JOURNAL OF SOLID STATE CHEMISTRY
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2025
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IF 3.5
Sheli Zhang,Yuerong Yan,Huijie Shan,Yunchang Fan,Haibao Zhu
The chemical fixation of carbon dioxide (CO 2 ) represents a viable strategy to achieve carbon neutrality. However, the conversion of CO 2 is still limited by the lack of efficient heterogeneous catalysts. To address this problem, a flexible linker-based metal-organic frameworks were synthesized using hard Lewis acid indium as metal center (In-MOFs) and their catalytic performance for the CO 2 cycloaddition with epoxides in the absence of solvent and co-catalyst was evaluated. Experimental results revealed that In-MOFs exhibited great catalytic activity (cyclic carbonate yield, 97.2 %) and selectivity (>98 %) for the cycloaddition of CO 2 and epichlorohydrin (ECH) under mild conditions (80 °C for 5 h, 0.1 MPa CO 2 ) due to the strong Lewis acidity of In (III), which significantly lowered energy barrier of epoxide ring opening and the insertion of CO 2 , consequently promoting the CO 2 cycloaddition reaction. These results suggested that the In-MOFs exhibited promising potential as catalysts for the CO 2 chemical fixation and may provide a new approach for the fabrication of MOFs-based catalysts for the CO 2 conversion.
研究领域:
材料科学
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催化化学
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环境化学
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无机化学
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可持续能源
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
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2021
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IF 8.067
Feihu Mu,Benlin Dai,Wei Zhao,Shijian Zhou,Haibao Huang,Gang Yang,Dehua Xia,Yan Kong,Dennis Y.C. Leung
To boost the visible light catalytic performance of typical metal-organic frameworks (MOFs) materials (MIL-68(In)-NH 2 ), a novel stable Z-scheme Ag/Ag 3 PO 4 /MIL-68(In)-NH 2 plasmonic photocatalyst was constructed by electrostatic attraction, co-precipitation reaction, and in-situ photoreduction reaction methods for the first time. The photocatalytic activities of the photocatalysts are systematically explored by the photocatalytic degradation of bisphenol A (BPA) and reduction of Cr(VI) under visible light. Ag/Ag 3 PO 4 /MIL-68(In)-NH 2 displays the best photocatalytic performance among the as-prepared photocatalysts. The rate constant of BPA degradation on Ag/Ag 3 PO 4 /MIL-68(In)-NH 2 is 0.09655 min −1 , which is better than many reported photocatalytic materials. It also achieved a maximum rate constant of 0.02074 min −1 for Cr(VI) reduction. The boosted photocatalytic performance is due to the improved absorption caused by localized surface plasmon resonance (LSPR), effective interface charge transfer and separation, and more reactive sites provided by the large specific surface area. Besides, the photocatalytic degradation pathway of BPA is concluded according to GC-MS analysis. Finally, a more reasonable Z -scheme mechanism is speculated and verified through a series of characterizations and simulations, such as time-resolved photoluminescence spectroscopy (TRPL), electron spin resonance (ESR), and finite difference time domain (FDTD) method.
研究领域:
材料科学
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环境科学
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化学
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光催化
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Qingrong Zhang,Yingcai Wang,Yuhui Liu,Qian Liu,Youqun Wang,Zhimin Dong,Xiaohong Cao,Zhibin Zhang,Yunhai Liu
In order to realize energy cost savings in waste salt recycling and electrolysis processes during the nuclear fuel cycle , this paper presents a novel approach for the purification of waste molten salt by employing molecular sieves to absorb excess fission products selectively. The method is founded on the principles of electrolytic refining to achieve sustainable development of reprocessing. In this study, a systematic investigation of the electrochemical reduction/oxidation processes of Y(III)/In(III) was performed on electrode, as well as the electrode reaction of Y(III) on an In electrode at 773 K. Constant-current electrolysis produced an extraction rate of 93.11 % for Y(III) on the In electrode. In order to improve the current efficiency, greatly save the processing cost, and realize the sustainable development of dry post-processing. Subsequently, the waste molten salt environment following electrolysis was simulated, and the fission product was effectively adsorbed utilizing 5A molecular sieves, resulting in a yttrium removal rate of up to 99.94 %. This process not only significantly reduces the cost of electrolysis but also enhances the removal efficiency of target nuclides. The study examined the molten salt adsorption mechanism of molecular sieve, determining the primary adsorption mechanism to be chemical one (ion exchange), through the application of pseudo-first-order, pseudo-second-order, and Weber-Morris kinetic models for re-evaluation.
研究领域:
核工程
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化学工程
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材料科学
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环境科学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2022
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IF 9.136
Yucheng Li,Xiangyu Wang,Zhengyin Duan,Dehai Yu,Qiang Wang,Dandan Ji,Wenxia Liu
Treating dye-contaminated wastewater using the visible light–driven photo-Fenton reaction is beneficial to environmental remediation. This paper reports the synthesis of a novel, highly effective photo-Fenton catalyst, the Zn/Co-ZIFs@MIL-101(Fe) composite, by a facile internal-growth method. The composite, which had an MOF-in-MOF structure, activated H 2 O 2 to decompose RhB, a polluting-dye model, under visible-light illumination. The transfer of the electron–hole pair was synergistically accelerated by the reaction centers of the composite (the MIL-101(Fe) shell and Zn/Co-ZIFs core), which enhanced H 2 O 2 activation. The generated OH, O 2 − , and 1 O 2 effectively decomposed RhB. The composite’s catalytic performance was significantly enhanced by the electronic hybridization of its Fe 3+ , Co 2+ , and Zn 2+ metal centers. Thus, the composite demonstrated a remarkable capability to remove RhB. The composite polymetallic MOFs loaded with 3% Zn/Co-ZIFs prepared by us showed good reusability and water stability, and their morphology and structure did not change significantly after four runs, depending on the iron, cobalt, and zinc metal leaching concentrations 0.134 mg/L, 0.06 mg/L and 0.054 mg/L respectively. This study provides a novel method to construct an Zn/Co-ZIFs@MIL-101(Fe) catalyst with dual reaction centers that enhance the transfer of electron–hole pairs. Our findings inspire the application of MOF-based photo-Fenton catalysts to wastewater treatment and environmental remediation.
研究领域:
环境科学
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催化
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材料科学
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水处理
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DOI
高影响因子
Materials Today Bio
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2024
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IF 8.7
Xuan Zhang,Xia Gao,Xiangzhou Yi,Hui Yu,Mingyang Shao,Yongcheng Li,Xuanri Shen
The pathogenesis of ulcerative colitis (UC) is closely related to severe inflammation, damaged colonic mucosal barrier, increased oxidative stress and intestinal ecological imbalance. However, due to the nonspecific distribution and poor bioavailability of drugs, UC treatment is still a serious challenge. Here, a mitochondria/colon dual targeted nanoparticles based on redox response was developed to effectively alleviate UC. Cannabidiol nanoparticles (CBD NPs) with a particle size of 143.2 ± 3.11 nm were prepared by self-assembly using polymers (TPP–IN–LA) obtained by modifying inulin with (5-carboxypentyl) triphenyl phosphonium bromide (TPP) and α-lipoic acid (α-LA). Excitingly, the constructed CBD NPs showed excellent mitochondrial targeting, with a Pearson correlation coefficient of 0.76 at 12 h. The results of animal imaging in vivo showed that CBD NPs could be effectively accumulated in colon tissue. Not only that, CBD showed significant glutathione stimulated release in the presence of 10 mM glutathione at pH 7.4. The results of in vivo animal experiments showed that CBD NPs significantly ameliorated DSS-induced colonic inflammation by modulating the TLR4-NF-κB signaling pathway. Moreover, CBD NPs significantly improved the histological damage of colon in UC mice, increased the expression level of tight junction protein ZO-1, and effectively restored the intestinal mucosal barrier function and intestinal mucosal permeability. More importantly, CBD NPs significantly improved the species composition, abundance and amount of short chain fatty acids of intestinal flora in UC mice, thus effectively maintaining the balance of intestinal flora. The dual-targeted and glutathione-responsive nanoparticles prepared in this study provide a promising idea for achieving targeted delivery of CBD for effective treatment of UC.
研究领域:
药学
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纳米技术
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炎症性肠病
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药物递送系统
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结直肠疾病
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产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
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2023
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IF 9.7
Yizhong Peng,Xuanzuo Chen,Zilong Rao,Wei Wu,Huiyin Zuo,Kaibin Chen,Kanglu Li,Hui Lin,Sheng Liu,Yan Xiao,BaiChuan Wang,Daping Quan,Xiangcheng Qing,Ying Bai,Zengwu Shao
Chronic low back pain mainly attributed to intervertebral disc (IVD) degeneration. Endogenous damage-associated molecular patterns (DAMPs) in the injured IVD, particularly mitochondria-derived nucleic acid molecules (CpG DNA), play a primary role in the inflammatory responses in macrophages. M1-type macrophages form a chronic inflammatory microenvironment by releasing pro-inflammatory factors and nerve growth factor (NGF) that induce nerve growth into the inner annulus fibrosus, resulting in persistent hyperalgesia. We fabricated an amphiphilic polycarbonate that naturally forms cationic nanoparticles (cNP) in aqueous solutions, with the hydrophobic core loaded with TrkA-IN-1, an antagonist against the NGF receptor (TrkA). The drug delivery nanoparticles were denoted as TI-cNP. TrkA-IN-1 and TI-cNP were added to the decellularized annulus fibrosus matrix (DAF) hydrogel to form hybrid hydrogels, denoted as TI-DAF and TI-cNP-DAF, respectively. As a result, TrkA-IN-1 showed a delayed release profile both in TI-DAF and TI-cNP-DAF. Each mole of cNP could bind approximately 3 mol of CpG DNA to inhibit inflammation. cNP-DAF and TI-cNP-DAF significantly inhibited the M1 phenotype induced by CpG DNA. TI-DAF and TI-cNP-DAF reduced neurite branching and axon length, and inhibited the expression of neurogenic mediators (CGRP and substance P) in the presence of NGF. Besides, TI-cNP-DAF relieved mechanical hyperalgesia, reduced CGRP and substance P expression in the dorsal root ganglion, and downregulated GFAP and c-FOS signaling in the spinal cord in the rat disc herniation model. Summarily, TI-cNP-DAF, a novel composite IVD hydrogel, efficiently mediated the inflammatory environment, inhibited nerve ingrowth and sensitization, and could be clinically applied for treating discogenic pain. Statement of Significance : Discogenic lower back pain, related to intervertebral disc degeneration (IDD), imposes a tremendous health and economic burden globally. M1-type macrophages release pro-inflammatory factors and nerve growth factor (NGF) that induce nerve growth into the inner annulus fibrosus, resulting in persistent hyperalgesia and discogenic pain. Reconstructing matrix integrity and modulating the inflammatory microenvironment are promising strategies for preventing the ingrowth and activation of neurites. The TI-cNP-DAF hydrogel recovers tissue integrity, alleviates inflammation, and delivers the TrkA antagonist to inhibit the activity of NGF, thus restraining hyperinnervation and nociceptive input. Due to its simple production process, injectability, and acellular strategy, the hydrogel is operable and holds great potential for treating discogenic lower back pain.
研究领域:
生物医学工程
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神经科学
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疼痛管理
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组织工程
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药物递送系统
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产品关联
DOI
PubMed
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
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2025
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IF 3.5
Li Xinyu,Li Jingqi,Li Na
This study investigated the effects of sequential acid treatment and phosphorus incorporation on the performance of Fe–Mn-Ce composite metal oxide catalysts. The FeMnCeO x catalyst was prepared using the sol–gel method and modified through two methods: treatment with phosphoric acid alone and a sequential treatment with phosphoric acid followed by sulfuric acid. The results show that the sequentially acid-treated catalyst exhibited over 90% NO x conversion and N 2 selectivity in the temperature range of 200–350 °C, outperforming other catalysts. Characterization analyses such as XRD and NH 3 -TPD revealed that acid modification enhanced the surface acidity and redox properties of catalysts. XPS analysis showed that sequential acid treatment increased the surface chemisorbed oxygen content of the catalyst and optimized its surface structure. In-situ DRIFTS spectroscopy further elucidated that the catalytic reaction follows both Langmuir–Hinshelwood and Eley–Rideal mechanisms concurrently.
研究领域:
环境科学
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催化化学
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材料科学
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化学工程
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物理化学
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2021
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IF 4.539
Yong Gao,Changsheng Sun,Chenze Qi
Room temperature ionic liquids (RTILs)-containing Pickering emulsions exhibit promising application potentials because of the integration of the “green” quality and the tunable applications of RTILs with the advantages of Pickering emulsions, such as the high stability and adjustable droplet size. In the present study, sterically-stabilized polymer nanoparticles (SSPNs) were first prepared via the reversible addition-fragmentation chain transfer (RAFT)-mediated non-aqueous dispersion polymerization , in which poly(lauryl methacrylate) (PLMA) and poly(4-vinyl pyridine) (P4VP) acted as the stabilizer block and the core-forming block, respectively. Kinetically-trapped PLMA- b -P4VP spheres and mixed spherical/worm-like morphologies could be achieved at a target copolymer composition . Subsequently, core cross-linked SSPNs (CSSPNs) were obtained by means of chemical cross-linking of P4VP cores of SSPNs with 1,4-dibromobutane in a diluted solution of SSPNs in toluene (0.4 mg/mL). Stable 1-butyl-3-methylimidazolium tetrafluoroborate-in-toluene ([Bmim][BF 4 ]-in-toluene) non-aqueous Pickering emulsions could be formed at a low emulsifier content of 0.005 wt% adopting CSSPNs with mixed spherical/worm-like morphologies as Pickering emulsifiers. Benefiting from large surface areas of Pickering emulsions and unique chemical/physical properties of RTILs, [Bmim][BF 4 ]-in-toluene Pickering emulsions provided readily available platforms for many organic reactions . As a proof of the concept, proline catalyzed Knoevenagel reaction of 4-nitrobenzaldehyde with malononitrile was chosen as a model here. Both high reaction efficiency and good recyclability were observed.
研究领域:
材料科学
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化学工程
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有机化学
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产品关联
DOI
高影响因子
Journal of Functional Foods
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2025
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IF 4
Yuting Jian,Xiaoqun Zhong,Junjing Wang,Feijie Wang,Shaokun Yu,Jiannan Guo,Xiaona Gan,Juntao Kan,Wei Guo
Hyperuricemia (HUA) is an independent risk factor for cardiovascular disease, chronic kidney disease, and gout. This paper explored a novel phytonutrients formula (PNF) for managing HUA. PNF's efficacy was evaluated through in vitro , in vivo , and in silico studies. Phytochemical profiling of PNF was performed using advanced chromatography. In vitro enzymatic assay and cell studies demonstrated key mechanisms of inhibiting xanthine oxidase (XOD) and promoting uric acid (UA) excretion. In hyperuricemia mice model, PNF significantly reduced plasma UA level, inhibited XOD activity, enhanced UA excretion, and demonstrated antioxidant effects. Potential molecular targets were predicted, and hyperuricemia-related genes were curated. Protein-protein interaction networks and functional enrichment analyses were conducted to elucidate underlying mechanisms. In conclusion, PNF ameliorates HUA by inhibiting UA production, enhancing its excretion and exerting multi-target anti-inflammatory and antioxidant effects, highlighting its potential for HUA management.
研究领域:
药理学
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生物信息学
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分子生物学
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产品关联
DOI
高影响因子
Drug Design Development and Therapy
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2025
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IF 5.1
Cong Xie,Tongshu Guan,Jin Huang,Jiayu Chen,Yilei Li,Ping Zheng
Purpose Lorlatinib, a third-generation inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1), undergoes extensive metabolism, with its disposition influenced by drug–drug interactions (DDIs). This study aimed to characterize its in vitro metabolism, in vivo pharmacokinetics (PK), tissue distribution, and the effects of cytochrome P450 3A4 (CYP3A4) modulation in rats.Methods Lorlatinib metabolism was investigated in human liver microsomes (HLM) and rat liver micro- somes (RLM) using ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) with selective CYP inhibitors. Pharmacokinetic (PK) studies were performed in Sprague–Dawley (SD) rats following oral and intravenous dosing, including coadministration with CYP3A4 inhibitors (voriconazole, itraconazole) and inducers (rifampicin, carbamazepine). Tissue distribution was assessed across major organs.Results In vitro assays confirmed CYP3A4 as the primary enzyme mediating lorlatinib metabolism, with distinct differences in kinetic parameters between HLM and RLM. In vivo, lorlatinib displayed nonlinear PK, low oral bioavailability (8.6%), and extensive first-pass metabolism. Voriconazole increased exposure [area under the curve from 0–24 h (AUC(0−24h))] by 120%, whereas rifampicin reduced it by 77%, demonstrating strong CYP3A4-dependent interactions. Lorlatinib distributed rapidly to highly perfused organs and achieved efficient brain penetration (brain-to-plasma ratio = 0.82).Conclusion Lorlatinib undergoes extensive CYP3A4-mediated metabolism, exhibits nonlinear PK, and shows poor oral bioavailability in rats. Significant interspecies differences between HLM and RLM emphasize the need for caution when translating preclinical findings. Coadministration with CYP3A4 modulators markedly altered systemic exposure, while effective brain penetration supports its therapeutic role in central nervous system (CNS) metastases.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
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2016
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IF 3.055
Zhong-Yan Zhou,Li-Yun Huan,Wai-Rong Zhao,Nuo Tang,Yu Jin,Jing-Yi Tang
Ethnopharmacological relevance Spatholobi Caulis is a traditional blood-activating and stasis-dispelling herb medicine, which has been used to treat diseases related to blood stasis syndrome (BSS) by inhibiting platelet aggregation, stimulate hematopoiesis, etc. It has been demonstrated that pro-angiogenesis could improve BSS. However, the pro-angiogenic activity of Spatholobi Caulis was not well elucidated Aim of study To determine the potential pro-angiogenic activity of Spatholobi Caulis and elucidate its underlying mechanism. The active fractions of Spatholobi Caulis were further screened. Material and methods Gelatin precipitation and reversed-phase liquid chromatography (RPLC) were used to purify the methanol extracts of Spatholobi Caulis , respectively. The RPLC was also used to prepare fractions. Total flavonoids of purified methanol extracts of Spatholobi Caulis (PSC) were determined using ultraviolet spectrophotometry. The morphological observation of subintestinal vessel plexus (SIVs) and tyrosine kinase inhibitor II (VRI)-induced intersegmental blood vessels (ISVs) loss in transgenic zebrafish Tg(fli-1a: EGFP)y1 were selected to evaluate the pro-angiogenic activity of PSC in vivo. Cell proliferation by MTT assay and cell migration assay were used to evaluate the pro-angiogenesis effect of PSC in human umbilical vein endothelial cells (HUVECs) in vitro . Both zebrafish and HUVECs were used in screening active fractions of PSC. The mechanism of PSC promoting angiogenesis were studied by real-time PCR in zebrafish and western blotting in HUVECs. Results Co-treatment PSC dramatically rescued VRI-induced ISVs loss in zebrafish embryos in a dose-dependent manner and 80% of the defective vascular recovered at the concentration of 30 μg/ml compared with VRI-only group. PSC also concentration-dependently increased average sprouting number and diameter of SIVs in zebrafish embryo. Real-time PCR assay proved that PSC significantly restored the down regulation of VEGFRs including Flt-1, Kdr and Kdrl induced by VRI in zebrafish (P<0.001). Furthermore, PSC not only promoted proliferation and migration of normal HUVECs but also ameliorated VRI-induced HUVECs cytotoxicity. Western blotting assay showed that co-treatment of PSC increased the expression of VEGFRs and phosphorylation of MAPKs which decreased by VRI treatment. In addition, quality evaluation experiments showed that the content of total flavonoids of PSC reached 56.36% and the main pro-angiogenic fractions of PSC were F3, F4 and F5 both in zebrafish and HUVECs. Conclusions Our data demonstrated that PSC presented pro-angiogenic activity both in zebrafish and HUVECs, and principal pro-angiogenic active components were likely flavonoids. Thus, the current study provided evidence for the clinical usage of Spatholobi Caulis in promoting blood circulation and removing stasis in traditional Chinese medicine (TCM).
研究领域:
民族药理学
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分子生物学
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心血管研究
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DOI
PubMed
高影响因子
Journal of Energy Chemistry
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2025
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IF 14.9
Chaoran Yang,Shuyu Liang,Cong Zhang,Tianyu Zhang,Wenfu Xie,Min Li,Qiang Wang
Copper (Cu)-based catalysts have demonstrated promising selectivity and activity in electroreducing CO 2 to multi-carbon (C 2+ ) products. Among them, oxide-derived Cu catalysts exhibit high selectivity for C 2+ products in the CO 2 electroreduction reaction (CO 2 RR). Cu chalcogenide-derived catalysts offer a promising approach to tune the electronic structure of Cu sites via surface reconstruction, thereby affecting the product distribution. However, the effect of in-situ anion dissolution, especially Se ions, on the electronic structure of Cu selenides at negative potentials remains overlooked, despite its potential to significantly affect catalytic activity. In this study, we developed a series of Cu selenide catalysts with varying Cu/Se ratios to optimize electronic structures and enhance CO 2 RR performance. Among them, Cu 1.8 Se, featuring Cu vacancies, exhibited the highest activity for C 2+ products formation and the highest C 2+ /C 1 products ratio, nearly 2–3 times greater than the others. This catalyst also demonstrated good stability over 38 h of electrolysis under −450 mA cm −2 , with a maximum C 2+ products Faradaic efficiency (FE) of up to 70 %. In-situ surface reconstruction analysis revealed Se loss and Cu + /Cu 2+ reduction of the initial Cu 1.8 Se catalyst, forming Cu/Cu x Se structures with Cu vacancies, identified as the real active sites. Density functional theory (DFT) calculations and in-situ infrared absorption spectroscopy confirmed that Cu vacancies play a critical role in stabilizing *CHOCO intermediates for C–C coupling while suppressing hydrogen evolution reaction and C 1 products formation. These findings highlight Cu vacancy engineering as an effective strategy for enhancing C 2+ selectivity in CO 2 RR.
研究领域:
电化学
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催化
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材料科学
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表面科学
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理论化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）