Nature Communications
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2024
·Vol. 15
·期 1
·1-21
·
IF 14.7
Tang Dongsheng,Cui Minhui,Wang Bin,Liang Ganghao,Zhang Hanchen,Xiao Haihua
Cationic polymers have great potential for cancer therapy due to their unique interactions with cancer cells. However, their clinical application remains limited by their high toxicity. Here we show a cell membrane-targeting cationic polymer with antineoplastic activity (P mt ) and a second near-infrared (NIR-II) fluorescent biodegradable polymer with photosensitizer Bodipy units and reactive oxygen species (ROS) responsive thioketal bonds (P Bodipy ). Subsequently, these two polymers can self-assemble into antineoplastic nanoparticles (denoted mt-NP Bodipy ) which could further accumulate at the tumor and destroy cell membranes through electrostatic interactions, resulting in cell membrane destabilization. Meanwhile, the photosensitizer Bodipy produces ROS to induce damage to cell membranes, proteins, and DNAs to kill cancer cells concertedly, finally resulting in cell membrane lysis and cancer cell death. This work highlights the use of near-infrared light to spatially and temporarily control cationic polymers for photodynamic therapy, photo-immunotherapy, and NIR-II fluorescence for bio-imaging.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 1
·1-10
·
IF 5.3
Yang Dou,Shao Tong,Wang Xiaoshuang,Hong Min,Li Rui,Li Chenzhong,Yue Qiaoli
New portable hydrogel sensors for Al 3+ and Fe 3+ detection were designed based on the aggregation-induced emission (AIE) and color change of N-doped carbon dots (N-CDs). N-CDs with yellow fluorescence were prepared by a one-pot hydrothermal method from 2,5-dihydroxyterephthalic acid and acrylamide. The fluorescence of N-CDs was enhanced by Al 3+ about 20 times and quenched by Fe 3+ . It was interesting that although Fe 3+ showed obvious quenching on the fluorescence of N-CDs it did not cause a noticeable change in the fluorescence of N-CDs + Al 3+ . The colorless solution of N-CDs appeared blue in the presence of Fe 3+ without the influence of Al 3+ . Therefore, the turn-on fluorometry and colorimetry systems based on N-CDs were constructed for the simultaneous detection of Al 3+ and Fe 3+ . Furthermore, the portable sensing of Al 3+ and Fe 3+ was realized with the assistance of hydrogel, filter paper, cellulose acetate, and cellulose nitrate film. The proposed approach was successfully applied to the detection of Al 3+ and Fe 3+ in food samples and cell imaging. Graphical Abstract
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JOURNAL OF FLUORESCENCE
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2025
·
IF 3.1
Han Bo-Ming,Zhang Hao-Rui,Gao Wen-Jie,He Xi-Wen,Li Wen-You,Zhang Yu-Kui
In this work, a dual-emission material based on lanthanide metals was synthesized and used as a ratio fluorescence sensor to respond to Hg 2+ and H 2 O 2 , respectively. Tb-BDC-NH 2 as a bimetal MOFs had double ligands and exhibited double fluorescence emission peaks at 550 nm and 450 nm. The two emission peaks of Tb-BDC-NH 2 can be quenched by Hg 2+ and H 2 O 2 respectively, forming a built-in calibration signal for ratio fluorescence detection. Based on the different detection conditions of the Hg 2+ and H 2 O 2 , the simultaneous detection of the two detection substances can be achieved with simple operation. This detection system had good stability and anti-interference ability. Under optimal conditions, the detection limit for Hg 2+ detection was 0.2 µM. Meanwhile, for the detection of H 2 O 2 , the detection limit was 11 µM and large linear ranges were obtained. Through actual sample testing, it had been proven that the ratio fluorescence sensor based on Tb-BDC-NH 2 had good application prospects. And the work also provided a new idea for double substances detection.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 7
·1-9
·
IF 5.3
Zhang Yue,Yu Wei,Zhang Wei,Lai Jinyu,Liu Lin,Wang Wei,Wang Xinghua
Abstract Ratiometric fluorescence and colorimetric strategies for detecting activity of butyrylcholinesterase (BChE) in human serum were developed by using g-C 3 N 4 nanosheets, silver ion (Ag + ) and o-phenylenediamine (OPD) as chromogenic agents. The oxidation-reduction reaction of OPD and Ag + generates 2,3-diaminophenazine (oxOPD). Under exciation at 370 nm, g-C 3 N 4 nanosheets and oxOPD emit fluorescence at 440 nm ( F 440 ) and 560 nm ( F 560 ), respectively. Additionally, oxOPD exhibits quenching ability towards g-C 3 N 4 nanosheets via photoinduced electron transfer (PET) process. Thiocholine (TCh), as a product of BChE-catalyzed hydrolysis reaction of butylthiocholine iodide (BTCh), can coordinate with Ag + intensively, and consequently diminish the amount of free Ag + in the testing system. Less amount of free Ag + leads to less production of oxOPD, resulting in less fluorescence quenching towards g-C 3 N 4 nanosheets as well as less fluorescence emission of oxOPD. Therefore, by using g-C 3 N 4 nanosheets and oxOPD as fluorescence indicators, the intensity ratio of their fluorescence ( F 440 /F 560 ) was calculated and employed to evaluate the activity of BChE. Similarly, the color variation of oxOPD indicated by the absorbance at 420 nm ( ΔA 420 ) was monitored for the same purpose. These strategies were validated to be sensitive and selective for detecting BChE activity in human serum, with limits of detection (LODs) of 0.1 U L −1 for ratiometric fluorescence mode and 0.7 U L −1 for colorimetric mode. Graphical abstract
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JOURNAL OF NANOBIOTECHNOLOGY
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2024
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IF 10.6
Jing Zhang,Liyuan Zhao,Along Liang,Xueyan Geng,Mengmeng Hou,Haojie Cheng,Shouren Zhang,Baocheng Yang,Junbo Li,Jian Chen
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease which is closely related with the overproduced reactive oxygen species (ROS), increased pro-inflammatory cytokines and disordered intestinal microbes. However, current therapeutic methods usually ignored the interrelation among the pathogenesis, and mainly focused on a single factor, inducing clinical outcomes unsatisfied. Herein, biocompatible infinite coordination polymers of drugs (Ce-SASP-RS ICPs) composed of Ce ions, FDA-approved drug sulfasalazine (SASP) and natural ingredient resistant starch (RS) were developed for synergistic treatment of IBD. The proper Ce 3+ /Ce 4+ ratio in Ce-SASP-RS ICPs can endow them with SOD-like activities, POD-like activities and •OH scavenging ability, which guarantee Ce-SASP-RS ICPs to simultaneously kill bacteria and maintain ROS balance through cascade reactions. Owing to the recovered redox balance microenvironment, SASP in Ce-SASP-RS ICPs can better play their anti-inflammatory function. Moreover, benefitting from the recovered metabolic balance of ROS and inflammatory cytokines in colon, resistant starch can also function better in modifying gut microbiota through generating short-chain fatty acids. Collectively, Ce-SASP-RS ICPs can synergistically restore intestinal metabolic microenvironment through modulating redox balance, attenuating inflammation and modifying intestinal flora. Hence, in view of the mutual influences among IBD pathogenesis, this work presents a synergistic intervention approach for effectively treating IBD.
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RARE METALS
·
2025
·
IF 11
Li Xiang,Li Gui-Dong,Chen Ye,Tian Meng-Kui
Lithium iron phosphate (LiFePO 4 , LFP) batteries have shown extensive adoption in power applications in recent years for their reliable safety, high theoretical capability and low cost. Nevertheless, the finite lifespan of these batteries necessitates the future processing of a significant number of spent LFP batteries, underscoring the urgent need for the development of both efficient and eco-friendly recycling methods. This study combines the advantages of wet leaching and direct regeneration methods, leveraging citric acid’s multifaceted role to streamline the combined leaching and hydrothermal processes. Results indicate that citric acid efficiently leaches all elements from spent LFP batteries. Furthermore, through its unique structure, it enhances hydrothermal regeneration by stabilizing metal ions and controlling crystal growth, and also acts as a carbon source for the surface carbon coating of regenerated LFP (R-LFP). The R-LFP shows outstanding electrochemical stability, achieving a discharge capacity of 155.1 mAh·g −1 at 0.1C, with a capacity retention rate of 93.2% after 300 cycles at 1C. Furthermore, economic and environmental analyses demonstrate this method’s superior cost-effectiveness and sustainability. Therefore, the method proposed in this study is efficient, simple and avoids the complex process of element separation, innovatively using a single reagent to achieve closed-loop recycling of LFP batteries, providing a novel and effective solution for the resource sustainability application. Graphical abstract
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Bioresources and Bioprocessing
·
2024
·Vol. 11
·期 1
·1-10
·
IF 4.3
Mei Jianfeng,Han Yanchao,Zhuang Shihang,Yang Zhikai,Yi Yu,Ying Guoqing
Biliverdin, a bile pigment hydrolyzed from heme by heme oxygenase (HO), serves multiple functions in the human body, including antioxidant, anti-inflammatory, and immune response inhibitory activities. Biliverdin has great potential as a clinical drug; however, no economic and efficient production method is available currently. Therefore, the production of biliverdin by the biotransformation of exogenous heme using recombinant HO-expressing yeast cells was studied in this research. First, the heme oxygenase-1 gene ( HO1 ) encoding the inducible plastidic isozyme from Arabidopsis thaliana , with the plastid transport peptide sequence removed, was recombined into Pichia pastoris GS115 cells. This resulted in the construction of a recombinant P. pastoris GS115-HO1 strain that expressed active HO1 in the cytoplasm. After that, the concentration of the inducer methanol, the induction culture time, the pH of the medium, and the concentration of sorbitol supplied in the medium were optimized, resulting in a significant improvement in the yield of HO1. Subsequently, the whole cells of GS115-HO1 were employed as catalysts to convert heme chloride (hemin) into biliverdin. The results showed that the yield of biliverdin was 132 mg/L when hemin was added to the culture of GS115-HO1 and incubated for 4 h at 30 °C. The findings of this study have laid a good foundation for future applications of this method for the economical production of biliverdin. Graphical Abstract
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-14
·
IF 14.7
Wang Chenlu,Zhou Liping,Liu Chengzhe,Qiao Jiaming,Han Xinrui,Wang Luyang,Liu Yaxi,Xu Bi,Qiu Qinfang,Zhang Zizhuo,Wang Jiale,Zhou Xiaoya,Zeng Mengqi,Yu Lilei,Fu Lei
Autonomic nervous system disorders play a pivotal role in the pathophysiology of cardiovascular diseases. Regulating it is essential for preventing and treating acute ventricular arrhythmias (VAs). Photothermal neuromodulation is a nonimplanted technique, but the response temperature ranges of transient receptor potential vanilloid 1 (TRPV1) and TWIK-related K + Channel 1 (TREK1) exhibit differences while being closely aligned, and the acute nature of VAs require that it must be rapid and precise. However, the low photothermal conversion efficiency (PCE) still poses limitations in achieving rapid and precise treatment. Here, we achieve a nearly perfect blackbody absorption and a high PCE in the second near infrared (NIR-II) window (73.7% at 1064 nm) via a Pt nanoparticle shell (PtNP-shell). By precisely manipulating the photothermal effect, we successfully achieve rapid and precise multimodal neuromodulation encompassing neural activation (41.0–42.9 °C) and inhibition (45.0–46.9 °C) in a male canine model. The NIR-II photothermal modulation additionally achieves multimodal reversible autonomic modulation and confers protection against acute VAs associated with myocardial ischemia and reperfusion injury in interventional therapy.
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JOURNAL OF POROUS MATERIALS
·
2024
·
IF 2.5
Zhang Zhizhen,Ouyang Xin,Wang Junzhang,Guo Xingzhong
Macroporous lithium manganese iron phosphate/carbon (LiFe 0.9 Mn 0.1 PO 4 /C) has been successfully synthesized via a sol-gel process accompanied by phase separation. Poly (ethylene oxide) (PEO) acts as a phase separation inducer, while polyvinylpyrrolidone (PVP) synergistically regulates the morphology of the gel skeleton and serves as a reducing agent. Propylene oxide (PO) works as a proton scavenger to initiate the homogeneous gelation and modify the macrostructure. An appropriate amount of PEO, PVP and PO led to the formation of xerogel monoliths characterized by a three-dimensional co-continuous skeleton and interconnected macropores. The amorphous xerogel upon heat treatment at 400 °C for 2 h under a N 2 atmosphere, formed carbon-coated LiFe 0.9 Mn 0.1 PO 4 /C crystals with excellent crystallinity and uniform elemental distribution. The resultant macroporous LFMP/C has a discharge capacity of 113.43 mA h g − 1 at 0.1 C, with a first coulombic efficiency of 90.1% and excellent capacity recovery rate after high-rate tests.
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Silicon
·
2025
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IF 3.3
Cui Meng-Jie,Muhammad Imran,Ren Tie-Zhen,Okitsu Kenji,Fan Wei,Zhang Xue-Jun
Rice husk ash (RHA), obtained through pyrolysis of rice husk (RH), is primarily composed of silicon dioxide (SiO 2 ). However, a conventional thermal treatment produces harmful byproducts, that can pollute the environment and harm biological health. Meanwhile, energy consumption hinders scaling up a conventional producing technique. Here, an electron-assisted thermal decomposition (EATD) technology was developed to obtain silicon dioxide (SiO 2 ), which included two mixed crystal phases: cristobalite and tridymite. The influence of temperature on the SiO 2 structure was examined through the various structural characterizations. Based on the experimental findings, we emphasized that the EATD process induced specific structural phase and glass transition owning to the radiated heat system. Notably, the prepared samples displayed the ability as a chemical sensor for Cr 6+ and photocatalyst for methylene blue (MB) degradation. This unique characteristic improved the detection signal for Cr 6+ by at least twofold, resulting in a streamlined detection technique that reduced the risk of secondary pollution.
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Journal of Coatings Technology and Research
·
2024
·
IF 2.3
Xu Rongkang,Ye Hong,Wu Mingyuan,Wu Qingyun,Yang Jianjun,Liu Jiuyi,Zhang Jianan
Superamphiphobic coating with excellent optical transmittance has immense potential for utilization in many fields. However, it is challenging to maintain superamphiphobic surface with high transparency. Herein, a lotus leaf-inspired double-layered coating is proposed. The bottom layer of the coating consisted of fluorosilane-modified epoxy resin, while the top layer was composed of fluorosilane-modified SiO 2 and cellulose nanofibers (CNFs). The trends of optical transmittance and oil-water contact angle of the coating at different mass ratios between SiO 2 and CNFs were systematically investigated, and the stability of the coating was further studied by means of immersion in water, tape peeling, falling sand abrasion, and ultraviolet radiation. Experimental results showed that the coating exhibited the best comprehensive performance when the mass ratio of SiO 2 to CNFs was 1:1. The coating exhibited optical transmittance of 79%, while the contact angles of water, glycerol, glycol, and hexadecane were up to 169°, 163.5°, 155.2°, and 125.4°, respectively. Even after the stability test, the coating still showed a good superamphiphobic performance. This demonstrates that the coating exhibited excellent optical transmittance, good chemical stabilities, and high mechanical stability. Graphical abstract
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Electrocatalysis
·
2024
·Vol. 15
·期 4
·281-290
·
IF 2.7
Xiang Qun,Wang Yizhong,Wang Shuang,Fu Xucheng,Gao Guiqi,Yan Ruiwen
In this work, the CeO 2 nanoparticles were dispersed onto the surface of graphene oxide (GO), followed by electrodeposition of Pt–Pd alloy nanoparticles on the CeO 2 surface to fabricate Pt–Pd@CeO 2 /graphene oxide composites (Pt–Pd@CeO 2 /GO). Morphological investigation was conducted using X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). The results of morphological characterization revealed that CeO 2 nanoparticles acted as cores, while Pt–Pd alloy nanoparticles formed shells. The electrocatalytic oxidation performance of Pt–Pd@CeO 2 /GO composites for methanol electro-oxidation reaction (MOR) was systematically investigated. The mass activity for MOR on Pt 1 Pd 1.3 @CeO 2 /GO electrocatalyst was 1128 mA·mg Pt+Pd −1 , which was 5.0-fold higher than that of Pt/C catalysts. The synergistic effect between Pt and Pd, along with the active oxygen-containing species of CeO 2 effectively enhanced catalytic activity. This work presents a novel approach to developing catalysts with high catalytic performance for MOR. Graphical Abstract
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