查找使用阿拉丁产品的科研文献

An eco-friendly approach to low-temperature and near-neutral bleaching of cotton knitted fabrics using glycerol triacetate as an activator

Zhou Yu,Zheng Guolin,Zhang Jinfang,Wang Qiang,Zhou Man,Yu Yuanyuan,Wang Ping

Near-neutral bleaching of cotton fabrics at low temperature is of great importance for saving energy and ecological friendliness in textile industry. In this work, glycerol triacetate (GT) was investigated as an activator of hydrogen peroxide (H 2 O 2 ) for low temperature bleaching of cotton knitted fabrics, and satisfactory whiteness was obtained. The bleaching properties of H 2 O 2 /GT system for cotton was assessed by the CIE whiteness index (WI), H 2 O 2 decomposition rate, concentration of generated peracetic acid and bursting strength. Possible factors affecting the properties of cotton bleached by H 2 O 2 /GT bleaching system were discussed in detail. At 60 °C, adding only 10 mmol/L GT to the hydrogen peroxide solution (60 mmol/L) to bleach cotton knitted fabrics for 60 min, the WI was significantly increased from 52.09 to 68.92. By using benzenepentacarboxylic acid as a fluorescent probe for hydroxyl radical (HO·) detection, it was found that GT could clearly promote HO· generation and its concentration closely related to the WI of cotton fabric. Furthermore, the bleaching mechanism of H 2 O 2 /GT system was proposed by exploring the relationship between WI and HO· concentration. GT as a bleach activator has more economical benefits and better water solubility than tetraacetylethylenediamine. The H 2 O 2 /GT system may provide a cost-effective and environmentally friendly bleaching approach of cotton as alternative to conventional alkaline high-temperature bleaching.

An aligned porous electrospun fibrous membrane with controlled drug delivery – An efficient strategy to accelerate diabetic wound healing with improved angiogenesis

Xiaozhi Ren,Yiming Han,Jie Wang,Yuqi Jiang,Zhengfang Yi,He Xu,Qinfei Ke

A chronic wound in diabetic patients is usually characterized by poor angiogenesis and delayed wound closure. The exploration of efficient strategy to significantly improve angiogenesis in the diabetic wound bed and thereby accelerate wound healing is still a significant challenge. Herein, we reported a kind of aligned porous poly ( l -lactic acid) (P l LA) electrospun fibrous membranes containing dimethyloxalylglycine (DMOG)-loaded mesoporous silica nanoparticles (DS) for diabetic wound healing. The P l LA electrospun fibers aligned in a single direction and there were ellipse-shaped nano-pores in situ generated onto the surface of fibers, while the DS were well distributed in the fibers and the DMOG as well as Si ion could be controlled released from the nanopores on the fibers. The in vitro results revealed that the aligned porous composite membranes (DS-PL) could stimulate the proliferation, migration and angiogenesis-related gene expression of human umbilical vein endothelial cells (HUVECs) compared with the pure P l LA membranes. The in vivo study further demonstrated that the prepared DS-PL membranes significantly improved neo-vascularization, re-epithelialization and collagen formation as well as inhibited inflammatory reaction in the diabetic wound bed, which eventually stimulated the healing of the diabetic wound. Collectively, these results suggest that the combination of hierarchical structures (nanopores on the aligned fibers) with the controllable released DMOG drugs as well as Si ions from the membranes, which could create a synergetic effect on the rapid stimulation of angiogenesis in the diabetic wound bed, is a potential novel therapeutic strategy for highly efficient diabetic wound healing. Statement of Significance A chronic wound in diabetic patients is usually characterized by the poor angiogenesis and the delayed wound closure. The main innovation of this study is to design a new kind of skin tissue engineered scaffold, aligned porous poly ( l -lactic acid) (P l LA) electrospun membranes containing dimethyloxalylglycine (DMOG)-loaded mesoporous silica nanoparticles (DS), which could significantly improve angiogenesis in the diabetic wound bed and thereby accelerate diabetic wound healing. The results revealed that the electrospun fibers with ellipse-shaped nano-pores on the surface were aligned in a single direction, while there were DS particles distributed in the fibers and the DMOG as well as Si ions could be controllably released from the nanopores on the fibers. The in vitro studies demonstrated that the hierarchical nanostructures (nanopores on the aligned fibers) and the controllable released chemical active agents (DMOG drugs and Si ions) from the DS-PL membranes could exert a synergistic effect on inducing the endothelial cell proliferation , migration and differentiation. Above all, the scaffolds distinctly induced the angiogenesis, collagen deposition and re-epithelialization as well as inhibited inflammation reaction in the wound sites, which eventually stimulated the healing of diabetic wounds in vivo . The significance of the current study is that the combination of the hierarchical aligned porous nanofibrous structure with DMOG-loaded MSNs incorporated in electrospun fibers may suggest a high-efficiency strategy for chronic wound healing.

An artificial protein modulator reprogramming neuronal protein functions

Lin Peihua,Zhang Bo,Yang Hongli,Yang Shengfei,Xue Pengpeng,Chen Ying,Yu Shiyi,Zhang Jichao,Zhang Yixiao,Chen Liwei,Fan Chunhai,Li Fangyuan,Ling Daishun

Reversible protein phosphorylation, regulated by protein phosphatases, fine-tunes target protein function and plays a vital role in biological processes. Dysregulation of this process leads to aberrant post-translational modifications (PTMs) and contributes to disease development. Despite the widespread use of artificial catalysts as enzyme mimetics, their direct modulation of proteins remains largely unexplored. To address this gap and enable the reversal of aberrant PTMs for disease therapy, we present the development of artificial protein modulators (APROMs). Through atomic-level engineering of heterogeneous catalysts with asymmetric catalytic centers, these modulators bear structural similarities to protein phosphatases and exhibit remarkable ability to destabilize the bridging μ 3 -hydroxide. This activation of catalytic centers enables spontaneous hydrolysis of phospho-substrates, providing precise control over PTMs. Notably, APROMs, with protein phosphatase-like characteristics, catalytically reprogram the biological function of α-synuclein by directly hydrolyzing hyperphosphorylated α-synuclein. Consequently, synaptic function is reinforced in Parkinson’s disease. Our findings offer a promising avenue for reprogramming protein function through de novo PTMs strategy.

An adaptive and fast emulsion separation Janus membrane

Yuyan Guo,Zhiguang Guo,Weimin Liu

Inspired by the capillary effect in nature (such as water transport in soils) and droplet-drive performance of Nepenthes, a new driving strategy for emulsion separation membrane based on the synergistic effect of capillary force and progressive wettability-induction force was proposed. It is prepared by a one-step, simple continuous, electrospinning process. By adjusting solutions and spinning parameters, the membrane obtains its capillary structure and progressive oleophilicity in one-step preparation. Attractively, the membrane shows separation efficiency and excellent permeability, with a flux of 384801 L m −2  h −1 bar −1 for the oil-water mixture, and the little water content of less than 18 ppm. And for emulsions, the flux even reaches 50000 L m −2  h −1 bar −1 and the separation efficiency reaches 99.95%. Furthermore, the membrane has excellent mechanical-stability: at 80 kPa transmembrane pressure, it can still effectively prevent water's penetration. Drawing inspiration from nature, the incorporation of capillary force and progressive wettability-induction force into the separation membrane as an additional dual emulsion separation driving force proves to be a highly effective and versatile approach. This method provides a way to solve the general flux-efficiency balance problem of oil-water separation and also provides a new strategy for the preparation of separation membranes for various purposes.

Biomimetic zwitterionic copolymerized chitosan as an articular lubricant

Junjie Deng,Rufang Wei,Haofeng Qiu,Xiang Wu,Yanyu Yang,Zhimao Huang,Jiru Miao,Ashuang Liu,Haiyang Chai,Xiao Cen,Rong Wang

Restoration of the lubrication functions of articular cartilage is an effective treatment to alleviate the progression of osteoarthritis (OA). Herein, we fabricated chitosan- block -poly(sulfobetaine methacrylate) (CS-b-pSBMA) copolymer via a free radical polymerization of sulfobetaine methacrylate onto activated chitosan segment, structurally mimicking the lubricating biomolecules on cartilage. The successful copolymerization of CS-b-pSBMA was verified by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and 1 H nuclear magnetic resonance. Friction test confirmed that the CS-b-pSBMA copolymer could achieve an excellent lubrication effect on artificial joint materials such as Ti6Al4V alloy with a coefficient of friction as low as 0.008, and on OA-simulated cartilage, better than the conventional lubricant hyaluronic acid, and the adsorption effect of lubricant on cartilage surface was proved by a fluorescence labeling experiment. In addition, CS-b-pSBMA lubricant possessed an outstanding stability, which can withstand enzymatic degradation and even a long-term storage up to 4 weeks. In vitro studies showed that CS-b-pSBMA lubricant had a favorable antibacterial activity and good biocompatibility. In vivo studies confirmed that the CS-b-pSBMA lubricant was stable and could alleviate the degradation process of cartilage in OA mice. This biomimetic lubricant is a promising articular joint lubricant for the treatment of OA and cartilage restoration.

Fluid-driven hydrogel actuators with an origami structure

Zhexin Huang,Cunyue Wei,Lina Dong,Anyang Wang,Hongyi Yao,Zhongwei Guo,Shengli Mi

Owing to the innate good biocompatibility, tissue-like softness and other unique properties, hydrogels are of particular interest as promising compliant materials for biomimetic soft actuators. However, the actuation diversity of hydrogel actuators is always restricted by their structure design and fabrication methods. Herein, origami structures were introduced to the design of fluid-driven hydrogel actuators to achieve diverse actuation movements, and a facile fabrication strategy based on removable templates and inside-out diffusion-induced in situ hydrogel crosslinking was adopted. As a result, three types of modular cuboid actuator units (CAUs) achieved linear motion, bending, and twisting. Moreover, combinations of multiple CAUs achieved different actuation modes, including actuation decoupling, superposition, and reprogramming. The diverse actuation functionality would enable new possibilities in application fields for hydrogel soft actuators. Several simple application demos, such as grippers for grasping tasks and a multi-way circuit switch, demonstrated their potential for further applications.

An environment-friendly synthesis of 4(3H)-quinazolinones

Haidong Wei,Lihong Zhou,Yue Zhou,Qingle Zeng

An elastic and lamellar piezoresistive graphene/MXene aerogel

Liu Linxiang,Zhang Jiaqi,Shi Ge,Zhang Huili,Wang Bing,Zhong Linxin

Recently, wearable electronic devices and human–computer interaction are developing prosperously, which expands the requirement of flexible sensing materials. Graphene and its derivatives with extraordinary advantages are highly attractive precursors. However, it is difficult to assemble graphene into macroscopic cubes with good fatigue resistance performance. Here, we propose an efficient way to manufacture a lamellar-structural rGO aerogel with enhanced stiffness and deflection of lamellae, by using MXene as a rigidity additive. The addition of MXene (Ti 3 C 2 T x ) improves the mechanical and fatigue resistance properties of the aerogel, making it super compressible and elastic. The highly stable structure of the aerogel can withstand extremely high compressive strain of 90% and long-term compression at 50% strain for at least 10,000 cycles. The lamellar structure makes a great contribution to achieve good sensing performance including high linear sensitivity, low testing limit, wide testing strain range and quick response. These features make the MXene/rGO aerogel a promising sensing material for flexible wearable devices to monitor the subtle and obvious biosignals of the human body movement. Graphical abstract

Trichothecenes from an Endophytic Fungus Alternaria sp. sb23

Ying Gao,Jia Zhou,Hanli Ruan

Three new (alterchothecenes A – C, 1 –3) and 3 known (4 –6) trichothecenes, along with 9 known compounds (7 –15), were isolated from the culture of Alternaria sp. sb23, an endophytic fungus separated from the root of Schisandra sphenanthera Rehd. et Wils. Their structures were elucidated by spectroscopic analyses, and the absolute configurations of 1–3 were determined through comparison of the experimental electronic circular dichroism (ECD) spectra and optical rotations with similar analogues. In vitro cytotoxicity tests of compounds 1–6 against human HT-29 colon carcinoma and human MCF-7 breast cancer cell lines indicated that 4–6 exhibited significant cytotoxic effects, with IC50 values ranging from 0.89 to 9.38 µM. And the potential of compounds 1–6 as tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) sensitizers in HT-29 cells was evaluated. The results revealed that combination treatment of TRAIL with compounds 1–6 synergistically decreased cell viability compared with the sole treatment with those compounds.

An iontronic reservoir for highly robust neuromorphic prosthesis

Pei Mengjiao,Gao Tian,Liu Li,Li Wenlong,Long Haotian,Luo Yifei,Teng Zhaogang,Cui Hangyuan,Li Xiang,Dai Qinyong,Shi Kailu,Qiao Lesheng,Peng Baocheng,Xing Qianye,Wen Manhua,Han Mengtao,Wan Zhenhua,Li Yun,Xue Bin,Cao Yi,Shi Yi,Wan Qing,Chen Xiaodong,Wan Changjin

Neuromorphic prosthesis demands not only the assembly of neural architectures and functions but also robustness against unpredictable failures in dynamic physiological environments. While self-healing electronics have been demonstrated to restore synapse-like functions, their application to higher-order cognitive functions remains limited. Here we present a hydrogel-based iontronic reservoir that demonstrates exceptional physical and functional robustness for neuromorphic prosthesis. The nonlinear dynamics of the hydrogel–electrode interface can serve as a physical reservoir to preprocess time series, with minimized susceptibility to physical damage. Our system based on the hydrogel-based iontronic reservoir achieves 95% accuracy in speech recognition and can restore such capability within 0.02 s after reattaching the fractured points, outperforming biological systems in the neurorehabilitation process. Moreover, its pH-sensitive dynamics enable adaptive closed-loop neural stimulation control in a rat model, validating its potential for neural rehabilitation and sensorimotor function restoration. We expect such a hydrogel-based iontronic reservoir to improve both processing efficiency and robustness for next-generation neuroprosthetics and human–machine interfaces.

An infrared-transparent flexible glass for adaptive optics

Li Saihui,Tan Linling,Ma Jianqiang,Kang Shiliang,Gao Chengwei,Dai Shixun,Lin Changgui

Transparent, flexible inorganic-organic composites are essential for next-generation adaptive optics, bio-integrated sensing, and reconfigurable photonics. Despite progress in hybrid material design, achieving a material that is simultaneously flexible and transparent across a broad infrared spectrum remains a fundamental challenge. Here, we report a S 60 Se 40 chalcogenide glass designed with a chain-ring dual-network architecture that overcomes this classic limitation. By integrating a dynamic covalent network of physical cross-links with heavy chalcogen elements (S, Se), this dual-network design suppresses multi-phonon absorption and ensures broadband transparency up to 21 μm, combining these optical properties with an ultralow Young’s modulus ( E  ≈ 0.0037 GPa), extreme tensile strain (~650%), and high elastic recovery (~80%). The material further exhibits autonomous self-healing and shape-memory behavior at room temperature. We demonstrate its applicability through IR deformable lenses with tunable focal length and real-time aberration correction, showcasing capabilities in adaptive imaging and wavefront control. This work provides a versatile material platform that bridges the gap between glass-like optical performance and polymer-like mechanics, opening avenues for soft infrared photonics and reconfigurable optical systems.

An ultrahigh performance alkaline CFx-Zn primary battery

Liangxue Bao,Congping Xu,Ruding Zhang,Hongjun Yue

With the increasing demand of high energy and power density for energy storage devices, aqueous zinc-based batteries with high safety and low-cost battery system, have attracted wide attention due to their inherent advantages. Herein, for the first time, fluorinated carbon (CF 0.95 ) materials are reported as cathodes for alkaline zinc batteries and exhibit unprecedented power and energy density. The results show that the material exhibits a very high specific capacity of 703.5 mAh/g as well as an ultrahigh energy density up to 795.5 Wh/kg at a current rate of 50 mA/g (0.071C). Besides, it still holds high capacity of 416.7 mAh/g when discharged at a rate of 50000 mA/g (71C), indicating an outstanding power performance of 25066.0 W/kg. The corresponding capacity can even reach to 170.6 mAh/g, 706 mAh/g and 562.6 mAh/g when it is evaluated at a current rate 0.71C under −20 °C, 0 °C and 50 °C respectively. Finally, electrochemical discharge mechanism based on the conversion reaction is also further uncovered by XRD and SEM characterization and EDS elemental analysis. In conclusion, the alkaline Zn/CF x new-type primary battery systems with excellent properties developed here might show broad application prospects.