EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2013
·
IF 3.499
Dacheng Fan,Weizhi Sun,Peiju Qiu,Zhiyong Wu,Yantuan Li,Shengbiao Wan,Tao Jiang,Lijuan Zhang
We synthesized a series of novel 3-indolyl cyclopent[ b ]indoles by trifluoroacetic acid mediated cyclodimerizations . The reaction showed high stereoselectivity and moderate to good yields. The influencing factors for stereoselectivity were systematically analyzed and a stepwise reaction mechanism was proposed. The cell viability tests in two colon and two lung cancer cell lines indicated the 1-benzyl-2-phenyl-group in 3-indolyl cyclopent[ b ]indoles was critical for the observed lower IC 50 s in these compounds. Western blot analysis demonstrated that the compound inhibited the expression and phosphorylation of EGFR through altered HSP90 expression. Further cell cycle and cell cycle check point protein analyses showed expected anti-cellular proliferation and cell cycle arresting properties associated with suppressed EGFR expression and phosphorylation. These data revealed a novel molecular mechanism explaining the observed cytotoxicities for these compounds.
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高影响因子
JOURNAL OF MOLECULAR NEUROSCIENCE
·
2025
·Vol. 76
·期 1
·4
·
IF 2.7
Wu Zhixuan,Wang Dianyi,Yao Jing,Zhang Yue,Liu Jiayu
Background Migraine is a complex neurological disorder. While acupuncture is effective in alleviating migraines, its molecular mechanisms remain unclear. This study aims to explore these mechanisms. Methods We used bioinformatics to identify differentially expressed microRNAs (miRNAs) in migraine patients after acupuncture. Subsequently, luciferase reporter assays were utilized to verify the interaction between miRNAs and their regulated target gene mRNAs. RT-qPCR and Western blot analyzed key miRNAs’ regulatory effects on target genes. We also employed Transwell migration assays and a nitroglycerin (NTG)-induced migraine mouse model to systematically evaluate acupuncture’s efficacy and mechanism. Results Bioinformatics analysis revealed a significant upregulation of Hsa-miR-550a-3-5p in the peripheral blood of migraine patients after acupuncture treatment. Hsa-miR-550a-3-5p could directly inhibit the mRNA and protein expression of platelet and endothelial cell adhesion molecule 1 (PECAM1), reducing nitroglycerin-induced human brain microvascular endothelial cells (HBMECs). Following the downregulation of PECAM1 by hsa-miR-550a-3-5p, the transendothelial migration capacity of monocytes-macrophages was significantly reduced, and reducing the secretion of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6. Furthermore, it alleviates inflammation by regulating M2 macrophage polarization. In NTG-induced mice, acupuncture relieved migraine-like behaviors, an effect abolished by a miR-550a-3-5p inhibitor. Conclusion This study is the first to reveal that after acupuncture treatment, hsa-miR-550a-3-5p can be upregulated to target and inhibit PECAM1, reducing the transendothelial migration of inflammatory cells and the release of inflammatory cytokines, thereby alleviating migraine symptoms. This discovery provides scientific evidence for the efficacy of acupuncture and offers a new target for developing miRNA-based precision treatment strategies.
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Bioengineered
·
2021
·
IF 3.269
Na Li,Xueyuan Guo,Rui Li,Jian Zhou,Fangfang Yu,Xianliang Yan
Macrophage infiltration is a hallmark pathological change observed in early stage myocardial ischemia/reperfusion (MI/R) injury and one of the main causes of myocardial damage. Here, we investigated the effects of p-Coumaric acid (p-CA) on macrophage polarization following MI/R injury and its mechanisms. In vitro, p-CA decreases the expression of LPS/IFN-γ-induced M1 macrophage markers (TNF-α, IL-6, iNOS and CCL2) and increases IL-4-induced M2 macrophage markers (IL-10, CD206, Arg1 and Mrc) in mouse bone marrow-derived macrophages (BMDMs). Additionally, p-CA elevated indoleamine 2, 3-dioxygenase (IDO) protein expression levels, M2 macrophage polarization and M2 macrophage markers through IL-4. In contrast, repression of IDO attenuated p-CA functions regulating BMDMs through IL-4. In vivo, IDO expression was downregulated in mouse hearts subjected to MI/R injury. Treatment of p-CA increased IDO expression in the hearts of MI/R mice. Functionally, p-CA decreases M1 macrophage markers, the number of M1 macrophages and inflammation around heart tissue following MI/R injury. Importantly, p-CA reduces cardiomyocyte apoptosis caused by MI/R. Altogether, our study identified that p-CA modulates macrophage polarization by promoting IDO expression and that p-CA attenuates macrophage-mediated inflammation following MI/R by promoting M2 macrophage polarization through IDO.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-20
·
IF 9.429
Deng Han,Shang Wenting,Wang Kun,Guo Kunxiong,Liu Yu,Tian Jie,Fang Chihua
Despite advancements in diagnostic methods and therapeutic strategies, the mortality rate of hepatocellular carcinoma (HCC) remains as high as its incidence rate. Most liver cancers are detected in the advanced stages, when treatment options are limited. Small HCC is difficult to diagnose and is often overlooked by current imaging methods because of the complexity of the liver environment, especially in cirrhotic livers. In the present study, we developed a tumor “cruise missile”, mesoporous Fe 3 O 4 -containing glucose oxidase-conjugated GPC3 peptide nanoparticles (FGP NPs). It was designed to enhance the accuracy of small HCC visualization to 85.7% using combined ultrasound/photoacoustic imaging in complex liver environment, which facilitated sequential catalytic targeted therapy for small HCC. In a carcinogen-induced mouse HCC model, FGP NPs could be used to accurately diagnose HCC in a liver cirrhosis background as well as distinguish HCC nodules from other abnormal liver nodules, such as cirrhosis nodules and necrotic nodules, by dynamic contrast-enhanced photoacoustic imaging. In a mouse xenograft HCC model, highly reactive oxygen species were formed by sequential catalytic reactions, which promoted HCC cell apoptosis, significantly increasing the survival of the model mice. The present study provides a basis for the precise detection and elimination of small HCCs in the complex liver environment. Graphical Abstract
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高影响因子
Journal of Energy Storage
·
2025
·
IF 9.8
Liqin Xiong,Zheng Cheng,Guorong Hu,Yanbing Cao,Zhongdong Peng,Bin Zhang,Ke Du
High-voltage spinel LiNi 0.5 Mn 1.5 O 4 (LNMO) emerges as an ideal cathode for high energy density lithium-ion batteries due to its 4.7 V operating voltage and low-cost manganese-rich composition. However, the severe interfacial degradation caused by transition metal dissolution and pervasive electrolyte decomposition compromises practical viability in commercial lithium-ion batteries, critically under elevated-temperature operation. To address this problem, we constructed a covalently anchored bis[3-(trimethoxysilyl)propyl]amine (BTPA) coating layer on the LNMO surface through atomic-scale grafting. The BTPA-coated LNMO confers exceptional cyclic stability and rate capability, representing a transformative advancement in cathode performance. At 50 °C, BTPA-coated LNMO cathode maintains 96.10 % capacity retention after 100 cycles at 1C, significantly outperforming pristine LNMO (58.92 % retention), while demonstrating exceptional rate capability with 109.42 mAh·g −1 delivered at 10C compared to 92.71 mAh·g −1 for the pristine LNMO. The synergistic suppression of Mn 3+ formation and parasitic reactions underpins unprecedented high-temperature cyclability, establishing a paradigm for extreme-condition energy storage.
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高影响因子
SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2025
·
IF 6.3
Mengzhu Li,Yanqing Wang,Zhiping Fang,Dongchen Guo,Min Fan,Hui Dai,Fuling Guo,Wangchao Chen,Chengwu Shi,Peng Cui
Antimony selenosulfide (Sb 2 (S,Se) 3 ) demonstrates strong potential for thin-film solar cells owing to its tunable bandgap, low toxicity, and high stability. However, conventional fabrication methods often yield films with small grain sizes and random orientations, which hinder device performance. Herein, an in situ polymerization-assisted grain growth (iPAGG) strategy was developed, specifically enabling the oriented growth of Sb 2 (S,Se) 3 on Cd-free TiO 2 substrates, by introducing acrylic acid (AA) into the chemical bath deposition process. The carboxylate groups from AA coordinate with Sb 3+ ions, promoting oriented growth of Sb 2 (S,Se) 3 film. This approach yields films with enlarged grains, reduced defect densities, and strengthened [ hk 1] preferred orientation. As a result, Cd-free Sb 2 (S,Se) 3 solar cells employing the optimized AA concentration yielded a champion power conversion efficiency (PCE) of 7.24%, outperforming the control device (6.70%). Further interfacial modification with poly (acrylic acid)-modified SnO 2 boosts the PCE to 7.55%. This work offers an effective way toward the fabrication of high-performance and environmentally friendly Sb 2 (S,Se) 3 photovoltaics.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Zhijuan Li,Minghao Hou,Baoye Yao,Chuhan Ma,Shitong Zhang,Honglei An,Yichen Liu,Haibao Duan,Tongfei Li,Yawen Tang
The development of high-entropy alloy (HEA) nanocatalysts with ultrasmall size and hollow structures is vital yet challenging for efficient hydrogen evolution reaction (HER) across all pH conditions. Herein, we present a mild and facile hydrothermal strategy for synthesizing hollow PtRuRhCoCu HEA nanospheres (NSs) via self-assembly of sub-3 nm alloy nanoparticles directed by N , N ′-methylenebisacrylamide (MBAA). The resulting PtRuRhCoCu HEA features a multielement composition, interconnected hollow architecture, and well-dispersed ultrafine particles, providing abundant active sites and strong synergistic electronic interactions. As a result, the PtRuRhCoCu HEA catalyst achieves remarkable HER activity with low overpotentials of 10 mV (1 M KOH), 15 mV (0.5 M H 2 SO 4 ) and 30 mV (1 M phosphate-buffered saline, PBS) at 10 mA cm −2 , outperforming commercial Pt black. Moreover, this catalyst also exhibits outstanding long-term stability across a broad pH range, operating continuously for 80 h under alkaline conditions at various current densities without noticeable degradation. The density functional theory (DFT) calculations confirm that this HEA exhibits optimized hydrogen adsorption energy and electronic structure. When integrated into a full electrolyzer, it delivers a cell voltage of 1.48 V at 10 mA cm −2 , demonstrating great potential for water splitting. This work presents an effective design strategy for next-generation HEA electrocatalysts toward green hydrogen production.
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高影响因子
Energy & Environmental Materials
·
2022
·Vol. 6
·期 6
·e12531
·
IF 13.443
Tian Gu,Likun Chen,Yanfei Huang,Jiabin Ma,Peiran Shi,Jie Biao,Ming Liu,Wei Lv,Yanbing He
The poor contact and side reactions between Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 (LATP) and lithium (Li) anode cause uneven Li plating and high interfacial impendence, which greatly hinder the practical application of LATP in high-energy density solid-state Li metal batteries. In this work, a multifunctional ferroelectric BaTiO 3 (BTO)/poly(vinylidene fluoride-co-trifluoroethylene-co-chlorotrifluoroethylene) (P[VDF-TrFE-CTFE]) composite interlayer (B-TERB) is constructed between LATP and Li metal anode, which not only suppresses the Li dendrite growth, but also improves the interfacial stability and maintains the intimate interfacial contact to significantly decrease the interfacial resistance by two orders of magnitude. The B-TERB interlayer generates a uniform electric field to induce a uniform and lateral Li deposition, and therefore avoids the side reactions between Li metal and LATP achieving excellent interface stability. As a result, the Li/LATP@B-TERB/Li symmetrical batteries can stably cycle for 1800 h at 0.2 mA cm −2 and 1000 h at 0.5 mA cm −2 . The solid-state LiFePO 4 /LATP@B-TERB/Li full batteries also exhibit excellent cycle performance for 250 cycles at 0.5 C and room temperature. This work proposes a novel strategy to design multifunctional ferroelectric interlayer between ceramic electrolytes and Li metal to enable stable room-temperature cycling performance.
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高影响因子
Advanced Science Letters
·
2013
·Vol. 19
·期 4
·1226-1228
·
IF 0
Chao Guoku,Shao Lianping,Yao Shuai,Hong Liming,Li Dashuai,Xiong Jing
7 Aza-Michael adducts, 3-(5-substituted-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid ethyl esters were synthesized by 5-subtituted uracils and ethyl acrylate with ammonia as a catalyst. It was significant that the synthetic compounds were collected in almost quantitive yields
without column chromatography. The structures of the compounds were determined by NMR, mass spectra, X-ray crystallography analyses and elemental analyses.
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JOURNAL OF LUMINESCENCE
·
2021
·
IF 3.599
Qinling Li,Chao Chen,Bingqing Shen,Bingcheng Yu,Yuepin Zhang
A series of Bi 3+ /Eu 3+ co-doped Ba 3 Y(BO 3 ) 3 red-emitting phosphors were successfully prepared by the combustion method. The crystal structure and photoluminescence properties of the as-prepared phosphors were investigated by X-ray powder diffraction, photoluminescence excitation and emission spectra . In this paper, the Bi 3+ ion was employed as a sensitizer to improve the red emission intensity of Eu 3+ . The optimal doping concentration of Bi 3+ was 1 mol%. The observed excitation broad bands centered at 300 nm confirmed Bi 3+ ion doped into the Ba 3 Y(BO 3 ) 3 host. The red emission intensity of Eu 3+ was significantly enhanced by doping a small amount of Bi 3+ . Furthermore, Bi 3+ /Eu 3+ co-doped phosphor possessed admirable thermal stability (the emission intensity of studied phosphor at 423 K maintained 80.7% of the initial intensity at room temperature). The results manifest that Bi 3+ ion is an efficient sensitizer for Eu 3+ ion and Ba 3 Y(BO 3 ) 3 : 24 mol% Eu 3+ , 1 mol% Bi 3+ phosphors possess a great potential for applications in white LEDs.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Dan Li,Yong Kang
A novel class of hybrid solvents (mEIP:Tetz) comprising of N-methylated ethylene imine polymer (mEIP) and 1-ethyl-3-methylimidazolium tetrazolate ([Emim][Tetz]) were developed for the highly efficient and reversible capture of SO 2 . The synergistic interactions rather than simple mixing between mEIP and [Emim][Tetz] were confirmed by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR) and density functional theory (DFT) calculations. Besides, it was experimentally demonstrated that mEIP:Tetz mixtures exhibited improved kinetics for SO 2 absorption, and the production of viscous solids were completely eliminated, compared with using mEIP alone. More significantly, an exceedingly high solubility of 0.308 g SO 2 ·g −1 absorbent in 2mEIP:8Tetz was received for trapping SO 2 from simulated flue gas containing 2000 ppm SO 2 , which was much higher than most of the results reported in previous literatures under the same conditions. Finally, the absorption and desorption mechanisms were proposed according to the results of FTIR and 1 H NMR analysis.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Shi-Ye Luo,Xiao-Tong Fan,Na-Li,Lei-Li,Yan-Xiang Bi,Li-Peng Du,Guang-Gang Xiang,Xiang-Xin Li,Xiao-Ming Fang
Kaempferol-3-O-sophoroside was a marker of Gentiana macrophylla Pall. • monofloral honey (GH). • SEM and UHPLC–DAD-QTOF-MS/MS enabled reliable botanical authentication of GH. • GH was enriched in flavonoids and phenolics compared with common honeys. • GH exhibited significant antioxidant and antibacterial activities. As a medicinal plant–derived honey, Gentiana macrophylla Pall. monofloral honey (GH) remains insufficiently characterized in terms of botanical authentication and characteristic chemical markers. The objective of this study was to identify a marker compound for GH and to evaluate the physicochemical characteristics and bioactive properties. The botanical origin of GH was verified by SEM observation, revealing that Gentiana macrophylla Pall. pollen grains are monad, isopolar, radially symmetrical, with a tricolporate aperture system. Kaempferol-3-O-sophoroside was identified as a potential characteristic compound by UHPLC–DAD-QTOF-MS/MS, with a content of 331.06 ± 19.96 μg/kg in GH. Due to the abundant total flavonoid (34.98 ± 0.31 mg Rutin/kg) and total phenolic contents (283.68 ± 3.07 mg GAE/kg) compared with other common commercial honeys, GH exhibited significant antioxidant capacity and antibacterial activity against E. coli MG1655 and S. aureus 23,923. Consequently, kaempferol-3-O-sophoroside, as a potential authentication marker for GH, contributes to the improvement of bioactivity. Download: Download high-res image (207KB) Download: Download full-size image
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