BIORESOURCE TECHNOLOGY
·
2026
·
IF 8.2
Hao Tong,Bin Li,Chenglong Fu,Yehan Tao,Jinwen Hu,Jian Du,Jie Lu,Haisong Wang
OE pretreatment fractionated reed into fermentable sugars and N-lignin. • The OE system gave 82.57 % delignification and 92.36 % glucose yield. • One-pot pretreatment simultaneously enabled two lignin amination pathways. • Aminated lignin showed an N content increase from 0 to 3.93 at%. The efficient pretreatment of waste biomass to achieve effective carbohydrate conversion and high-value lignin valorization has consistently been regarded as one of the most critical challenges in the field of biomass refining. In this study, an oxygen-driven ethanolamine (OE) pretreatment strategy was developed using reed as the feedstock, enabling efficient carbohydrate recovery while simultaneously driving lignin structural transformation and in situ nitrogen functionalization via a coupled oxidative ammonolysis pathway. Under the selected pretreatment conditions (85 wt% ETA, 1 MPa O 2 , 170 °C, 30 min), the OE system achieved highly efficient biomass fractionation. Cellulose retention exceeded 90 %, while the delignification rate reached 82.57 %, substantially enhancing cellulose enrichment and enzymatic accessibility. As a result, enzymatic hydrolysis delivered a glucose yield as high as 92.36 %. Meanwhile, the nitrogen-functionalized lignin preserved most of the native lignin side-chain architecture, which confers superior practical application potential compared with highly condensed traditional kraft lignin. Overall, the OE system represents a synergistic fractionation strategy integrating efficient cellulose preservation, enhanced enzymatic hydrolysis, and functionalized lignin recovery. This work provides a new perspective for sugar-platform construction and lignin valorization in the green biorefining of lignocellulosic biomass. Download: Download high-res image (155KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
POLYMER BULLETIN
·
2026
·Vol. 83
·期 10
·561
·
IF 4.2
Sebbar Khaoula,Ibnsouda Saad Koraichi,Damiri Fouad,Fatimi Ahmed,Moudani Nada Al,Aarab Lotfi,Ilhan Elif,Altan Eray,Gunduz Oguzhan,Houmada Amine Ait,Lyamlouli Karim,Elabed Soumya
Argan nutshell lignin (ANS-LIG) is a sustainable biomaterial recognized for its notable antioxidant and antimicrobial properties. This study investigates its application in 3D-printed (3DP) wound dressings, infused with Moroccan essential oils (EOs), specifically Mentha pulegium (MPEO) and Rosmarinus officinalis (ROEO), to reinforce its antibacterial efficacy. ANS-LIG and EOs were integrated into Eudragit RS PO (EudRP) matrices and printed at room temperature to protect the bioactive properties. Analyses using SEM, ATR-FTIR, and XRD revealed the formation of highly porous, lightweight meshes, with ANS-LIG crystallographic planes becoming partially amorphous when combined with EUD and EOs. Thermal analysis demonstrated improved stability for LIG/EUD + EOs compared to LIG/EUD alone. Studies on hydrophilicity and swelling indicated substantial water absorption, while DPPH assays confirmed strong antioxidant activity within 15 min. Antibacterial tests against gram-positive and gram-negative bacterial strains demonstrated significant activity; in particular, Staphylococcus aureus viability was reduced by 93% after 24 h using the LIG/EUD+MPEO 3D printed patch. Lastly, for the in vitro biocompatibility assay, mouse dermal fibroblasts (MTT assay) were utilized, confirming promising cytocompatibility, with ROEO-loaded meshes exhibiting the highest cell viability of 220%, while MPEO demonstrated more efficient antimicrobial results across all tested strains. Ultimately, the obtained 3D-printed scaffolds efficiently integrated sustainable biopolymers mixed with potent antimicrobials and antioxidant agents, alongside impressive biocompatibility, indicating their potential as advanced wound dressings. This study underscores the advantages of incorporating ANS-LIG and EOs into 3D-printed formulations for future biomedical applications. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
BIOMASS & BIOENERGY
·
2026
·
IF 7
Fang Xu,Mingjun Liu,Wenxiao Wang,Mohan Zhao,Rui Zhang,Shuang Wu,Shuo Pan,Jingru Bai,Qing Wang
The synergistic mechanism of lignin and PS was investigated at multiple scales. • The addition of PS effectively improved the quality of bio-oil derived from lignin. • The addition of PS promoted C-C bond cleavage while suppressing C-O bond cleavage. • The synergistic effect of lignin and PS significantly inhibited secondary reactions. The co-pyrolysis of lignin with waste plastics serves as an effective approach for both upgrading lignin-derived oil and mitigating white pollution. In this study, the synergistic mechanism of lignin and polystyrene (PS) co-pyrolysis was comprehensively explored through a combination of experiments, ReaxFF-MD simulations, and kinetic analysis. TG analysis revealed a notable interaction between lignin and PS during co-pyrolysis, which facilitated the release of volatiles. Both Py-GC/MS and ReaxFF-MD findings demonstrated that the introduction of PS significantly improved oil quality, facilitating the production of non-oxygenated compounds. ReaxFF-MD simulations further elucidated the role of synergy in oil production and chemical bond evolution. The findings indicated that PS donated abundant active radicals that promoted the rupture of C-C bonds while suppressing the rupture of C-O bonds, guiding the reaction pathway toward the formation of oil, especially non-oxygenated oil. Moreover, PS further stabilized oil through radical stabilization effects, suppressing the secondary reactions. Kinetic analysis indicated that lignin and PS displayed positive synergy during co-pyrolysis, greatly reducing the apparent activation energy. This study provides theoretical guidance for the preparation of high quality oil via lignin/plastics co-pyrolysis.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Miaomiao Liu,Peiru Wang,Yao Tong,Yuhan Wu,Zuoyi Xiao,Shangru Zhai,Qingda An,Bita Farhadi,Kai Wang
Interface engineering has emerged as a pivotal strategy to overcome the intrinsic limitations of transition metal layered double hydroxides (LDHs), particularly their severe restacking tendency and sluggish reaction kinetics in supercapacitor applications. Herein, we propose a heterointerface construction paradigm through the assembly of lignin-derived hollow carbon (LHC) spheres on pseudocapacitive nickel–cobalt–manganese LDH (NiCoMn-LDH) nanosheets via a facile co-precipitation methodology. The incorporation of LHC nanospheres serves as an effective separator to suppress the interlayer restacking of NiCoMn-LDH nanosheets while maximizing the accessibility of electroactive sites. Our density functional theory (DFT) calculations reveals the synergistic coupling between the faradaic NiCoMn-LDH and electric double-layer capacitive LHC, which endows the composite structure with exceptional charge storage characteristics; a specific capacity of 1144.60C g−1 is achieved at 0.5 A g−1, together with exceptional high-rate capability, which is evidenced by 74.80% capacity retention at 10 A g−1. The engineered interface further mitigates structural degradation during cycling, enabling an asymmetric supercapacitor with a record-breaking energy density of 67.86 Wh kg−1 at 399.99 W kg−1 and superior cycle ability (the device retains 87.15% of its initial capacity after 10 000 charge–discharge cycles). This study provides fundamental insights into interfacial charge storage mechanisms for next-generation energy storage devices, in addition to establishing a sustainable pathway for biomass-derived carbon architectures.
✓ 已验证
产品关联
DOI
高影响因子
POLYMER
·
2025
·
IF 4.5
Xiaopeng Yue,Xian Shang,Jinghan Li,Lixiang Guan,Zhiwei Wang
A bio-based flame retarded thermo-reversible polymer was fabricated using furan-terminated lignin (FL) and furan-functionalized epoxidized soybean oil (FE) via Diels-Alder reaction. Two kinds of 9,10-Dihydro-9-Oxa-10-Phosphaphenanthrene-10-Oxide (DOPO) based flame retardants, including ESO ring-opening derivative (DE) and furanized reactive flame retardant (DF), were synthesized and incorporated into the networks. The incorporation of FL increased the crosslinking density, and reinforced the as-prepared FL/FE network. However, its rigid macromolecular structure also impaired the self-healing properties of network. The addition of DE and DF both improved the flame retardant properties, and they also exhibited synergistic effect during combustion. The LOI value of 80FE/10FL/5DE/5DF reached 29.3 %, and the UL-94 test also reached V-0 level. Whereas, due to the rigid molecular structure similar to lignin and the increased local cross-linking density, the incorporation of DF deteriorated the self-healing efficiency of network. On the contrary, the specimen with the incorporation of DE exhibited relative high self-healing efficiency due to the existence of hydrogen bonds. Typically, 80FE/10FL/10DE exhibited a high tensile strength (11.91 MPa), while maintained a relative high self-healing efficiency (80.45 %). These properties provide valuable insights for the practical application of bio-based polymers in sustainability and flame-retardant fields, and may have application potential in the packaging field in the future.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 2
·121531
·
IF 7.2
Binyuan Gao,Zhuoran Dong,Lizhen Jia,Dumengfei Chen,Haina Cheng,Hongbo Zhou,Yuguang Wang,Zhu Chen
Acid mine drainage (AMD) is a notorious environmental issue, and its economically and environmentally sustainable management remains challenging. A major driving force of AMD formation is the biooxidation of pyrite, largely mediated by acidophilic bacteria like Leptospirillum and Acidithiobacillus . Our previous study demonstrated that lignin can effectively inhibit pyrite oxidation by Acidithiobacillus ferrooxidans, thereby preventing AMD formation at the source. Building upon this, the current study investigated the structure-activity relationship of lignin in inhibiting A. ferrooxidans activity. Our findings indicated that low-molecular-weight lignin exhibits superior antibacterial activity, primarily through the induction of reactive oxygen species both intracellularly and extracellularly. Furthermore, transcriptomic analysis revealed that lignin influences critical bacterial pathways, including membrane biogenesis, carbohydrate metabolism, and signal transduction. This influence leads to an excessive consumption of the bacteria's internal carbon sources and disrupts their internal signal transduction system, ultimately inhibiting biofilm formation. This disruption culminates in cellular damage and bacterial cell death. Overall, this study offers technical guidance for selecting and preparing lignin with high antibacterial activity to enhance AMD control. It also sheds light on the molecular inactivation mechanism of lignin inhibiting A. ferrooxidans , providing a scientific basis for preventing acidification and supporting ecological restoration in new mining areas.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF WOOD CHEMISTRY AND TECHNOLOGY
·
2015
·
IF 1.588
Jingyang Tian,Shiyu Fu,Lucian A. Lucia
The oxidative degradation of eucalyptus kraft lignin as a function of an oxygen-enriched ionic liquid (IL) medium was investigated as part of a fundamental study to examine its capacity to degrade lignin into a suite of potentially valuable by-products relative to a standard sodium hydroxide solution (control). The variables of temperature, oxygen pressure, reaction time, and catalyst on the aromatic monomer products were controlled, whereas it was found that the yields of various aromatic monomer products were significantly improved when ionic liquid was used as the solvent instead of sodium hydroxide solution. These yields increased more substantially when a mixture of ionic liquid and sodium hydroxide was exploited as the reaction solvent. A quantity of 105.3 mg/g aromatic monomer products can be obtained at a temperature of 150°C, reaction time of two hours, and oxygen pressure of 6 MPa using CuO as the catalyst. In addition to the formation of aromatic monomer products, there were a number of other fascinating functional group and chemical linkage changes observed in the lignin macromolecule within the IL-based reaction system.
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Cheng Zuo,Xin-Yi Hui,Pin-An Xin,Hao-Nan Qi,Xiaojun Shen,Jia-Long Wen,Tong-Qi Yuan
The sustainable biorefinery of lignocellulosic biomass (LCB) is pivotal for a circular bioeconomy, yet conventional fractionation often requires harsh conditions that compromise lignin functionality and carbohydrate integrity. Here we report an integrated strategy for dual valorization of industrial xylose residue (XR) by combining a mild alkaline hydrogen peroxide (AHP) pretreatment with pH-dependent lignin fractionation. Under 2 wt% AHP (pH 11.5, 60 °C, 1 h), the pretreatment achieved 90.04% delignification while producing a cellulose-rich residue that delivered a glucose yield of 98.12% at 5 wt% solids (10 FPU/g, 100 mg/g and 48 h), corresponding to a glucose concentration of approximately 45.90 g/L (16.98 and 78.52 g/L at 2 and 10 wt% solids, respectively). Crucially, the recovered lignin fractions retained key near-native, non-condensed structure and possesses reactive functionalities, enabling versatile lignin valorization including lignin nanoparticles, antioxidant performance, and a fully lignin-based adhesive formulated by water-only adjustment (25 wt% solids) that exhibited excellent dry and wet bonding strengths of 2.69 MPa and 1.24 MPa, respectively, exceeding the Chinese national standard. In summary, this work establishes an integrated and sustainable biorefinery paradigm for the valorization of agricultural and forestry wastes into fermentable sugars and high-performance fully lignin-based adhesive.
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2026
·
IF 26.8
Jie Chen,Xintao Luo,Zhuzuan Chen,Shengzhi Li,Xueqing Qiu,Yong Qian
Bio-based binders exhibit outstanding advantages in maintaining electrode stability and suppressing the shuttle effect in lithium-sulfur (Li–S) battery. However, their inherent insulation and poor dispersion severely hinder Li + transport within electrode, resulting in slow S reaction kinetics and low energy density. Here, a series of lignin-based ionic conductive binders (DAL-AA) were synthesized by mussel-mimicking demethylation and amino acids grafting modifications on alkali lignin (AL). It is found that acidic amino acids, e.g. phosphoserine, more easily restructure the spatial conformation via electrostatic repulsion and steric effect. It significantly eases the aggregation of lignin binder as well as bond active/conductive materials. Li + diffusion coefficient in corresponding electrode improves 40% and lithium polysulfide conversion effectively accelerates. The Li–S battery delivers an initial discharge capacity of 971 mAh·g − 1 at a current density of 0.5 C and can stably run 500 cycles. Moreover, the high-loading pouch cell with a capacity of 1.125 Ah achieves gravimetric and volumetric energy densities of 328 Wh·kg − 1 and 517 Wh·L − 1 respectively. This work provides guidance on designing high-loading cathodes for advanced Li–S batteries.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Cleaner Production
·
2026
·
IF 10.7
Li-Li Sun,Jiao Zhao,Lian-Jie Zhao,Shao-Ni Sun,Xue-Fei Cao
Gel is one of the most promising flexible sensing materials for wearable devices, health monitoring, and electronic skin. However, their inherent brittleness, low-temperature freezing, and poor mechanical properties have greatly hindered their practical applications. In this study, a series of lignin-containing cellulose nanofibrils (LCNFs) reinforced deep eutectic solvent (DES) gels were successfully prepared. The effects of LCNFs concentration, CaCl 2 dosage and solvent exchange time on the conductivity, antifreeze and mechanical properties of the DES gels were systematically investigated. Results demonstrated that the optimized DES gel (Ca 18 L 0.75 PAM-3h) exhibited outstanding mechanical properties (0.75 MPa stress, 1593% strain), high conductivity (2.29 S/m), and excellent antifreeze properties (−80 °C) due to the multiple molecular interactions among polyacrylamide (PAM) chains, LCNFs, Ca 2+ , and DES. Additionally, the DES recovered during LCNFs preparation was reused for gel fabrication, thereby enhancing resource efficiency and minimizing waste generation. When used as a strain sensor for real-time human motion monitoring, the DES gel showed excellent sensitivity (GF = 13.66) and stability. This work provided a feasible pathway for developing high-performance DES gels based on the synergistic effects of LCNFs and DES, and which showed great potential for applications in flexible sensing.
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Zhu Shan,Bo Jiang,Sehrish Manan,Peng Wang,Wenjuan Wu,Yongcan Jin
Dual dynamic bond hydrogel dressings, known for their exceptional self-healing abilities and stimulus responsiveness, offer significant benefits in promoting wound healing. Hence, a multifunctional hydrogel (OCMC/LA/AP/PVA E ) was developed by forming dynamic imine and borate ester bonds among oxidized carboxymethyl cellulose, aminated lignin, modified sodium alginate, poly (vinyl alcohol) and epigallocatechin-3-gallate (EGCG). This adaptable network structure via segmental exchange driven by dual dynamic bonds in a microenvironment enhanced the stability of hydrogels, improved mechanical properties, and exhibited unique pH-sensitive responsiveness, making it well suited for the dynamic wound environment. This responsiveness facilitated the controlled release of drugs and lignin, achieving 75.11% cumulative release of EGCG and 72.09% of lignin and nearly 100% antibacterial rate, further enhancing biological activity. Additionally, dual action of lignin as both structural framework and bioactive substance contributes to the high-value utilization of biomass materials. The hydrogels also exhibited good UV–vis resistance, biocompatibility, and adhesion properties, and enabled the monitoring of drug and lignin release through changes in conductivity. In vivo testing on mice whole skin defect model revealed that the hydrogel significantly accelerated wound healing and supported tissue regrowth. The developed dual dynamic bonds improve the hydrogel's functionality and pave the way for innovative applications in biomedicine.
✓ 已验证
DOI
PubMed
高影响因子
Pharmaceutics
·
2026
·Vol. 18
·期 3
·363
·
IF 6.9
Meitong Liu,Kai Wang,Can Zeng,Yijiang Jia,Jiaqi Wang,Ayijiang Taledaohan,Yuji Wang,Xiaobing Guan
Purpose:Due to the lack of effective local therapeutic strategies for oral squamous cell carcinoma (OSCC), this study aimed to develop a novel gelatin/lignin hydrogel loaded with mesenchymal stem cell (MSC)-derived exosomes enriched in microRNA-185 (miR-185 EV) for intraoral delivery, followed by systematic evaluation of its therapeutic efficacy and underlying molecular mechanisms.Materials and Methods:The gelatin/lignin hydrogel was prepared and subsequently loaded with miR-185 EV. The physicochemical properties of the hydrogel, including microstructure, swelling behavior, chemical composition, and rheological characteristics, were systematically evaluated. Next, the stability, viscosity, biocompatibility, and exosome release kinetics of the hydrogel were further assessed. A 4-nitroquinoline-1-oxide (4NQO)-induced mouse tongue carcinogenesis model was established to assess the in vivo antitumor activity of the hydrogel via intraoral administration. Moreover, a proteomic analysis was conducted to investigate the molecular mechanisms of miR-185 EV on OSCC.Results:The miR-185 EV-loaded gelatin/lignin hydrogel exhibited favorable physicochemical properties, stability, and biocompatibility while prolonging the tissue retention time of miR-185 EV. In vivo antitumor efficacy experiments showed that the miR-185 EV-loaded hydrogel significantly inhibited tumor occurrence and alleviated epithelial dysplasia. Immunohistochemical analyses revealed significant suppression of tumor proliferation and epithelial–mesenchymal transition (EMT) of the hydrogel. Proteomic analysis indicated that miR-185 EV suppressed OSCC progression by downregulating interleukin-1β (IL-1β), consequently inhibiting the NF-κB signaling pathway.Conclusion:The findings demonstrate the successful development of the miR-185 EV-loaded gelatin/lignin hydrogel that represents an effective nanomedicine platform for intraoral drug delivery, providing a promising strategy for the clinical treatment of OSCC.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）