INORGANIC CHEMISTRY COMMUNICATIONS
·
2025
·
IF 5.4
Xiaoyu Qiu,Linting Zou,Jianmei Cen,Xingnian Duan
In this research, Mo-oxides complexes combined with Co(OH) 2 grown on three-dimensional (3D) nickel foam (Mo-Co(OH) 2 /NF) were developed as a peroxymonosulfate (PMS) activator enabling a pathway transition from radical to non-radical for efficient degradation of organic pollutants. The incorporation of high-valence Mo species promoted the formation of sheet structure and facilitated the Co(II)/Co(III) ratio, while Co served as the primary active site for PMS activation. Consequently, complete removal of 40 mg/L Rhodamine B (RhB) in optimized conditions (catalyst = 1.5 cm 2 , 0.4 g/L PMS dosage, reaction temperature = 25 °C) was achieved within 2 min. In addition, excellent adaptability was exhibited over a wide pH (3.0–9.0) and versatility (99 %, 80.94 % and 91.54 % for MB, LFX, and TC, respectively) in Mo-Co(OH) 2 /NF + PMS system. Impressively, radical scavenging experiments and electron spin resonance (ESR) analyses revealed that the degradation process was mainly dominated by the conversion of O 2 •– to non-radical 1 O 2 . Hence, this work demonstrates the potential of high-valent metal-oxides complexes integrated with Co(OH) 2 as effective PMS activators for non-radical degradation of dye and other refractory antibiotics, significantly broadening their applications in environmental remediation.
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LIFE SCIENCES
·
2025
·
IF 5.1
Jianglin Zhang,Fan Yang,Xia Sun,Lingyu Gao,Jing Yan,Xiuxian Chen,Yuhua Gu,Shuaijie Song,Fuliang Hu,Xu'’ai Lin,Simon Duttwyler,Hao Cheng,Stijn van der Veen
Aims This study explored botanical extracts to guide discovery of alternative antimicrobials with activity against the multidrug-resistant bacterial pathogen Neisseria gonorrhoeae . Materials and methods In vitro antimicrobial activity was analyzed by agar dilution method and time-kill assays, while in vivo activity was evaluated in a mouse infection model. The antimicrobial target was identified by pull-down assays and validated by interaction studies with wild-type and targeted mutant proteins. Key findings The extract of Chinese Populus spp. propolis (CPP) displayed the most potent antigonococcal activity. Subsequently, galangin was identified as the most active compound in CPP. However, galangin showed no in vivo activity in the mouse infection model. Screening for active structural analogues of galangin resulted in the identification of 2-hydroxychalcone (2-HC), which showed a minimum inhibitory concentration (MIC) of 8–16 μM, and enhanced gonococcal clearance in the infection model. Pull-down experiments identified EF-Tu and butanediol dehydrogenase (Bdh) as putative 2-HC targets. Further binding analysis of 2-HC with recombinant purified proteins showed an equilibrium dissociation constant ( K D ) of 1.28 μM for EF-Tu and 5.97 μM for Bdh. Finally, 2-HC binding pockets on EF-Tu and Bdh were identified by molecular docking studies showing that 2-HC interacted with Glu260 of EF-Tu and Ser273 of Bdh, which was validated by mutagenesis studies. For Bdh, we furthermore demonstrated that 2-HC impacted its enzyme activity with and IC 50 of 44–64 μM, resulting in perturbed NAD + /NADH ratios. Significance 2-HC displays a bimodal antigonococcal mechanism, making it an interesting candidate for further development as antigonococcal therapy.
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高影响因子
Pharmaceuticals
·
2025
·Vol. 18
·期 8
·1185
·
IF 4.8
Ya Li,Siyang Liu,Meng Zhou,Zihan Zhao,Dongfan Song,Hongqian Guo,Rong Yang
Background: Bladder cancer is a common and heterogeneous malignancy of the urinary tract. Traditional chemotherapy using bivalent platinum drugs such as cisplatin(CDDP) is often limited by severe side effects and acquired resistance. To overcome these limitations, we explored a novel Pt(IV) prodrug, DNP, designed to release both cytotoxic cisplatin and the anti-inflammatory cyclooxygenase-2 (COX-2) inhibitor naproxen(NPX).Methods: We evaluated the cytotoxic activity of DNP using both two-dimensional (2D) monolayer and three-dimensional (3D) spheroid models of bladder cancer cells. Transcriptomic analysis via RNA-seq identified apoptosis- and inflammation-related signaling pathways modulated by DNP. RNA-seq-based transcriptomic profiling revealed that DNP regulates signaling pathways associated with apoptosis and inflammation. The anti-inflammatory effects were evaluated using a lipopolysaccharide (LPS)-induced macrophage model, while the in vivo antitumor efficacy was assessed in an orthotopic MB49 bladder cancer model.Results: Compared with CDDP, DNP significantly increased intracellular platinum accumulation and exhibited superior cytotoxicity. It effectively inhibited tumor proliferation, induced apoptosis, and attenuated inflammation both in vitro and in vivo.Conclusions: These findings suggest that DNP exerts dual antitumor effects through enhanced delivery of cytotoxic and anti-inflammatory agents, offering a promising strategy for bladder cancer therapy.
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JOURNAL OF POWER SOURCES
·
2025
·
IF 7.9
Wenxing Jiang,Qiqi Wan,Endao Zhang,Yingying Liu,Junbo Hou,Min Yang,Xiaodong Zhuang,Changchun Ke
This study presents a novel direct methylhydrazine fuel cell (DMHFC) utilizing a hydrothermally synthesized Pd-Ni(OH) 2 composite catalyst supported on nickel foam (Pd-Ni(OH) 2 /NF) as the anode. The Pd-Ni(OH) 2 /NF features a three-dimensional hierarchical architecture with dispersed Pd nanoparticles (0.08 mg cm −2 ) chemically anchored via Pd-O-Ni bonds in the Ni(OH) 2 nanosheet matrix, as confirmed by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS) analyses. The electrode demonstrates superior electrocatalytic activity for the methylhydrazine oxidation reaction (MHOR), attributed to enhanced active site accessibility, charge transfer efficiency, and optimized mass transport. Differential electrochemical mass spectrometry (DEMS) reveals complete oxidation of hydrazine fragments to N 2 with suppressed NH 3 byproduct formation relative to Pd/C. Systematic optimization of operating conditions yields a peak power density of 30.5 mW cm −2 (oxygen as the oxidant, 80 °C) and 110 mW cm −2 (hydrogen peroxide as the oxidant, 80 °C), with performance trade-offs observed between reaction kinetics and fuel crossover. This work validates the feasibility of DMHFC technology, highlighting the potential of methylhydrazine as a high-energy-density fuel for portable systems, while providing insights into electrode design and performance optimization for advanced energy conversion devices.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 31
·1-11
·
IF 2.8
Li Shanshan,Zhang Duo,Tian Zhongqing,Wang Fei,Meng Fancheng
Ba[(Zn 0.6 Mg 0.4 ) 1/3 Nb (2- x )/3 Sb x /3 ]O 3 (BZMNS, x = 0.15, 0.2, 0.25, 0.3, 0.35) ceramics were synthesized by the conventional solid-state reaction method. The crystal structure and microwave dielectric properties of the ceramics were investigated. X-ray diffraction (XRD) analysis revealed that the BZMNS ceramics exhibit a cubic perovskite structure. The crystal structures were refined, and no secondary phases were detected in all compositions. The doping of Sb 5+ hinders grain growth, and the average grain size first increases and then decreases with the increase of the x value. The dielectric constant shows a downward trend due to the influence of the ionic bond character of B-site ions and the B-site Rattling effect. The packing fraction is the main factor affecting the Q × f value of BZMNS ceramics. As the x value increases, the temperature coefficient of the resonant frequency ( τ f ) gradually decreases. Ion polarizability dilution is the primary mechanism for regulating τ f of BZMNS ceramics. The BZMNS ceramics sintered at 1480 °C with x = 0.3 exhibit optimal microwave dielectric properties ( ε r = 31.44, Q × f = 62,273 GHz (at f₀ = 6.5 GHz), τ f = + 2.48 ppm·°C −1 ), indicating that this ceramic has good application prospects.
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高影响因子
JOURNAL OF PHYSICS D-APPLIED PHYSICS
·
2025
·Vol. 58
·期 38
·385502
·
IF 3.2
Qixiong Zhang,Jiujun Zhu,Yafei Hou,Qi Yang,Hai Jiang,Jing Cuan,Weiping Li
Dielectric capacitors offer fast charge/discharge rates and high-power density but are limited by low energy density, requiring bulky stacking. Although single-layer composites attempt to combine both high dielectric constant and breakdown strength, a trade-off often limits their effectiveness. To resolve this conflict, sandwich-structured composites spatially separate polarization and insulation functions into different layers. However, the abrupt dielectric contrast at interlayer interfaces often results in localized electric field distortion, undermining breakdown reliability. In this work, we develop filler-gradient composites by varying the loading of Ni(OH)2 nanosheets to construct transitional interlayers. This design mitigates electric field imbalance in conventional sandwich structures, enhancing dielectric constant, breakdown strength, and energy density. The results demonstrate that the filler-gradient structure facilitates uniform electric field distribution and enhanced interfacial polarization, resulting in a high energy density of 21.1J cm−3 at 685.5MV m−1, and discharge efficiency of 70.1%.
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JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Ying Yang,Jixiang Hu,Hui Wang,Lei Qiao,Yan Wang,Wenhua Tong,Liming Zhao
Eugenol (EGL) and 2-methylpyrazine (2-MTP) are common food additives that are used as flavors in a variety of foods. To study the effect of food additives on human serum albumin (HSA), it is necessary to deeply study the interaction of EGL and 2-MTP with HSA. Fluorescence, UV–vis absorption, circular dichroism (CD) and computational techniques showed EGL and 2-MTP bind statically to HSA, inducing conformational changes of HSA. We calculated the quenching constants (k sv ), binding constants (k q ), binding distances (r) and thermodynamic constants (ΔH 0 , ΔS 0 , ΔG 0 ) at four different temperatures. Based on thermodynamic analysis and molecular dynamics (MD) simulations, the main forces of 2-MTP-HSA and EGL-HSA systems are hydrophobic interaction and π-π accumulation, respectively. In addition, the interaction alters the physiological activity of HSA, esterase activity and free radical scavenging ability. This study provides valuable insights into the molecular interactions of food additive compounds EGL and 2-MTP with HSA, the findings provide theoretical reference for the development of new food additives and drugs in the future.
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高影响因子
Science China-Materials
·
2025
·
IF 7.4
Yan Ziting,Chu Dongdong,Yang Zhihua,Pan Shilie,Zhang Min
Birefringence, as a crucial linear optical property of optical crystals, is pivotal for polarization modulation in birefringent crystals and phase-matching in nonlinear optical (NLO) crystals. Based on anionic group theory, the arrangement of advantageous B–O functional motifs in borate anionic frameworks can be adjusted by rational application of modification strategies, which can effectively promote the exploration of novel structures and optimization of optical properties. In this work, two novel borates containing distinct assembly modes of [B 3 O 7 ] groups, Li 2 Rb 2 BaB 18 O 30 (LRBBO) and K 0.7 Rb 1.3 BaB 6 O 11 (KRBBO), were designed and synthesized based on the dimension reduction strategy induced by cation modification using LiB 3 O 5 as the parent structure. Notably, KRBBO features an unprecedented 2 ∞ [B 3 O 5 ] layered structure and exhibits significantly enhanced birefringence (Δ n = 0.08@546 nm) compared to both the parent compound and other compounds consisting of only [B 3 O 7 ] groups. This work provides an effective strategy for designing novel short-wavelength borate optical crystals with large birefringence and enhancing the birefringence of [B 3 O 7 ]-based NLO crystals to expand the deep-ultraviolet phase-matching capability.
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Materials
·
2019
·Vol. 12
·期 9
·1507
·
IF 2.972
Jiarui Han,Jiaxin Shi,Zhining Xie,Jun Xu,Baohua Guo
A novel biobased and biodegradable polyester, i.e., poly(butylene succinate-co-butylene 2-methylsuccinate) (P(BS-BMS)) was synthesized by succinic acid (SA), 2-methylsuccinic acid (MSA), and 1,4-butanediol (BDO) via a typically two-step esterification and polycondensation procedure. The chemical structure and macromolecular weight of obtained copolymers were characterized by1H NMR,13C NMR, and GPC. The melting temperature and degree of crystallinity were also studied by DSC, and it was found that the values were gradually decreased with increasing of MSA content, while the thermal stability remained almost unchanged which was tested by TGA. In addition, the biodegradation rate of the P(BS-BMS) copolymers could be controlled by adjusting the ratio of SA and MSA, and such biodegradability could make P(BS-BMS) copolymers avoid microplastic pollution which may be brought to the environment for applications in agricultural field. When we applied P(BS-BMS) copolymers as pesticide carriers which were prepared by premix membrane emulsification (PME) method for controlling Avermectin delivery, an improvement of dispersion and utilization of active ingredient was obviously witnessed. It showed a burst release process first followed by a sustained release of Avermectin for a long period, which had a great potential to be an effective and environmental friendly pesticide-release vehicle.Keywords:biodegradable copolyesters;crystallinity;degradation property;pesticide-loaded microparticles;pesticide release
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高影响因子
MOLECULES
·
2022
·Vol. 27
·期 12
·3669
·
IF 4.927
Yi Wang,Xiangli Zhang,Wenya Zhuang,Yanlei Yu,Xuanrong Sun,Hong Wang,Fengzhi Li,Qingyong Li
Irinotecan and Topotecan are two Camptothecin derivatives (CPTs) whose resistance is associated with the high expression of breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp). To reverse this resistance, two novel CPTs, FL77-28 (7-(3-Fluoro-4-methylphenyl)-10,11-methylenedioxy-20(S)-CPT) and FL77-29 (7-(4-Fluoro-3-methylphenyl)-10,11-methylenedioxy-20(S)-CPT), were synthesized by our group. In this study, the anti-tumor activities of FL77-28, FL77-29, and their parent, FL118 (10,11-methylenedioxy-20(S)-CPT), were evaluated and the results showed that FL77-28 and FL77-29 had stronger anti-tumor activities than FL118. The transport and uptake of FL118, FL77-28, and FL77-29 were investigated in Caco-2 cells for the preliminary prediction of intestinal absorption. The apparent permeability coefficient from apical to basolateral (Papp AP-BL) values of FL77-28 and FL77-29 were (2.32 ± 0.04) × 10−6cm/s and (2.48 ± 0.18) × 10−6cm/s, respectively, suggesting that the compounds had moderate absorption. Since the transport property of FL77-28 was passive diffusion and the efflux ratio (ER) was less than 2, two chemical inhibitors were added to further confirm the involvement of efflux proteins. The results showed that FL77-28 was not a substrate of P-gp or BCRP, but FL77-29 was mediated by P-gp. In conclusion, FL77-28 might be a promising candidate to overcome drug resistance induced by multiple efflux proteins.Keywords:Camptothecin derivatives;cytotoxicity;bioavailability;Caco-2 cells model;drug resistance
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高影响因子
POSTHARVEST BIOLOGY AND TECHNOLOGY
·
2020
·
IF 4.303
Xueyin Ru,Ning Tao,Yanyan Feng,Qingqing Li,Qingguo Wang
Enzymatic browning is one of the essential issues affecting the quality of fresh-cut produce. In this study, we identified a novel, safe, and effective anti-browning agent, 3-mercapto-2-butanol, which can prevent fresh-cut potatoes from browning for 5 d under the concentration of 25 μL L −1 at 5 °C. The inhibitory effect of 3-mercapto-2-butanol was close to sodium bisulfite. 3-Mercapto-2-butanol was further identified as a competitive inhibitor which directly inhibited the activity of polyphenol oxidase (PPO) by enzyme kinetic analysis, and the expression levels of PPO-related genes ( POT32 and POT33 ) were decreased after 3-mercapto-2-butanol treatment. Besides, the concentration of enzymatic browning substrate tyrosine (Tyr) in the potato chips was found significantly higher in 3-mercapto-2-butanol treatment group than in the control group. We speculated that 3-mercapto-2-butanol could reduce the consumption of Tyr by inhibiting the activity of PPO. Our finding not only provided a novel and safe anti-browning agent candidate (3-mercapto-2-butanol) to efficiently solve the browning issue for fresh-cut food products, but also preliminarily revealed its mechanism in browning inhibition.
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高影响因子
CELL BIOCHEMISTRY AND FUNCTION
·
2025
·Vol. 43
·期 12
·e70143
·
IF 2.7
Hao Song,Dongxu Tang,Buyu Wang,Yanfei Luo,Changzheng Yan,Shiqiang Ruan
To explore the effects of a collagen-binding domains-bone morphogenetic protein 2 (CBD-BMP-2) scaffold on repairing cartilage defects. A chitosan-collagen scaffold was prepared and its physicochemical properties were evaluated. A plasmid encoding the CBD and BMP-2 was constructed, a CBD-BMP-2 composite scaffold was prepared, and the controlled release of BMP-2 was assessed in vitro. Knee cartilage defect model rabbits were divided into the control, CBD, and CBD-BMP-2 groups ( n = 9). Gross observation, MRI, staining, and IHC were performed to evaluate the cartilage repair outcomes. CBD-BMP-2 composite scaffold provided sufficient support and promoting cell attachment and proliferation. It consistently released BMP-2 for over 30 days in vitro. It significantly enhanced cartilage regeneration and repair. After surgery, cartilage growth in the CBD-BMP-2 group was superior to the control and CBD groups. The CBD-BMP-2 group demonstrated better coverage of new cartilage tissue. In the CBD-BMP-2 group, new cartilage tissue was tightly structured and cells were neatly arranged, and there were a rich cartilage matrix and dense collagen fibers. Type II collagen expression was significantly increased in the CBD-BMP-2 group. CBD-BMP-2 composite scaffold has excellent physicochemical properties and controlled-release functionality, providing superior repair effects for rabbit knee joint cartilage defects. Summary Cartilage injuries are difficult to treat due to limited self - healing capacity. Current treatments offer only temporary relief. The CBD - BMP - 2 slow - release composite scaffold combines the ability of BMP - 2 to promote cartilage regeneration with the collagen - binding property of CBD. Our study shows it has excellent mechanical properties and controlled - release functionality, providing superior repair for rabbit knee cartilage defects, offering a novel solution for cartilage injury repair.
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