Journal of Physical Chemistry C
·
2026
·
IF 3.4
Chu Sun,Rui Bi,Chunhui Song,Deyang Zhao,Zhiguo Zhu,Kaixuan Yang,Christophe Len,Hongying Lü,Ting Su
2,5-Diformylfuran (DFF) is an important biomass-derived platform chemical, widely recognized as a key intermediate building block in the synthesis of biodegradable polymers and pharmaceutical compounds. The mild and sustainable nature of photocatalysis has attracted considerable attention for such valorization processes, highlighting the need for in-depth exploration of heterostructure-based photocatalysts to enhance catalytic performance. In this study, we report the fabrication and photocatalytic application of a Nb2CTx MXene/ZnIn2S4 (ZIS) Schottky heterojunction with intimate interfacial contact. This heterostructure significantly enhances the separation efficiency of photogenerated charge carriers while prolonging their lifetime. The observed enhancement is attributed to the synergistic interaction between the n-type ZIS semiconductor and the two-dimensional metallic conductor MXene, which induces favorable band bending in ZIS and facilitates the formation of a Schottky barrier at the MXene–ZIS interface. This barrier effectively inhibits electron backflow, thereby promoting charge carrier separation and enhancing interfacial charge dynamics. Compared to pristine ZIS, the Nb2CTx/ZIS heterojunction catalyst achieves a significantly higher DFF yield under ambient temperature and pressure, without the need for additional oxidants. This finding not only demonstrates a highly efficient route for DFF production under mild conditions but also offers a new design strategy for MXene-based Schottky heterojunctions in biomass valorization via photocatalysis.
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ACS Applied Energy Materials
·
2026
·
IF 5.5
Zhou Zhou,Yifan Zhou,Jiaxin Kang,Bohao Han,Huamin Qiu,Hao Jia,Shuqin Song,Yi Wang
Lithium-mediated electrochemical ammonia synthesis (Li-MEAS) is a promising green route for ammonia production. However, the widely used tetrahydrofuran (THF)-based electrolytes exhibit intrinsic drawbacks of high volatility and poor anodic stability, which necessitate frequent and excessive electrolyte replenishment, further resulting in increased operating costs and environmental risks. Therefore, developing electrolytes with low/nonvolatility and high electrochemical stability is critical to enable lean-electrolyte operation of Li-MEAS systems. In this work, we systematically evaluated ethylene carbonate (EC)-, propylene carbonate (PC)-, and 1-ethyl-3-methylimidazolium tetrafluoroborate ([EMIM][BF4])-based electrolytes for Li-MEAS. All three solvents show significantly lower volatility and higher anodic stability than the THF-based electrolyte. When employed in a Li-MEAS reactor, EC-based and PC-based electrolytes achieve Faradaic efficiencies (FE) of 83.05 and 74.76%, respectively, which are comparable to that of the THF-based benchmark electrolyte (85.91%). Owing to their low volatility, high electrochemical stability, and favorable solid electrolyte interphase (SEI) formation capability, the cyclic carbonate-based electrolytes enable stable Li-MEAS operation for over 40 min under lean-electrolyte conditions. In contrast, the [EMIM][BF4]-based electrolyte yields ammonia primarily from cation degradation rather than selective N2 reduction under the tested conditions, leading to false positive results. This study confirms the great potential of EC and PC as THF substitutes, and provides experimental insights and practical guidance for optimizing Li-MEAS electrolytes in flow reactors.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Yongqi Luo,Zhiyi Zhu,Tao Zhang,Xinglong Zhang,Xiang Wu,Qinlin Yao,Chengsheng Chu,Hang Li,Fanchen Meng,Suoying Zhang,Fengwei Huo
Electrically tunable soft lenses are essential for emerging applications in soft robotics, adaptive optics, and minimally invasive biomedical imaging. Among various materials, electroactive hydrogels have emerged as ideal candidates for constructing such lenses due to their tissue-like softness and intrinsic electrical actuation capabilities. However, current hydrogel-based actuators often face a fundamental trade-off between high optical transparency and low-voltage responsiveness due to the uncontrolled aggregation of conductive fillers. Herein, we report a transparent, low-voltage-driven electroactive hydrogel lens based on a polyacrylamide (PAM) matrix incorporated with sodium-functionalized multiwalled carbon nanotubes (Na-MWCNTs). By engineering the interfacial chemistry of the nanotubes with surface carboxylate groups (–COONa), uniform dispersion of nanotubes in PAM via electrostatic repulsion at a low loading (≤0.1 mg mL–1) was achieved. Consequently, this well-dispersed state preserves high visible-light transmittance, while the incorporation of Na-functionalized MWCNTs modulates the overall charge transport behavior within the hydrogel matrix, facilitating rapid charge redistribution. Under a 30 V stimulus, the focal length of the hydrogel lens can be tuned from 73.6 mm to 53.7 mm, achieving a 27% tunability. Mechanistically, this focal tuning is realized through the asymmetric modulation of surface curvature, driven by an electric-field-induced osmotic pressure gradient. Ultimately, this PAM/Na-MWCNT hydrogel platform offers a versatile solution for next-generation adaptive biomimetic optical devices, endoscopic probes, and soft robotic vision.
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BIOMACROMOLECULES
·
2026
·
IF 5.9
Dayang Wang,Pengbao Shi,Jiashuo Ye,Ziyan Wang,Hailin Cong,Bing Yu
Melanoma is one of the most lethal cancers in the clinic; cationic peptides have shown great potential in the treatment of melanoma. The large pore volume and high specific surface area of mesoporous silica nanoparticles (MSNs) allow for efficient loading of drugs, while surface-functionalized MSNs can further improve drug stability and carrier targeting. Polydopamine (PDA) coating is an effective surface modification method that provides an additional protective layer to prevent premature drug release during delivery and can prolong the treatment time. Hyaluronic acid (HA) is a commonly used tumor-targeting molecule that binds to HA receptors on the surface of tumor cells, thereby facilitating drug internalization and enhancing the therapeutic effect of the drug. In this paper, the cationic short peptide RKIIIRW, which can effectively inhibit B16F10 cells, was successfully screened by solid-phase synthesis combined with MTT assay and cell membrane chromatography. By combining the cationic short peptide RKIIIRW with MSNs and further surface modification with PDA coating and HA targeting molecules, a nanodrug delivery system with targeted and controllable release characteristics was prepared. This drug-delivery system enhances the efficacy of cationic short peptides while minimizing side effects, offering a more effective therapeutic strategy for melanoma.
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RSC Advances
·
2026
·
IF 6.1
Zhenhua Zeng,Ayang Wu,Haimin Gao,Yanping Zheng,Huicong Yang,Xiaojie Yao,Zhongjie Yang
MicroRNAs (miRNAs) are important liquid biopsy biomarkers, and their multiplex detection is highly important for the early screening of hepatocellular carcinoma. This work developed a CRISPR/Cas13a biosensing platform based on near-infrared (NIR) light and glutathione (GSH) dual activation for highly sensitive and specific determination of miRNA-21, miRNA-155, and miRNA-224. The advantages of this platform lie in the introduction of GSH-responsive mesoporous silica carriers and photolytic linkers (pc-linkers), which transform the sensing process from “passive triggering” to “controllable activation”, effectively suppressing nonspecific signals. Specifically, GSH can degrade mSiO 2 with tetrasulfide bonds, thereby degrading the carrier. It will release the CRISPR/Cas13a system loaded on the carrier, thereby achieving specific recognition and cleavage of miRNA-21/155; at the same time, 808 nm NIR light excites upconversion nanoparticles (UCNPs) to generate ultraviolet light, which cleaves the pc-linker to activate the detection of miRNA-224. The detection limits of the developed assay for detecting miRNA-21, miRNA-155, and miRNA-224 were 4.2 pM, 5.7 pM, and 0.205 nM, respectively. The recoveries in the serum spiked experiments were 98.97–109.24%, with a relative standard deviation of less than 4.613%, indicating that the method has good accuracy and reliability. This work proposes a novel and reliable strategy for detecting multiple miRNAs in complex biological samples. MicroRNAs (miRNAs) are important liquid biopsy biomarkers, and their multiplex detection is highly important for the early screening of hepatocellular carcinoma.
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ACS Applied Polymer Materials
·
2026
·
IF 5.2
Chuanqiang Sun,Xingyao Wang,Huajie Xu,Xiaohu Xia,Yujing Zhang,Feng Yang,Jinchuan Chen,Chuntai Liu,Changyu Shen
The integration of excellent mechanical performance with multifunctionality is a permanent pursuit for gels. In this work, a double modification sequencing in time of silk fibroin nanofiber (SNF) is adopted to achieve this for 2betaine:tartaric (BTB)-based ionogel (ABSH). Initially, the enhanced interfacial interaction between 4-hydroxybutyl acrylate glycidyl ether-modified SNF (SNF-4H) and BTB elevates SNF dispersity in the matrix. Subsequently, both the in situ interfacial enhancement and the elastic-state supramolecular network with no significant chain entanglement in the polymer phase are realized simultaneously by leveraging the kinetic impedance of polyacrylamide chain growth in BTB. By controlling the content of SNF-4H, the mechanical properties of ABSH ionogels can be effectively tuned. In particular, ABSH0.5% exhibits the highest tensile strength (10.05 MPa), a large elongation at break of 2210%, and ultrahigh toughness (172.12 MJ·m–3), increasing by 2692%, 70%, and 3795% compared with its hydrogel counterpart, respectively. It displays excellent environmental stability to withstand extreme temperatures and proper humidity, convenient recyclability, good crack resistance, and rubber-like impact resistance. Furthermore, its temperature sensing exhibits a broad operating range (−78.5 to 80 °C) with a maximum Temperature Coefficient of Resistance (TCR) of about −2.11% °C–1. This work affords an insight into high-performance ionogels with multifunctionality utilizing synchronous regulation of nanofiber reinforcement and polymer matrix in ionic liquid.
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BMC MICROBIOLOGY
·
2026
·
IF 5.4
Yuan Junjie,Wang Jing,Wang Hui,He Zhenzhen,Chen Zhongju,Hu Yating,Zhou Xuan,Yan Shaozhen,Wei Lijie,He Mengzhou,Jiang Yi,Su Rui,Yu Huihui,Wang Shaoshuai,Tan Weidong,Ding Wencheng,Feng Ling,Wang Zerui
Background Members of the genus Corynebacterium are widely distributed across human mucosal surfaces and are increasingly recognized as important components of the female reproductive tract microbiota. However, their diversity is underestimated due to limitations of conventional cultivation approaches. Results In this study, a novel bacterial strain, designated TJG_1 T , was isolated from vaginal swab samples of a pregnant woman with preeclampsia (PE) using droplet-based microfluidic single-cell cultivation. Strain TJG_1 T was characterized as a Gram-positive, non-spore-forming, non-motile short rod. Phylogenetic analysis based on the 16 S rRNA gene sequence placed the strain within the genus Corynebacterium , with the highest sequence similarity to Corynebacterium coyleae (97.39%). Whole-genome sequencing revealed a genome size of 2,481,283 bp with a G + C content of 61.52 mol%. Average nucleotide identity (ANI) and digital DNA–DNA hybridization (dDDH) values between strain TJG_1 T and its closest relatives were below the accepted species thresholds, supporting its classification as a novel species. Functional genome annotation identified genes associated with metabolism, transport systems, putative antimicrobial resistance, and predicted host interaction-related traits. In vitro assays showed that neither bacterial metabolites nor live cells significantly affected trophoblast cell viability or oxidative stress-related gene expression under the tested conditions. Although alterations in cell migration behavior were observed following exposure to live bacteria, these changes were not accompanied by significant differences in migration-related gene expression. Conclusions Strain TJG_1 T represents a novel species within the genus Corynebacterium . This study highlights the utility of droplet-based cultivation for recovering previously underrepresented vaginal bacteria and expands current knowledge of Corynebacterium diversity in the female reproductive tract.
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Hepatology Communications
·
2026
·Vol. 10
·期 5
·e0916
·
IF 6
Xiao-Wen Wang,Wen-Jie Zheng,Hao-Qi Chen,Tao Huang,Yuan Zhang,Xi-Jing Yan,Wen-Chao Li,Long Zou,Jie-Zhong Wu,Wen-Feng Zhu,Qi-Wei Yang,Gen-Shu Wang,Kun-Peng Hu
Background: Hepatic ischemia–reperfusion injury (IRI) is an important factor affecting the prognosis of liver transplantation patients. The role of Arrb2 in liver injury is unclear. Our study aimed to determine the role of Arrb2 in hepatic IRI and to identify its underlying mechanisms. Methods: An analysis of clinical samples was conducted to assess the association between Arrb2 expression and the prognosis of liver transplantation. A 70% hepatic ischemia/reperfusion model in mice was established to verify the mechanism of Arrb2 in hepatocytes promoting M2 macrophage polarization in attenuating hepatic IRI by regulating 6-ketoLCA. A model of hypoxia/reoxygenation in vitro was established to investigate the molecular mechanism of 6-ketoLCA in promoting M2 macrophage polarization and pharmacological screening. Results: Arrb2 in hepatocytes has been shown to provide significant liver protection against hepatic IRI, primarily through promoting the polarization of liver macrophages to M2. Arrb2 remodels bile acids and upregulates 6-ketoLCA through Cyp7a1 in hepatocytes, promoting M2 polarization of macrophages, thereby alleviating hepatic IRI. Mechanistically, TGR5 plays a crucial role in promoting the induction of M2 polarization in macrophages by 6-ketoLCA. Pharmacological screening indicates that dutasteride enhances the activity of the Arrb2 promoter and upregulates Arrb2 expression in hepatocytes, thereby mitigating hepatic IRI. Conclusions: Arrb2 in hepatocytes attenuates hepatic IRI by promoting macrophages toward the M2 phenotype through bile acid. Moreover, dutasteride, a selective agonist of Arrb2, emerges as a promising targeted therapeutic agent for the clinical management of liver injury.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·Vol. 65
·期 30
·16281-16300
·
IF 3.9
Zhang Xuan,Wang Bo,Hu Zhi,Wang Yue,Feng Ru,Liu Shucheng
Agricultural
waste peanut shells are rich in cis -diol flavonoid
luteolin (LTL). However, conventional separation
materials suffer from insufficient specific sites, binding limitations
only under alkaline environments, and poor anti-interference performance
in complex matrices. Herein, an integrated fabrication strategy combining
in situ polymerization in mesoporous soft confined space and teamed
boronate (TBA)-functional molecular imprinting technology is innovatively
proposed. The hierarchical substrate of GO@MS was covalently assembled
via a thiol–ene click reaction, and a boronate affinity-imprinted
polymer was grown confinedly inside mesoporous channels. The TBA molecular
group as a functional monomer would be used for specific recognition
of LTL under neutral conditions. As a result, the prepared MI-GO@MS@GLYMO-TBA
exhibits high binding capacity (61.78 μmol g –1 ) for LTL at 308 K under physiological pH (7.4), with an equilibrium
time of 360 min. In addition, MI-GO@MS@GLYMO-TBA could be recycled
six times with a slight loss of 8.00% in adsorption. Meanwhile, the
commercially available LTL with 85% purity could be easily enriched
and further extracted with high selectivity (up to 93.67%). Remarkably,
the purified LTL solutions displayed lasting antibacterial performance
against Staphylococcus aureus ( S. aureus ) with an inhibition zone of 12.15 mm. Therefore,
the MI-GO@MS@GLYMO-TBA nanocomposite could be potentially developed
as a feasible and efficient method to achieve the goals of green sustainable
chemistry for precise identification and separation of LTL from complex
samples from agricultural wastes.
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ACS Applied Materials & Interfaces
·
2026
·Vol. 18
·期 31
·43333-43344
·
IF 7.8
Xu Longjun,Wang Xinyue,Xu Longqing,Zhang Weiqiang,Hu Baoye,Wei Zhengrong,Chu Ya,Pan Fuxing,Zhao Jinsheng
Lead-free halide perovskites have attracted considerable attention as promising optoelectronic materials owing to their low toxicity and tunable electronic structures. However, poor stability and an insufficient understanding of excited-state regulation remain major challenges. A synergistic Rb + /Sb 3+ codoping strategy is employed here to construct a series of highly stable Cs 3 Bi 2 Br 9 :x%Rb + ,25%Sb 3+ ( x = 3, 5, 8, and 10) microcrystals. Structural characterization has shown that codoping forms a relatively stable perovskite structure. Spectroscopic experiments have identified that Sb 3+ substitution enhances electron–phonon coupling and strengthens the formation of self-trapped excitons (STEs), and Rb + modifies STE relaxation dynamics and suppresses radiative recombination to improve carrier utilization efficiency. Femtosecond transient absorption (fs-TA) indicates controlled excited-state evolution and enhanced charge-transfer characteristics. Therefore, Cs 3 Bi 2 Br 9 :x%Rb + ,25%Sb 3+ has achieved a hydrogen evolution rate of 144 μmol·g −1 h −1 , which is 5.8 times higher than that of pristine Cs 3 Bi 2 Br 9 , and after adding Pt, this rate further increased to 393 μmol·g −1 h −1 due to accelerated charge separation and proton reduction. This paper proposes a structure-excited state-function relationship and shows how to optimize photocatalytic hydrogen evolution in lead-free perovskites by exciton engineering.
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ACS Applied Materials & Interfaces
·
2026
·Vol. 18
·期 30
·41245-41258
·
IF 7.8
Zhang Xiangyu,Hu Yuanyuan,Xu Chunlong,Cheng Lin,Gao Dangli
Rational design of Eu 2+ -activated red phosphors under visible light excitation remains a critical challenge in various fields such as photonics, optoelectronics, and white-light-emitting diodes. Herein, we engineer high density traps with a double metastable state in the SrZnOS matrix by constructing the reversible infinitesimal photoelectrochemical layered micro-unit battery structure via co-doping Eu 2+ and Dy 3+ ions for achieving robust red luminescence. The resulting SrZnOS:Eu 2+ ,Dy 3+ phosphor exhibits intense red photoluminescence at 620 nm under 468 nm excitation, matching the emission intensity of commercial SrAl 2 O 4 :Eu 2+ ,Dy 3+ under UV irradiation. Notably, this material exhibits multi-modal luminescence, encompassing red persistent luminescence along with tunable photo/thermo/mechano-stimulated luminescence. These properties make SrZnOS:Eu 2+ ,Dy 3+ highly promising for applications in secure information storage and advanced displays. Our work establishes a design principle for manipulating multi-mode luminescence in oxide hosts through photoelectrochemical cell engineering, opening avenues for next-generation functional materials.
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ANALYTICAL CHEMISTRY
·
2026
·Vol. 98
·期 31
·23266-23279
·
IF 7.3
He Feng,Xu Xinxin,Liu Liqiang,Wu Aihong,Qu Aihua,Xu Chuanlai,Kuang Hua
The
widespread application and environmental persistence of three
spirocyclic tetronic/tetramic acid derivatives (STADs)─spirodiclofen
(SDF), spiromesifen (SMF), and spirotetramat (STM)─have raised
sustained concerns regarding their residue accumulation, potential
ecotoxicity, and risks to human health, underscoring the urgent need
for rapid detection methods. Herein, six haptens were rationally designed
and screened using computational chemistry-assisted molecular modeling
tools, followed by the successful generation of specific monoclonal
antibodies against SDF, SMF, and STM via hybridoma technology, with
half-maximal inhibitory concentrations of 4.91, 0.56, and 1.03 ng/mL,
respectively. On this basis, a multiplex immunochromatographic assay
was developed for the first time using red, purple, and blue polystyrene
microspheres as tracer labels for the three antibodies. Coupled with
a portable reader, it enables simultaneous detection of the three
STADs in lake water, soil, and tomato samples within 15 min. This
assay achieves visual limits of detection (LODs) of 2–10 ng/g
and quantitative LODs of 0.48–2.29 ng/g across these matrices.
Recovery experiments and blinded sample analyses yielded results consistent
with those obtained by reference instrumental methods, confirming
the assay’s accuracy and reliability-and thereby providing
a sensitive, deployable, and practical tool for on-site, multiresidue
monitoring of STADs in environmental and agricultural samples.
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