RSC Advances
·
2022
·Vol. 12
·期 18
·11119-11127
·
IF 4.036
Bei Liu,Lirong Sun,Xijian Lu,Yuping Yang,Hongshang Peng,Zhaogang Sun,Juan Xu,Hongqian Chu
Real-time monitoring of drug release behaviors over extended periods of time is critical in understanding the dynamics of drug progression for personalized chemotherapeutic treatment. In this work, we report a metal–organic framework (MOF)-based nanotheranostic system encapsulated with photothermal agents (CuS) and therapeutic drug (DOX) to achieve the capabilities of real-time drug release monitoring and combined chemo-photothermal therapy. Meanwhile, folic acid-conjugated polyethylene glycol (FA-PEG) antennas were connected to the MOF through coordination interactions, endowing the MOF with an enhanced active targeting effect toward cancer cells. It is anticipated that such a theranostic agent, simultaneously possessing tumor-targeting, real-time drug monitoring and effective treatment, will potentially enhance the performance in cancer therapy.
研究领域:
纳米技术
·
癌症治疗
·
药物递送系统
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
VACUUM
·
2023
·
IF 4
Zhihua Liu,Qiaoling Liu,Xiaoyu He,Yihai Zhu,Qunlong Pan,Rongmou Zhang,Haiming Yu
Failure of surgical treatment is usually the result of bacterial colonization around the implant. This subsequently brings about various diseases such as peri-implantitis and sepsis. The purpose of this study was to develop and evaluate the antimicrobial properties of polydopamine adhered eggshell powder-loaded copper sulfide antimicrobial coatings. Here, we used eggshell powder-loaded copper sulfide as an antimicrobial agent to form an antimicrobial coating on the surface of titanium alloy screws using the chelating action of polydopamine. The coating showed good antibacterial effects against both Gram-positive and Gram-negative bacteria represented by Staphylococcus aureus and Escherichia coli . A series of subsequent characterizations confirmed the perfect loading of the material on the screws, and subsequent friction experiments on porcine femurs also demonstrated the good adhesion of the antimicrobial coating. Meanwhile, cytotoxicity assessment was performed by the CCK-8 method, confirming cellular biosafety. This work explores the value of eggshell-loaded CuS nanomaterial coatings in the prevention and treatment of orthopedic endothelial infections, which contributes to the translational application of novel antimicrobial materials in the clinical setting and has important social and economic value.
研究领域:
材料科学
·
生物材料
·
生物医学工程
·
抗菌技术
·
骨科
✓ 已验证
产品关联
DOI
高影响因子
Theranostics
·
2020
·
IF 8.579
Jie Yang,Dihua Dai,Xinyue Lou,Lianjun Ma,Bailiang Wang,Ying-Wei Yang
Multifunctional supramolecular nanoplatforms that integrate the advantages of different therapeutic techniques can trigger multimodal synergistic treatment of tumors, thus representing an emerging powerful tool for cancer therapeutics. Methods : In this work, we design and fabricate a multifunctional supramolecular drug delivery platform, namely Fa-mPEG@CP5-CuS@HMSN-Py nanoparticles (FaPCH NPs), consisting of a pyridinium (Py)-modified hollow mesoporous silica nanoparticles-based drug reservoir (HMSN-Py) with high loading capacity, a layer of NIR-operable carboxylatopillar[5]arene (CP5)-functionalized CuS nanoparticles (CP5-CuS) on the surface of HMSN-Py connected through supramolecular host-guest interactions between CP5 rings and Py stalks, and another layer of folic acid (Fa)-conjugated polyethylene glycol (Fa-PEG) antennas by electrostatic interactions capable of active targeting at tumor lesions, in a controlled, highly integrated fashion for synergistic chemo-photothermal therapy. Results : Fa-mPEG antennas endowed the enhanced active targeting effect toward cancer cells, and CP5-CuS served as not only a quadruple-stimuli responsive nanogate for controllable drug release but also a special agent for NIR-guided photothermal therapy. Meanwhile, anticancer drug doxorubicin (DOX) could be released from the HMSN-Py reservoirs under tumor microenvironments for chemotherapy, thus realizing multimodal synergistic therapeutics. Such a supramolecular drug delivery platform showed effective synergistic chemo-photothermal therapy both in vitro and in vivo . Conclusion : This novel supramolecular nanoplatform possesses great potential in controlled drug delivery and tumor cellular internalization for synergistic chemo-photothermal therapy, providing a promising approach for multimodal synergistic cancer treatment.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
THERMOCHIMICA ACTA
·
2023
·
IF 3.5
Lei Liu,Runfeng Li,Min Guo,Linjun Wang,Mei Zhang
In this manuscript, CuS-ZnS/SiO 2 @n-octadecane nanocapsules were prepared by a simple one-step Cu 2+ and Zn 2+ co-deposition method. The results of XRD, SEM, TEM, FTIR and XPS show that nanocapsules composed of CuS-ZnS/SiO 2 shell and n-octadecane core material were successfully prepared, and the particles deposited was proved to be composite structure of CuS-ZnS. The solution concentration, reaction temperature and pH value have significant effects on the morphology of the nanocapsules prepared. The appropriate conditions are 0.02 mol/L CuSO 4 , 0.02 mol/L Zn(CH 3 COO) 2 , 60 °C, and no additional pH adjustment. Under the optimum conditions, the melting enthalpy reached 45.11 J/g, and after 100 times of cold and hot cycles, the melting enthalpy of the sample only decreased by 3.2%, showing good thermal stability. The CuS-ZnS composite structure makes CuS-ZnS/SiO 2 nanocapsules exhibit a wider spectrum absorption performance. The absorption effect of CuS-ZnS/SiO 2 nanocapsules to ultraviolet light is significant, compared to the slight reducing of the visible light, while the absorption of near-infrared light is strong. The photothermal conversion efficiency of the samples is significantly improved from 9.7% to 86.6%. Hence, the prepared nanocapsules achieve full spectral absorption, which has a broad application prospect in solar thermal utilization.
研究领域:
材料科学
·
能源科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2023
·Vol. 11
·期 10
·3589-3602
·
IF 6.6
Bo Huang,Wei Guan,Chaofeng Wang,Shuilin Wu,Zhenduo Cui,Yufeng Zheng,Zhaoyang Li,Shengli Zhu,Hui Jiang,Paul K. Chu,Xiangmei Liu
Charge transfer and separation play a critical role in the photocatalytic efficiency of photoresponsive materials and their subsequent applications. Herein, for the first time, we constructed a homo-heterostructured S–Cu–FC/CuS modified carboxymethyl cellulose (CMC) hydrogel doped with graphene oxide (GO) (S–Cu–FC/CuS/GO@CMC) through an in situ ionic complexation reaction, which exhibited enhanced photocatalytic performance under 808 nm near-infrared (NIR) light irradiation. On the one hand, photo-excited charges can rapidly transfer across the homo-heterojunction interface with copper atoms in S–Cu–FC/CuS as both donors and acceptors. On the other hand, the interface between GO and S–Cu–FC/CuS also favors the fast transfer of photogenerated charges. Hence, with the assistance of a photothermal effect, the enhanced photocatalytic performance of S–Cu–FC/CuS/GO endowed the hydrogel with robust sterilization ability for killing 99.5% S. aureus and 100.0% E. coli under 10 min NIR light irradiation. An in vivo test disclosed that this hydrogel could also accelerate the healing of bacteria-infected wounds.
研究领域:
材料科学
·
光催化
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Rongrong Mu,Guoquan Suo,Chuanjin Lin,Jiarong Li,Xiaojiang Hou,Xiaohui Ye,Yanling Yang,Li Zhang
In recent years, aqueous zinc-ion batteries (ZIBs) have emerged as a prominent research topic due to their inherent safety attributes, relatively low cost, and comparatively higher energy density. However, the challenges associated with the zinc metal anode in the form of dendrite formation, hydrogen evolution, and severe side reactions have proven to be particularly vexing. Thus, it is imperative to investigate novel intercalation-type anode materials for ZIBs that exhibit exceptional structural properties and appropriate redox potentials based on conversion mechanisms. In this work, through adding polyvinylpyrrolidone (PVP) surfactant to precursors and tailoring reaction time, hierarchical CuS hollow spheres are successfully constructed by a facile one-step hydrothermal process. When applied as an anode in ZIBs, the hollow hierarchical CuS with large surface area can effectively reduce the transport distance of electrons and Zn 2+ and alleviate volume expansion during the insertion/extraction of Zn 2+ . The hierarchical CuS hollow spheres prepared over 8 h (CuS-8) exhibit a specific capacity of 126 mAh/g and long-term cycle life (1500 cycles) at a current density of 3 A/g. In addition, CuS-8//MnO 2 @CNTs full-cell shows a capacity retention of 117 mAh/g after 300 cycles at 1 A/g current density, which proves the advantage of hierarchical CuS hollow spheres in serving as an efficient and durable anode material for ZIBs.
研究领域:
材料科学
·
电化学
·
能量存储
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2017
·Vol. 164
·期 4
·H215
·
IF 3.259
Xiaohui Song,Jinfeng Wang,Xingna Liu,Menglin Xie,Yongyong Wang,Xiao Dong,Yong Yan,Congxin Xia
CuS nanoplate films were synthesized on FTO conducting glass substrates via a facile microwave-assisted hydrothermal (MHT) route and applied directly as a low-cost and high-efficiency counter electrode (CE) for liquid-junction quantum dot-sensitized solar cells (QDSSC). The two-dimensional structure of nanoplate provide high surface area for more active catalytic sites and easy accessibility for polysulfide electrolyte, which leads to the remarkable decrease in charge transfer resistance and the enhancement of catalytic activity of CE. As a result, the liquid-junction QDSSC assembled with the prepared CuS-2 CE achieves maximum power conversion efficiency (PCE) of 4.97%, which is superior than that of CuS fabricated by conventional chemical bath deposition method based cell (PCE 4.06%) and the 100 nm thin sputtered Pt/FTO CE based cell (PCE 3.08%). Furthermore, the prepared CuS exhibits highly chemical stability in polysulfide electrolyte, resulting in reproducible performance. These results show the potential application of MHT synthetic method in preparing metal chalcogenide CE for high-performance liquid-junction QDSSC in the future.
研究领域:
材料科学
·
能源技术
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Jiahuan Liu,Xiaowan Li,Shangyu Xie,Ruirui Ma,Hongfei Wang,Shu-Rong Ban,Chengwu Zhang,Lixia Guo
Titanium has been widely used as a bone implant material due to its high mechanical strength and good biocompatibility. However, implant-related infections and insufficient osteogenic activity can lead to implant failure or delay patient recovery. With that in mind, we fabricated one multifunctional implant coating material, PDA-NOate@CuS. In the as developed material, CuS, deposited in the outermost layer, not only significantly improved the photothermal properties of polydopamine (PDA), but also released Cu ion to effectively prevent bacterial adhesion. The NO-donor (NOate) with near-infrared irradiation, generated NO which strenthened antibacterial effect of materials. The in vitro antibacterial experiments proved that PDA-NOate@CuS displayed excellent S.aureus and E. coli inhibitory effect. MC3T3-E1 cells experiments results showed that PDA-NOate@CuS promoted cell adhesion, growth and mineralization. Moreover, in vivo study demonstrated that titanium implant coated with Ti@PDA-NOate/CuS markedly enhanced osseointegration, inhibited infection, with good biocompatibility. Present study paves ways for developing novel materials for implant modification, which would benefit the treatment of orthopedic disease.
研究领域:
生物材料
·
骨科
·
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xiaotong Mu,Xinxin Zeng,Zhiwei Xu,Hongpeng Zhang,Chenzhao Bai,Yucai Xie,Yu Liu
Solar-powered steam generation and thermoelectric generation, as sustainable green technologies, have emerged as effective strategies to tackle the worldwide issues of water and energy scarcity. However, existing photothermal interfacial evaporation materials generally suffer from low evaporation efficiency and poor energy utilization, significantly limiting its practical applications. Therefore, developing high-performance three-dimensional (3D) solar-driven interfacial evaporation materials is crucial for advancing the construction of photothermal-thermoelectric evaporation systems. Herein, inspired by the multiscale array structure of Roman broccoli, an MXene-CuS@CF interfacial evaporator based on a multiscale pyramid photothermal structure was designed and fabricated by mimicking the optical enhancement and pore transport mechanisms observed in Roman broccoli photosynthesis. Under 1 kW m −2 illumination, the evaporator achieved an evaporation rate of 3.25 kg m −2 h −1 , five times higher than pure water. The maximum output power density reached 1.52 W m −2 . After 50 evaporation cycles in simulated seawater, MXene-CuS@CF demonstrated good evaporation stability. Under outdoor sunny conditions with 8 h of natural sunlight exposure, the freshwater output reached 9.1 kg m −2 . The bionic MXene-CuS@CF interfacial evaporator significantly enhances evaporation performance and energy utilization through its multiscale structural design and efficient photothermal synergy. This research provides a novel ideas for constructing efficient and stable photothermal-thermoelectric hybrid systems in the future.
研究领域:
材料科学
·
可再生能源
·
仿生学
·
光热转换
·
海水淡化
·
热电发电
✓ 已验证
产品关联
DOI
高影响因子
RARE METALS
·
2023
·Vol. 42
·期 6
·1899-1911
·
IF 8.8
Li Zhao,Xie Cheng-Jia,Ren Xiao-Wei,Zhang Qun,Ma Bao-Jin
Nanoenzyme-mediated antibacterial strategies have been widely exploited to overcome the shortcomings (such as drug resistance and mild-to-severe side effects) of antibiotic therapy. The peroxidase-like activity of nanoenzymes possesses great potential against bacterial infection by the generation of hydroxyl radical (·OH) in the specific microenvironment. However, the lifetime of ·OH is extremely short, and a large amount of the ·OH generated within the infection microenvironment cannot come into contact with bacteria quickly enough, thus resulting in low treatment efficiency. Here, chitosan-oligosaccharide-modified CuS nanoparticles possessing positive charges (PCuS NPs) were prepared using a one-pot method. PCuS NPs exhibited efficient peroxidase-like activity. Importantly, the PCuS NPs can combine with bacteria via electrostatic attraction. The direct contact between the PCuS NPs and bacteria enabled the generation of ·OH in situ on the bacterial surface, ultimately leading to a high antibacterial efficacy at a low concentration in the presence of H 2 O 2 . At an effective antibacterial concentration, the PCuS NPs exhibited high cytocompatibility. Furthermore, in vivo results revealed that PCuS NPs not only decreased the size of abscesses but also reduced inflammation and promoted collagen fiber formation. Therefore, PCuS NPs possess great potential against bacterial infection via in situ ·OH generation based on electrostatic attraction. Graphical abstract
研究领域:
纳米技术
·
生物医学工程
·
微生物学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Xiangmei Liu,Tianshe Yang,Yifan Han,Liang Zou,Huiran Yang,Jiayang Jiang,Shujuan Liu,Qiang Zhao,Wei Huang
A scalable and low-cost strategy is developed to fabricate a novel CuS/SiO2-based nanotherapeutic agent for dual-model imaging-guided photothermal/photodynamic combined therapy. In this design, mesoporous silica nanoparticles (MSNs) with CuS bundled in the channel are obtained in aqueous solution via in situ growth route for the first time. Furthermore, to achieve a more efficient therapy, photosensitizer (complex Ir-2) and bovine serum albumin are sequentially assembled via layer-by-layer method. The as-prepared complex Ir-2 presents a remarkably high 1O2 generation (ΦΔ = 1.3) under light illumination to offer effective photodynamic cell killing, and MSN/CuS exhibits high photothermal conversion efficiency (η = 31.7%) under illumination by 808 nm light to offer hyperthermia tumor ablation. In vitro and in vivo analyses show that the as-obtained nanotherapeutic agents exhibit excellent performance in tumor therapy even under irradiation with low power because of the high yield of 1O2 combined with the high photothermal conversion efficiency. Additionally, the nanotherapeutic agents are readily visualized in vivo via near-infrared fluorescence and thermal imaging. More importantly, based on the strategy of in situ growth and layer-by-layer assembly developed in this study, the development of other “all-in-one” multifunctional theranostic platform with high efficiency can be predictable.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Research
·
2021
·Vol. 15
·期 3
·2288-2299
·
IF 8.897
Du Yan,Liu Di,Sun Mingchen,Shu Gaofeng,Qi Jing,You Yuchan,Xu Yiting,Fan Kai,Xu Xiaoling,Jin Feiyang,Wang Jun,Shen Qiying,Zhu Luwen,Ying Xiaoying,Ji Jiansong,Wu Liming,Liu Daren,Du Yongzhong
Hepatocellular carcinoma (HCC) is a life-threatening disease for which there is no effective treatment currently. Novel theranostics simultaneously having excellent imaging and therapeutic functions are highly desired in cancer therapy. Herein, we develop the sialic acid (SA) modified polymeric micelles at an upper critical solution temperature (UCST) of 43 °C (sialic acid-polyethylene glycol)-poly(acrylamide- co -acrylonitrile), SA-PEG-p(AAm- co -AN)), which further encapsulated with doxorubicin (DOX) and Gd-CuS nanoparticles (Gd-CuS NPs) for chemo-photothermal treatment of HCC guided by magnetic resonance (MR)/photoacoustic (PA) dual-mode imaging. The resultant SA-PEG-p(AAm- co -AN)/DOX/Gd-CuS (SPDG) had an excellent photothermal conversion efficiency, enabling SPDG with an instantaneous release behavior of DOX under near-infrared (NIR) irradiation. This study also revealed that SPDG could actively target to HCC, which was due to that SA had a high affinity with E-selectin overexpressed at the tumor site. Moreover, benefiting from the HCC-targeted ability and NIR light-controlled on-demand delivery of DOX, SPDG showed a superior potential in MR/PA dual-mode imaging-guided chemo-photothermal treatment. Overall, our study reveals that the designed SPDG may be used as an ideal multifunctional nanoplatform for cancer theranostics.
研究领域:
生物医学工程
·
纳米技术
·
癌症治疗
·
分子成像
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）