JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Lan Haibo,Wu Zede,Xia Jinghua,Li Qiuyu,Gao Mengdan,Cai Zhuoxiu,Tan Weijing,Liu Minyi,Xu Ziting,Gao Yang,Zhang Li,Zhao Bingxia,Li Yingjia,Liang Yu
Introduction The efficacy of immunotherapy in triple-negative breast cancer (TNBC) is primarily challenged by its inherent low immunogenicity, which is further undermined by the immunosuppressive activity of tumor-associated polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). The hypoxic microenvironment renders PMN-MDSCs susceptible to ferroptosis and exacerbates immunosuppression. Objectives This study aimed to design a multifunctional nanoplatform comprising Cu/Mn bimetallic metal-organic frameworks decorated with gold (Au) nanozymes (CMAP MOFs) that simultaneously enhances tumor immunogenicity and alleviates immunosuppression. Methods The characteristics of the nanosystem were evaluated using transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and ultraviolet-visible spectrophotometry. In vitro experiments employed Western blotting, immunofluorescence, and flow cytometry to investigate the mechanisms of enhanced immunogenicity and alleviated immunosuppression in 4T1 cells. In vivo experiments evaluated the therapeutic efficacy of the nanosystem in BALB/c mice bearing implanted 4T1 tumors. Results Within tumor cells, the CMAP MOFs undergo GSH-responsive disintegration. The released Cu/Mn ions catalyze Fenton-like reaction to induce tumor cell ferroptosis and mitochondrial DNA damage, activating cGAS-STING pathway, and facilitating CD8 + T cells recruitment. Simultaneously, released Au nanozymes catalyze H 2 O 2 conversion to O 2 , alleviating hypoxia and preventing PMN-MDSCs ferroptosis and associated immunosuppression. While the immunogenicity-enhancing CMP MOFs group increased CD8⁺ T cell infiltration from 21% to 28.3% with 74.1% tumor growth inhibition, the combined immunogenicity enhancement and immunosuppression relief CMAP MOFs group further boosted CD8⁺ T cell infiltration to 32.4% with superior tumor growth inhibition of 81.3%, with IFN-γ and GZMB expression elevated by 2.2-fold and 2.0-fold (CMP MOFs) and 3.4-fold and 3.0-fold (CMAP MOFs) compared to control. This strategy offers a promising approach for enhancing immunotherapy in TNBC patients. Graphical The alternative text for this image may have been generated using AI.
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高影响因子
ADVANCED ENGINEERING MATERIALS
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2026
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IF 3.6
Xianmei Yuan,Lei Fan,Rongjun Hu,Mingwei Wang,Lang Wu,Shanlin Wang,Fang Li,Jianwen Zhang
Magnesium alloys are used in ultrahigh voltage (UHV) insulator connections due to their high specific strength, vibration damping, and shielding properties. However, their low electrochemical potential (−2.37 V) leads to porous oxide films in tidal flats, humid conditions, and salt spray environments, causing pitting and cracking. Subsequently, microorganisms attach to the surface, secreting metabolites that acidify the area in synergy with Cl − , forming biofilm-corrosion coupling and accelerating failure. To address this, we developed a porous Cu-MOFs/CuS composite coating on AZ31B magnesium alloy using a hydrothermal method (160°C, 10 h) and stearic acid modification, creating a superhydrophobic surface (contact angle of 162°). After 50 cycles of simulated sandpaper abrasion, the contact angle remained above 150°, demonstrating superior mechanical stability compared to pure Cu-MOFs coatings. Immersion tests in acids, bases, and salts, as well as dynamic potentiodynamic polarization curves, proved that the Cu-MOFs/CuS composite coating has superior acid–base-salt stability and corrosion resistance compared to a pure MOFs coating. Moreover, the Cu 2+ released from the coating show high inhibitory and antibacterial effects on Escherichia coli and Staphylococcus epidermidis, significantly reducing the risk of microbially induced corrosion. This provides an innovative solution for the long-term reliable service of magnesium alloys in UHV transmission and transformation equipment.
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ACS Applied Energy Materials
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2026
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IF 5.5
Liang Wan,Shaoyan Wang,Can Lei,Chuqian Xiao,Sheng Hu,Yikai Yang,Xingchen Ye,Dongqi Liu,Xiuming Bu,Ming Gong,Xiulan Hu,Xianying Wang
Electrocatalytic 5-hydroxymethylfurfural oxidation (HMFOR) is a sustainable route for biomass valorization to 2,5-furandicarboxylic acid (FDCA), yet balancing the competitive adsorption of HMF and OH− at the electrode−electrolyte interface is pivotal for boosting catalytic activity and selectivity. Herein, we report a terephthalic acid (PTA) modification strategy to tailor Cu-Ni(OH)2 with tunable metal valence and controllable surface charge, fabricating positively charged Cu-Ni(OH)2 and negatively charged Cu-Ni(OH)2-PTA. PTA functionalization elevates the Ni oxidation state and reinforces HMF adsorption on the catalyst surface. In situ surface-enhanced Raman spectroscopy and electrochemical impedance spectroscopy confirm that the negatively charged surface of Cu-Ni(OH)2-PTA efficiently mitigates the steric hindrance of hydrated ions and preserves a fully hydrated Cs+ interfacial microenvironment. This synergy optimizes the adsorption equilibrium of HMF and OH− via efficient and persistent HMF capture, enabling continuous enhancement of HMFOR activity. Consequently, Cu-Ni(OH)2-PTA delivers superior HMFOR performance in CsOH electrolyte, including a high FDCA Faradaic efficiency (98.2%), large current density, excellent cycling stability over 10 cycles, and stable operation for 120 h in a membrane electrode assembly (MEA) system. Notably, a high FDCA Faradaic efficiency of ∼86% is retained even in a pH 13 electrolyte with 1 M Cs+. This work elucidates the coupled effects of metal valence, surface charge, cation hydration, and interfacial water structure on HMFOR, providing a universal interfacial engineering principle for designing advanced electrocatalysts for efficient biomass electrooxidation.
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APPLIED SURFACE SCIENCE
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2026
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IF 6.6
Gujie Yao,Xilai Wang,Yanyan Feng,Xiaoqing Wang,Da Jin,Xue you Wen,Zhixiang Fu,Tianxiang Guo
A promising dual-coping Ag,S-Cu x O/Cu foam electrocatalyst was synthesized for CO 2 RR. • The synergistic effect of Ag and S for CO 2 RR toward HCOOH and CH 3 OH was elucidated. • The Ag-S synergistic mechanism governing HCOOH and CH 3 OH formation was revealed. The electrochemical reduction of CO 2 into value-added fuels such as formic acid and methanol presents a promising approach to mitigating climate change, yet it is constrained by the rational design of efficient electrocatalysts and the understanding of structure-efficiency relationships. Here, a highly efficient Ag,S-Cu x O/Cu catalyst was developed via a facile in situ dual-doping strategy, incorporating Ag and S onto pre-oxidized copper foam. Comprehensive multimodal characterization (SEM, EDS, XRD, XPS, AES) and electrochemical measurements (LSV, EIS, GC, 1 H NMR) were conducted to elucidate the catalyst’s structural properties and CO 2 reduction performance. Results indicate that Ag/S dual doping synergistically enhances catalytic activity by reducing solution mass transfer resistance through improved catalyst nanostructures and expanding the electrochemical active surface area (ECSA). Ag incorporation effectively suppresses the competitive hydrogen evolution reaction (HER), while S incorporation lowers charge transfer resistance ( R ct ). Compared with the Cu x O/Cu foam catalyst, the Ag,S-Cu x O/Cu foam catalyst exhibits increased partial current densities for formic acid (HCOOH) and methanol (CH 3 OH) by 17.09 and 5.70 mA·cm −2 , respectively. Furthermore, the reaction pathways for the electrochemical conversion of CO 2 to HCOOH and CH 3 OH are systematically elucidated. This study proposes a dual-doping strategy to achieve sustainable CO 2 electroreduction and delivers fundamental insights into the external parameters that govern the selective formation of high-value products. Download: Download high-res image (142KB) Download: Download full-size image
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INORGANIC CHEMISTRY
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2026
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IF 4.6
Yanmei Chen,Qirtas Malik,Bolun Wang,Yu Wang,Mian Li,Tao Bo,Jianming Xue,Jianxin Zou,Qing Huang
The development of earth-abundant, low-cost, highly active catalysts to accelerate hydrogen absorption/desorption kinetics in Mg-based materials is critical for hydrogen energy applications. Here, we synthesize three MAX phases with nonconventional A-site elements─Nb2FeC, Nb2NiC, and Nb2CuC─and directly incorporate them into MgH2 matrices without hazardous HF etching. All three MgH2-10 wt % Nb2AC (A = Fe, Ni, Cu) composites exhibit a reduction in onset dehydrogenation temperature from 320 °C to approximately 190 °C, and their dehydrogenation temperature and kinetic behavior are markedly superior to Nb2AlC, demonstrating that substituting the A-site element Al with late transition metals substantially enhances catalytic performance toward MgH2 dehydrogenation. Among them, the MgH2-10 wt % Nb2NiC composite shows optimal performance, releasing ∼6.30 wt % H2 at 300 °C within 10 min and absorbing ∼5.01 wt % H2 at 175 °C within 3 min, while maintaining good cyclic stability. Experimental and theoretical results jointly confirm that Nb2NiC functions as an efficient electron-mediated catalyst, weakening Mg–H bonds and promoting H2 dissociation via interfacial electron transfer, thus significantly improving hydrogen storage kinetics.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Yunwei Li,Xiangmin Xu,Jinchao Chen,Kaiyi Hu,Xingran Zhang,Fang Li
Alkali recovery from industrial wastewater is crucial for resource sustainability, yet conventional electrodialysis technology suffers from a trade-off between hydroxide transfer and ion selectivity, alongside poor alkaline stability. Herein, we fabricated a high-performance chitosan-based composite membrane (CS-Cu) featuring charged sub-nanochannels constructed via a facile coordination strategy. The coordination between Cu 2+ and the amino/hydroxyl groups of chitosan transforms the polymer matrix into a short-range ordered structure, creating charged and confined transport pathways. Electrodialysis results demonstrate that the CS-Cu composite membranes achieve an exceptional OH − / WO 4 2 − selectivity of 227.43, significantly outperforming most reported polymer membranes. This superior selectivity is attributed to a synergistic mechanism involving enhanced electrostatic attraction from the charged short-range nanochannels walls, size sieving, and the Grotthuss mechanism within the nano-confined hydrogen-bonding network. Transition state theory analysis further revealed that the energy barrier for OH − transport is approximately 2.44 times lower than that for WO 4 2 − , confirming the kinetic advantage of hydroxide permeation. Furthermore, the composite membranes exhibit good operational stability during cycling tests. This work provides a novel strategy for designing ion exchange membranes with high-precision alkali separation for industrial alkali recovery.
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MICROPOROUS AND MESOPOROUS MATERIALS
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2026
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IF 4.5
Nguyen Quang Tu Le,Van-Hien Pham,Bich-Ngoc Duong,Duy-Khoi Nguyen,Thi-Phuong-Tu Nguyen,Thien-Hoang Ho,Ngoc-Quyen Tran,Van-Phuc Dinh
Highly crystalline ETS-10 zeolite was prepared with a surface area of 250 m 2 /g and an average pore size of 1.67 nm. • Adsorption was highly pH-dependent, reaching peak efficiency at pH 5.0 for Pb(II) and pH 6.0 for both Cu(II) and Cd(II). • The Sips model best described the adsorption without being limited by concentration. • The adsorption kinetic of Pb(II) follows the PSO model, whereas the ID model controls the removal of Cd(II) and Cu(II). • The removal of Pb, Cu, Cd occurred via stoichiometric Na+/K+ ion exchange within 12-membered rings and surface complexation. Understanding adsorption kinetics and mechanisms play an instrumental role to determine the speed, efficiency, and pathways by which adsorbents remove pollutants. In this study, kinetics and mechanisms of the adsorption of Pb(II), Cu(II) and Cd(II) onto ETS-10 are investigated based on the combination of experimental, theoretical models (Langmuir, Freundlich, Sips, Pseudo-First-Order (PFO), Pseudo-Second-Order (PSO), Intraparticle diffusion (ID)), and modern analytical techniques (XRD, SEM-EDX, FT-IR and BET-BJH). Obtained results show that Sips models give the best fit with experimental data for three ions, while kinetic of Pb(II) adsorption follows PSO and kinetics of Cu(II) and Cd(II) uptakes follow ID models. The adsorption rates of Pb(II) > Cd(II) > Cu(II) during the diffusion process on the surface, whereas the ones of Pb(II) > Cu(II) > Cd(II) in the intraparticle diffusion process. The mechanisms of intraparticle diffusion, ion-exchange and complexion play mainly roles in the removal of Pb(II), Cd(II) and Cu(II). Download: Download high-res image (302KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Yonggang Gang,Zijiang Zhao,Zemin Xu,Xuping Ren,Jun Wang,Wenjun Zhang,Yanhui Long,Liboting Gao,Xiaodong Li,Jianhua Yan,Hao Zhang
Ga doping constructs novel LaGaO x /Cu interfacial structure. • LaGaO x /Cu interfaces stabilize Cu + species by electronic metal-support interaction (EMSI) for methanol synthesis. • Ga incorporation promotes adsorption of H 2 , CO 2 and CO. • LOC/Cu:5Ga delivers a methanol space-time yield of 306.7 g kg cat −1 h −1 . • Ga-induced interfaces shift the reaction from a single to a dual-path mechanism. Developing efficient copper-based catalysts for CO 2 hydrogenation to methanol remains a key challenge in catalytic CO 2 utilization. Irreducible rare-earth oxides offer outstanding thermal stability and structural robustness, yet their limited activity and selectivity restrict methanol productivity. Herein, we propose a promoter-induced interfacial engineering strategy to activate La 2 O 2 CO 3 (LOC)-supported Cu catalysts by incorporating Ga as a heteroatom promoter. A series of Ga-doped LOC/Cu catalysts (denoted as Cu:xGa) were synthesized via a two-step co-precipitation method, exhibiting a pronounced dependence of catalytic performance on Ga loading. The optimized Cu:5Ga catalyst achieved a CO 2 conversion of 9.2% and a methanol space-time yield of 306.7 g kg cat −1 h −1 (3 MPa, 260 °C), corresponding to a 9.8-fold enhancement relative to undoped Cu. Comprehensive structural and spectroscopic characterizations reveal that Ga doping induces the formation of highly dispersed LaGaO x /Cu interfacial sites. The enhanced electronic metal-support interaction (EMSI) at these interfaces optimizes the electronic structure of Cu sites, facilitating reactant activation and further boosting methanol synthesis. These interfaces stabilize interfacial Cu + species, facilitating the dissociation and adsorption of reactants, and fundamentally modify the reaction pathway from a single formate route to a dual mechanism involving both the formate pathway and the RWGS–CO hydrogenation pathway. This work demonstrates an effective strategy to activate irreducible rare-earth oxide–supported Cu catalysts and provides mechanistic guidance for the rational design of efficient and stable catalysts for CO 2 hydrogenation to methanol. Efficient synthesis of methanol via a promoter (Ga)-induced interfacial engineering strategy to activate La 2 O 2 CO 3 (LOC)-supported Cu catalysts, corresponding to a 9.8-fold enhancement relative to undoped LOC/Cu catalyst. Download: Download high-res image (133KB) Download: Download full-size image
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2026
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IF 19.7
Jing Lan,Yuran Yu,Luyao Xing,Fujun Miao,Guosheng Shao,Peng Zhang
Self-supporting Cu/TiN nano-furry serves as a superior bifunctional catalyst for ORR/OER. • DFT reveals Cu/TiN heterojunctions facilitate uniform Li 2 O 2 film growth via enhanced LiO 2 affinity. • Carbon-free catalytic system effectively suppresses Li 2 CO 3 byproduct formation, reducing overpotential. • Delivers ultralow overpotential, high areal capacity and superior stability, outperforming Au-based counterparts. The major hindrance against developing high-performance lithium oxygen batteries (LOBs) lies in their infamously sluggish redox kinetic processes involving undesirable parasitic reactions, which results in large overpotential, low capacity and inferior cycling stability. The rational catalyst design is proposed as an efficient strategy to address the above issue. Herein, we have developed a self-supporting nano-furry cathode based on a Cu foam-supported hierarchical nanotube array architecture decorated with Cu/TiN nanojunctions, which contributes to a fresh bifunctional catalytic mechanism for enhancing ORR/OER catalytic kinetics. Such an integrated cathode with Cu/TiN nanojunctions catalyst enables resilient LOBs through minimizing the energy barriers and excessive input energy to form/decompose Li 2 O 2 , outperforming similar Au-based system. DFT simulation elaborates that the Cu-based heterojunctions with favorable LiO 2 -affinity tend to promote surface deposition of uniform Li 2 O 2 film, alleviating disproportionated reaction and achieving remarkably enhanced capacity. Consequently, this rationally designed cathode for LOBs achieved high area capacity up to 25.6 mAh cm −2 with a small overpotential of 0.37 V at 0.1 mA cm −2 , and exceptional cycle stability with over 350 cycles at 0.2 mA cm −2 under a fixed capacity of 0.25 mAh cm −2 . This work provides an insightful approach towards designing efficient, clean and cheap cathode with abundant metal-based catalysts for LOBs. Download: Download high-res image (278KB) Download: Download full-size image
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2026
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IF 19.7
Juhee Jang,Ernest Pahuyo Delmo,Yushen Liu,Guimei Liu,Yinuo Wang,Tiehuai Li,Minhua Shao
Cu-MOFs have shown great potential as electrocatalysts for selective methane production through the carbon dioxide reduction reaction (CO 2 RR). However, achieving coordination-induced tuning over the desired coordination environment of multi-functional Cu-MOFs remains a challenge, which is closely related to regulating the surface binding energy with reactants. Here we develop a modulator-assisted synthesis method for fabricating nanosized Cu-aminoterephthalic acid (Cu-NH 2 BDC) MOFs, aiming to modify the coordination geometry, which leads to the regulation of charge transfer ability. By incorporating a trace amount of 2-methylimidazole (MIm), the crystallinity of Cu-NH 2 BDC can be improved compared to traditional synthesis, which can be attributed to the influence of the coordination environment within the MOFs. The modulation of electrochemical properties, including the redox potential for the evolution of Cu active species and charge transfer resistance, resulting from additional Cu oxidation state by the amino functional groups, contributed to the enhancement of CH 4 FE (63%) and partial current density (−53 mA cm −2 ) in an H-type cell, while effectively suppressing the parasitic hydrogen evolution reaction. This modulator-assisted synthesis approach presents a promising strategy for optimizing the performance of Cu-NH 2 BDC electrocatalysts in CO 2 -to-CH 4 conversion, offering valuable insights into structural modifications and charge transfer processes involved in the reaction.
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高影响因子
APPLIED SURFACE SCIENCE
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2026
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IF 6.6
Ning Liu,Yujie Zhao,Yan Liang,Rong Tian,Siqi Wu,Bo Wang,Xi Yao,Yanping Wang,Dianming Li
As global water scarcity intensifies, interfacial evaporation emerges as a promising technology to address this challenge. However, the practical implementation of these systems is hindered by numerous factors, including water surface fluctuations and changing climatic conditions. The present paper proposes a self-floating composite membrane (PPHC) based on modified Cu foam and polyacrylonitrile (PAN) fibres for the purpose of enhancing solar interfacial evaporation. It has been demonstrated that PPHC exhibits excellent bending resistance, thereby ensuring structural integrity during real-world water surface fluctuations. The integration of a hydrophobic foam metal design with a polymer fibre network’s capillary action enables the device to achieve high thermal localization and expeditious water transportation. In the context of solar irradiation, the PPHC exhibits an evaporation rate of 1.38 kg m −2 h −1 , thereby demonstrating consistent performance even within a high-salinity environment, characterized by a salt content of 25 wt%. Outdoor testing further validates its adaptability under varying weather conditions, with a peak evaporation rate of 2.96 kg m −2 h −1 recorded. This work presents a novel approach for constructing robust, durable, and highly efficient integrated interfacial evaporators.
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产品关联
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高影响因子
JOURNAL OF FLUORESCENCE
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2026
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IF 3.4
Gu Jianlong,Gao Li,Cai Jieyun,Liu Yuchen,Meng Hongming,Long Jie,Ma Jing,Yang Bing,Wang Chunqiong,Yang Yaling
Carbon dots-based nanozymes show great potential for chemiluminescence (CL) detection due to their stability, excellent catalytic properties, good biocompatibility, and facile synthesis. In this study, bimetallic carbon dot nanoenzymes (Cur/Cu, Fe@CDs) that promote the chemiluminescence signal of luminol were synthesized. Cur/Cu, Fe@CDs possess high peroxidase (POD) activity and can catalyze the luminol/hydrogen peroxide reaction to generate a strong chemiluminescence intensity, which is approximately 8.98 times higher than the chemiluminescence spectral signal produced by the same concentration of K 3 [Fe(CN) 6 ]. Additionally, a sensitive and rapid method for detecting magnesium ions (Mg 2+ ) was developed by leveraging the enhancing effect of Mg 2+ on the CL signal in this system. The proposed CL technique for Mg 2+ demonstrated a linear response range from 3.33 to 166.67 µM and a detection limit of 0.99 µM. Moreover, the method was successfully applied to analyze Mg 2+ in cigarette paper samples through a spiking procedure, achieving a recovery rate of 91.1% to 109.0%. This research offers substantial evidence supporting the advancement of efficient and sensitive platforms for Mg 2+ CL detection.
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高影响因子
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