Food Packaging and Shelf Life
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2022
·
IF 8.749
Xingzi Lan,Tingting Luo,Zhixin Zhong,Dongchao Huang,Chengfeng Liang,Yurong Liu,Han Wang,Yadong Tang
Gelatin nanofibrous membrane has attracted increasing attention as biodegradable and edible food packaging. However, the lack of bioactivity and the weak water resistance of gelatin nanofibrous membrane severely limits its application in food preservation. Therefore, in this study, antioxidant agent tea polyphenol (TP) and antibacterial agent ε-poly ( L -lysine) (ε-PL) were incorporated into gelatin nanofibrous membrane. To enhance the water resistance, the TP and ε-PL loaded gelatin nanofibrous membrane was cross-linked at high temperature. And the antibacterial activity and antioxidant activity of gelatin/TP/ε-PL nanofibrous membrane after cross-linking were investigated. The results showed that the gelatin/TP/ε-PL nanofibrous membrane exhibited homogenous bead-free structure. The UV–vis spectra confirmed the successful incorporation of TP and ε-PL into nanofibers . The water contact angle of the gelatin/TP/ε-PL nanofibrous membrane after cross-linking was increased. The fabricated nanofibrous membrane could prevent microbial penetration. And the nanofibrous membrane still exhibited excellent antibacterial activity and antioxidant activity after cross-linking. Finally, the MTT assay demonstrated the biocompatibility of nanofibrous membrane. The above results suggested that the prepared gelatin/TP/ε-PL nanofibrous membrane exhibited great potential in bioactive food packaging.
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INDUSTRIAL CROPS AND PRODUCTS
·
2023
·
IF 5.9
Shuai Zhang,Huangjingyi Chen,Zicong Shi,Ying Liu,Liang Liu,Juan Yu,Yimin Fan
A green and effective method was proposed for producing amino cellulose nanofibers (ε-PL-TOCNs) with a yield of > 60%, which was obtained via ε-poly- L -lysine-grafting of 2, 2, 6, 6-tetramethylpiperidine-N-oxyl (TEMPO)-oxidized cellulose (TOC). The different carboxyl group content of TOC, EDC/NHS molar ratio and their adding ways, ε-poly- L -lysine concentration on the yield, amino content and physicochemical properties of ε-PL-TOCNs were systematically investigated and optimized. The ε-PL-TOCNs with the characteristics of enhanced thermal stability, improved mechanical strength, and fluorescence properties was successfully produced. Moreover, the ε-PL-TOCNs was zwitterionic with both anionic and cationic charges due to the co-existence of carboxyl and amino groups, thus showed excellent dispersion stability in a wide pH range except for the isoelectric point around pH 9. Notably, the ε-PL-TOCNs possessed an excellent anti-microbial effect (>99%) against Escherichia coli and Saccharomyces cerevisiae at 200 μg/mL loading dosage because of the positive role of amino groups, which made it applicable to extend the freshness of fruits. This preparation approach of amino cellulose nanofibers was advantageous over traditional methods owing to green and efficient methods, which expanded the application of cellulose nanofibers in anti-microbial agent and food preservation.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Liang Cheng,Shuilai Qiu,Jing Wang,Weijian Chen,Jingwen Wang,Wenxiang Du,Lei Song,Yuan Hu
Human health is being seriously harmed by tumors. In order to obtain excellent anti-tumor effects, platinum (Pt) nanozyme-modified black phosphorus (BP) loading with L -Arginine (LArg) (BPPL) is prepared to realize nitric oxide (NO) therapy and sonodynamic therapy (SDT), achieving a synergistic effect to therapy. In this system, BP is utilized as the sonosensitizer. Pt can catalyze the decomposition of hydrogen peroxide (H 2 O 2 ) to produce oxygen (O 2 ) and relieve the hypoxic environment of tumor tissue. The increase in O 2 concentration is conducive to the generation of ROS under ultrasound (US) stimulation. The deposition of precious metals hinders the recombination of some electrons (e ) and holes (h + ), and further improves the yield of reactive oxygen species (ROS). LArg is employed as the exogenous NO supplementation. Under the stimulation of US and ROS, NO is generated to cause further cell apoptosis. Tests in vitro and in vivo have proved the great potential of the combination of SDT and gas therapy in tumor treatment.
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FOOD RESEARCH INTERNATIONAL
·
2022
·
IF 7.425
Zuoyong Zhang,Shudong He,Luji Zhang,Xinjiang Li,Risheng Jin,Qian Liu,Shuguan Chen,Junhui Wang,Hanju Sun
Vegetable oils with different unsaturated degrees (corn > peanut > olive > palm > coconut) and corresponding enzymatic hydrolysis-thermal oxidation (ENTH) oils were added into D-xylose and L-cysteine Maillard reaction (MR) system, respectively, for potential meaty aroma production. Results indicated that coconut oil and palm oil had lower peroxide, p -anisidine, total antioxidant values, and malondialdehyde content after ENTH and MR. Corn, peanut, and olive oils after ENTH could significantly promote MR because they caused the lower pH, higher reactants depletion, and higher browning degree in the water phase separated from the oil-Maillard reaction system. Additionally, the volatiles were mainly formed from oil phase. Corn, peanut, and olive oils were beneficial to volatiles formation in the oil-MR system due to fatty acid oxidation, especially oleic acid and linoleic acid. Meanwhile, compared to raw oils, adding ENTH oils to the MR system could reduce the content of oxygen, nitrogen, and sulfur-containing heterocycles.
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高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2022
·
IF 3.656
Yue Chen,Shaobin Li,Li Zhang,Tao Jing,Jianxin Wang,Lijie Zhao,Fengbo Li,Chao Li,Jingyu Sun
Rational design and constructed new electrode material as high performance electrochemical sensor with outstanding selectivity, reproducibility and stability is an urgent demand for trace detection. Herein, a novel Ce-MOF/Ti 3 C 2 T X MXene composite as electrochemical sensor for L-Tryptophan (L-Trp) was constructed by utilizing the three-dimensional straw-sheaf-like Ce-MOF and Ti 3 C 2 T X MXene nanosheets . The combination of Ce-MOF and Ti 3 C 2 T X MXene not only significantly improves the conductivity of metal-organic framework (MOF) but also effectively prevents the stacking of Ti 3 C 2 T X MXene nanosheets. The electrochemical properties of the proposed sensor were investigated by electrochemical techniques in detail. The L-Trp sensor exhibits a wide linear range (0.2 μM–139 μM) and a low limit of detection (0.19 μM, S/N = 3). Moreover, the proposed sensor exhibits excellent selectivity, good reproducibility and long-term stability, as well as satisfactory practical ability in real blood serum samples.
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INDUSTRIAL CROPS AND PRODUCTS
·
2022
·
IF 6.449
Peng Zhou,Min Zheng,Xiangzhou Li,Jun Zhou,Yaxuan Shang,ZhaoShuang Li,Limin Qu
With the proposal of the Paris Climate Agreement and double carbon policy, production enterprise is now facing green and low-carbon transformation. To promote green and low-carbon development, optimizing the production process and improving utilization rate of raw materials for the reduction of production cost is an significant technological path for the plant extract industry. Thus, the aim of this work was to develop a consecutive extraction process of pectin and hesperidin with lower cost and higher purity, as well as better properties of extract. The process parameters will be put forward through single-factor experiments, Plackett-Burman design and Box-Behnken design. The experimental results showed that the consecutive extraction process was effective and feasible. Pectin with excellent properties was obtained, and the solid-liquid ratio of extraction process parameters of hesperidin was reduced to 1:8 (g: mL). The problems of environmental pollution and high energy consumption in traditional extraction could be solved. The consecutive extraction process, an innovative, economic and environmental-friendly process, may be realized easily in industrial application. At the same time, the consecutive extraction process mechanism was revealed with the help of microscopy analysis of the plant tissue structure. The results demonstrated that preferential extraction of pectin process was helpful for the exposure and dissolution of hesperidin crystallization in cells and thus can improve extraction efficiency of hesperidin. The purity of the obtained hesperidin was up to 91.7%, which can be further purified depending on application requirements. A large amount of pectin was obtained (23.3% ± 0.5% yield), and the pectin has superior gel-property, strong antioxidant activity and certain antibacterial activity. The pectin and hesperidin obtained will have better application prospects in medicine and food because of their unique characteristics.
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MATERIALS & DESIGN
·
2022
·
IF 9.417
Fan Liu,Lei Xue,Li Xu,Jun Liu,Chungang Xie,Cen Chen,Yi Liu
The development of bioactive carrier with controlled delivery of Bone morphogenetic protein (BMP-2) is an important part in bone regeneration. Our study fabricated novel modified nanomaterials based on poly-l-lysine functionalized graphene oxide (GO-PLL) and explore its potential applications for BMP-2 delivery. GO-PLL was used to modify BMP-2 encapsulated bovine serum albumin (BSA) nanoparticles (GO-PLL/BMP-2) by self-assembling technology. The physiochemical and biological properties of GO-PLL modified BSA nanoparticles were investigated in vitro . Additionally, rabbit calvarial bone defects were created to investigate bone formation ability in the presence of GO-PLL/BMP-2 loaded alginate/gelatin scaffolds. The results suggested BSA particles were spatially interacted with GO-PLL complexes by strong electrostatic attraction. When compared with BMP-2 encapsulated BSA nanoparticles, a pronounced decrease in BMP-2 gentle release was observed in the presence of GO-PLL/BMP-2 nanoparticles, and extended to over 14-day release periods. More importantly, GO-PLL/BMP-2 nanoparticles significantly enhanced alkaline phosphatase activity (ALP) and matrix mineralization, and exhibited favorable bone formation ability when loaded into alginate/gelatin scaffolds. These results demonstrated that PLL functionalized GO complexes are considered as appropriate delivery system for BSA modification, and have great potential for BMP-2 delivery in bone regeneration.
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MICROCHEMICAL JOURNAL
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2022
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IF 5.304
Jilan Qi,Xiaolei Zhang,Qiangyan Zhang,Ying Xue,Fei Meng,Yuanhua Liu,Gongjun Yang
In this work, a “signal on” electrochemiluminescence (ECL) strategy was proposed to detect Apolipoprotein-A1 (Apo-A1), a common tumor biomarker for bladder cancer. The tris(2,2′-bipyridyl)-ruthenium(II) [Ru(bpy) 3 2+ ] was used as luminophor captured by three-dimensional (3D) zinc oxalate metal–organic frameworks (MOFs), which constructed as the ECL nanoprobe (Ru-MOF) for detecting Apo-A1. Meanwhile, L-cysteine (L-Cys) as the co-reactant was connected to the [email protected] core–shell nanostructure through Au-S bond, which was directly modified on the glassy carbon electrode (GCE) to significantly reduce the electron transfer distance between the luminophor and co-reactant. The ECL intensity was “signal on” when the ECL probe of Ru-MOF was linked to the electrode by the immunoreaction of antigen–antibody. Based on these principles, the quantitative relationship between the concentration of Apo-A1 and the ECL intensity was obtained in the range of 1.00 fg·mL −1 to 1.00 ng·mL −1 with a linear coefficient of 0.9968. The proposed ECL immunosensor showed some great advantages, such as simplification, rapidity, stability and selectivity. It was also successfully applied for the determination of Apo-A1 in real serum and urine samples with the recovery of 98.0% ∼ 115.0% (RSD < 5.2%). To sum up, a “signal on” ECL immunosensor was successfully constructed for Apo-A1 detection, and it may facilitate the diagnosis of bladder cancer in clinic.
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CHEMOSPHERE
·
2022
·
IF 8.943
Zhihong Li,Danquan Lan,Zuji Li,Jiangli Sun,Shuo Chen,Jinhang Yang,Jingwen Wei,Zebing Yu,Shuangfei Wang,Yanping Hou
Development of efficient photocatalysts for efficient recalcitrant organic pollutants degradation is of great significance. Herein, the step-doped disulfide vacancies S-scheme Cu 3 SnS 4 /L-BiOBr (CTS/L-BiOBr) heterojunction photocatalyst was prepared for ciprofloxacin (CIP) degradation. X-ray photoelectron spectroscopy (XPS) analysis, ultraviolet photo-electron spectroscopy (UPS) analysis, band structure and dominant radicals’ identification together verified that the transfer of photogenerated carriers conformed to the S-scheme mechanism. Benefited from the interfacial electric field (IEF) of the S-scheme heterojunction and incorporation of L-cysteine with introducing S-vacancies and surface functional groups (-NH 2 , -COO - ), photogenerated charges generation and separation of the CTS/L-BiOBr (10) were greatly improved. With ·OH and h + as dominant reactive species, CIP removal reached 93% using CTS/L-BiOBr (10) within 180 min of visible light irradiation, which was 3.5 times and 2.6 times of pristine Cu 3 SnS 4 and L-BiOBr, respectively. Moreover, possible CIP degradation pathways were proposed and the degradation intermediates ecotoxicity were evaluated. This study could provide reference for designing efficient S-scheme photocatalysts for recalcitrant wastewater treatment .
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2022
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IF 10.753
Kangling Tang,Yu Chen,Sisi Tang,Xiaodan Wu,Pengfei Zhao,Jinli Fu,Huibin Lei,Zhaoxia Yang,Zhaohui Zhang
Establishment of a rapid, sensitive, visual, accurate and low-cost fluorescence detection system to detect multiple targets was of great significance in food safety evaluation, ecological environment monitoring and human health monitoring. In this work, a smartphone-assisted down/up-conversion dual-mode ratiometric fluorescence sensor was proposed based on metal-organic framework (NH 2 -MIL-101(Fe)) and CdTe quantum dots (CdTe QDs) for visual detection of mercury ions (Hg 2+ ) and L-penicillamine (L-PA), in which NH 2 -MIL-101(Fe) was used as the reference signal and CdTe QDs was used as the response signal. The down-conversion fluorescence system at excitation wavelength of 300 nm (ex: 330 nm) was used to detect Hg 2+ and L-PA, in which the detection limit of Hg 2+ was 0.053 nM with the fluorescence color changed from green to blue, and the detection limit of L-PA was 1.10 nM with the fluorescence color changed from blue to green. Meanwhile, the up-conversion fluorescence system at excitation wavelength of 700 nm (ex: 700 nm) was used to detect Hg 2+ and L-PA. The detection limits of Hg 2+ and L-PA were 0.11 nM and 2.93 nM, respectively. The detection of Hg 2+ and L-PA were also carried out based on the color extraction RGB values identified by the smartphone with a detection limit of 0.091 nM for Hg 2+ and 8.97 nM for L-PA. In addition, the concentrations of Hg 2+ and L-PA were evaluated by three-dimensional dynamic analysis in complex environments. The smartphone-assisted down/up-conversion dual-mode ratiometric fluorescence sensor system provides a new strategy for detection Hg 2+ and L-PA in food safety evaluation, environmental monitoring and human health monitoring.
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Membranes
·
2022
·Vol. 12
·期 6
·568
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IF 4.562
Huijie Yu,Chi Zhang,Yao Xie,Jun Mei,Jing Xie
This study aimed to develop active films based on carboxymethyl chitosan (CMCS)/locust bean gum (LBG) films containingMelissa officinalisL. essential oil (MOEO) nanoemulsions. The results showed that the active films incorporated with MOEO nanoemulsion resulted in an increase in the elongation of break, water resistance and improved the film hydrophilicity. Elongation of break increased from 18.49% to 27.97% with the addition of 4% MOEO nanoemulsion. Water resistance was decreased from 56.32% to 25.43%, and water contact angle was increased from 75.13 to 83.86 with the addition of 4% MOEO nanoemulsion. However, the water vapor barrier properties and tensile strength decreased with the addition of MOEO nanoemulsions. The scanning electron microscopic images and Fourier transform infrared spectroscopy results showed that the MOEO was very compatible with the film materials and dispersed evenly in the films. At the same time, the addition of MOEO nanoemulsion significantly enhanced antioxidant and antibacterial activities of C/L-MOEO films. The antioxidant and antimicrobial activities of C/L-MOEO films were increased from 7.16% to 33.81% and 3.52% to 54.50%, respectively. In general, C/L-MOEO film has great application prospects.Keywords:essential oil;active film;nanoemulsions;antibacterial activity
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AAPS PHARMSCITECH
·
2022
·Vol. 23
·期 7
·1-10
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IF 4.026
Lv Jianhua,Ou Xiaoyu,Fang Yaru,Wu Mi,Zheng Fanghao,Shang Lei,Lei Kaijun,Liu Yunen,Zhao Yan
Deep eutectic solvents (DESs) based on choline chloride (C) and l -(+)-tartaric acid diethyl ester (L) were prepared and used in transdermal drug delivery system (TDDS). The internal chemistry structure including the formation and changes of hydrogen bonds of choline chloride and l -(+)-tartaric acid diethyl ester DES was characterized via attenuated total reflection Fourier transform infrared (ATR-FTIR) and 1 H nuclear magnetic resonance ( 1 H NMR) spectroscopy. The stoichiometric ratio of choline chloride to l -(+)-tartaric acid diethyl ester as well as water content affected the viscosity, glass transition temperature ( T g ), and drug solubility of the DES. The viscosity and glass transition temperature of the DES (CL14) prepared at the ratio of 1:4 of choline chloride to l -(+)-tartaric acid diethyl ester were 1.19 Pa·s and − 44.01°C, respectively, and decreased to 0.10 Pa·s and − 55.31°C when 10% water (CL1410) was added. Taking diclofenac diethylamine (DDEA), the nonsteroidal anti-inflammatory drug as model, drug solubility was as high as 60 mg/ml and 250 mg/ml in CL14 and CL1410, respectively. The cumulative amount of DDEA was 4.63 ± 2.67 μg/cm 2 and 15.27 ± 4.63 μg/cm 2 for CL14 and CL1410, respectively, at 8 h. The mechanism of percutaneous permeability by the DES may be the disturbance of stratum corneum (SC) lipids as well as changes in the protein conformations. CL14 and CL1410 were also verified as low-cytotoxic and nonirritant. Therefore, the DESs studied are promising to be used in drug solubilization enhancement and transdermal drug delivery system. Graphical abstract
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危险品化学品经营许可证（带存储）