COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Chong Wang,Rong-Chao Xue,Ze-Zhong Lin,Xing-Ping Zhang,Pei-Yao Chen,Yu Chen,Hai-Chao Li
Flexible plasticized poly(vinyl chloride) (PPVC) is widely used in medical devices; however, achieving persistent antibiofouling functionality after significant mechanical deformation and long-term water exposure remains a critical challenge. In this work, we introduce amphiphilic heterografted multi-arm star copolymers, polyethylenimine (PEI) cores functionalized with polyethylene glycol (PEG) and poly(ε-caprolactone) (PCL) arms (denoted as PEI-g-PEG-PCLs), as multifunctional additives for modifying PPVC. Dynamic light scattering (DLS) and optical transmittance measurements confirmed the formation of PEI-g-PEG-PCL micelles within the PPVC matrix. The incorporation of PEI-g-PEG-PCLs improved not only the mechanical and thermal properties of PPVC but also its surface hydrophilicity. The resulting composites demonstrated exceptional resistance to biofouling, reducing protein adsorption by 96.2–97.3 % for bovine serum albumin and 98.0–99.8 % for lysozyme, and lowering bacterial adhesion rates to 11 % for Escherichia coli and 19 % for Staphylococcus aureus. Furthermore, platelet adhesion and hemolysis assays confirmed the biocompatibility of the PEI-g-PEG-PCL/PPVC composites. Notably, even after undergoing three cycles of 50 % strain, the optimal PEI-g-PEG-PCL/PPVC composite retained over 91 % of its initial anti-protein fouling performance. Long-term immersion in physiological conditions (28 days) further demonstrated its durability, with more than 92 % of the original antifouling efficacy maintained. The multi-arm star topology accompanied with the long PCL arm is proposed to resolve the “entanglement–migration paradox” commonly encountered in linear or less branched polymer additives. This study presents a molecular engineering strategy for developing durable antibiofouling polymers capable of withstanding both mechanical stress and prolonged aqueous exposure in medical applications.
研究领域:
高分子科学
·
生物医学工程
·
材料科学
·
抗污材料
·
医疗器械
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·
IF 3.1
Tianyu Liu,Yunjie Cai,Tong Shen,Yunhan Wu,Qi Mu,Ranxue Chen,Zezhong Lin,Rongchao Xue,Chong Wang,Guiying Zhu
Polyvinyl chloride (PVC) is an important plastic material. How to enhance the stability of plasticizers in PVC materials is crucial. In this work, internal plasticization was achieved through the ring-opening polymerization (ROP) of polycaprolactone (PCL) grafted from the unsubstituted hydroxyl groups of cellulose acetate (CA). A series of hyperbranched copolymers (CA-HPCL) with CA acetate-rich hard core and PCL-rich soft shell were prepared. Under similar elongation at break conditions, PVC plasticized with CA-HPCL shows higher modulus, strength, and toughness than linear plasticized PVC and other traditional low-molar-mass plasticizers without hard cores. The obtained plasticized PVC material exhibits a high modulus of approximately 30 MPa while ensuring an elongation at break of more than 300%. Further DSC and FTIR characterizations, combined with a comparison with the linear C 5 H 12 O-PCL plasticizer, reveal that this high rigidity is attributed to the physical cross-linking effect of CA-HPCL on PVC chains. Meanwhile, the migration stability test shows that CA-HPCL exhibits excellent anti-migration properties in PVC matrix. The migration rates of all CA-HPCL-PVC samples are lower than 5%, which is only 0.072 times that of DOP-PVC. Therefore, such films with excellent flexibility, elongation and high modulus are expected to be widely applied in the medical industry.
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2026
·Vol. 31
·期 11
·1816
·
IF 5.1
Sanyuan Qiao,Luoqi Cui,Li Cai,Zhenzhong Fan
ASP flooding wastewater contains crude oil, suspended solids, anionic polymers and surfactants, with high viscosity, high zeta potential, difficult demulsification, flocculation and slow separation and sedimentation. In order to solve the problem of wastewater treatment of ASP flooding in oil fields, a magnetic branched core was prepared from ethyl silicate (TEOS), nano Fe3O4and aminopropyl triethoxysilane (APTES), and then reacted with polyamine and methyl acrylate to synthesize the magnetic hyperbranched molecule FSNMN with demulsification ability. Using acrylamide (AM), acryloxyethyl trimethylammonium chloride (DAC) and maleic anhydride (MA) as raw materials, cationic polymer long chain (CAMHA) with flocculating properties was synthesized and grafted with hyperbranched molecules. The demulsification flocculation ability of the product regarding ASP flooding wastewater was evaluated, and the demulsification flocculation mechanism was summarized. The results showed that the average molecular weight of 3-FSNMN4-C was 4.7 million, the cationic degree was 20.5%, and the saturation magnetization was 20 EMU/g. The removal rate of oil and suspended solids was 93.82% and 91.95% respectively when the simulated sewage was treated by magnetic field for 30 min. Magnetic hyperbranched star chain polymer provides a solution to the serious ecological environment problems caused by ASP flooding.
✓ 已验证
DOI
PubMed
高影响因子
Electronics
·
2024
·Vol. 13
·期 11
·2057
·
IF 2.6
Antonios Chatzisavvas,Michael Dossis,Minas Dasygenis
The A-star algorithm (A*) is a traditional and widely used approach for route planning in various domains, including robotics and automobiles in smart agriculture. However, a notable limitation of the A-star algorithm is its tendency to generate paths that lack the desired smoothness. In response to this challenge, particularly in agricultural operations, this research endeavours to enhance the evaluation of individual nodes within the search procedure and improve the overall smoothness of the resultant path. So, to mitigate the inherent choppiness of A-star-generated paths in agriculture, this work adopts a novel approach. It introduces utilizing Bezier curves as a postprocessing step, thus refining the generated paths and imparting their smoothness. This smoothness is instrumental for real-world applications where continuous and safe motion is imperative. The outcomes of simulations conducted as part of this study affirm the efficiency of the proposed methodology. These results underscore the capability of the enhanced technique to construct smooth pathways. Furthermore, they demonstrate that the generated paths enhance the overall planning performance. However, they are also well suited for deployment in rural conditions, where navigating complex terrains with precision is a critical necessity.
✓ 已验证
DOI
高影响因子
Polymers
·
2022
·Vol. 14
·期 17
·3691
·
IF 4.967
Yuan Zhang,Peng Wang,Nan Li,Chunyan Guo,Sumin Li
Linear and star block copolymer (BCP) nanoparticles of (polystyrene-block-poly(4-vinylpyridine))n(PS-b-P4VP)nwith arm numbers of 1, 2, 3, and 4 were prepared by two methods of polymerization-induced self-assembly (PISA) and general self-assembly of block copolymers in the low-polar organic solvent, toluene. The effect of the arm number on the size and/or morphology of the (PS-b-P4VP)nnanoassemblies synthesized by the two methods in toluene and on the polymerization kinetics was investigated in detail. Our results show that in toluene, a low-polar solvent, the topology not only affected the morphology of the BCP nanoparticles prepared by PISA, but also influenced the BCP nanoparticles synthesized through general self-assembly.
✓ 已验证
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2014
·Vol. 292
·期 9
·2071-2082
·
IF 2.41
Fu Yutong,Xia Xinyu,Zhang Yan,Ye Jinhai,Lang Meidong
Functional star-shaped 4-arm poly(ethylene glycol)- b -poly[( ε -caprolactone- co - γ -amino- ε -caprolactone)] (4-arm PEG- b -P(CL- co -ACL) was synthesized through ring-opening polymerization. The structure of the copolymer was confirmed by 1 H NMR, Fourier transform infrared spectroscopy (FTIR), and gel permeation chromatography (GPC). To further understand the copolymers, the difference of the conversion rate between ε -caprolactone (CL) and γ -(carbamic acid benzyl ester)- ε -caprolactone (CABCL) and the detailed deprotection condition were studied. The thermal property of the copolymer was analyzed by WAXR and differential scanning calorimetry (DSC), which demonstrated that the thermal property could be well adjusted. The pH-responsive behavior of the copolymers was studied in detail by dynamic light scattering (DLS), pH titration, and pyrene fluorescence methods, which indicated that it could form micelles and exhibit pH responsibility. Moreover, the copolymer was nontoxic and had good biocompatibility according to the results by 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay.
研究领域:
高分子化学
·
生物材料
·
药物递送
·
纳米技术
·
响应性材料
✓ 已验证
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2020
·Vol. 222
·期 3
·2000379
·
IF 2.335
Hanhong Li,Zhenqi Cheng,Yang Wang,Dong Zhou,Mingji Su,Xianxun Wang,Peixin He,Yuhong Zhang
As matters stand, chemotherapy is faced with high toxic and side effects, high risks, and long treatment cycles. Thus, stability, high encapsulation efficiency, intelligent controllability, and good biocompatibility are of great importance for drug delivery vehicles. Herein, a novel doxorubicin hydrochloride (DOX)-loaded micelle-like nanoparticle with pH responsive star-shaped polycaprolactone–polyethyleneglycol copolymer (sPCL–PEG–CT, sPP) is developed through esterification with inositol–polycaprolactone (sPCL) and carboxylated polyethylene glycol (TC–PEG–CT). sPP nanomicelles (sPP NMs) have a high encapsulation efficiency of greater than 85%, an average size of 95 nm, and a zeta potential of −18 mV. In addition, in vitro release tests show that ≈70% of the drug is released from sPP/DOX NMs into phosphate buffer saline solution (PBS) (pH 5.0) at 37 °C for 12 h. More importantly, the cumulative release is ≈90% for 170 h, displaying a more sustainable drug release behavior. The work explores a new synthesis route of star-shaped polycaprolactone–polyethyleneglycol copolymer NMs. The sPP NMs have a promising future in drug carrier, especially for hydrophobic drugs.
研究领域:
药剂学
·
生物材料
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2017
·
IF 4.873
Ailian Wang,Hao Xu,Xu Liu,Shi Wang,Qian Zhou,Jie Chen,Liaoyun Zhang
Here, two type of composite star polymer electrolytes enhanced by carbon nano-tube (CNT) or fullerene (C 60 ) prepared through a solution-casting technique are investigated. The as-prepared free-standing carbon nano-composite polymer electrolyte membranes exhibit excellent comprehensive performances including high thermal stability (initial thermal degradation temperatures about 383 °C) and good electrochemical properties . However, different carbon nanomaterials bring different influence on electrochemical performances of composite polymer electrolytes. The ionic conductivity of carbon nanotube composite polymer electrolyte (HBPS-(PMMA- b -PPEGMA) 30 /CNT/LiTFSI) is higher than that of fullerene composite polymer electrolyte. The highest ionic conductivity of HBPS-(PMMA- b -PPEGMA) 30 /CNT/LiTFSI electrolyte can reach 1.06 × 10 −5 S cm −1 at 30 °C and lithium-ion transference number reaches 0.52. In addition, two types of carbon nano-composite star polymer electrolytes both exhibit wide electrochemical window with oxidation potential above 5.2 V, good interfacial stability and interfacial compatibility. Moreover, assembled Li/LiFePO 4 cells based on HBPS-(PMMA- b -PPEGMA) 30 /CNT/LiTFSI electrolytes possess good specific capacity with the highest value of 133 mAhh g −1 , while the cells based on HBPS-(PMMA- b -PPEGMA) 30 /C 60 /LiTFSI electrolytes show a great cycle stability.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2011
·Vol. 49
·期 10
·2303-2313
·
IF 3.894
Tianbin Ren,An Wang,Weizhong Yuan,Lan Li,Yue Feng
Star-shaped amphiphilic poly(ε-caprolactone)- block -poly(oligo(ethylene glycol) methyl ether methacrylate) with porphyrin core (SPPCL- b -POEGMA) was synthesized by combination of ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Star-shaped PCL with porphyrin core (SPPCL) was prepared by bulk polymerization of ε-caprolactone (CL) with tetrahydroxyethyl-terminated porphyrin initiator and tin 2-ethylexanote (Sn(Oct) 2 ) catalyst. SPPCL was converted into SPPCLBr macroinitiator with 2-bromoisobutyryl bromide. Star-shaped SPPCL- b -POEGMA was obtained via ATRP of oligo(ethylene glycol) methyl ether methacrylate (OEGMA). SPPCL- b -POEGMA can easily self-assemble into micelles in aqueous solution via dialysis method. The formation of micellar aggregates were confirmed by critical micelle formation concentration, dynamic light scattering, and transmission electron microscopy. The micelles also exhibit property of temperature-induced drug release and the lower critical solution temperature (LCST) was 60.6 °C. Furthermore, SPPCL- b -POEGMA micelles can reversibly swell and shrink in response to external temperature. In addition, SPPCL- b -POEGMA can present obvious fluorescence. Finally, the controlled drug release of copolymer micelles can be achieved by the change of temperatures. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
研究领域:
高分子化学
·
材料科学
·
药物递送
✓ 已验证
产品关联
DOI
高影响因子
PHYTOCHEMISTRY
·
2018
·
IF 3.186
Xuchao Jia,Haihui Xie,Yueming Jiang,Xiaoyi Wei
Thirteen flavonoids were isolated from the fresh sweet fruit of Averrhoa carambola L. (Oxalidaceae), commonly known as star fruit, and their structures were determined by spectroscopic and chemical methods. 8-Carboxymethyl-(+)-epicatechin methyl ester , pinobanksin 3- O -β- d -glucoside, and carambolasides M–Q were undescribed structures. (+)-Epicatechin, aromadendrin 3- O -β- d -glucoside, helicioside A, taxifolin 3′- O -β- d -glucoside, galangin 3- O -rutinoside, and isorhamnetin 3- O -rutinoside were reported from this species for the first time. Pinobanksin 3- O -β- d -glucoside and carambolasides M–Q showed more potent 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical cation scavenging activity (IC 50 = 5.3–2.3 μM) than l -ascorbic acid (10.5 μM). Further, (+)-epicatechin, pinobanksin 3- O -β- d -glucoside, isorhamnetin 3- O -rutinoside, and carambolasides O–Q exhibited weak porcine pancreatic lipase inhibitory activity.
研究领域:
植物化学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2015
·
IF 0
Qiu Li,Yiguang Jin,Miao Li,Jun-Xing Dong
Tumor targeting and controlled drug release at the target are the key problems for cancer pharmacotherapy. A simply structured pH-responsive nanocarrier was prepared to achieve the above aims in this study. A four-armed star copolymer, tetra-(methoxy-poly(ethylene glycol)-poly(2-(N,N-diethylamino)ethyl methacrylate)-poly(ε-caprolactone) pentaerythritol ((mPEG-pDEA-PCL)4-PET, PDCP), was synthesized via the ring-opening polymerization, atom transfer radical polymerization and click chemistry, which formed a monomolecular nanocarrier in water. Its size and zeta potential were strongly pH-dependent from 71 nm and 2.1 mV at pH 8 to 127.5 nm and 25.4 mV at pH 5. The morphological change of pDEA chains was the basic reason. The chains were protonated at lower pH so as to freely extend to the aqueous media, though they were hydrophobic at higher pH to coat on the surface of hydrophobic cores. The star-shaped PDCP had a large hydrophobic core to load hydrophobic drugs (e.g., paclitaxel). High effective drug entrapment in the blood circulation and rapid drug release at the tumor tissues was achieved in PDCP due to its pH-responsive function. The MCF-7 cytotoxicity of the paclitaxel-loaded PDCP nanocarriers at pH 6.5 was similar to free paclitaxel. And the PDCP nanocarriers were well internalized by the MCF-7 cells according to the flow cytometry and laser confocal microscopy. The paclitaxel-loaded PDCP nanocarriers showed the comparable in vivo anticancer effect to the paclitaxel solution (Taxol) although the former’s toxicity was much lower than the latter. The star-shaped pH-responsive monomolecular PDCP nanocarriers are suitable to deliver hydrophobic anticancer drugs for cancer therapy with tumor targeting and controlled drug release.
研究领域:
药学
·
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2018
·
IF 2.829
Weiwei Liu,Shuangkun Zhang,Zhi Qiao,Qi Li,Xiaoyu Li,Haiqiao Wang
A series of PEG-based star polymers with hexa(eugenol) cyclotriphosphazene (HECTP) core and controlled number of PEG arms have been prepared in high yields via simple thiol-ene click reaction combining Dicyclohexylcarbodiimide/4-Dimethylaminopyridine (DCC/DMAP) esterification under very mild experimental conditions, and their potential for application as surfactants was investigated. The surface activities, including the critical micelle concentration (CMC) and surface tension at CMC, of the polymer aqueous solutions were studied. The results showed that PEG-based star polymers with two arms have good surface activities such as low surface tension (low to 36.1 mN/m), good emulsification ability, due to their structural features similar to Gemini surfactants . Whereas, the PEG-based star polymers with more than two arms exhibited very low CMC values (low to 0.004 mg/ml) and strong emulsification ability, therefore they could be utilized as surfactants to form high internal phase emulsions (HIPEs). Using these new PEG-based star polymers as surfactants, a very low surfactant concentration (0.01 wt %) was sufficient to form oil-in-water emulsions with long-term stability more than 6 months. Although further studies are necessary to clarify the interfacial properties , this work opens a new study field for this kind of important organic-inorganic hybrid materials.
研究领域:
材料化学
·
界面科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）