ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2021
·Vol. 414
·期 1
·507-513
·
IF 4.157
Shen Haicong,Song Eunyeong,Wang Yang,Meng Lingyan,Dong Jing,Lin Bingqian,Huang Di,Guan Zhichao,Yang Chaoyong,Zhu Zhi
As a paper-based analytical platform, lateral flow assay (LFA) gets benefit from the rapid analysis, low cost, high selectivity, good stability, and user-friendliness, and thus has been widely used in rapid screening or assisted diagnosis. Nevertheless, LFA still suffers from low detection sensitivity via the naked eye, limiting its applications to qualitative and semi-quantitative tests. To enhance the signal readout, various nanoparticle signal tags have been employed to replace traditional colloidal gold nanoparticles (AuNPs), such as fluorescent nanoparticles (FNPs), magnetic nanoparticles (MNPs), and Raman reporter-labeled nanoparticles. In particular, Raman reporter-labeled nanoparticles are extremely sensitive due to remarkable signal enhancement effect on metal surface. However, the application of LFA is still hampered by the poor stability of Raman reporter-labeled nanoparticles. Herein, we developed an in situ Raman enhancement strategy to create a surface-enhanced Raman scattering (SERS) signal on the AuNPs, shortened as “i-SERS,” which not only preserves the original advantages of the colloidal gold strip (AuNPs-LFA), but also realizes highly sensitive and quantitative detection. We applied the i-SERS for procalcitonin (PCT) detection. The experimental process takes only 16 min, and the limit of detection (LOD) is 0.03 ng mL −1 , far below the value using AuNPs-LFA. These results indicate that i-SERS assay was highly sensitive and suitable for the rapid detection of PCT. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS RESEARCH
·
2021
·Vol. 36
·期 9
·1883-1898
·
IF 3.089
Liu Mingxing,Liu Jian,Wang Yu,Wang Wanxia,Zhu Hongda,Guo Huiling,Sun Hongmei
Abstract Redox-responsive colloidal mesoporous silica nanoparticles (CMS) drug delivery systems based on fluorescence resonance energy transfer (FRET) was successfully designed for targeting and real-time monitoring in potential cancer therapy. FRET-CMS indicated the typical type IV isotherm with uniform distribution and wormhole arrangement of mesopores. In vitro release studies indicate the redox-sensitive drug release behaviors. Furthermore, the release of entrapped drugs in real time is monitored by the changed FRET signals of FRET-CMS, which is effectively controlled due to the eliminating FRET with the dissociation of FRET donor–acceptor pair. Fluorescent images of cellular uptake and cell viability test revealed that FRET-CMS enhanced significantly 6-MP accumulation in Hela cells with CD44 receptor over-expressed compared to MCF-7 cells due to the existence of hyaluronic acid and subsequently induced selective cytotoxicity to Hela cells. The obtained results illustrate that FRET-CMS may be a promising nanocarrier for drug delivery systems in cancer therapy. Graphic abstract
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2021
·Vol. 37
·期 3
·549-557
·
IF 1.307
Wang Yan,Xi Peng,Shu Dengkun,Meng Shuang,Liu Kai,Wang Xiaoqing,Cheng Bowen
M ulti-functional nanofibers are playing an important role in the optical field, and are widely used in fluorescence indication, product anti-counterfeit identification and smart clothing. Nanofibers with photoluminescence and photochromic functions are already attracting more interest from researchers. In this work, based on electrospun technology, the modified-PMMA nanofibers[PMMA=poly(methyl methacrylate)] with photoluminescence and photochromic functions were prepared through the design of the sheath-core structure(SCNFs 1–4). Compared with other samples, SCNF-4 shows outstanding photoluminescence and photochromic functions. SCNF-4 can produce green light and its fluorescence intensity and fluorescence lifetime can reach 7144 a.u. and 1031.32 µs, respectively. In photochromic functions, SCNF-4 can show purple in 1 min under the 365 nm ultraviolet light, and the color can be preserved for more than 4 h under the sunlight. When SCNF-4 is irradiated by far infrared light, the color of the samples can fade quickly in 40 s. Under the irradiation of ultraviolet light of different wavelengths, SCNF-4 can display multi-color fluorescence and achieve a reversible transition between white and purple. The design of the sheath-core structure realizes the complementarity of photoluminescence and photochromic functions of the electrospun modified-PMMA nanofibers, which is important to promote the wide application of multi-functional nanofibers in the optical field.
✓ 已验证
产品关联
DOI
高影响因子
Biomass Conversion and Biorefinery
·
2021
·Vol. 12
·期 8
·3503-3511
·
IF 4.987
Huang Xin,Xu Anbang,Bu Xinyuan,Huang Yong,Ran Jingyu
Levoglucosenone (LGO), derived from catalytic pyrolysis of cellulose, has shown its potential as a bio-renewable platform for the production of fine and commodity chemical. In this study, we report a biphasic system for conversion of LGO to 5-hydroxymethylfurfural (HMF) and levulinic acid (LA) with a substantial yield. The hydrolysis parameters, including single-biphasic phase, catalyst, temperature, and reaction time, were investigated on LGO conversion, respectively. The results showed that NaCl/H 2 O-MIBK biphasic system led to a profoundly increase of HMF selectivity by 37% compared to aqueous phase. An increase of acid site significantly enhanced LGO conversion and meanwhile promoted overreaction of HMF to LA and humins. Thus, HMF yield was observed firstly increased and then decreased with a maximum yield of 53.6% by using oxalic acid as a catalyst. The biphasic system effectively suppressed the humins formation and resulted in a maximum total HMF and LA yield of 86.7%.
✓ 已验证
DOI
高影响因子
Journal of Analysis and Testing
·
2021
·Vol. 5
·期 3
·210-216
·
IF 0
Liu Chun,Pang Qiwei,Wu Tong,Qi Wenjing,Fu Wensheng,Wang Yi
A rapid and sensitive colorimetric detection of ascorbic acid (AA) through the morphology transformation of silver triangular nanoplates (Ag TNPs) is developed. By virtue of the redox reaction among silver nitrate and AA, the newly formed Ag atoms deposited on the surfaces of Ag TNPs. Subsequently, the morphology of Ag TNPs transforms from triangle to circle, resulting in a more than 160 nm blue shift of localized surface plasmon resonance absorption peak. The corresponding color of the solution converting from blue to yellow with the concentration of AA can be observed by naked eyes within 15 min. A linear relationship between the blue shift of absorption peak and the concentration of AA ranging from 0.2 to 6 μM is obtained with a limit of detection (LOD) of 100 nM (3 σ ). Some potential species (e.g., glucose, urea and various amino acids) coexisting in the system showed little or no interference. The proposed assay is successfully employed to determine the amount of AA in pharmaceutical products with recoveries from 96.9 to 106.5% and offers a sensitive, low-cost, rapid and simple assay of visual analysis of ascorbic acid.
✓ 已验证
产品关联
DOI
IONICS
·
2021
·Vol. 27
·期 8
·3615-3626
·
IF 2.817
Lu Yao,Yang Quanling,Wang Shan,Liu Man,Chen Yu,Zhao Zhenghui,Akbar Abdul Rehman,Xiong Chuanxi,Hu Guo-Hua
The electrochemical performances of reduced graphene oxide (RGO)/poly-3,4-dioxyethylenethiophene (PEDOT) aerogels as supercapacitor electrode materials were evaluated. The PEDOT was synthesized by oxidative polymerization of 3,4-dioxyethylenethiophene (EDOT). It was doped by nonylphenol polyoxyethylene ether sulfate (NPES) in order to become a flowable material (F-PEDOT) at or near room temperature. Hydrothermal treatment of a mixture of graphene oxide (GO) and F-PEDOT led to reduced graphene oxide (RGO) and dedoped PEDOT (RGO/PEDOT) aerogels which possessed a high specific surface area and a good compressive modulus. When used as a supercapacitor electrode material, it exhibited a high capacitance of 400 F·g −1 at a current density of 0.5 A·g −1 , and 234 F·g −1 at a high current density of 20 A·g −1 in the three-electrode test system. It retained almost its initial capacitance over 6000 charge–discharging cycles even at a current density of 10 A·g −1 . Moreover, the RGO/PEDOT//RGO asymmetric supercapacitor (ASc) exhibits a maximum energy density of 14.16 W h·kg −1 at a power density of 1.53 kW·kg −1 and displays an acceptable cycle stability with 83.4% of the initial capacitance retention after 8000 charging–discharging cycles at a high rate of 6.25 A·g −1 .
✓ 已验证
产品关联
DOI
高影响因子
Food Analytical Methods
·
2021
·Vol. 14
·期 9
·1964-1976
·
IF 3.366
Chen Guanhua,Yang Guotai,Wang Yutong,Deng Mei,Wang Zhengzheng,Aguilar Zoraida P.,Xu Hengyi
Sensitive, simple, and rapid pathogen separation and detection methods are essential for the early diagnosis and immediate medical treatment of bacterial infections. In this study, a novel strategy based on vancomycin (Van)-modified ovalbumin (OVA) mediated magnetic nanoprobes (MBs-OVA-Van) combined with multiplex polymerase chain reaction (mPCR) was developed for efficient isolation and detection of Staphylococcus aureus ( S. aureus ) and Bacillus cereus ( B. cereus ). Van conjugated to ovalbumin coated magnetic microcarrier via strong covalent interaction. In addition, Van binds through hydrogen bonds with d -alanyl- d -alanine moieties on the surface of gram-positive bacteria cell wall. Under optimum conditions, the MBs-OVA-Van showed that the capture efficiency (CE) for S. aureus and B. cereus in PBS and juice samples were around 91%, 92% and 89%, 85%, respectively. In addition, with a mixture containing both target bacteria in PBS and juice samples, the CE for S. aureus and B. cereus were recorded at about 90%, 91% and 80%, 84%, respectively. The MBs-OVA-Van plus mPCR method applied in PBS and juice samples for both bacteria showed limits of detection at 10 2 CFU mL -1 in a < 3 h total assay time. The results indicated that the method holds promise for isolation and enrichment of gram-positive bacteria with S. aureus and B. cereus as models.
✓ 已验证
产品关联
DOI
高影响因子
CELLULOSE
·
2021
·Vol. 28
·期 9
·5421-5431
·
IF 5.044
Qiao Liangzhi,Liang Chao,Du Kaifeng
Carbon nanotubes (CNTs) have been proposed as next-generation lightweight structural materials, yet their application is facing challenges due to the poor dispersity in most solvents, especially in aqueous solution. Here, we report a facile and robust strategy for the rapid and scalable preparation of homogeneous and stable CNT dispersion assisted by cellulose in NaOH/thiourea aqueous solution. The whole process only needs a mild stirring procedure at ice-bath without any pre-treatment of raw materials. It is demonstrated that the suitability of the CNT dispersion for aqueous self assembly of various functional materials, ranging from zero-dimensional (0D) microsphere to three-dimensional (3D) monolith through various molding techniques. Also, the CNT dispersion can be used as ink to prepare CNT-based paper and textile through simply dyeing commercial filter paper and textile, and to directly write on the paper by syringe, indicating the great potential for flexible and wearable devices.
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2021
·Vol. 28
·期 5
·1-12
·
IF 3.097
Yao Jianqi,Luo Faliang,Mao Jie,Li Yuting,Sun Xiaolei,Ma Dequan,Luo Chunhui,Li Lei
The nanocrystalline with different crystal planes often displayed diverse physical and chemical properties. However, the effects of crystal planes of inorganic nano-particle have been few focused on. Here, two kinds of nano-crystal ZnO with different crystal planes were used to explore their effect on the crystallization nucleation, crystal morphologies, thermal and thermal-oxidation stability of iPP. The results shown that the (1010) and (0002) planes possessed different effects for iPP. The (1010) planes with non-polar and low surface energy has highly nucleating effective for iPP, the crystallization temperature increased by 11 °C, the size of spherulites decreased, the number of spherulites increased, the nucleation efficiency and crystallization rate up to 57.81% and 1.27 min −1 , the thermal and thermal oxidation stability (TG, OIT, OOT) of iPP improved by 6 °C, 6 min and 12 °C. In contrast, the (0002) planes with polar and high surface energy have no effect for iPP. Our research results indicate that the wettability and interface compatibility between crystal planes and iPP matrix, which was caused by the polarity and surface energy of (1010) or (0002) planes played key role in improving the performance of polymers.
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2021
·Vol. 28
·期 28
·37781-37792
·
IF 4.223
Wang Dan,Lou Jiangfei,Xu Jin,Yuan Jiugang,Wang Qiang,Wang Ping,Fan Xuerong
Alkylphenol polyethoxylates (APEO n ) are the second-largest category of commercial nonionic surfactants, which are difficult to degrade naturally in the environment. This study examined the degradation of octylphenol polyethoxylate (OPEO n ) by laccase and its laccase-mediated systems. The results showed that OPEO n was poorly degraded by laccase alone. 2, 2′-azino-bis [3-ethylbenzothiazoline-6-sulphonic acid] (ABTS), 1-hydroxybenzotriazole (HBT), and 2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPO) were selected as the redox mediators. Experimental results also indicated that 52.4% of the initial OPEO n amount was degraded by laccase in the presence of TEMPO. The degradation efficiency was analyzed using high-performance liquid chromatography. Furthermore, the structural characteristics of the degradation products were measured using matrix-assisted laser desorption/ionization-time of flight mass spectrometry and nuclear magnetic resonance spectroscopy, and it could be found that the laccase-TEMPO system could gradually shorten the ethoxylate chain by oxidizing the primary hydroxyl group of OPEO n , thereby degrading the OPEO n of the macromolecule into small molecules. The maximum of the ion peak distributions of OPEO n decreased from n = 8 finally down to 3. The novel enzymatic system introduced by this study will become a promising alternative method for high-efficiency APEO n conversion and had great potential value in wastewater treatment. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
AAPS PHARMSCITECH
·
2021
·Vol. 22
·期 3
·1-12
·
IF 3.246
Zhang Xueting,Chen Zhenzhen,Tao Chun,Zhang Jing,Zhang Minxin,Zhang Jialiang,Liu Zhihong,Lin Jiao,Xu Hang,Zhang Qian,Song Hongtao
The combination of self-microemulsifying drug delivery system (SMEDDS) and mesoporous silica materials favors the oral delivery of poorly water-soluble drugs (PWSD). However, the influence of the surface property of the mesopores towards the drug release and in vivo pharmacokinetics is still unknown. In this study, SBA-15 with hydroxyl groups (SBA-15-H), methyl groups (SBA-15-M), amino groups (SBA-15-A), or carboxyl groups (SBA-15-C) was combined with SMEDDS containing sirolimus (SRL). The diffusion and self-emulsifying of SMEDDS greatly improved the drug release over the raw SRL and SRL-SBA-15-R (R referred to as the functional groups). Results of drug absorption and X-ray photoelectron spectroscopy (XPS) showed strong hydrogen binding between SRL and the amino groups of SBA-15-A, which hindered the drug release and oral bioavailability of SRL-SMEDDS-SBA-15-A. The favorable release of SRL-SMEDDS-SBA-15-C (91.31 ± 0.57%) and SRL-SMEDDS-SBA-15-M (91.76 ± 3.72%) contributed to enhancing the maximum blood concentration (C max ) and the area under the concentration-time curve (AUC 0→48 ). In conclusion, the release of SRL-SMEDDS-SBA-15-R was determined by the surface affinity of the SBA-15-R and the interaction between the SRL molecules and the surface of SBA-15-R. This study suggested that the SMEDDS-SBA-15 was a favorable carrier for PWSD, and the surface property of the mesopores should be considered for the optimization of the SMEDDS-SBA-15. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Scientific Reports
·
2021
·Vol. 11
·期 1
·1-9
·
IF 4.38
Chen Xi,Wang Qi,Wang Xiao-Ju,Li Jie,Xu Guo-Bin
In this study, the ZnO quantum dots (QDs) water-based fluorescent anti-counterfeiting ink was prepared with the polyvinylpyrrolidone (PVP) content of 0.15–0.17 g/mL, the ZnO QDs concentration of 4% and water as the solvent, which has good fluorescence, printability and resistance. According to the halftone technology, fluorescence quenching of the ZnO QDs by acid, and acid resistance of the organic fluorescent ink, a high-quality anti-counterfeiting method of fluorescent discoloration was proposed. The QDs ink has broad application prospects in the field of anti-counterfeiting green packaging.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）