years to treat cough and vomiting. P. ternata is rich in polysaccharides; however, current research on the bioactivity of polysaccharides from P. ternata is relatively limited. In particular, there are no reports on their application in the treatment of osteoporosis. In this study, two β -glucan-like polysaccharides were isolated from P. ternata . The primary structures of PTTP50–1-3 and PTTP50–1-4 were comprehensively analyzed using high performance liquid chromatography, gas chromatography–mass spectrometry, and nuclear magnetic resonance. The results indicated that they possess a similar backbone structure. Notably, compared with PTTP50–1-3, PTTP50–1-4 exhibits characteristics of a higher degree of branching, a higher β -glucan content, and a lower molecular weight. In vitro experiments demonstrated that both PTTP50–1-3 and PTTP50–1-4 could increase the alkaline phosphatase activity of MC3T3-E1 cells. In addition, PTTP50–1-4 was able to enhance the mineralization of MC3T3-E1 cells by upregulating the expression of Runx2 , Osx , Bmp2 , Ocn , Opn , and Bsp mRNA. These findings suggest that P. ternata polysaccharides with a β -glucan-like structure may possess strong anti-osteoporotic potential, which provides a theoretical foundation for further research and development of P. ternata polysaccharides in the prevention and treatment of osteoporosis.
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ADVANCED MATERIALS
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2026
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IF 26.8
Xuecheng He,Wei Huang,Wensheng Lin,Binbin Cui,Xinyu Tian,Jing Bai,Dingyao Liu,Ivo Pang,Hao Huang,Shixian Lin,Jixiang Zhu,Jinqiang Wang,Shiming Zhang
Effective blood glucose management is an increasing demand worldwide. Traditional solutions separate glucose detection and insulin delivery, which is less efficient compared to emerging closed-loop wearable systems controlled by continuous glucose monitors (CGMs). However, CGM-controlled systems raise new safety risks, as false CGMs readings can cause insulin overdose, which results in hypoglycemia and fatal consequences. This work proposes a concept of a dual closed-loop insulin delivery system (DuoLoop) to mitigate the risk issue of CGM-controlled systems. The first closed-loop is automated insulin delivery controlled by CGM. The second closed-loop is the controlled release of glucose-responsive insulin (GRI), whose release rate depends on actual glucose levels. A customized algorithm is trained and embedded into the wearable CGMs for edge computing. The DuoLoop system shows improved safety in preliminary in vivo test (longer normoglycemia durations, 98.82% vs 92.10%), encouraging its deployment toward precision diabetes care.
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Journal of Materials Chemistry B
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2026
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IF 5.7
Hao Wang,Jiaxin Wang,Rui Wang,Liang Zhou
Functional 1,8-naphthalimide derivatives are rapidly developing in the field of anticancer research. However, the unpredictable side effects of 1,8-naphthalimide derivatives limit their transition from clinical trials to clinical drugs. To low down the overall cytotoxicity of 1,8-naphthalimide derivatives after coordination with metals, we have synthesized and characterized three new rare earth naphthalene dicarboxylate complexes with the general molecular formula of [Ln(TTA)3NI-Phen], where Ln=Er, Nd, Yb, respectively. In vitro antitumor screening revealed that all three complexes exhibit better inhibitory activities against A549 and H1299 cancer cell lines compared with the commercial anticancer drug cisplatin. Especially, Er(TTA)3NI-Phen exhibited specific cytotoxicity to H1299 cancer cells in micromole magnitude and lower toxicity to normal human cells Beas-2b. Interestingly, Er(TTA)3NI-Phen triggers lung cancer cells apoptosis via a mitochondrial dysfunction pathway, which is caused by dysfunction of mitochondria and cell cycle arrest. Most importantly, Er(TTA)3NI-Phen demonstrates an inhibition rate of up to 84% against H1299 tumors.
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APPLIED SURFACE SCIENCE
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2026
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IF 6.9
Qiongmiao He,Xing Cao,Shichang Sun,Qinhao Zhong,Rui Wang,Yaofeng Zhu,Rui Ma
Photocatalytic dissolution represents a promising alternative to conventional, highly toxic, and energy-intensive palladium (Pd) recovery technologies. However, achieving efficient recovery under visible-light illumination in aqueous solution remains a challenge. Herein, we constructed a visible-light-responsive heterojunction photocatalyst by in-situ growing BiOBr nanosheets on nanostructured g-C 3 N 4 . Under simulated sunlight irradiation (AM 1.5G, 100 mW/cm 2 ), the optimized BiOBr/g-C 3 N 4 achieved 88 % Pd dissolution from waste palladium/carbon catalyst (w-Pd/C) within 3 h, outperforming single-component catalysts. Free radical trapping experiments and electron spin resonance (ESR) analysis revealed that efficient separation and migration of photogenerated charge carriers at the heterojunction interface generated abundant reactive species. The photogenerated e − reacted with O 2 to produce •O 2 − , while h + reacted with H 2 O to generate •OH. Simultaneously, Br − was oxidized by h + and •O 2 − to form bromine radicals (•Br), which then combined to form Br 2 . These reactive species (•O 2 − , •OH, and Br 2 ) accumulated on the w-Pd/C surface and collectively promoted the oxidative dissolution of Pd. This study highlights the potential of combining heterojunction engineering with halogen coordination in sustainable metal recovery, providing novel insights and technical support for the green recovery of precious metals, with significant implications for environmental protection and resource cycling.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9
Ruifang Qi,Yue Zhao,Jinming Lei,Huixian Jia,Chenghong Feng
Metal-free covalent organic frameworks (COFs) often face a critical trade-off wherein high photocatalytic activity relies on complex, expensive designs while cost-effective alternatives lack efficiency and stability. To address these issues, a nitro-functionalized COF (COF-NO₂) was developed via a one-step condensation method for bisphenol A (BPA) degradation. The –NO₂ groups act as intramolecular electron traps, narrowing the bandgap and boosting charge separation. COF-NO₂ achieved 97.3% BPA degradation within 120 min ( k = 0.031 min −1 ) with over 85% efficiency across five consecutive cycles. Moreover, it exhibited high efficiency across a broad pH range (3−11) and showed broad-spectrum activity toward various bisphenols, including bisphenol S, bisphenol F, bisphenol C, and 4-chlorophenol. Quantitative structure–activity relationship analysis identified HOMO energy as the key descriptor governing degradation kinetics for bisphenols. In pretreated petrochemical wastewater, COF-NO₂ also attained over 75% BPA removal, demonstrating practical potential. This molecular design promoted ·O₂ − generation and selective bond cleavage in BPA, thereby enabling efficient mineralization and a 44% reduction in toxicity. A continuous-flow fluidized bed reactor was designed and achieved 97.4% BPA removal in 180 min through optimized light-flow coupling. Furthermore, low-cost g-C₃N 4 was introduced to integrate with highly active COF-NO₂, forming a composite that reduced material costs by 20% while maintaining over 80% degradation efficiency. This work presents a synergistic strategy combining molecular orbital engineering with heterojunction design, offering a feasible route to cost-effective and scalable metal-free COFs.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2026
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IF 21.1
Yifei Liu,Kaicai Fan,Cheng-Hao Chuang,Porun Liu,Zumin Wang,Lingbo Zong,Lei Wang
The nanoconfined environment offers a synergistic combination of physical confinement and electronic regulation, yet its underlying microscopic mechanisms remain to be systematically elucidated. Herein, we fabricate atomically dispersed homonuclear Mn catalytic pairs through the perhalate cascaded oxidation strategy within nanoconfined pores on activated mesoporous carbon spheres (Mn 2 -N-AMC). Finite element method (FEM) simulations and density functional theory (DFT) calculations reveal that nanoconfinement enhances O 2 transport and weakens the adsorption of oxygen intermediates. Furthermore, the bridge adsorption configuration of intermediates on Mn pairs promotes the subsequent O* protonation and reduces the energy barrier for OH* desorption. Consequently, Mn 2 -N-AMC exhibits superior radical scavenging capability and delivers excellent oxygen reduction reaction (ORR) performance with a half-wave potential (E 1/2 ) of 0.90 V and remarkable stability. Additionally, Mn 2 -N-AMC-based aqueous Zn-air batteries (A-ZABs) achieve an ultrahigh power density of 256.7 mW cm −2 and long-life stability (> 800 h). Quasi-solid-state ZABs also display a long-life operation over 100 h across various current densities, with negligible voltage gap decay. This work provides mechanistic insights, advancing the rational design of nanoconfined ORR catalysts for sustainable energy conversion and storage.
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8
Kang Wei,Lanlan Peng,Qiurong Wei,Yang Wei,Li Wang,Yuzhi Zhu,Yanxiang Wei,Xinlin Wei
Fecal microbiota transplantation (FMT) using donor microbiota modulated by tea represents an emerging approach to ameliorate ulcerative colitis (UC). This study aims to demonstrate the amelioration of dextran sulfate sodium (DSS)-induced colitis by donor microbiota modulated with tea-derived bioactive ingredients—tea polyphenols (TPP), tea polysaccharides (TPS), or theabrownin (TB). Following transplantation of fecal microbiota modulated by TPP, TPS, or TB from donors into colitis mice, significant reductions in Disease Activity Index (DAI) were observed, alongside attenuated intestinal histopathological damage. Additionally, gut barrier integrity was enhanced, as indicated by upregulated expression of occludin and Muc2. Fecal microbiota modulated by TPP and TPS showed superior efficacy in alleviating colitis compared with TB-modulated microbiota. The mechanism involved that marked enrichment of beneficial genera, including Akkermansia (TPP-enriched) and Allobaculum / Lactobacillus (TPS-enriched), which promoted the biosynthesis of short-chain fatty acids (SCFAs) and secondary bile acids, while reducing primary bile acids levels. These metabolic changes enhanced intestinal barrier function and suppressed suppressing pro-inflammatory cytokines through the modulation of TLR4/NF-κB p65 and Nrf2/ARE signaling pathways. This study not only elucidates the mechanism of tea bioactive ingredients-modulated donor microbiota alleviates colitis through regulation of the gut-microbiota-metabolite axis, but also provides a foundation for FMT-based strategies in colitis intervention.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 13.2
Jianqing Peng,Yuanhu Mao,Lei Huang,Qin Wang,Yun Zhao,Yi Chen,Lei Tang,Zipeng Gong
Inhalable liposomes modified with polyethylene glycol (PEG) serve as effective carriers for pulmonary drug delivery. However, the significantly lower protein concentration in the pulmonary microenvironment compared to plasma disrupts the exchange between protein and PEG-lipid, resulting in high retention of PEG which impedes cellular uptake. Furthermore, accelerated blood clearance mediated by anti-PEG IgM antibodies diminishes therapeutic outcomes and increases adverse reactions. To address these issues, we developed a novel strategy to construct inhalable dePEGylated liposomes using amino acid lipids (ALs) that were composed of anionic head groups, L-aspartic acid or L-glutamic acid linker and double alkyl chains. The dePEGylated liposomes are utilized to facilitate pulmonary delivery of asiatic acid (AA) for the treatment of idiopathic pulmonary fibrosis (IPF). Compared to PEGylated liposomes, dePEGylated liposomes exhibited promoted cellular uptake and transcellular transport by lung epithelial cells, effectively evaded clearance by alveolar macrophages, and enhanced pulmonary drug exposure, leading to improved therapeutic efficacy against IPF in mice. Our findings highlight the novel ALs-incorporated dePEGylated liposomes as a promising strategy to enhance treatment efficacy for IPF and overcome the limitations of PEGylated liposomes, which offers an efficient pulmonary drug delivery strategy for the other pulmonary diseases as well.
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ANALYTICAL CHEMISTRY
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2026
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IF 6.7
Longxue Yu,Yao Zhou,Xin Wang,Lingyun Xue,Shuo Wang,Yi Liu,Xuezhen Gao,Xunyong Liu
Cysteine (Cys) is essential in human physiological processes, and its abnormal levels are linked to various diseases, necessitating real-time monitoring in biological samples. Conventional detection methods, however, are often limited by the operational complexity and susceptibility to interference. To overcome these issues, we developed a chitosan–gold nanoparticle (CS–Au NP) gel sensor for dual-mode visual detection of Cys via gel–sol transition and colorimetry. This approach significantly reduces false positives that are common in single-signal methods. The sensor utilizes chitosan as an in situ reductant to form Au NPs, which together with chitosan amine groups and hydrogen bonding construct a 3D gel network. In the presence of Cys, its thiol groups competitively bind to Au NPs, disrupting cross-linking and triggering a gel–sol transition. Quantitative analysis based on the coverage ratio (Cr) on paper substrates showed high sensitivity with a detection limit of 2.08 μM and strong linearity (R2 = 0.9981). Concurrently, Au NPs released from the gel assemble into nanoaggregates, causing a red-to-blue-gray color shift due to SPR changes. This allows both visual qualitative assessment and smartphone-based RGB quantification, achieving a linear range of 20–1000 μM and an LOD of 2.23 μM. The dual-mode design ensures high selectivity, with minimal response to 19 interfering amino acids. Practical tests in human urine and bovine serum yielded recoveries of 100.24%–125.80%, confirming accuracy in complex matrices. Integrated with smartphone imaging, this portable system is ideal for point-of-care testing, offering a reliable and cost-effective platform for Cys monitoring and precision medicine.
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ACS Applied Polymer Materials
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2026
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IF 4.7
Chi Zhang,Ruru Huang,Gaiping Guo,Huafeng Tian,Yuge Ouyang,Yujuan Jin,Jian Li,Rakesh Kumar
To solve the problem of white pollution and petroleum energy consumption, zein/PVA blended fibers were prepared by wet-spinning technology to replace petroleum-based synthetic fibers. Zein has the environmentally friendly and resource-abundant characteristics, but its low viscosity makes it difficult to process via wet-spinning. By enabling the successful wet-spinning of inherently poorly spinnable zein, the introduction of PVA yielded blended fibers that retained more than 81% of the zein content. The zein/PVA blended fibers exhibit a maximum tensile strength of 32.38 MPa, a maximum elongation at break of 561.80%, a moisture regain of 4%, and a dye-uptake rate of 59.68%. This work lays the foundation for using zein/PVA blended fibers as a sustainable alternative to petroleum-based synthetic fibers in the textile industry.
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危险品化学品经营许可证（带存储）