NEW JOURNAL OF CHEMISTRY
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2026
·Vol. 50
·期 22
·9462-9471
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IF 2.6
Chaojie Yu,Yuxin Sang,Ziqi Liu,Haihong Huang,Zuwei Song,Weina Li,Qinxing Sun
This work presents a reusable and visual sensing platform for tetracycline (TC) detection by covalently locking carbon dots (CDs) within molecularly imprinted chitosan gel beads. The key to this design is the use of epichlorohydrin (ECH) as a dual-role agent, which simultaneously crosslinks the chitosan network and forms stable covalent bonds with the CDs. This “covalent locking” strategy not only prevents fluorophore leaching but also induces a permanent blue-shift in the CDs emission from red to green, creating an intense and stable visual signal under UV light. Coupled with the TC-selective cavities created by molecular imprinting, the resulting gel beads exhibit concentration-dependent fluorescence quenching with high specificity. The sensor achieves a low detection limit of 12.23 nM (spectrometric) and, importantly, enables on-site quantitative analysis via a smartphone by monitoring the attenuation of the green emission, yielding a comparable detection limit of 10.69 nM. Demonstrating excellent robustness over a wide range of pH and ionic strength, the sensor retains over 90% of its initial response after 10 regeneration cycles. It was successfully applied to the analysis of spiked milk samples with accurate recoveries (97.3–103.2%) and high reproducibility (RSD ≤ 2.64%). This study highlights a straightforward yet effective material design paradigm where covalent immobilization and molecular imprinting are synergistically integrated to create stable, reusable, and equipment-light sensors for point-of-care applications.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Lanlan Dong,Xin Zheng,Zhongwang Li,Reyihanguli Alimu,Houfeng Jiang,Wurikaixi Aiyiti,Cijun Shuai,Patiguli Aihemaiti
Dual-ion-enhanced hydrogel with high stretchability and toughness • 3D-printed hydrogel structures enable tunable strain sensing. • Triangular sensor shows fast response and high gauge factor. • Hydrogel demonstrates underwater sensing and biocompatibility. As a core component of wearable devices, flexible sensors remain limited by the challenge of simultaneously optimizing their mechanical strength, sensing sensitivity, and strain range. In this study, an ion-conductive double-network hydrogel was developed using direct ink writing (DIW) three-dimensional printing technology. The hydrogel was synthesized via a one-pot method using carboxymethyl chitosan, N-acryloyl glycinamide, and methyl cellulose, and then sequentially soaked in Fe 3+ and Li + solutions to form a dual crosslinked network composed of covalent bonds and coordination/hydrogen bonds. The resulting hydrogel exhibited high stretchability (breaking elongation of 418.56%), excellent toughness (1175.53 KJ/m 3 ), strong fatigue resistance (stable stretching for 12 cycles at 150% strain and stable compression for 30 cycles at 50% strain), high ionic conductivity (3.38 mS/cm), and excellent anti-swelling, antioxidant, and biocompatibility. Furthermore, we fabricated sensors with various topologies (triangle, honeycomb, and concentric) using DIW. Among them, the triangle sensor demonstrated high sensitivity (gauge factor up to 10.08), fast response (463 ms), a wide detection range (0–400%) and reliable monitoring of multiscale human physiological activities and underwater motion. Additionally, the sensor showed potential for information encryption and signature recognition. This study provides an integrated materials-to-structure strategy for developing next-generation high-performance and customizable flexible electronic devices.
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高影响因子
ACS Applied Polymer Materials
·
2026
·
IF 5.2
Xiaoyang Qi,Yingxin Lv,Bo Xu,Man Zhou,Ying Liu,Ying Zhang,Li Cui,Ping Wang,Qiang Wang,Yuanyuan Yu
This study proposes a strategy for preparing colored flexible chitosan fibers (PPs-TA-CS fibers) via a dual-interpenetrating multinetwork structure. By linking rigid chitosan (CS) chains to flexible thioctic acid (TA) polymers via dynamic disulfide bonds, the flexibility and mechanical properties of the fibers are significantly enhanced. Meanwhile, the incorporation of polyphenols (PPs) enables in situ coloring, eliminating the need for additional dyeing processes. The experimental results show that, compared to CS fibers, the tensile strength of the three types of PPs-TA-CS fibers increased by 97.90%, 116.25%, and 95.28%. PPs-TA-CS fibers also exhibit excellent bending flexibility and deformation capacity. Furthermore, the PPs-TA-CS fibers exhibit excellent UV-blocking and antibacterial properties. This study provides an innovative and sustainable approach for the development of high-performance, biodegradable functional fibers.
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ACS Biomaterials Science & Engineering
·
2026
·
IF 6
Weng Sheji,Lin Zhongqin,Tan Kai,Long Zhengyang,Yang Lei,Chen Bin,Zhang Qin,Chen Weikai
Conventional wound dressings often fail to integrate rapid hemostasis, antibacterial protection, and a pro-regenerative microenvironment, leading to persistent infection and delayed healing in complex wounds. Herein, we report a multifunctional self-adhesive hydrogel for integrated hemostatic, antibacterial, and regenerative wound management with a synergistic dual-crosslinked network. The hydrogel is composed of methylacrylamide-modified type I collagen (ColMA), o -nitrobenzene-modified hyaluronic acid (HANB), and methylacrylamide-modified chitosan (CSMA), and can rapidly form in situ under UV irradiation through free-radical polymerization of methacrylamide groups and Schiff base reactions between HANB and amino groups on ColMA/CSMA. Once applied to infected wounds, the hydrogel rapidly seals the wound bed and adheres tightly to the tissue, where HANB contributes hemostatic and adhesive properties, CSMA provides intrinsic antibacterial activity to inhibit bacterial colonization, and ColMA offers extracellular matrix-mimicking cues to support cell adhesion and tissue regeneration. Through this coordinated mechanism, the hydrogel not only controls bleeding and reduces infection risk at the early stage but also promotes the growth of granulation tissue, re-epithelialization, and matrix reconstruction during the subsequent repair phase. This platform integrates wound closure, antibacterial defense, and tissue regeneration into a single dressing system, acting as a promising strategy for the treatment of infected wounds.
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APPLIED CLAY SCIENCE
·
2026
·
IF 5.2
Nan Liu,Xu Zhang,Xuemei Sun,Na Meng,Bingnan Du
Traditional wound dressings lack antibacterial properties and may cause wound damage during dressing changes, impairing healing. Therefore, single-function dressings cannot meet the multifaceted requirements of modern wound healing processes. This study successfully prepared a Cu 2 O/PDA-MMT by loading cuprous oxide nanoparticles (Cu 2 O NPs) onto polydopamine (PDA)-modified montmorillonite (MMT), which was then incorporated with chitosan (CS)/polyvinyl alcohol (PVA) via a one-step blending method to fabricate CS/PVA/Cu 2 O/PDA-MMT hydrogels. Characterization techniques including XRD, FTIR, TG, and SEM confirmed the successful preparation of the material, while systematic evaluation demonstrated its physicochemical properties such as gel fraction, porosity, and mechanical performance. Antimicrobial experiments, cell compatibility tests, mouse tail-amputation hemorrhage models, and full-thickness skin wound infection models demonstrated that the 1% CS/PVA/Cu 2 O/PDA-MMT hydrogel not only exhibited over 95% antimicrobial inhibition rates against both test bacterial strains but also possessed excellent biocompatibility. It significantly reduced blood loss in rat tail hemorrhage models. When treating full-thickness skin wounds, this hydrogel effectively controlled infection, accelerated healing, achieved a wound healing rate exceeding 97% by day 12, and promoted tissue regeneration. These outstanding properties position it as a wound dressing material with significant clinical application potential.
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Biomolecules
·
2026
·Vol. 16
·期 8
·1140
·
IF 5.6
Xinyu Lyu,Xiaotong Xu,Mengqi Shi,Rui Wang,Xiaoqing Yu,Yan Liu,Xiangyu Xue,Fengmin Zhang,Xiuhong Wang
Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by immune dysregulation, microbiota imbalance, and intestinal barrier damage. Unconjugated bilirubin (UCB) shows promise in treating UC due to its anti-inflammatory properties but is limited by poor solubility and potential toxicity. This study developed a chitosan-based controlled-release microsphere (CBMS) treatment to overcome these issues. CBMS utilizes the mucoadhesive properties of chitosan to achieve targeted, controlled UCB release in the colon, enhancing its stability and bioavailability. In a DSS-induced UC mouse model, CBMS alleviated clinical symptoms, reduced colon shortening, and improved histological outcomes, including reduced inflammation and enhanced mucosal repair. The mechanism involves CBMS retention in the intestinal lumen, UCB inactivation of digestive proteases, and restoration of microbiota balance, suppressing pro-inflammatory pathways. CBMS offers a promising new therapeutic strategy for UC and insights into polysaccharide-based drug delivery systems.
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EUROPEAN POLYMER JOURNAL
·
2026
·
IF 6.8
Jingjing Ning,Jie Hu,Qing Li,Chen Xu,Su Chen
Hydrogel is increasingly appreciated as a reliable dressing for wound repair and regeneration due to the established favorable microenvironment for healing. Thus, hydrogel with multiple synergistic functions are of particular interest in biomedicine. Herein, we develop a double network hydrogel with low swelling property, outstanding adhesive capacity, good biocompatibility, excellent anti-bacterial and ROS scavenging capacity, which shows potential for accelerating wound healing. Quaternized chitosan serves as the first network to endow the hydrogel with anti-bacterial capacity (75.18% for E. coli and 93% for S. aureus ). Zwitterionic monomer is copolymerized with acrylic acid to form the second network, which improves the mechanical properties and reduces the swelling behavior (ultralow swelling ratio of 2.42%). Tannic acid and dihydrocaffeic acid contribute excellent tissue adhesion (adhesion strengths of 124.4 kPa to pig skin) and antioxidant capacity (ROS scavenging rate of 96%). Based on these advantages, the hydrogel greatly facilitates the wound closure, as well as promotes epithelialization, collagen deposition and neovascularization.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Yuanzhu Long,Wei Xu,Fengxiang Huang,Lu Peng,Yingqian Duan,Diansan Su,Zhaoqiong Zhu
Chitosan hydrogels are widely recognized as promising wound dressings. However, traditional preparation methods often rely on crosslinkers, which pose challenges in terms of biocompatibility and cost. This study introduces a new approach for the spontaneous formation of chitosan hydrogels via carbonic acid modulation, which is crosslinker-free, rapid, simple, and economical. By adding ammonium bicarbonate to acetic acid-solubilized chitosan, an unstable solution is formed. This solution spontaneously releases CO 2 and transforms into a gel within 30 min at 40 °C. Subsequent purification yields a pure chitosan hydrogel composed solely of chitosan and water. The prepared hydrogel demonstrates excellent biocompatibility and significantly promotes wound healing, achieving over 90 % closure of a 1 cm diameter full-thickness skin defect within 10 days. Key performance metrics include a compressive strength of 55.26 kPa, a water retention capacity of 7880.5 %, and a water vapor transmission rate of 496.2 g/(cm 2 ·day). This methodology not only circumvents the limitations of crosslinker-dependent methods but also establishes new possibilities for the biomedical applications of chitosan hydrogels, particularly in advanced wound care and other therapeutic contexts.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Leqi Gao,Licheng Ma
Chitosan (CTS), well known for its abundant amine (−NH 2 ) and hydroxyl (-OH) groups have potential application for the adsorption of gold ions. However, its low chemical stability and mechanical strength in acidic solution have barely been explored in gold ions sorption. Herein, cross-linked chitosan microspheres were prepared by pre-crosslinked the amino groups on the chitosan molecular chains with formaldehyde which can efficient and selective gold recovery from gold-bearing leaching solution. The cross-linked chitosan microspheres (CTS-GA) were characterized by FTIR, XPS, SEM and BET, and subsequently applied for gold recovery in an actual gold-bearing mineral leaching solution. The maximum adsorption capacity of CTS-GA for Au(III) can reach 614.08 mg/g (C 0 = 100 mg/L, t = 24 h, pH = 2). The CTS-GA was analyzed by ZETA, XRD, TEM, and XPS after the adsorption of Au(III). The results reveal the adsorption mechanism of CTS-GA on gold ions. At pH 2, the amino groups on CTS-GA become protonated and generate a positive charge that electrostatically attracts the negatively charged AuCl 4 − . This interaction allows the nitrogen atoms to complexation with the gold ions, forming a complex that enhances adsorption. Additionally, the amino groups of CTS-GA facilitate the reduction of Au(III) to Au(0). Compared with chitosan, the formaldehyde pre-crosslinking strategy effectively retains active amine sites, thereby enhancing adsorption capacity and stability. In exploration of a complex metal ion environmenniulat in an actual gold-bearing mineral leaching solution, it was indicated that the cross-linked chitosan microspheres possess a significant gold recovery efficiency of 96.56 % at gold concentration of 15.97 mg/L. The CTS-GA can selectively recovery gold from gold-bearing leaching solution.
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CARBOHYDRATE RESEARCH
·
2025
·
IF 2.5
Yongsheng Zheng,Kai You,Cuiping Guo,Zhijie Geng,Yuwei Gao,Zhaoming Liu,Dong Yang,Huilong Guo,Jun Huang
We report a hydrogel platform that integrates a natural antimicrobial as part of the network rather than as a releasable additive. Creatine was first grafted onto methacrylated hydroxybutyl chitosan to obtain an injectable, thermoresponsive, and photocurable backbone (HBC_m_Cre). Reuterin (Reu) was subsequently incorporated through dynamic imine (Schiff-base) coupling, functioning as structural crosslinks that both reinforce the network and sustain local antimicrobial activity. 1 H NMR and FTIR confirmed the successful synthesis. The resulting HBC_m_Cre/Reu hydrogel exhibited smooth injectability, rapid photocuring, and stepwise enhancement in mechanical performance (HBC: 0.45 ± 0.09 N, HBC_m_Cre: 1.27 ± 0.08 N, HBC_m_Cre/Reu: 1.96 ± 0.09 N), indicating that the integration of Reu as a network-forming unit significantly strengthens the gel architecture. The system maintained high biosafety (NIH 3T3 viability >95 %, hemolysis <2 % at 10 mg/mL) and showed potent antibacterial activity, achieving >95 % killing of E. coli and S. aureus and effective biofilm disruption. In vivo rat tail-amputation experiments further demonstrated efficient bleeding control, with creatine grafting markedly reducing bleeding time and blood loss, while Reu primarily contributed to mechanical reinforcement and antibacterial protection rather than direct hemostatic enhancement. These findings establish a distinct structural design strategy where a natural metabolite and antimicrobial are co-integrated into a single hydrogel network, providing a robust and multifunctional platform for potential application in infection-resistant wound care.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Qi Dong,Siyu Xiong,Xiongwei Dong,Yihang Tang,Xuan Dai,Peng Chen,Zhaowei Zhang
Current surgical adhesives struggle with slow curing, weak wet adhesion, and a lack of antimicrobial properties, leading to ineffective hemostasis and infection control. We developed a novel light-activated chitosan hydrogel (GTCS) through initiator-free photopolymerization via disulfide ring opening. Unlike toxic acrylate-based systems requiring photoinitiators, this method eliminates cytotoxicity risks in existing photopolymerized biomaterials. The GTCS is dual-functionalized with gallic acid (GA) and α-thioctic acid (TA), enabling fast initiator-free photopolymerization (11 s) under UV light. The optimized GTCS2 hydrogel demonstrates superior adhesion strength (31.40 ± 5.09 kPa) and shows broad-spectrum antibacterial efficacy (>98 % killing against E. coli and S. aureus ) via membrane disruption and ROS generation. Crucially, GTCS2 achieves hemostasis in 32 ± 3.6 s (vs. 158.33 ± 13.05 s for gelatin sponge) with a 70 % reduction in blood loss (0.81 ± 0.16 g vs. 2.62 ± 0.42 g). In infected wounds, it accelerates healing (93.23 % closure at day 14 vs. 86.05 % of commercial 3 M dress) by suppressing bacterial colonization, scavenging pathological ROS, and modulating pro-inflammatory cytokines (TNF-α, IL-6). Integrating injectability, rapid light-triggered curing, robust adhesion, and intrinsic antibacterial/antioxidant activity, this multifunctional platform offers a transformative solution for emergency hemorrhage control and infected wound management.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
·
IF 4.9
Haohao Zhang,Mingyuan Pang,Min Yang,Zhen Kong,Jiajia Ye,Wensi Li,Yen Leng Pak,Juan An,Koulong Wu,Jibin Song
Chemotherapy, as a primary cancer treatment modality, faces limitations in efficacy and patient tolerance due to non-specific cytotoxicity, drug resistance, and adverse effects. This study develops a multifunctional nanoplatform (DOX-FA-CS-BiO 1 . 5 ) for NIR-Ⅱ photoacoustic imaging-guided visualized synergistic photothermal-chemotherapy, aiming to achieve enhanced therapeutic outcomes. The BiO 1 . 5 component ensures superior photothermal conversion efficiency and photoacoustic imaging performance, while the synergistic platform's high drug loading capacity and pH-responsive controlled release profile significantly improve tumor cell eradication rates. The chitosan-folic acid dual coating enhances biocompatibility and tumor-targeting specificity. Through synergistic effects, this nanoplatform demonstrates superior antitumor efficacy, offering a novel paradigm for constructing integrated platforms for imaging-guided visualized cancer theranostics.
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