COLLOIDS AND SURFACES B-BIOINTERFACES
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2025
·
IF 5.6
Xiaohua Su,Wenqiang Li,Renzhao Huang,Jingting Huang,Wenyong Huang,Xide Chen,Xiaodong Wu,Jianfeng Li,Xinting Li,Deguang Qin,Yi Zhan
The course of the skull defect is long, with multiple factors involved. Traditional treatment methods are not sufficient to completely restore the skull defect in a short period. Biomaterial scaffold could replace traditional approaches to bone reconstruction. A major challenge in designing a scaffold for cranial defect repair is to be non-toxic, low swelling, biodegradable, and pro-osteogenic. Herein, a biodegradable aerogel scaffold composed of methylcellulose (MC), thiolated chitosan (TCS), Zn 2 + and nano hydroxyapatite (nHA) was designed for repairing the skull defect. MC/TCS-nHA aerogel was formed by the ionic cross-linking of hydroxyl, amino and thiol groups with Zn 2+ . The prepared scaffolds exhibited a uniform pore structure and structural stability. Interestingly, TCS was used to enhance biocompatibility and biodegradability, Zn 2+ to enhance antibacterial properties and nHA to enhance pro-osteogenicity. In vivo and in vitro tests confirmed that chitosan-based aerogel could promote macrophage polarization into the M2 phenotype and promote angiogenesis and osteogenesis. The micro-CT characterization analysis and immunofluorescence analysis after 12 weeks indicated that MC/TCS-nHA aerogel could accelerate skull defect repair. Therefore, the chitosan-based aerogel showed great promise as an implant material for medical applications involving the repair of the skull.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Manqi Yan,Menglu Huang,Xinyin Cao,Ziqi Zhou,Yangfeng Chen,Ye Zhang,Le Yin,Wei Zhao,Yong Hu
Strongly adhesive hydrogels show great promise for wound management yet frequently induce secondary tissue damage during dressing removal. To overcome this limitation, we designed a cationic hydrogel dressing with self-regulating adhesion using gelatin/carboxymethyl chitosan and MPTAC through UV-initiated crosslinking. The hydrogel achieved robust initial adhesion (8.39 ± 0.59 kPa) via electrostatic interactions with negatively charged skin surfaces, which progressively decreased to 2.21 ± 0.36 kPa over 7 days, enabling painless detachment. The material demonstrated a compressive strength exceeding 70 kPa, effective fluid absorption capacity, and potent antibacterial activity (>99 % against S. aureus ). It significantly accelerated hemostasis, reducing clotting time to 62.96 ± 3.95 s, and promoted wound healing in a full-thickness defect model, achieving 62 % wound closure within 7 days. These findings highlight the translational potential of this smart hydrogel as a next-generation wound dressing that combines secure wound protection with on-demand, trauma-free removal.
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高影响因子
Innovative Food Science & Emerging Technologies
·
2025
·
IF 6.8
Chenchen Li,Xintong Zhang,Weiye Xiu,Mingfu Yuan,Jingyang Wang,Diaomei Ma,Chunran Han
Astaxanthin (AST) bioavailability is inherently limited by poor stability. In this study, pH/glutathione (GSH) dual-responsive carboxymethyl chitosan (CMCS) superparamagnetic iron oxide (SPION) nanoparticles were prepared, loaded with AST (CMCS-SPION-AST), and characterized. Its stability, responsive release, and kinetics were studied. The results showed that CMCS-SPION successfully encapsulated AST. The composite showed excellent stability (88.66 % AST retention at 4 °C, light-protected) and the highest cumulative release (82.11 % at pH 5.5/10 mM GSH), which was higher than the release rates of previously reported single pH-responsive carriers. The release curves of CMCS-SPION-AST at pH 5.5, pH 7.4/10 mM GSH, and pH 5.5/10 mM GSH showed good model fit (R 2 > 0.9), indicating non-Fickian diffusion. The release process represents a synergistic effect of diffusion and dissolution. This study provides novel insight for the development of responsive drug delivery systems and expands the application prospects of AST as a functional natural pigment in the food industry.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Nan Cui,Yiyi Li,Haiyu Du,Liwen Liang,Yongqiang Wen,Zhu Zhu
The shelf-life of fruits and vegetables is significantly affected by atmospheric conditions and the microbial contaminations. The use of porous materials for packaging can help regulate the internal atmosphere within packaging. In this study, a chitosan-based film with enhanced gas permeability and antimicrobial properties was developed through the incorporation of polyethyleneimine (PEI)-modified mesoporous silica SBA-15. The mesoporous structure of SBA-15 enhances gas exchange, leading to superior permeability for oxygen, carbon dioxide, and water vapor compared to neat chitosan films. Additionally, the addition of polyethyleneimine (PEI) endows the composite film with remarkable antimicrobial efficacy, effectively inhibiting the growth of Escherichia coli , Staphylococcus aureus and Botrytis cinerea . The composite film also exhibited good transparency, UV-blocking capabilities, and mechanical strength. Preservation tests conducted on mangoes indicated that composite film was capable of regulating the internal atmosphere and delaying the deterioration of the fruit. Furthermore, the films exhibited excellent biodegradability and biocompatibility. Therefore, this composite film with enhanced gas transmission rate and antimicrobial properties presents considerable potential for the preservation of fresh produce.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yicheng Yang,Qinan Huang,Lipei Miao,Qihong Zhang,Chongyang Wu,Weike Su,Jingbo Yu
Crocetin (CT), a natural carotenoid dicarboxylic acid known for its high medicinal value, faces challenges such as poor water solubility, low bioavailability and instability, limiting its therapeutic applications. To overcome these challenges, this study introduces a novel Pickering emulsion gel stabilized by naturally sourced chitosan (CS) and γ -polyglutamic acid ( γ -PGA) nanoparticles (CS/ γ -PGA NPs) as a potential transdermal carrier for CT. The CS/ γ -PGA NPs were synthesized using an electrostatic crosslinking method pretreated by mechanical ball-milling, producing uniform and stable nanoparticles. These NPs stabilized a CT-loaded Pickering emulsion gel (CT-PE) with cornmint oil as the oil phase, achieving up to 98.53 % encapsulation efficiency. The CT-PE exhibited enhanced rheological properties, storage stability, sustained and targeted in vitro transdermal release, potent antioxidant activity, and effective antimicrobial effects with no cytotoxicity. Microstructural analysis revealed a dense network of aggregated particles forming a moderately strong gel structure, wherein encapsulated CT enhances emulsion stability through interaction with the gel network. The synergy between CS and γ -PGA facilitated a biocompatible and efficient carrier system, markedly boosting CT's therapeutic effectiveness. These results highlight CT-PE's potential as an effective transdermal carrier for CT, promising for future dermatological treatments and drug delivery systems.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yan Li,Lingying Xie,Jingyi Liu,Sisi Tang,Hang Lei,Yuxia Zhong,Yue-Fei Zhang
In this study, an imidazole cross-linked chitosan hydrogel (I/CS-4) was synthesized through the Debus-Radziszewski reaction, resulting in a multifunctional adsorbent with both dye adsorption and antimicrobial capabilities. I/CS-4 effectively removed orange G (OG) and metanil yellow (MY) dyes under various environmental conditions, including pH, initial concentration, temperature, and contact time. The hydrogel demonstrated high stability and efficiency over a broad pH range (2−10), attributed to its abundant amino and imidazole groups, which facilitate electrostatic, hydrogen bonding, and π-π stacking interactions. The maximum adsorption capacities for OG and MY were 565.00 mg/g and 490.20 mg/g, respectively, following the Langmuir isotherm and pseudo-second-order kinetic models. Additionally, I/CS-4 showed excellent recyclability, maintaining over 80 % removal efficiency after five cycles. It also exhibited potent antibacterial activity against E. coli and S. aureus while being biocompatible. These results highlight I/CS-4's potential as an effective material for treating dye-containing wastewater, combining efficient contaminant removal with microbial inhibition.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yang Liu,Chuang Lang,Kai Zhang,Linlin Feng,Junying Li,Tingting Wang,Siyu Sun,Guangwei Sun
To develop a submucosal injection material with sustained submucosal lifting for endoscopic submucosal dissection (ESD), this study designed and prepared a novel composite thermosensitive hydrogel system with high pH chitosan-polyvinylpyrrolidone-β-glycerophosphate (HpHCS-PVP-GP). HpHCS improved the injectability of the hydrogels and retained the rapid gelation ability at low concentrations. The modification of PVP significantly improved the stability of low-temperature hydrogel precursor solutions and the integrity of hydrogels formed at 37 °C through hydrogen bonds between PVP and HpHCS. A mathematical model was established using response surface methodology (RSM) to e v aluate the synergistic effect of HpHCS, GP , and PVP concentrations on gelation time. This RSM model and submucosal lifting evaluation using in vitro pig esophageal models were used to determine the optimal formula of HpHCS-PVP-GP hydrogels. Although the higher PVP concentration (5 % ( w / v )) prolonged gelation time, it improved hydrogel mechanical strength , resulting in better submucosal lifting performance. The experiments of Bama mini pigs showed that the heights of the cushions elevated by the HpHCS-5%PVP-GP hydrogel remained about 80 % 1 h after injection. Repeated injections were avoided, and the hydrogel had no cytotoxicity after electric cutting. Therefore, the HpHCS-PVP-GP thermosensitive hydrogel might be a promising submucosal injection material for ESD.
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高影响因子
Food Bioscience
·
2025
·
IF 5.9
Lei Sun,Jianxin Zhao,Wei Chen,Gang Wang
The present study fabricated melatonin-loaded sodium alginate/carboxymethyl chitosan (Mel/SA-CMC) microgel as a colon-targeted therapeutic strategy for ulcerative colitis. Optimization of the SA/CMC ratio (1:1) and voltage (15 kV) produced Mel/SA-CMC microgels with maximum encapsulation efficiency (91.8 % ± 1.2 %) and loading capacity (16.4 % ± 0.1 %). Characterization techniques, including scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analyses, elucidated the physicochemical properties of the microgels. Simulated digestion experiments and pharmacokinetic analyses indicate that the microgels remain stable in the gastric environment (pH = 3.5) and release melatonin in a controlled manner in the colonic environment (T max = 4 and AUC = 16,208 pg h/mL). In a dextran sodium sulfate (DSS)-induced Caco-2 cell inflammation model, Mel/SA-CMC enhanced cell viability and attenuated oxidative stress and inflammatory response. Furthermore, administration of Mel/SA-CMC to mice with DSS-induced acute colitis alleviated the deleterious effects of DSS, as evidenced by preserved colon length (9.2 ± 0.9 cm), mitigated histological damage (histological injury score: 1.5 ± 0.5), and reduced expression of inflammatory cytokines (IL-4, IL-6, IL-1β and TNF-α). Notably, Mel/SA-CMC restored gut microbiota composition by enriching beneficial genera, including Bifidobacterium , Ruminococcus2 , and Lactobacillus , leading to elevated concentrations of short-chain fatty acids. In conclusion, the Mel/SA-CMC microgel demonstrates potent antioxidant and anti-inflammatory properties as a potential therapeutic intervention for inflammatory bowel disease.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yue Zhu,Teng Chen,Xiujuan Wan,Guiqin Zhu,Zhiyong Chen,Zhoujie Yang,Jing Yang,Tingting Feng,Zuhua Wang,Ying Zhou
Persistent intraoperative hemorrhage is the major cause of trauma-related mortality, emphasizing the need for hemostatic dressings with improved efficacy. In this study, we designed a PLGA-CTS-TXA composite sponge, which was fabricated by grafting of poly (lactic- co -glycol acid) (PLGA) and hemostatic small molecule tranexamic acid (TXA) onto chitosan (CTS), for rapid hemostasis. The sponge integrates the advantages of CTS, PLGA and TXA, showcasing superior porosity (nearly 85 %) and water absorption capacity (3197 ± 105 % within 30 s). It also demonstrates good biocompatibility (hemolysis <1.2 %, RCV > 125 %), low blood clotting index (12.4 %) and abbreviated clotting times (<30 s). The incorporation of TXA substantially augmented the hemostatic capability of the composite sponge. Compared to CTS alone, PLGA-CTS-TXA demonstrated a significantly reduced hemostatic time in both rat tail and mouse liver hemostatic models. Its hemostatic mechanism was further analyzed from the perspective of the actual interface created by the interaction between the material and the biological fluid (ie., protein corona). The results demonstrated that the swift hemostatic mechanism involves modulation of erythrocyte and platelet aggregation/adhesion and fibrin degradation, etc. , thereby influencing the coagulation cascade. This research extends the utility of TXA in hemostasis and offers novel idea into the development and hemostatic mechanism of new high-efficiency hemostatic dressings.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2015
·
IF 4.529
Hongxiang Ou,Qunhui Chen,Jianming Pan,Yunlei Zhang,Yong Huang,Xueyong Qi
Magnetic imprinted polymers (MIPs) were synthesized by Pickering emulsion polymerization and used to adsorb erythromycin (ERY) from aqueous solution. The oil-in-water Pickering emulsion was stabilized by chitosan nanoparticles with hydrophobic Fe 3 O 4 nanoparticles as magnetic carrier. The imprinting system was fabricated by radical polymerization with functional and crosslinked monomer in the oil phase. Batches of static and dynamic adsorption experiments were conducted to analyze the adsorption performance on ERY. Isotherm data of MIPs well fitted the Freundlich model (from 15 °C to 35 °C), which indicated heterogeneous adsorption for ERY. The ERY adsorption capacity of MIPs was about 52.32 μmol/g at 15 °C. The adsorption kinetics was well described by the pseudo-first-order model, which suggested that physical interactions were primarily responsible for ERY adsorption. The Thomas model used in the fixed-bed adsorption design provided a better fit to the experimental data. Meanwhile, ERY exhibited higher affinity during adsorption on the MIPs compared with the adsorption capacity of azithromycin and chloramphenicol. The MIPs also exhibited excellent regeneration capacity with only about 5.04% adsorption efficiency loss in at least three repeated adsorption–desorption cycles.
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POLYMERS FOR ADVANCED TECHNOLOGIES
·
2020
·Vol. 31
·期 5
·1164-1171
·
IF 2.578
Mengmeng Song,Meng Zhou,Hengfeng Hu,Heqing Fu
First, attapulgite-Fe 3 O 4 magnetic filler (ATP-Fe 3 O 4 ) was prepared by using a chemical precipitation method. Subsequently, graphite oxide (GO) was prepared through Hummer method, and then reduced GO (RGO) was prepared through GO reduced by chitosan (CS). Finally, a series of WPU-RGO/ATP-Fe 3 O 4 /CS composites were prepared by introduced RGO/ATP-Fe 3 O 4 /CS to waterborne polyurethane. The structure and properties were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR), X-ray diffraction (XRD), vibrating sample magnetometry (VSM), thermogravimetric analysis TGA, conductivity test, and tensile test. The experimental results indicated that thermal stability and tensile strength of nanocomposites were improved with the increase of the content of RGO/ATP-Fe 3 O 4 /CS. Meanwhile, with the increase of the RGO/ATP-Fe 3 O 4 /CS content, the electrical and magnetic properties of WPU-RGO/ATP-Fe 3 O 4 /CS composites were improved. When the content of RGO/ATP-Fe 3 O 4 /CS was 8 wt%, the electrical conductivity and the saturation magnetic strength of WPU-RGO/ATP-Fe 3 O 4 /CS composites were 3.1 × 10 −7 S·cm −1 and 1.38 emu/g, respectively. WPU-RGO/ATP-Fe 3 O 4 /CS composites have excellent electrical and magnetic properties.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Junjie Hu,Chaozhang Huang,Anda Gong,Huanle Chen,Shilin Liu,Bin Li,Yan Li
In the present study, we prepared cinnamaldehyde (CA) conjugated chitosan-stabilized emulsions (CSCAEs), and the influence of pH on their properties and lipolysis behavior was investigated. Compared to the emulsions stabilized by chitosan itself (CSEs), CSCAEs had better stability against pH during storage. As pH increased from 2.5 to 6.25, the viscosity and modulus of CSCAEs increased. However, when pH shifted from 6.25 to 6.5, emulsion showed lower viscosity and modulus. Confocal laser scanning microscopy results demonstrated that oil droplets still kept intact and individually distributed, and chitosan homogenously covered on the oil droplets at low pH conditions (pH 2.5, 4.0). At higher pH conditions (pH 5.0, 5.5), a few chitosan aggregates on the oil droplets were observed. At pH 6.0 and 6.25, the compact gel network structure was formed. At pH 6.5, some void was found among the chitosan gel network. In vitro simulated digestion experiments presented that pH had no significant effect on the lipolysis process of emulsions. When the oil content varied from 10% to 50%, emulsions still kept good stability against pHs, but the lipolysis extent after digestion decreased. This knowledge provides a strategy for improving stability of chitosan-stabilized emulsion against harsh pH conditions.
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