Materials Research Express
·
2021
·Vol. 8
·期 6
·065306
·
IF 1.62
Shangjie Jiang,Shisheng Zhou
In this paper, a simple method for preparing high stability superhydrophobic paper with pH-induced wettability transition was proposed. Firstly, the pH-responsive monomer 2- (dimethylamino) ethyl methacrylate (DMAEMA), the silicon-containing crosslinking monomer 3-trimethoxysilyl propyl methacrylate (TSPM) and the fluorine-containing monomer hexafluorobutyl methacrylate (HFMA) were polymerized to prepare the pH-responsive polymer PHFMA-PTSPM-PDMAEMA. Afterwards, the amino-modified SiO2 was grafted onto the polymer to provide roughness and then coated on the paper to prepare the superhydrophobic paper with pH-responsive properties. Further research found that the modified paper prepared by this method not only has strong stability and transparency, but also can realize the reversible regulation of superhydrophobic & lipophilic and super-oleophobic & hydrophilic properties under different pH-induction, and it has important application value in the field of oil-water separation in industrial applications.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2021
·
IF 6.558
Yanqi Li,Yu Wang,Shuqin Chen,Zhenming Wang,Liang Feng
In this work, a novel paper-based colorimetric sensor array was developed by inkjet printing method with polyethylene glycol (PEG) immobilization system. Eight commercially available pH indicators with sequential pH segments in nearly whole pH range were dissolved in nine mixed inks to fabricate the 3 × 3 sensor array on mixed cellulose ester (MCE) paper. Based on homogeneous deposition of inkjet printing, the eight pH indicators were sufficiently immobilized on MCE paper with the assistance of PEG-400, which guaranteed pH detection of aqueous samples on sensor array without hydrophobic barriers. Besides, the indicating range of each indicator obtained an extension through the addition of PEG 400, which remarkably enriched the distinguishable capability of sensor array and benefited for high resolution of pH detection. As such, the as-fabricated paper-based sensor array exhibited an excellent discrimination ability in pH range of 1.00–13.60 with a high resolution of 0.20 pH unit, not only for standard pH buffer solutions but for real aqueous samples.
研究领域:
分析化学
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生物医学工程
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DOI
高影响因子
DRUG DELIVERY
·
2020
·
IF 4.902
Chunyun Wang,Peilan Qi,Yan Lu,Lei Liu,Yanan Zhang,Qianli Sheng,Tianshun Wang,Mengying Zhang,Rui Wang,Shiyong Song
The Editors and Publisher of the journal Drug Delivery, have retracted the following article:Chunyun Wang, Peilan Qi, Yan Lu, Lei Liu, Yanan Zhang, Qianli Sheng, Tianshun Wang, Mengying Zhang, Rui Wang & Shiyong Song (2020) Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin, Drug Delivery, 27:1, 344–357, DOI: 10.1080/10717544.2020.1726526Since publication, concerns have been raised about the integrity of the data in the article. When approached for an explanation, the authors have been unable to fully address the concerns raised. As verifying the validity of published work is core to the integrity of the scholarly record, we are therefore retracting the article. All authors listed in this publication have been informed.We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.
研究领域:
药学
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生物材料
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肿瘤治疗
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DOI
高影响因子
MRS Communications
·
2022
·Vol. 12
·期 5
·850-855
·
IF 2.935
Ren Yihong,Zhu Jinxing,Tian Saiqi,Ding Sheng
In order to monitor the wound healing status with the naked eye, a pH-sensitive polyurethane hydrogel (PUH-DCT) was prepared by incorporated with anthocyanins as a wound dressing. Results showed that the color of PUH-DCT changed from pale violet to deep violet then to blue when the pH increased from 5.0 to 9.0. PUH-DCT had good porous structures, mechanical properties, and swelling behavior. PUH-DCT was antibacterial, non-hemolytic, and cytocompatible, which appears very promising applications as a wound dressing. Graphical abstract
研究领域:
生物材料学
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医学工程
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组织工程
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DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2013
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IF 3.479
Minghui Xu,Junmin Qian,Aili Suo,Hongjie Wang,Xueqing Yong,Xuefeng Liu,Rongrong Liu
To minimize the side effect of chemotherapy, a novel reduction/pH dual-sensitive drug nanocarrier, based on PEGylated dithiodipropionate dihydrazide (TPH)-modified hyaluronic acid (PEG-SS-HA copolymer), was developed for targeted delivery of doxorubicin (DOX) to hepatocellular carcinoma. The copolymer was synthesized by reductive amination via Schiff's base formation between TPH-modified HA and galactosamine-conjugated poly(ethylene glycol) aldehyde/methoxy poly(ethylene glycol) aldehyde. Conjugation of DOX to PEG-SS-HA copolymer was accomplished through the hydrazone linkage formed between DOX and PEG-SS-HA, and confirmed by FTIR and 1 H NMR spectra. The polymer–DOX conjugate could self-assemble into spherical nanoparticles (∼150 nm), as indicated by TEM and DLS. In vitro release studies showed that the DOX-loaded nanoparticles could release DOX rapidly under the intracellular levels of pH and glutathiose. Cellular uptake experiments demonstrated that the nanoparticles could be efficiently internalized by HepG2 cells. These results indicate that the PEG-SS-HA copolymer holds great potential for targeted intracellular delivery of DOX.
研究领域:
药学
·
肿瘤学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Qiang Huang,Shichao Zhang,Xinxin Li,Yuying Wu,Yahua Liu,Jin Ran,Peng Cui,Cen-Feng Fu,Liang Ding,Tongwen Xu
Adaptive membranes that can intelligently control their permeability or selectivity depending on the surrounding environments are of extraordinary importance in the separation technology area. Herein, we report the pH responsive membranes through covalently grafting weak Polyelectrolytes (poly(acrylic acid) (PAA) or poly(4-vinylpyridine) (P4VP)) onto the regular two dimensional (2D) channels stacked by Graphene oxide (GO) nanosheets . Attributed to the reversible shrinking/stretching function of PAA (or P4VP) chains with the variation of external pH, the switchable 2D GO channels are thus established successfully. Correspondingly, the resulting PAA@GO and P4VP@GO 2D membranes show promising nano-gating ratios of ∼ 5 accompanied by satisfactory water permeances. Furthermore, the pH responsive 2D channels render these two types of membranes with the adaptive ability of rejecting different sized species according to separation requirements. For disposing industrial alkaline (or acid) effluents, PAA@GO (or P4VP@GO) membranes exhibit outstanding alkaline (or acid) recovery performance as well.
研究领域:
材料科学
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环境工程
·
化学工程
✓ 已验证
DOI
高影响因子
CARBON
·
2025
·
IF 11.6
Tianhao Zhang,Junjie Fan,Wenxiu Qiu,Xinyu Yuan,Jianwen Hu,Haotian Gao,Wenqing Xie,Chunling Li,Shuangqing Sun,Songqing Hu
This study reports the development of two pH-responsive Pickering emulsifiers utilizing carbon dots (CDs) as the core component. Both emulsifiers were fabricated via a post-synthetic method, involving the grafting of poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) onto the surface of CDs to create CD-based emulsifier. Notably, despite employing an identical synthetic route, the two CD-based emulsifiers exhibit markedly distinct pH-responsive behaviors. The findings demonstrate that both CD-based emulsifiers effectively stabilize Pickering emulsions, and their emulsification and demulsification behaviors can be precisely controlled by adjusting the pH, displaying excellent reproducibility in their pH-responsive performance. To elucidate the underlying reason for this differing pH-responsiveness, the concept of hydrophilic-lipophilic balance (HLB) was introduced. The analysis of the HLB values of the two CD-based emulsifiers revealed that their hydrophilic-lipophilic properties exhibit opposite trends under differing pH conditions, contributing to their contrasting pH-responsive behaviors. This study not only lays a fundamental basis foundation and offers guidance for further research and applications of CD-based smart-responsive emulsifiers but also presents novel insights into design and development of more intelligent and functional emulsifying agents. Moreover, owing to the enhanced fluorescence characteristics of CDs, these pH-responsive emulsifiers hold significant potential for interdisciplinary applications, such as oil and gas exploration and fluorescent labelling.
研究领域:
材料科学
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化学工程
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生物医学工程
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Xiangping Hao,WenHui Wang,Zhaoqing Yang,Longfei Yue,Haiyun Sun,Hongfen Wang,Zhanhu Guo,Frank Cheng,Shougang Chen
The settlement and growth of marine organism increased sharply with the ships in a static environment, although the release rate of antibacterial agent decreased smoothly. Besides of a rapid release rate of the antibacterial agents, a destruction of films by sand and rocks restricted the long-term antibacterial efficiency of antifouling films on voyage. In this work, intelligent bacterial-triggered multilayer films are prepared via adding pH responsive nanocapsules to control releasing of antifouling agents during bacterial growth. Chitosan (CS) has a capability to change the swelling of capsules by amino protonation and deprotonation upon the change of the environmental pH. It is combined with capsaicin (CAP) to form nanocapsules for accomplishing a pH responsive behavior. The intelligent CAP@CS nanocapsules are added in polydopamine/sodium alginate (PDA/Alg) m PEM multilayer films to enable the (PDA/Alg-CAP@CS-n) m films with a pH-triggered antifouling agents (CAP) releasing performance. The results demonstrate that there are outstanding pH-triggered activities for the (PDA/Alg-CAP@CS-8) 20 multilayer films. The released CAP concentration decreased by nearly 42% from pH 4 to pH 8.5. The bacteriostatic percentages of (PDA/Alg-CAP@CS-n) m against S. aureus and P. aeruginosa are 79% and 74%, respectively, after 60 days of immersion in pH 8.5 PBS buffer solutions. The amino deprotonation of CS in alkaline condition prevents the CAP release, resulting in an extended antibacterial performance. The electrostatic interaction between Alg and PDA in solutions leads to (PDA/Alg-CAP@CS-n) m films to exhibit the self-healing behaviors since the ions penetrate and free chins transfer in artificial seawater solutions after mechanical scratching.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
Polymers
·
2022
·Vol. 14
·期 20
·4425
·
IF 4.967
Shulan Jiang,Li Xia
Soft actuators have attracted extensive attention for promising applications in drug delivery, microfluidic switches, artificial muscles and flexible sensors. However, the performance of pH-responsive hydrogel actuators, such as regarding reversible bending property and adhesive property, remains to be improved. In this study, inspired by drosera leaves, we have fabricated high-performance bilayer, pH-responsive poly(acrylamide-acrylic acid-3-acrylamidophenylboronic acid)(P(AAm-AAc-3-AAPBA)) based on the copolymers of AAm, AAc and 3-AAPBA. The pH-sensitive actuators were fabricated by ultraviolet polymerization of the P(AAm-AAc-3-AAPBA) layer as the active actuating layer and the PAAm layer as the auxiliary actuating layer. The effects of pH, glucose concentration and content of 3-AAPBA on bending behavior of P(AAm-AAc-3-AAPBA)/PAAm bilayer actuators were discussed. By tuning the pH of media, the soft actuator could achieve fast and large-amplitude bidirectional bending behaviors. The bending orientation and bending degree can be reversibly and precisely adjusted. More importantly, P(AAm-AAc-3-AAPBA) hydrogel shows good adhesive property in polyvinyl alcohol (PVA) solution; thus, complex structures have been fabricated. In addition, the bilayer hydrogel structures have been demonstrated as soft actuators, bionic flowers and bionic manipulators. The proposed pH-responsive bilayer actuator shows great potential for drug delivery and other medical systems.Keywords:bilayer hydrogel;soft actuator;pH-responsive;bending;adhesive property
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2015
·
IF 4.152
Liufeng Lin,Wei Xu,Hongshan Liang,Lei He,Shilin Liu,Yan Li,Bin Li,Yijie Chen
Novel nano-particles were developed from lysozyme-pectin through self-assembly, and the nanogels could be used as a carrier for the antitumor agent, methotrexate (MTX). The nanogels exhibited spherical with diameters about 109 ± 2 nm and narrow particle size distribution, as well as negative surface charge. Furthermore, the particle size and morphology of the nanogels hardly changed with the incorporation of MTX. The loading capacity of MTX in nanogels could reach 17.58 ± 0.85%. MTX-loaded nanogels were pH-dependent, accelerated release of MTX at a decreasing pH from 7.4 to 5.3. The MTT assay indicated that encapsulated MTX exhibited higher anticancer activity than free MTX. Meanwhile, MTX-loaded nanogels could be effectively endocytosed by HepG2 cells, resulting in enhanced cancer-cell apoptosis comparing to free MTX. It indicated that the nanogels had good biocompatibility and low toxicity. The obtained nanogels had great potential in the development of a new nanocarrier for anti-cancer drug delivery.
研究领域:
生物材料
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药物递送
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2018
·
IF 2.829
Guohai Yang,Qian Zhang,Yuan Liang,Hong Liu,Lu-Lu Qu,Haitao Li
The activity of many cells is closely related to the pH of their internal environment, and the increase of intracellular pH value is a common feature of many drug-resistant tumors. The intracellular pH needs to be determined as the research basis when studying the intracellular transport protein and ion concentration changes. Nanomaterials are now widely used as the effective imaging and drug delivery vehicles , but it remains to be studied as a sensor for intracellular environment. Based on this, we have constructed a nanoprobe with fluorescence and surface-enhanced Raman scattering (SERS) dual-signal for sensing intracellular pH. The principle of this strategy is to construct fluorescence-SERS dual-signal nanoprobes by modifying pH-responsive fluorescent probes and SERS reporter molecules on the surface of gold nanorods (AuNRs) with the core-shell structure. The fluorescence-SERS dual response of the nanoprobe to pH can be achieved by investigating the fluorescence and SERS spectra of nanoprobes at different pH. Moreover, by incubating the nanoprobes into different cells, different double-signal response results can be obtained, thereby achieving intracellular pH sensing. The nanoprobe has dual responsiveness to fluorescence and SERS, which makes up for many of the deficiencies of single-signal probes, and realizes high sensitivity, accuracy and stability of intracellular pH detection. It is expected to be widely applied in the fields of medicine, chemistry and biology.
研究领域:
生物学
·
医学
·
化学
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产品关联
DOI
高影响因子
POLYMER
·
2020
·
IF 4.231
Xian-Ling Yang,Wan-Xia Wu,Jun Li,Zu-E. Hu,Na Wang,Xiao-Qi Yu
Aliphatic polyesters have led to significant advancements in drug delivery systems spanning decades owing to their biocompatibility and biodegradability . A series of pH-sensitive aliphatic polyesters were synthesized by facile enzymatic polymerization , which could be post-modified by click chemistry to form multifunctional graft copolymers . Typically, the hydrophilic methoxy polyethylene glycol (mPEG) and fluorescent coumarin were grafted onto the polyester backbone to constitute a multifunctional amphipathic graft copolymer , serving as a trackable pH-responsive drug delivery vehicle . This amphipathic graft copolymer could encapsulate hydrophobic doxorubicin (DOX) via self-assembly in aqueous solutions and performed superior controlled drug release . And the in vitro cellular uptake and cytotoxicity results showed the feasibility of this system for drug delivery application. Collectively, this copolymer offers a potential route of constructing controlled drug delivery system.
研究领域:
生物材料学
·
药剂学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）