APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Xinqi Wang,Fuping Bian,Xinxin Cai,Jiwen Hu,Shudong Lin
The advent of the 5G era has significantly increased device power density and integration, intensifying heat dissipation challenges in electronic devices. The exploration and development of novel thermally conductive materials have become critical for the next generation of electronic devices. This work presents a novel method for the efficient and energy-saving preparation of advanced thermal conductive materials. A high-performance, thermally conductive bio-based UV-cured polymer (AESO-GAGMx) was synthesized from epoxy soybean oil (ESO) and gallic acid (GA). Its intrinsic in-plane thermal conductivity of 1.08 Wm −1 K −1 exceeds most reported polymer materials. Furthermore, composite films (A-BNx) with superior thermal conductivity were fabricated by the novel method, using AESO-GAGMx and hexagonal boron nitride (h-BN). This material shows potential for application in thermal management of electronic devices. The A-BNx composite thermally conductive film and its preparation method offer a novel approach to designing thermal management materials.
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2025
·
IF 12.1
Quan Zhang,Bang-Xian Yu,Jun Long,Xue-Wu Chen,Fang Huang,Wen-Qi Wu,Yong-Da Liu,Guo-Hua Zeng,Ling-Hong Huang,Xin-Yuan Sun
Kidney stones, which have high prevalence and recurrence rates, often cause severe oxidative damage and inflammation. The ultrasmall hydrodynamic diameter of nanoparticles is crucial for their enrichment in the kidneys to exert biological activity. However, integrating crystallization inhibition and therapeutic functions into a single ultrasmall nanoparticle is challenging. A novel ultrasmall iron (Fe)–gallic acid (Ga) metal–phenolic networks (Fe–Ga MPNs) is developed for treating calcium oxalate (CaOx) nephropathies. These MPNs can specifically adsorb on the high-energy ( 1 ¯ 01 $\bar{1}01$ ) crystal face to inhibit the growth of CaOx monohydrate (COM), promoting the phase transition from highly toxic COM to low-risk CaOx dihydrate. Fe–Ga MPNs have broad-spectrum free radical scavenging abilities, reducing oxidative damage and inhibiting cell apoptosis. They exhibit sensitivity toward kidney damage, accumulating in injured renal tissue, reducing tubule injury and inflammation, improving tubule function, and inhibiting crystal formation. Fe–Ga MPNs also inhibit pro-inflammatory macrophage polarization and upregulate anti-inflammatory and highly phagocytic macrophage polarization. RNA sequencing analysis shows that Fe–Ga MPNs induce transcriptomic changes mainly involving immune regulation and citrate homeostasis pathways. In conclusion, the multifunctional nanonetwork Fe–Ga MPNs, with crystallization inhibition, antioxidant, and immune regulation properties, show great potential in treating CaOx nephropathies.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Junling Wang,Nannan Song,Liping Yin,Zhe Cui,Yong Wang,Chengyan Zhou,Jianheng Li,Jianglei Qin
When the barrier function of the skin tissue is destroyed, the burn wound is prone to bacterial infection and difficult to repair during the healing process. Therefore, there is an urgent need to design functional dressing materials to promote burn wound repairing. In this research, injectable hydrogel with mussel-inspired tissue adhesion was fabricated from dopamine grafted oxidized pectin (OP-DA) and hydrazide terminated polyethylene oxide (PEO-AH) as dressing material for burn wounds. The catechol moiety on the grafted dopamine (DA) enhanced the tissue adhesion of hydrogel and the wound sealing performance, which can well adhere onto the skin to cover irregular wounds for consistent sealing under body moving. On this basis, the hydrogel also showed hemostatic performance based on liver and tail hemostasis model. The hydrogel was further loaded with gallic acid (GA) to enhance the antibacterial property to E. coli and S. aureus to inhibit wound infection. Along with good biocompatibility and biodegradability, the hydrogel showed improved burn wound repairing performance to second-degree burn wound models on mice. As a result, the OP-DA/PEO-AH hydrogel showed great advantage as GA carrier in wound healing applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xian Liu,Qiwu Yuan,Yang Yang,Ke Li,Nanjiong Pang,Jiangtao Wang,Ming Yang,Xia Li,Junling Guo,Xuepin Liao,Bi Shi
Antibiotic resistance poses a significant threat to global public health, urgently demanding the development of new antibacterial agents with high efficacy and low resistance potential. In this study, we engineered self-assembled nanocomplexes of the gallic acid (GA) with rare earth (Re) ions (Ce 3+ , Gd 3+ , and Yb 3+ ), leveraging the unique multidentate structures of polyphenols to enhance antibacterial performance while minimizing resistance. These GA-Re nanocomplexes demonstrated potent activity against both antibiotic-sensitive Staphylococcus aureus (ASSA) and methicillin-resistant S. aureus (MRSA), with minimum inhibitory concentrations as low as 0.5 mmol/L. Viable MRSA cell numbers decreased from 7.40 × 10 7 CFU/mL to 8.43 × 10 6 and 7.33 × 10 2 CFU/mL when treated with penicillin (PEN) and GA-Gd for 24 h, respectively, indicating higher bactericidal efficiency of GA-Gd. Remarkably, no resistance developed in ASSA even after 60 days(d) of continuous exposure to GA-Gd, in contrast to the significant resistance observed with PEN (1024-fold) and neomycin (256-fold) after 28 d. The multidentate structure of GA facilitated versatile interactions with bacterial surface structures, enabling multiple mechanisms of action targeting cell walls, membranes, DNA, and cellular metabolism. Moreover, in vivo studies revealed that GA-Gd was effectively metabolized and excreted without accumulation or toxicity, and also accelerates the healing of MRSA infected wounds. These findings suggest the potential of self-assembled Re-based phenolic nanocomplexes as promising candidates for combating antibiotic-resistant bacterial infections, and pave the way for next-generation antibacterial agents.
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Chenyang Zhao,Chen Wang,Yue Li,Wenlin Yuan,Yi Huang,Di Cheng,Tao Shen,Ji Zhang,Jie Liu,Libei Jiang,Chao Yang,Qianhong Shen,Hui Yang
Two-dimensional Metal-organic frameworks have recently emerged as promising materials for enhancing the anticorrosion protection performance of polymeric coatings. In this study, ZIF-ZG@PEG-GA nanofiller was synthesized by modifying zeolitic imidazolate framework nanosheets with a polyethylene glycol-gallic acid (PEG-GA) complex shell, and subsequently incorporated into waterborne epoxy matrix. Potentiodynamic polarization analysis revealed that the addition of ZIF-ZG@PEG-GA to a 3.5 wt% NaCl solution reduced the corrosion current density from 5.528×10 −6 A/cm 2 to 1.892 × 10 −6 A/cm 2 . Electrochemical impedance spectroscopy (EIS) analysis revealed that ZGPG/EP exhibited superior protective performance after 42 d of immersion, with the highest |Z| f=0.01Hz (1.87 × 10 9 Ω·cm 2 ), R coat (4.27 × 10 8 Ω·cm 2 ), and R ct (1.43 × 10 9 Ω·cm 2 ). Furthermore, EIS analysis of scratched coatings demonstrated that ZIF-ZG@PEG-GA effectively impeded corrosion propagation and prevented further coating degradation. The enhanced anticorrosion performance is attributed to the passive protection by increasing the diffusion resistance of corrosive species, and the active protection through the release of gallic acid from the PEG-GA complex.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POROUS MATERIALS
·
2025
·
IF 3.2
Zhao Mengyuan,Zhang Peng,Wu Tingting,Cao Wenwen,Xu Xinya,Li Ang,Li Qiang,Zhao Hongyuan
In this work, we prepared an innovative nanocomposite by integrating stellate monodisperse mesoporous silica nanospheres (SMMS) into the high-purity whisker carbon nanotubes (WCT) networks through an efficient ultrasonic-assisted process. This nanocomposite was employed as sensing sensitizer to modify glassy carbon electrode (GCE) for the fabrication of highly sensitive WCT@SMMS/GCE sensing platform for electrochemical analysis of gallic acid (GA). SMMS showed more complex and richly connected pore structure with large pore size and high porosity, which might be beneficial for the adsorption of GA. WCT with good dispersibility could enhance the efficiency of charge transport. Moreover, WCT with multi-layered hollow structure had extremely high electrolyte adsorption capacity, which promoted the penetration of electrolyte for the efficient enrichment of GA molecules on electrode surface. The WCT@SMMS/GCE sensor demonstrated excellent GA electrochemical detection performance (LOD: 8.99 nM, GA concentration: 0.1–20 µM). Additionally, the developed sensor with good repeatability and anti-interference performance obtained satisfactory recovery rates of 94.08–104.78% and RSD values of 1.34–4.84 for the GA quantitative analysis in food samples.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xue Tang,Gisèle Ineza Urujeni,Xu Ni,Ziwei Lu,Dan Wang,Jie Gao,Fizir Meriem,Hua He,Deli Xiao,Pierre Dramou
An innovative and simple nanocomposite denoted as MHNTs@PEI was synthesized for gallic acid (GA) analytical sample pretreatment. Polyethyleneimine (PEI) functionalized was binded onto magnetic halloysite nanotubes (MHNTs) to inhence adsorption capacity. MHNTs@PEI was obtained only through two steps modification (amination and PEI modification). Characterizations showed that there are layers of synthetic PEI on the tubular structure of the material and magnetic spheres on its surface, both indicating successful synthesis of the nanocomposite. Furthermore, the adsorption isotherms and kinetic modeling showed that the Langmuir model and pseudo-first-order model fit the adsorption data, respectively. MHNTs@PEI achieved an adsorption capacity of 158 mg·g −1 . Overall, the abundant adsorption sites significantly improved the adsorption performance of the MHNTs@PEI. Regeneration tests demonstrated that the MHNTs@PEI exhibits effective adsorption, even after undergoing five consecutive cycles. Optimization of key parameters (ratio, volume of elution, elution time and frequency) in the process of adsorption and desorption was also conducted. The limit of detection (LOD) and that of the quantification (LOQ) were 0.19 and 0.63 μg·mL −1 , respectively, and the recoveries were 95.67–99.43 %. Finally, the excellent magnetism (43.5 emu·g −1 ) and the adsorption feature of MHNTs@PEI enabled its successful utilization in analytical sample pretreatment through the extraction of GA from green tea.
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Hong Zhang,Xin Zhang,Bo Wang,Bo Ren,Xiaodong Yang
Food spoilage leads to plenty of food being wasted every year. Safe and multifunctional food preservation packaging is urgently required to prevent food from contamination. Chitosan/gallic acid/Fe 3+ (CSGA-Fe 3+ ) composite films were synthesized by incorporating gallic acid (GA) and Fe 3+ into a chitosan solution. The integration of GA forms covalent and hydrogen bonds with chitosan, whereas Fe 3+ addition establishes metal-ligand interactions with both chitosan and GA, resulting in a film characterized by a multi-crosslinked network structure. This multi-crosslinked system substantially enhanced the material's mechanical properties and increased resistance to oxidation and ultraviolet degradation. The data indicate that the mechanical strength of chitosan/gallic acid (CSGA) films, with an inclusion of 0.3 mmol of GA, improved by 37.5 % over pure chitosan (CS) films. Moreover, the mechanical strength of the CSGA-Fe 3+ films saw a significant increase of 124.2 %, escalating from 1.32 MPa to 17.72 MPa. Additionally, the free radical scavenging capacities of the CSGA and CSGA-Fe 3+ films rose by 279.4 % and 255.0 %, respectively, compared to the pure CS film. The UV-blocking efficacy of the CSGA-Fe 3+ films, evaluated at 365 nm, reached 84.9 %. The water contact angle of the CSGA-1.5Fe 3+ film increased by 18.08 % compared to the CS film. This study provides innovative ideas to promote the broader application of safe and multifunctional chitosan-based composite films in food preservation packaging.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2022
·
IF 6.978
Xin-Chuang Wang,Hai-Bo Huang,Wei Gong,Wan-Ying He,Xiang Li,Yu Xu,Xiao-Jie Gong,Jiang-Ning Hu
Programing self-assembly of naturally bioactive molecules has been a wide topic of great significance for biomedical uses. Despite the fact that plant-derived polyphenols with catechol or pyrogallol moieties have been widely studied to construct nanocomplexes or nanocoatings via self-polymerization, there is no report on the self-assembly of these polyphenols into therapeutic hydrogels for potential applications. Here, we reported that adding a very small amount of resveratrol (Res) into the gallic acid (GA) aqueous solution could trigger the quick self-assembly of GA to form a fibrous hydrogel within 5 min through hydrogen bonds and π–π interactions. The length of GA/Res (GR) fibrils in gels varied from 100 to 1000 microns, with a diameter of around 1 μm. Notably, these GR hydrogels showed excellent colloid stability, providing better slow release and outstanding biocompatibility. Also, in vivo experiments indicated the hydrogels had high antibacterial effects and excellent wound healing capabilities in a total skin defect model via regulating the expression of inflammatory factors (IL-6, IL-1β, and TNF-α) due to the release of therapeutic agents (GA and Res) into the matrix. Overall, our results provide a new strategy to accelerate self-assembly of GA by adding Res to form hydrogels, which is further proved as a promising therapeutic carrier for wound healing.
✓ 已验证
DOI
PubMed
高影响因子
POLYMER SCIENCE SERIES B
·
2023
·
IF 1.2
Lin Liu,Xu Xin,Wu Jing,Zhang Lin,Li Jialiang,Zeng Xiaoyu
Abstract Inspired by mussel heuristic chemistry, a novel method for improving surface wettability and adhesion of carbon fibers with epoxy resins was proposed by codepositing gallic acid and polyethylene imine on the carbon fiber surfaces in a convenient operation. The results of scanning electron microscopy, infrared, Raman and X-ray photoelectron spectra revealed that gallic acid and polyethylene imine could undergo Michael addition or Schiff base reaction and codeposit on the carbon fiber surfaces successfully. The gallic acid-polyethylene imine codeposited carbon fibers were used to fabricate epoxy matrix composites. The results of mechanical tests showed that interlaminar shear strength, flexural modulus and strength of the gallic acid-polyethylene imine codeposited carbon fiber composite were increased by 27, 38, and 27% respectively, compared with those of the untreated carbon fiber composite. The conclusion can be drawn that the gallic acid-polyethylene imine codeposition is an effective method for improving interfacial properties of carbon fiber reinforced epoxy resin matrix composites.
✓ 已验证
DOI
高影响因子
Frontiers in Nutrition
·
2024
·
IF 4
Jiasheng Li,Jiahui Lin,Tao Luo,Junjie Liu,Jiyang Liu,Wuning Zhong
Sensitive detection of gallic acid (GA) in foods is of great significance for assessing the antioxidant properties of products and ensuring consumer health. In this work, a simple electrochemical sensor was conveniently fabricated by integrating vertically-ordered mesoporous silica film (VMSF) with electrochemically reduced graphene oxide (ErGO) and nitrogen graphene quantum dots (NGQDs) nanocomposite, enabling sensitive detection of GA in food sample. A water-soluble mixture of graphene oxide (GO) and NGQDs was drop-cast onto the common carbon electrode, glassy carbon electrode (GCE), followed by rapid growth of VMSF using an electrochemically assisted self-assembly method (EASA). The negative voltage applied during VMSF growth facilitated the in situ reduction of GO to ErGO. The synergistic effects of ErGO, NGQDs, and the nanochannels of VMSF led to nearly a tenfold enhancement of the GA signal compared to that obtained on electrodes modified with either ErGO or NGQDs alone. Sensitive detection of GA was realized with a linear concentration range from 0.1 to 10 μM, and from 10 to 100 μM. The limit of detection (LOD), determined based on a signal-to-noise ratio of three (S/N = 3), was found to be 81 nM. Combined with the size-exclusion property of VMSF, the fabricated sensor demonstrated high selectivity, making it suitable for the sensitive electrochemical detection of gallic acid in food samples.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2024
·
IF 12.8
Jiani Huang,Fei Wu,Wenzhao Cao,Yuhan Chen,Qiong Yao,Peili Cen,Jing Wang,Lu Hong,Xiaohui Zhang,Rui Zhou,Chentao Jin,Mei Tian,Hong Zhang,Yan Zhong
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder globally, with no effective treatment available yet. A crucial pathological hallmark of AD is the accumulation of hyperphosphorylated tau protein, which is deteriorated by reactive oxygen species (ROS) and neuroinflammation in AD progression. Thus, alleviation of ROS and inflammation has become a potential therapeutic strategy in many studies. Herein, we reported ultrasmall coordination polymer nanoparticles formed by ferric ions and gallic acid (Fe-GA CPNs), which owned antioxidant and anti-inflammation properties for AD therapeutics. The facilely prepared Fe-GA CPNs exhibited remarkable superoxide dismutase, peroxidase enzyme activity, and ROS eliminating ability with great water solubility, compared with gallic acid. We demonstrated that Fe-GA CPNs effectively relieved oxidative stress, ameliorated inflammation by downregulating TLR4/NF-κB and modulating microglial polarization towards anti-inflammation phenotype, and reduced hyperphosphorylated tau protein levels. Furthermore, Fe-GA CPNs treatment significantly improved cognitive function in tauopathy-induced AD rats, and achieved a neuroprotective effect against AD pathology. This study highlights the potential of coordination polymer nanoparticles as promising therapeutic candidates for AD and other tau-related neurodegenerative diseases.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）