TALANTA
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2022
·
IF 6.556
Xiaoqing Cui,Yu Bao,Tingting Han,Zhenbang Liu,Yingming Ma,Zhonghui Sun
Here, we developed a wearable electrochemical sensor for pH and K + monitoring in sweat. The sensor was composed of flexible reference electrode, pH response electrode and K + selective electrode, which were prepared through printing β-CD functionalized graphene (β-CD/RGO) water suspension on conductive PET substrate with microelectronic printer. β-CD/RGO not only served as the pH sensitive material for pH response electrode with good sensitivity, selectivity and reproducibility due to its abundant oxygen-containing functional groups, but also worked as the ion-to-electron transducer for K + selective electrode with good sensitivity. The wearable sensor exhibited good potential stability at different bending states. On-body sweat pH and K + measurements showed high accuracy compared with ex-situ analysis.
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RSC Advances
·
2022
·Vol. 12
·期 18
·11534-11542
·
IF 4.036
Bohan Wang,Zhihao Wang,Peng Mao,Yu Wang
Conventional luminescent materials generally exhibit uni-color and transient emission under UV excitation, which makes them mediocre in the field of anti-counterfeiting. The high-level anti-counterfeiting techniques are always becoming more complicated and in need of multi-color and persistent luminescent materials. Herein, we report a series of β-NaYF4:RE3+ (RE = Sm, Tb, Dy, Pr) persistent luminescent phosphors with multi-color emitting and ultra-long persistent luminescence under the irradiation of X-rays. The effects of doping concentrations of RE3+ on the size, morphology, radioluminescence and afterglow performance of the products are investigated in detail. Hexagonal structured rod-like β-NaYF4:Tb3+ crystals show super strong X-ray response and the afterglow signal lasts for up to seven days after X-rays are turned off. Upon X-rays irradiation, some of the F− ions are expected to escape from the crystal lattice by elastic collisions, leading to the generation of Frenkel defects: the F vacancies and interstitials , which capture electrons and release them slowly to achieve different afterglow emission times. Taking advantages of the extraordinary radioluminescence performance of the β-NaYF4:RE3+ persistent luminescent phosphors, the dynamic anti-counterfeiting patterns that containing rich time-resolved information were successfully designed.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2022
·
IF 9.136
Xiaoping Bai,Jian Ke,Xin Qiu,Huixian Liu,Yibing Ji,Jianqiu Chen
The separation of racemic drugs remains significance and challenge for pharmaceutical production. Recently, chiral drugs permeation separation based on membrane is a promising technology with advantages of energy efficient, continuous operation and cost-effectiveness. Herein, ethylenediamine-β-cyclodextrin (EDA-β-CD) mixed matrix membranes (EDA-β-CD MMMs) and EDA-β-CD modified graphene oxide thin-film nanocomposite membranes (GO/EDA-β-CD TFNMs) were fabricated via precipitation phase inversion and interfacial polymerization process, respectively. The corresponding membrane structure and GO nanosheets were characterized by SEM, TEM, ATR FT-IR, EA. Subsequently, the water flux, BSA rejection and stability of the membranes were studied. Moreover, enantioseparation performances of GO/EDA-β-CD TFNMs and EDA-β-CD MMMs toward (DL)-tryptophan (Trp) and (RS)-propranolol (Prop) were examined. Results showed that the GO/EDA-β-CD TFNMs exhibited extraordinary enantioselectivity, which remained high percent enantiomeric excess (ee.%) of Trp (100.00%) and Prop (75.34%). GO nanosheets with a multilayer structure and an interlayer spacing not only provided bonding site of EDA-β-CD but also improved permeation flux of the membrane. Finally, molecular docking technology was used to study the separation mechanism of the membranes. These findings demonstrate that GO/EDA-β-CD TFNMs might possess possibilities of high permeability and high enantioselectivity for chiral drugs separation.
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Journal of Orthopaedic Translation
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2022
·
IF 4.889
Feng-wei Zhang,Li-yang Peng,Chuan-Jian Shi,Jian-chi Li,Feng-xiang Pang,Wei-ming Fu,Xiao-hua Pan,Jin-fang Zhang
Background Osteosarcoma (OS) is a common type of malignant bone tumor in adolescents with high risk of metastasis. However, the clinical management still remains unsatisfactory. Traditional Chinese medicine (TCM) has been widely considered as an alternative treatment, and their extracts have proved to possess great potential for drug discovery. Baicalein (BA), the active pharmaceutical ingredient of rhizoma coptidis , was proved to have anti-tumor properties in OS, but the mechanism remains poorly understood. Methods The potential anti-cancer effects on cell growth, cell cycle, apoptosis and migration were examined in OS cells. Moreover, the lncRNA-Neighboring Enhancer of FOXA2 (lncRNA-NEF) and Wnt/β-catenin signaling were detected by qPCR and Western blotting assays. The in vivo effect of GA on tumor growth was investigated using a xenograft mice model. Results In the present study, BA was found to significantly suppress tumor growth in vitro and in vivo. And it was also found to inhibit the invasion and metastasis as well. As for the mechanism investigation, lncRNA-NEF was obviously upregulated by BA in OS cells, and thus induced the inactivation of Wnt/β-catenin signaling. Moreover, lncRNA-NEF knockdown partially reversed the BA-induced anti-cancer activities; and successfully compensated the suppressive effect on Wnt/β-catenin signaling. We therefore suggested that BA induced the inactivation of Wnt/β-catenin signaling through promoting lncRNA-NEF expression. Conclusions In conclude, our results demonstrated that BA suppressed tumor growth and metastasis in vitro and in vivo through an lncRNA-NEF driven Wnt/β-catenin regulatory axis, in which lncRNA-NEF was upregulated by BA, and thus induced the inactivation of Wnt/β-catenin signaling. The Translational potential of this article The findings derived from this study validates the anti-cancer activity of BA in OS and provides a novel underlying mechanism, which suggest that BA may be a potential candidate to develop the effective drug for OS patients.
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ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Xingang Liu,Yinghao Shang,Jingfeng Liu,Zhuzhu Shao,Chuhong Zhang
Piezoelectric energy harvesters (PEHs) with a three-dimensional (3D) structure are arousing increasing interest because of the ability to efficiently convert mechanical energy into electricity catering for self-powered systems. Among them, 3D PEHs composed of 1–3-type piezoelectric composites which exploit one-dimensional (1D) piezoceramic fillers rather than conventional powders are particularly attractive. However, an issue involving the orientation of the 1D fillers to utilize the piezoelectric effect renders the 3D structural design for high-efficiency energy conversion more challenging. Herein, for the first time, we introduce the fused deposition modeling (FDM) 3D printing to the flexible construction of poly(vinylidene fluoride) (PVDF)-based 3D PEHs by incorporating 1D BaTi2O5 (BT2) nanorods as piezoelectric fillers. The shearing force generated by FDM successfully realizes the in situ uniform orientation of BT2 nanorods in the PVDF (98% β crystals) matrix along the nozzle extrusion direction. Besides, by coupling 3D printing with the appealing piezoelectric anisotropy feature of BT2 nanorods, the 3D PEH is able to generate different piezoelectric responses to the same applied external force from X, Y, and Z directions. Furthermore, an optimized 3D conical array structure is constructed to amplify the effective deformation of the PEH to enhance its piezoelectric output. As expected, customized PEH can continuously power commercial electronic devices and monitor various human motions, indicating 3D printing as a multifunctional strategy to fabricate 3D PEHs with 1–3-type piezoelectric composite materials for self-powering microelectronic applications.
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Catalysis Science & Technology
·
2022
·Vol. 12
·期 20
·6163-6173
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IF 6.177
Jin Zhang,Mengting Gao,Ruiyi Wang,Xincheng Li,Pengqi Zhu,Yunwei Wang,Zhanfeng Zheng
Selective hydrogenation of α,β-unsaturated aldehydes under mild conditions is a great challenge in the synthesis of the corresponding alcohols. Herein, we report that a series of oxygen vacancy enriched MgAl-LDH coordinated transition metal hydroxide M(OH)x (M = Ru, Pt, Pd, Ag, Rh, Fe, Co, Ni and Cu) photocatalysts were successfully prepared taking advantage of the “memory effect” of MgAl-LDH. A high yield of α,β-unsaturated alcohols was achieved under visible light irradiation. DFT simulations and DRIFTS results show that oxygen vacancies facilitate the adsorption of –CO groups and hinder the adsorption of –CC groups in cinnamaldehyde, which ensures the high selectivity to cinnamyl alcohol. The highly dispersed and electron-rich transition metal hydroxides facilitated the activation of isopropanol to provide active H species under light irradiation and then enhanced the photocatalytic performance. This study demonstrated oxygen vacancy enriched MgAl-LDH supported transition metal hydroxide M(OH)x photocatalysts for efficient selective hydrogenation under visible light irradiation.
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EUROPEAN POLYMER JOURNAL
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2022
·
IF 5.546
Pu Li,Changqing Tu,Miao-Miao Xun,Wan-Xia Wu
Vinyl-functionalized poly( β -thioether ester) (PVTE) was synthesized by enzyme-catalyzed polymerization using immobilized lipase B from Candida antarctica (CALB) for the first time. Four different functionalized monomers were prepared and three polymerization strategies including polycondensation (PC), ring-opening polymerization (ROP), and ring-opening and condensation copolymerization (ROCCP) were investigated. The influences of reaction conditions such as polymerization temperature, time, and monomer ratio on the molecular weight of functionalized poly( β -thioether ester)s were also studied. Both the homopolymer and copolymers were characterized by NMR, SEC, TGA and DSC. Moreover, these poly( β -thioether ester)s containing pendant double bonds toward postfunctionalization were demonstrated by photoinitiated thiol-ene click chemistry and Michael addition reaction, providing a way to cross-linked polyester gels.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2022
·
IF 9.136
Zunbin Duan,He Bian,Lijun Zhu,Daohong Xia
Efficient removal of thiophenic sulfides is important for the purification of fuel. Herein, 2-hydroxypropyl- β -cyclodextrin polymers (2-HP- β -CDPs) with micro-mesopores are synthesized using 2-HP- β -CD and tetrafluoroterephthalonitrile (TFTPN) for removing thiophenic sulfides. The cross-linking of 2-HP- β -CD and TFTPN units forms the mesopores, and the cyclodextrin cavity acts as the micropores. The 2-HP- β -CDP 1:4 (1:4 is the molar ratio of 2-HP- β -CD and TFTPN in preparation) possesses a surface area of 197.49 m 2 g –1 , and most of pores are at 1.09 nm of micropores and 6.06 nm of mesopores. The synergistic effect of the micro-mesopores promotes 2-HP- β -CDP 1:4 to remove the thiophenic sulfides in the order of benzo[ b ]thiophene > 4,6-dimethyldibenzothiophene ≈ dibenzothiophene > thiophene. The removal efficiency and rate using 2-HP- β -CDP 1:4 are better than those of CD-based and most traditional adsorbents that have been reported. Most of sulfides adsorbed by mesopores diffuse rapidly to micropores from the wide end of cyclodextrin and then are selectively captured by the cyclodextrin units in 2-HP- β -CDP 1:4 . These findings can guide the synthesis of CD-based polymers and the application of fuel purification.
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Foods
·
2022
·Vol. 11
·期 10
·1443
·
IF 5.561
Hongbo Li,Suya Xie,Shangqiao Cao,Liangbin Hu,Dan Xu,Jiayi Zhang,Haizhen Mo,Zhenbin Liu
Edible fungi play an important role in material and energy cycling. This study explored the role ofPleurotus eryngiimycelia in the transformation of potato high-calorie starch to low-calorie β-glucan. First, the 3D printing performance of the potato medium was optimized. After inoculating the fermentation broth ofPleurotus eryngiiin 3D printing, we studied the microstructure and material composition of the product. Along with the increase in 3D printing filling ratio, the starch content of the culture product decreased from 84.18% to 60.35%, while the starch content in the solid medium prepared using the mold was 67.74%. The change in β-glucan content in cultured products was opposite to that of starch, and the content of the culture product increased from 12.57% to 24.31%, while the β-glucan content in the solid medium prepared using the mold was 22.17%. The amino acid composition and content of the 3D printing culture system and solid culture products prepared using the mold were similar. The 3D printing culture system promoted the bioconversion efficiency of mycelia. It also showed high application potential ofPleurotus eryngiimycelia for the preparation of low-calorie food.Keywords:bioconversion;Pleurotus eryngiimycelia;starch;3D printing;β-glucan
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BONE
·
2022
·
IF 4.626
Senxin Cai,Yuchun Zou,Yong Zhao,Hanyu Lin,Dali Zheng,Linyu Xu,Youguang Lu
Aims Mechanical stress overload in the temporomandibular joint (TMJ) is an important cause of TMJ osteoarthritis (TMJOA). Whether secreted frizzled-related proteins (SFRPs) play important roles in the development of mechanical stress-induced TMJOA remains controversial. In this study, we investigated the roles of the Wnt/β-catenin signaling and SFRPs in the progression of mechanical stress-induced TMJOA. Methods We investigated the progression of mechanical stress-induced TMJOA using an in vivo model via modified increased occlusal vertical dimension (iOVD) malocclusion and an in vitro model in which isolated chondrocytes were subjected to mechanical stress. The effects of inhibition of Wnt/β-catenin signal on TMJOA induced by mechanical stress were studied by in vitro drug added and in vivo intra-articular injection of XAV-939. TMJOA progression, Wnt/β-catenin signaling and SFRPs was assessed by Cone beam computed tomography (CBCT) analysis, histochemical and immunohistochemical (IHC) staining, quantitative real-time PCR (qRT–PCR), Western blotting (WB), and immunofluorescence (IF) staining. Results Our in vivo results showed that iOVD-induced mechanical stress in the TMJ disrupted mandible growth, induced OA-like changes in TMJ cartilage, and increased OA-related cytokine expression. In addition, iOVD activated Wnt/β-catenin signaling and suppressed Sfrp1 , Sfrp3 , and Sfrp4 expression in condylar cartilage. Moreover, our in vitro study showed that stress disrupted homeostasis , activated Wnt/β-catenin signaling and inhibited SFRP3 and SFRP4 expression in chondrocytes. Suppression of Wnt/β-catenin signaling with XAV-939 promoted SFRP3 and SFRP4 expression and rescued mechanical stress-induced cartilage degeneration in vivo and in vitro. Conclusions Our work suggests that mechanical stress reduces SFRPs expression both in vivo and in vitro and promotes TMJOA via Wnt/β-catenin signaling. Suppression of Wnt/β-catenin signaling promotes SFRPs expression, especially SFRP3 and SFRP4 expression, and rescues mechanical stress-induced cartilage degeneration. Wnt/β-catenin signaling and SFRPs may represent potential therapeutic targets for TMJOA.
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INORGANICA CHIMICA ACTA
·
2022
·
IF 3.118
Chang-Qing Miao,Ni Wang,Yan-Ni Ling,Xia-Qing Ma,Yu-Xin Chen,Rui-Feng Wang,Li-Hua Hou,Yu-Peng Hua,Min-Yan Kang,Ming Fang
Four new Ln III 2 compounds [Ln 2 (dbm) 2 (L) 2 (CH 3 OH)] (Ln(III) = Gd ( 1 ), Tb ( 2 ), Ho ( 3 ), and Tm ( 4 )), where H 2 L is 2-hydroxyamino-propionic acid (3,5-di- tert -butyl-2-hydroxy-benzylidene)-hydrazide and Hdbm is dibenzoylmethane, were successfully synthesized via solvothermal method and characterized structurally and magnetically. Magnetic studies reveal the anti-ferromagnetic interaction was existed in compound 1 . Moreover, magnetic refrigeration property study suggests that compound 1 exhibits magnetocaloric effect with − Δ S m = 21.07 J kg −1 K −1 for Δ H = 7.0 T at 2.0 K. Alternating-current (ac) magnetic susceptibility study of 2 and 3 suggests that single-molecule magnet (SMM) behavior occurs for 2 and 3 under H dc = 0 Oe with the effective energy barrier Δ E / k B of 20.05 K and τ 0 of 2.93 × 10 −6 s for 2 and Δ E / k B = 0.85 K and τ 0 = 3.47 × 10 −5 s for 3 .
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ANALYST
·
2022
·Vol. 147
·期 16
·3652-3661
·
IF 5.227
Qinghao Cao,Chao Chen,Jun Huang,Dantong Shen,Haolin Chen,Huiqing Zhong,Zhiming Liu,Zhouyi Guo
The flexible surface-enhanced Raman scattering (SERS) platform has ceaselessly propelled the development of point-of-care testing (POCT) in diverse fields. Herein, we report a facile strategy for the SERS-chemometric analysis of four β-blockers (bisoprolol, metoprolol, acebutolol and esmolol) based on a super-sticky mussel-inspired hydrogel SERS tape. The surface morphology and mechanical properties of the hydrogel tape can be easily controlled by adjusting the compositional ratio. The optimized tape with excellent toughness and adhesiveness allows efficient collection of analytes through a simple “paste and peel off” approach, further by spraying with silver nanoparticles using a household sprayer to instantly assemble a flexible SERS substrate, the analytes can then detected by a portable Raman spectrometer. This POCT strategy enables the identification and discrimination of four similar β-blockers with high sensitivity and accuracy in combination with the statistical algorithms. The developed SERS tape is finally utilized for the recognition of β-blockers in simulated urine solution, which realizes a limit of detection of 1.0 ng mL−1, revealing a promising potential of this SERS-based POCT for the clinical detection of doping abuse.
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