Advanced Healthcare Materials
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2026
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IF 11
Jingfei Wang,Shuting Li,Liwu Liu,Fukai Liu,Cheng Lin,Yanju Liu,Jinsong Leng
Nowadays, the implantation of occluder is an effective approach for treating patent foramen ovale (PFO); however, the slow endothelialization poses significant complications associated with occlusion devices. Herein, a 4D-printed intelligent reconfigurable PFO occluder with pro-endothelialization, anti-thrombosis, and absorbability is designed. The combination of the occluder implantation and topical drug delivery of anti-thrombosis drugs offers a solution to stroke. The occluder is designed based on the biomimetic structure, facilitating the integration of mechanical response behavior compatible with cardiac tissue. In vitro degradation and in vivo histological examination demonstrate the bioabsorbability of the occluder, and the anti-thrombosis efficacy is preliminarily demonstrated through anti-thrombosis experiments. The effective expression of VWF and CD31 markers validates the superior pro-endothelial efficacy of the occluder. To summarize, the 4D-printed occluder in this work represents an accessible strategy to combat PFO through integrated occlusion and topical drug delivery.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19.9
Xinqiuyue Wang,Lei Zhang,Jiajia Su,Haokun Xue,Han Zhou,Fanglei Xue,Yajie Wang,Danyi Quan,Jianping Liu,Wenli Zhang
Conventional therapy for Helicobacter pylori ( H. pylori ) is often compromised by host autophagy dysfunction. Host-directed therapy (HDT) presents a viable solution; however, its efficacy is hindered by biological barriers and the difficulty in targeting infected cells. Herein, we developed BPI-CD-L CR , a self-propelled “Trojan Horse” nanoplatform functionalized with bacterial-targeting peptide (B-mBPI) and urease-powered motor (TPGS-β-CD@Urease), in which TPGS-β-cyclodextrin (TPGS-β-CD) plays multiple critical roles from drug delivery to autophagy modulation. Initially, TPGS-β-CD maximizes urease motor activity against the gastric environment by forming a dynamic complex with urease, thereby powering active propulsion for deep mucus penetration. Upon reaching the infection site, BPI-CD-L CR employs a Trojan horse mechanism by tracking bacteria and mediates opsonophagocytosis by macrophages. Meantime, TPGS-β-CD outside facilitates BPI-CD-L CR phagocytosis by increasing the membrane fluidity of infected macrophage via cholesterol extraction. Intracellularly, BPI-CD-L CR modulates the autophagy pathway by promoting autophagosome-lysosome fusion with the aid of TPGS-β-CD and restoring lysosomal function through resveratrol (Res), thereby reactivating the clearance of intracellular bacteria. In the murine infection model, BPI-CD-L CR achieved a remarkable 33-fold reduction in gastric bacterial load compared to antibiotic-based triple therapy. Overall, this platform represents a nanoengineered delivery strategy for intractable infections, providing a promising solution for guiding HDT to achieve on-demand antimicrobial activation within infected cells.
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Advanced Science
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2026
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IF 14.1
Binbin Cui,Shilei Dai,Ivo Pang,Dingyao Liu,Xinran Zhang,Jing Bai,Xinyu Tian,Shiming Zhang
Synthetic bioelectronics is rapidly advancing, propelled by breakthroughs in synthetic biology and bioelectronics. This convergence is key to next-generation wearable and implantable devices, enabling seamless integration with living systems. Here, we introduce an enzymatic hydrogel electrode (GelZymes) developed via a synthetic bioelectronic strategy to overcome the mechanical and interfacial limitations of conventional enzyme electrodes. GelZymes deliver two core advances: i) a monolithic and scalable 3D architecture that unifies the enzyme membrane and electrode, simplifying fabrication and eliminating interfacial instability; and ii) tissue-like viscoelasticity—combining stretchability and adhesiveness—rarely achievable with rigid enzyme membranes. GelZymes are synthesized through three steps: engineering a stretchable, mixed-conducting 3D hydrogel; implementing an enzyme-compatible, cascading crosslinking scheme to immobilize enzymes within the network; and balancing the trade-off between electronic/ionic conductivity and the density of redox-active enzyme sites to maximize bio-electrochemical performance. We further show that GelZymes enable a shift from invasive, tissue-interfaced biosensing to noninvasive, tissue-integrated biosensing, offering a practical pathway to bridge current biosensor technologies with living systems.
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Advanced Science
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2026
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IF 14.1
Lixia Feng,Simei Zhao,Zheng Wei,Wenwen Wang,Feiquan Ying,Lin Huang,Mengna Zhu,Mengqing Chen,Qiang Yang,Si Sun,Dawei Jiang,Lingling Gao,Jing Cai
Therapy targeting cancer stem cells (CSCs) has been proposed as a promising strategy to reduce chemoresistance and relapse risks in ovarian cancer (OC) patients. However, the lack of targetable markers impedes research progress. Here, we demonstrate that CXC motif chemokine receptor 4 (CXCR4) may be a targetable functional marker of ovarian CSCs and propose a new translational model incorporating targeted imaging and CXCR4 blockade in CXCR4 + tumors. Expression profile analysis of chemoresistant CSC-like ovarian cancer cells highlighted that CXCR4 functions as a potential stemness marker. CXCR4 + ovarian cancer cells exhibited high self-renewal capacity in vitro and in vivo, and an association with chemoresistance. CXCR4 inhibitor AMD3100 significantly impaired the self-renewal ability of CSC-like ovarian cancer cells and enhanced their sensitivity to cisplatin. CXCR4-targeted [ 68 Ga]Ga-Pentixafor was highly specific in delineating CXCR4-high cell line-derived xenografts and patient-derived xenografts (PDXs) via positron emission tomography (PET) imaging, with precise tumor-targeting and persistent retention. A combination of AMD3100 and CDDP exerted an excellent antitumor effect in CXCR4-high PDXs, but not in CXCR4-low PDXs. These results suggest that CXCR4 may represent a functional CSC marker associated with chemoresistance. Moreover, [ 68 Ga]Ga-Pentixafor PET imaging can guide decision-making for AMD3100 therapy, paving the way for further clinical translation.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Dapeng Cui,Ziyuan Yang,Yupeng Zhang,Xiaopeng Suo,Ming Cheng,Shuang Fan,Cheng Yang,RuiXia Yu,Tao Wang,Lei Li,Jiaxin Cui,Zhongdi Liu,Runjia Fu,JianDong Fei
Effective remodeling of the wound regenerative microenvironment is pivotal for achieving rapid and high-quality healing in diabetic wounds. Yet, current therapeutic strategies are largely constrained by their inability to orchestrate temporally programmed drug delivery that aligns with the dynamic and stage-specific demands of the healing process. To address this challenge, we engineered a sequentially dual-drug releasing wound dressing (PCC-PF), designed to deliver time-resolved biochemical and biophysical cues that reprogram the regenerative microenvironment and accelerate wound repair. The PCC-PF scaffold markedly enhanced the regenerative activity of key cell populations, including fibroblasts and endothelial cells, while fostering a favorable tissue microenvironment. Importantly, dual-phase delivery of the incorporated drugs accelerated the closure of infected wounds in diabetic rats. This sequential drug release strategy, enabling precise and dynamic microenvironmental remodeling, presents a promising paradigm for advancing the clinical management of diabetic wounds.
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FOOD CHEMISTRY
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2026
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IF 10.4
Ruican Wang,Ying Zhang,Haoxin Cui,Wenhui Fu,Dongfei Tan,Qisijing Liu,Xuemeng Ji,Liye Zhu,Shuo Wang
Keratin-rich pig hoof waste remains underutilized due to poor solubility and limited bioavailability. This study aimed to evaluate structural, functional, and bioactive properties of hydrolyzed pig hoof keratin (HPHK) obtained via commercial protease hydrolysis of native keratin (PHK). PHK and HPHK were compared for amino acid profile, molecular weight (SDS-PAGE, SEC), thermal stability (TGA), and structure (FTIR), with further assessment of functionalities and bioactivities. Hydrolysis reduced β-sheet content and molecular weight (~13 → 3.1 kDa), improving solubility and digestibility. HPHK exhibited excellent oil-holding (>4 g/g) and foaming (>200%) capacities but poor emulsification. Antioxidant (IC 50 ~ 1 mg/mL) and ACE-inhibitory (IC 50 ~ 8 mg/mL) activities were confirmed by in vitro and in silico analyses. Acid, heat, and simulated digestion contributed to reduced bioactivity. These findings highlight HPHK's potential as a functional and bioactive ingredient and underscores the need to optimize hydrolysis condition for desired functionalities and bioactivity.
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CHEMISTRY OF MATERIALS
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2026
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IF 7
Wanqi Li,Qinqin Cui,Xu Fei,Yao Li,Cong Wang,Sheng Cheng,Longquan Xu
Achieving precise and controllable drug release remains a significant challenge for hydrogel dressings. In this study, the hydrogel network was modified with functionalized cyclodextrin to enhance its thermal responsiveness and shrinkage capacity. Additionally, cuttlefish ink nanoparticles were incorporated as a natural photothermal agent to enable precise temperature regulation. As a result, the modified hydrogel exhibited controllable drug release behavior within a temperature range of 36 to 46.5 °C. Under this strategy, a shrinkage ratio of 60.54% and gallic acid release rate of 85.17% were achieved. Furthermore, the hydrogel demonstrated antibacterial performance (>90%), high biocompatibility (cell viability >90%), and significant antioxidant activity. This hydrogel system shows significant potential for application in intelligent drug delivery platforms, infected wound dressings, and combined photothermal therapy.
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APPLIED SURFACE SCIENCE
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2026
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IF 6.6
Mingli Yue,Zhikuan Feng,Long Gao,Ying Fu,Fei Ye
Drug delivery systems utilize micro-nanomaterials as drug carriers, encapsulating drugs within micro-nanoparticles and releasing them to target tissues or cells via specific pathways. This technology enhances drug stability, prolongs drug retention time in the body, and reduces damage to healthy tissues. This study successfully synthesized novel carbon-doped zinc oxide (C/ZnO) micro-nanomaterials and employed polydopamine (PDA) for surface modification, resulting in the construction of C/ZnO/PDA carriers. Experimental results demonstrate that PDA modification significantly enhances the drug delivery performance of the material. This composite material exhibits a 5-Fu loading efficiency of 37.8%, representing a 1.15-fold increase compared to unmodified C/ZnO. In vitro release tests demonstrate sustained drug release characteristics, showing a 1.62-fold increase over the unmodified system. In addition, these medicine particles significantly enhanced the indicators of antibacterial and bactericidal efficacy. In vitro cell experiments also confirmed that the drug carrier can enhance the lethality of the drug against HepG2 cells. Research on the binding energy between the carrier and the drug revealed that PDA modification promotes drug-carrier binding, resulting in more stable overall adsorption. These findings demonstrate the potential application value of micro-nanoparticle-based targeted drug delivery systems in disease prevention and treatment.
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DYES AND PIGMENTS
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2026
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IF 3.9
Shen Zhang,Zhuo Wang
In consideration of the potential threat, the establishment of efficient approach for fluazinam determination is necessary. Based on the superior property of carbon dots and biomass, sulfur doped biomass-based carbon dots (SBCDs) were constructed using a simple hydrothermal approach, in which peanuts were applied as carbon sources with the addition of methionine. The well-dispersed SBCDs displayed optimal emission wavelength of 435 nm under the excitation wavelength of 364 nm. Owing to the detection principle of fluorescence quenching through static quenching and inner filter effects, the SBCDs were used to detect fluazinam with a broad linear range of 0-100 μM and a detection limit of 0.026 μM. Additionally, the SBCDs also exhibited temperature sensing with a wide linear range of 15-95 °C. Moreover, the as-prepared SBCDs were effectively used for the determination of fluazinam in tap water and orange juice samples. The SBCDs displayed tremendous potential for the sensing of fluazinam and temperature.
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CHINESE JOURNAL OF CATALYSIS
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2026
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IF 17.2
Miao-Miao Shi,Yue-Xuan He,Ning Zhang,Di Bao,Da-Ming Zhao,Hai-Xia Zhong,Jun-Min Yan,Qing Jiang
Ammonia (NH 3 ) is seen to be promising hydrogen carrier, but its decomposition into hydrogen (H 2 ) has been plagued by high operating temperature (400‒700 °C) and long start-up time. Here, we present that directly electrochemical liquid NH 3 decomposition (ELADH) method could realize efficient onsite H 2 generation at room-temperature, whereas active and stable electrocatalytic system is challenging. Through rationally optimizing the electrolysis system with Ru catalysts, we achieved an active and durable ELADH into H 2 under ambient temperature. It was found that Ru nanoparticles (Ru NPs) with (101) facet could effectively promote the favorable N-H dissociation and hydrogen desorption, and thus accelerate the slow reaction kinetics. The as-prepared Ru NPs on nitrogen carbon exhibit lower potential of ‒1.01 V vs . NHE at ‒10 mA cm ‒2 and larger current density of ‒910 mA cm ‒2 at ‒1.47 V vs . NHE, superior to Ru single atoms and commercial Pt/C. Importantly, this system affords stable H 2 evolution under 100 h continuous electrolysis without apparent degradation, far beyond the reported catalysts. This work paves the new way of room-temperature onsite H 2 production and presents insightful understanding of the electrochemical liquid ammonia splitting process.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.7
Ziyue Ju,Ruichan Lv,Ji Zhang,Delong Shi,Yitong Chen,Anees A. Ansari
Conventional techniques such as screen printing and hand-brushing, though scalable, often compromise on patterning resolution and material waste. In contrast, advanced inkjet printing offers a promising route for high-resolution and efficient manufacturing. In this study, a flexible electrode based on Ni-MOF material used high-precision scalable inkjet printing was developed for glucose sensing in human body fluids for wearable devices. Initially, Ni-MOF material with a high specific surface area and porous structure was synthesized via a hydrothermal method, and its potential for electrochemical detection was investigated. Experimental results demonstrated that the material exhibited high sensitivity and a broad detection range for glucose. Importantly, graphite and carbon nanotubes were incorporated to construct a Ni-MOF composite material with the composition ratio optimized to enhance conductivity and mechanical stability, for further application in flexible electrodes. Typically, a cost-effective, high-efficiency, and scalable fabrication process was achieved through high-precision inkjet printing technology, which enables 1200 dpi resolution while supporting ultra-large-scale printing up to 1200 × 1200 mm. Simutaneously, simulation-based optimization was conducted to determine the most effective electrode shape. As a result, the detection range of the inkjet-printed flexible electrode was extended to 0.005–2.63 mM, with an improved sensitivity of 12.2 μA·μM −1 ·cm −2 . Moreover, excellent mechanical stability and long-term durability were achieved, enabling precise differentiation of glucose fluctuations in low-concentration simulated sweat. Finally, a microfluidic channel to provide environment for the reaction was designed, thereby establishing a fundamental foundation for applying the flexible electrode in wearable devices.
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Molecular Catalysis
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2026
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IF 4.9
Hui-Li Wu,Jia-Wei Liu,Chang-Long Tan,Zi-Rong Tang
Selective photocatalytic dehydrogenation of saturated N-heterocycles represents a sustainable photoredox route for synthesizing valuable nitrogen-containing unsaturated heteroaromatic organics. Herein, we report a Ni-decorated 3D sea urchin-like CdS composite (Ni/CdS) as a dual-functional photocatalyst for the efficient and selective semi-dehydrogenation of 1,2,3,4-tetrahydroisoquinoline (THIQ) to 3,4-dihydroisoquinoline (DHIQ) coupled with H 2 evolution under visible light irradiation. The surface-decorated Ni nanoparticles significantly enhance the separation and transfer of photogenerated electron–hole pairs over Ni/CdS, and act as reactive sites for proton reduction to H 2 , thereby leading to the improved dual-functional photoredox catalysis. Mechanistic studies identify the carbon-centered radical (•CH(NH)C 8 H 8 ) as a pivotal intermediate in the photocatalytic semi-dehydrogenation of THIQ. This study establishes an effective strategy for designing noble-metal-free photocatalytic systems that integrate selective organic transformations with H 2 evolution in a cooperative manner.
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