Surfaces and Interfaces
·
2026
·
IF 6
Shuya Lu,Yunsi Wang,Yongcheng Li,Guanshun Xie,Hongling Ge,Zerongruo Sun,Peng Zhang,Benhua Xu,Bingxin Liu
Two-dimensional Ti 3 C 2 T x MXene exhibits promising application prospects in the field of resistive random-access memory (RRAM) owing to its unique layered structure, abundant surface functional groups, and tunable band structure. However, the modulation of its electronic structure is critical for promoting the application of Ti 3 C 2 T x MXene in such semiconductor devices. Herein, chitosan (CS) was incorporated with Ti 3 C 2 T x MXene to construct CS-MXene composite films, which were subsequently employed as the resistive layer in the RRAM devices. The conductivity of Ti 3 C 2 T x MXene can be switched from a metallic-like state to a semiconducting state, and the resistive switching behaviors of CS-MXene hybrid films could be regulated by adjusting the mass ratio of Ti 3 C 2 T x MXene to CS. When the mass ratio of two components was 0.5, the as-fabricated Al/CS-MXene/ITO/glass device exhibited the most outstanding resistive switching (RS) performance, characterized by a lower operating voltage, a higher on/off ratio, excellent retention, and reliable endurance. Mechanistic analysis revealed that the RS behavior originates from the electron trapping/detrapping dynamics within the CS-MXene resistive layer. This work demonstrates high-performance RRAM devices based on CS-MXene composites, offering a feasible strategy for modulating the electronic structure of two-dimensional Ti 3 C 2 T x MXene. Chitosan (CS) was incorporated with Ti 3 C 2 T x MXene to construct CS-MXene composite films, which were subsequently employed as the resistive layer in the RRAM devices. The conductivity of Ti 3 C 2 T x MXene can be switched from a metallic-like state to a semiconducting state, and the resistive switching behaviors of CS-MXene hybrid films could be regulated by adjusting the mass ratio of Ti 3 C 2 T x MXene to CS. When the mass ratio of two components was 0.5, the as-fabricated Al/CS-MXene/ITO/glass device exhibited the most outstanding resistive switching (RS) performance, characterized by a lower operating voltage, a higher on/off ratio, excellent retention, and reliable endurance. Mechanistic analysis revealed that the RS behavior originates from the electron trapping/detrapping dynamics within the CS-MXene resistive layer. Download: Download high-res image (133KB) Download: Download full-size image
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INTERNATIONAL DENTAL JOURNAL
·
2026
·Vol. 76
·期 5
·109799
·
IF 5.2
Xinda Li,Zhijia Liu,Xinzhu Liu,Jianing Wang,Jinlai Bao,Wuwei Li
Background To explore the osteogenic promotion of carboxymethyl chitosan (CMCS), clarify the signalling pathways involved and preliminarily evaluate the translational potential of CMCS in transcrestal sinus floor elevation. Methods Overlapping targets were identified by integrating potential CMCS targets and bone regeneration-related genes, and protein-protein interaction and GO/KEGG enrichment analyses were conducted. The GEO dataset GSE50743 was externally validated. Bone marrow-derived mesenchymal stem cells from mice were induced to osteogenic differentiation in vitro and treated with CMCS alone or in combination with the p38 inhibitor SB203580 or the VEGFR2 inhibitor SU5416. The osteogenic phenotypes and mechanism-related changes were determined by ALP, Alizarin Red S staining, RUNX2 immunofluorescence, qPCR and Western blotting. A retrospective comparative clinical study further evaluated radiographic, functional and patient-reported outcomes after transcrestal sinus floor elevation. Results We identified 187 common targets of CMCS-bone regeneration. Enrichment analyses revealed that these targets were primarily involved in cell adhesion, inflammatory and immune regulation, extracellular matrix remodelling, and osteogenesis-related pathways, including MAPK and VEGF signalling. Validation with GSE50743 confirmed significant positive enrichment of candidate gene set under osteogenic conditions. In vitro, CMCS increased ALP activity, mineralised nodule formation and the expression of RUNX2, ALP and OPN, whereas inhibition of p38 or VEGFR2 partially reduced these effects. Clinical findings showed that the two groups were generally similar in terms of safety, implant stability and patient-reported outcomes, whereas the CMCS group had better volume maintenance. Conclusions CMCS promotes osteogenesis and mineralisation, at least partly via p38 MAPK and VEGF–VEGFR2 signalling. Retrospective clinical findings also indicate its potential utility in transcrestal sinus floor elevation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Hanchen She,Huiru Zhao,Qilin Guo,Peng Gu,Hua Qiu,Yangyi Sun,Kunlin Chen
Flexible conductive coatings enhance textiles with functions like heating, luminescence, and sensing. However, they tend to break under external forces, limiting long-term use. Here, a waterborne polyurethane containing disulfide bonds and aldehyde groups was synthesized using 2-hydroxyethyl disulfide as a chain extender and vanillin as a chain terminator. The resulting polyurethane was then blended with chitosan-modified Ti 3 C 2 T X MXene nanosheets to create a flexible conductive fabric coating. The innovative fabric coating exhibits outstanding mechanical properties and self-healing performance, driven by a synergistic dual dynamic covalent bonding mechanism. Dynamic disulfide bonds within the polyurethane matrix enable main-chain reconstruction, while reversible Schiff base linkages between vanillin and chitosan enhance interfacial healing efficiency. After being developed into sensors, the coating effectively monitored human joint movements in real time, achieving a sensitivity of 8 once the strain exceeded 50%. Furthermore, due to the abundance of -OH and -NH 2 groups on chitosan-modified MXene, the conductive fabric coating sensor exhibited humidity responsiveness. It displayed a high sensitivity of −71%, a rapid response and recovery time of less than 10 s, and a wide sensing range of 33% to 97% relative humidity, thereby facilitating real-time monitoring of respiratory status during physical activity. This flexible coating holds significant potential for functional flexible electronics.
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Advanced Healthcare Materials
·
2026
·
IF 11
Yi Luo,Na Li,Shijun Lu,Yingchao Shen,Minxuan Han,Feng Zhang,Xue Wang
Wound healing remains a critical clinical challenge due to uncontrolled bleeding, bacterial infections, poor vascularization, and cell migration at damaged tissue sites. To address this challenge, we developed a radially structured, multifunctional biomimetic scaffold. Tussah silk was subjected to physical shearing and alkaline hydrolysis treatment to obtain tussah silk nanofibers (TSn). The TSn, chitosan (CS), and graphene oxide (GO) were then processed into radially aligned TSn/CS/GO scaffolds. These anisotropic composite scaffolds demonstrated not only antibacterial activity and rapid hemostatic properties but also effectively guided cell migration from the wound periphery toward the center. To achieve multifunctionality, including antioxidant activity, enhanced cell migration, and vascularization, the central void of the TSn/CS/GO scaffold was filled with a silk fibroin hydrogel integrated with Puerarin (PUE). In vivo studies using rat models confirmed that the TSn/CS/GO@PUE3 scaffold significantly accelerated wound healing (99.98 ± 0.02%), angiogenesis (the positive expression rates of CD31 and α-SMA were 21.66 ± 0.74% and 41.28 ± 1.09%, respectively), and collagen deposition (75.26 ± 2.10%). This study thus provides a valuable strategy for developing multifunctional biomimetic scaffolds to accelerate wound repair.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Qing Chen,Sitian Wang,Jiarui Jiang,Lianwen Hu,Fuge Niu,Weichun Pan,Yanbo Wang,Xiaoxiang Han
To develop novel antibacterial agents, chitosan (CS) was converted into O -carboxymethyl chitosan (O-CMC), which was then reacted with perillaldehyde and perilla essential oil to synthesize Schiff base derivatives (P-CCSB and PEO-CCSB). Comprehensive characterization via FTIR, 1 H NMR, SEM, EA, XRD, DSC, TGA, and XPS verified the successful synthesis and structural features of these compounds. The derived carboxymethyl chitosan Schiff base (CCSB) exhibited superior antibacterial performance compared to CS and O-CMC, attributable to its reactive Schiff base moiety, nanoscale particle size, elevated cationic charge density, and improved water solubility. After 10 days of storage of large yellow croaker, the total volatile basic nitrogen (TVB-N) and total viable count (TVC) values of the PEO-CCSB group decreased by 10.30 mg/100 g and 1.31 lg (CFU/g), respectively, compared with those of the blank group. These results highlight PEO-CCSB as a promising antimicrobial coating for food preservation.
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ACS Applied Polymer Materials
·
2026
·
IF 4.7
Zhibo Zhou,Yunqing Gu,Yun Ren,Zhou Li,Denghao Wu,Zhenxing Wu,Jiegang Mou
In order to enhance the actuation performance of photoresponsive hydrogels in view of their slow response rate and limited functionality, a photoresponsive hydrogel was prepared in this study. The hydrogel was constructed with a thermo-responsive poly(N-isopropylacrylamide-co-acrylamide) (P(NIPAM-AM)) matrix cross-linked by chitosan (CS) and incorporated a photothermal conversion component based on the Fe3+/tannic acid (TA) complex. We characterized the hydrogel’s microscopic morphology and measured its water absorption/desorption rates, mechanical properties, temperature sensitivity, photothermal conversion ability, actuation performance, and sensing performance. Results show that adding chitosan and acrylamide together produced a more tightly cross-linked structure. This improved the hydrogel’s mechanical strength, water retention, and actuation performance. Key performance values include a maximum stress of 101 kPa, maximum strain of 100%, and maximum bending angle of 104.8°. The hydrogel achieved a fast actuation response time of 0.732 s, a bending rate of 0.22 mm/s, and a conductivity of 1.154 (Ω·m)−1. It also demonstrated efficient photothermal conversion, NIR-responsive actuation, and conductive sensing performance. This work provides a useful strategy for developing high-performance light-responsive smart materials and a practical solution for multifunctional flexible actuators.
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CARBOHYDRATE POLYMERS
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2026
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IF 13.2
Jiyang Zeng,Wei Li,Yawei Li,Zhiming Tu,Hong Ma,Yuliang Dai,Bing Wang,Hongbing Deng
Bone defects caused by trauma, tumor resection, or infection represent significant clinical challenges in orthopaedic practice. Current bone graft materials are often limited by suboptimal osteogenic capacity, donor site morbidity, and insufficient mechanical properties. In this study, we developed a composite bone regeneration scaffold composed of chitosan, silk fibroin fibers, and strontium alginate microspheres (CS/SF@SrAlg) via microfluidic electrospray coupled with fiber fragmentation-recombination techniques. This chitosan-based composite scaffold combines excellent biocompatibility, wide availability, and enhanced mechanical properties. Chemical cross-linking and physical interactions among the components facilitated the formation of a composite system for controlled Sr 2+ release. The scaffold exhibits a hierarchically porous architecture that promotes cellular infiltration, while the silk fibroin fibers improve mechanical integrity and help maintain an optimal microenvironment. In vitro experiments demonstrated that the scaffold significantly enhanced cell proliferation, migration, and osteogenic mineralization, with a cell proliferation rate of more than 120%. In a rat calvarial defect model, the scaffold markedly promoted angiogenesis and osteogenesis, with 81.8% ± 1.48% bone regeneration coverage observed at 8 weeks post-implantation. Mechanistically, RNA transcriptomics revealed that it promoted osteogenesis through modulation of the key PI3K-Akt signaling pathway. Collectively, the CS/SF@SrAlg scaffold represents a promising biomaterial strategy for bone defect repair with substantial potential for clinical application.
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Journal of Functional Biomaterials
·
2026
·Vol. 17
·期 4
·177
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IF 5.9
Jingwen Yang,Zihao Zhao,Zengtao Song,Lei Cao,Xifan Mei,Xing Zhang
Segmental bone defects are large, non-healing injuries characterized by insufficient structural support and limited bioactivity, posing a significant clinical challenge. In this study, we developed biomimetic chitosan/polyvinyl alcohol–glycerol (CS/PG) scaffolds inspired by porcupine quills, which were fabricated via fused deposition modeling and unidirectional freeze casting. The as-prepared scaffold featured a dense outer layer of polyvinyl alcohol–glycerol (PG) with high compressive strength (24.21 ± 0.11 MPa at 25% strain) and an oriented inner foam of chitosan (CS). The CS foam was further incorporated with poly (3,4-ethylenedioxythiophene) polystyrene sulfonic acid (PEDOT:PSS, denoted as PP) and amorphous zinc phosphate (AZP) to form PP-AZP-CS/PG, aimed at enhancing neural conductivity and stimulating blood vessel formation, respectively. The in vitro results indicated that the biomimetic scaffolds exhibited excellent biocompatibility while significantly enhancing angiogenesis and osteogenesis capabilities. In a rabbit radial segmental defect model, PP-AZP-CS/PG achieved robust bone regeneration, attaining a bone volume/total volume of approximately 26.22% after implantation for 8 weeks. Overall, this biomimetic scaffold demonstrated that integrating hierarchical design with additional bioactive components enhanced mechanical support while promoting new bone regeneration, addressing critical challenges in segmental bone defect repair.
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高影响因子
JOURNAL OF POLYMER RESEARCH
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2026
·Vol. 33
·期 4
·169
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IF 3.5
Pan Chang,Miao Yanting,Zhai Guangchao,Zhou Xinyue,Xing Zheng
Hydrogels possess high water content, tunable mechanical properties, and excellent biocompatibility, making them promising candidates for surface protective materials for jade artifacts. However, the rapid dehydration rate and inherent brittleness of traditional hydrogels restrict their widespread application in the protection of fragile cultural relics. Herein, polyacrylamide/chitosan (PAM/CS) dual-network hydrogels with enhanced water retention, adhesion, and toughness were fabricated by the introduction of aluminum ions (Al 3+ ) and ethylene glycol (EG). The Al 3+ ions form coordination cross-links with the polymer network, while the EG molecules reconstruct the hydrogen bonding system, significantly improving the moisture-locking capability and mechanical stability of the hydrogel. The optimized PAM/CS hydrogel exhibited a maximum lap shear strength of 23.2 kPa on metal substrates and maintained excellent flexibility and transparency at -20 °C. Furthermore, the modification with EG endowed the hydrogel with superior anti-drying properties and high toughness, effectively addressing the issues of desiccation and cracking. Finally, the hydrogel was applied as a fully wrapping coating for fragile Xiuyan jade artifacts, demonstrating remarkable capabilities in moisturizing, buffering against impact from a 2-meter free fall, and removing surface dust. Consequently, this study not only promotes the broader use of hydrogels in artifact conservation but also offers a feasible solution for the effective protection of other soft jade materials, holding profound significance for the inheritance of Chinese jade culture.
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ChemistrySelect
·
2026
·Vol. 11
·期 13
·e05110
·
IF 2.3
Jiyang Zuo,Jiheng Ding,Hao Wang,Hao Rong,Xu Zhang,Xin Fan,Kai Xie,Yuna Zhang,Qi Yang,Zhisen Shen,Xiaoqing Liu
Chronic wound management requires multifunctional biomaterials integrating antibacterial and tissue-repair capacities. To address this clinical demand, we developed a composite hydrogel by incorporating quercetin-loaded TiO 2 @CNTs heterojunctions into chitosan, leveraging their complementary properties: chitosan's excellent biocompatibility as the matrix, quercetin's natural anti-inflammatory effects, TiO 2 ’s photocatalytic antibacterial activity, and CNTs’ structural reinforcement. The TiO 2 @CNTs heterojunction was synthesized hydrothermally, with characterization confirming uniform TiO 2 dispersion on CNTs, anatase-phase crystallinity, and robust interfacial bonding. The composite hydrogel showed thermoresponsive gelation at 37 °C, favorable porcine skin adhesion, and a porous microstructure. In vitro tests revealed >90% L929 fibroblast viability (25 µM quercetin optimal), enhanced cell migration, and hemolysis rates <5%. Antibacterial assays against Escherichia coli demonstrated significantly larger inhibition zones (18.2 ± 1.3 mm) and lower bacterial counts for the composite hydrogel than those for the chitosan-only or control groups. In a rat skin wound model, the hydrogel achieved 60% wound closure at 7 days, outperforming the chitosan (50%) and control (40%) groups. Furthermore, histological and blood biochemical analyses confirmed no systemic toxicity, organ damage, or TiO 2 /CNT accumulation in major organs. This multifunctional hydrogel exhibits synergistic antibacterial, biocompatible, and pro-healing properties, making it a promising candidate for advanced chronic wound care applications.
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Regenerative Biomaterials
·
2026
·
IF 8.7
Chen Xianglong,Gao Ren,Liang Xinyue,Liu Kun,Wei Zhong,Wu Xiaopei,Goto Takashi,Xiong Chengjie,Xu Feng,Dai Honglian
Peripheral nerve injury (PNI) triggers excessive oxidative stress and inflammation that impede nerve regeneration, leading to target organ atrophy and incomplete functional recovery. Conventional drug-loaded nerve conduits release anti-inflammatory drugs sustainably via filled hydrogels, requiring a precisely engineered hydrogel systems to match drug release kinetics without impeding regenerating nerve tissue growth. Meanwhile, constructing complex conduit systems may introduce potential cytotoxic factors and induce aseptic inflammation via acidic degradation products. Herein, we fabricated a ROS-scavenging CS-LA/P(MMD-CL) composite nerve conduit with rapid photo-crosslinking (365 nm UV irradiation, photoinitiator-free) via integrating lipoic acid-modified chitosan (CS-LA) hydrogel into oriented P(MMD-CL) conduit. Disulfide bonds in CS-LA scavenged ROS to alleviate oxidative stress, modulate inflammatory factor expression and resolve excessive inflammation, while the oriented P(MMD-CL) provided physical support and directional guidance for axon growth. In vivo studies on SD rats revealed that CS-LA/P(MMD-CL) promoted nerve regeneration through enhancing cell proliferation and angiogenesis, improving maturity of regenerative peripheral nerve, mitigating gastrocnemius atrophy and promoting nerve function recovery (SFI: -77.51 ± 1.51), and exhibited great biosafety—no organ damage from degradation byproducts. This simple, multifunctional composite conduit effectively modulates the PNI microenvironment and promotes peripheral nerve regeneration, offering a promising strategy for PNI repair.
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FOOD CONTROL
·
2026
·
IF 7
Yangchun Ge,Zhuochao Shen,Yuying Xie,Jiangkuan Tang,Haohua Zhang,Yupeng Qiu,Xuqiang Peng,Lanlan Zhai,Zhongyu Li
This study reports the rational design and fabrication of an intelligent, self-healing hydrogel tailored for fruit preservation via the dynamic cross-linking of chitosan (CS) with a synthesized phenylboronic acid-based crosslinker (DMSA-PBA). The strategic introduction of dynamic boronate ester bonds as the key crosslinking nodes is pivotal, granting the material not only rapid gelation (<60 s) and autonomous self-healing capabilities but also dual responsiveness to pH and reactive oxygen species (ROS). The resulting hydrogel network exhibits a suite of exceptional properties: superior mechanical robustness, a high swelling ratio (∼1000%), and outstanding water vapor barrier performance. Furthermore, the inherent synergistic antibacterial activity, stemming from the chitosan and the DMSA-PBA components, was confirmed. When evaluated as a protective coating on mangoes, this multifunctional hydrogel significantly delayed quality deterioration during ambient storage, effectively reducing weight loss and decay incidence while maintaining firmness and acidity. This work underscores the immense potential of dynamic covalent chemistry in designing advanced coatings for sustainable food preservation, presenting a feasible and eco-friendly strategy grounded in a well-defined material design.
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