MEDICINAL CHEMISTRY RESEARCH
·
2012
·Vol. 22
·期 2
·986-994
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IF 1.271
Zhang Mao,Lu Xiang,Zhang Hong-Jia,Li Na,Xiao Yu,Zhu Hai-Liang,Ye Yong-Hao
A series of derivatives of cinnamic amide (compounds 2a – 2v ) were synthesized and evaluated for antiproliferative activities against the human breast cancer cell line MCF-7- and EGFR-inhibitory activities. The structures of compounds 2b and 2i were determined by single-crystal X-ray diffraction analysis. Compounds 2f and 2j showed moderate EGFR inhibitory activity with IC 50 values of 5.16 and 7.37 μM, respectively. Docking simulation of compound 2f was carried out to illustrate the binding mode of the molecule into the EGFR active site. Structure–activity relationship analysis found that the N -phenyl rings are required for enhancing the activities.
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Nano Research
·
2023
·
IF 9.9
Zhu Yuhang,Liu Tingting,Li Lin,Cao Maosheng
Currently, as the electromagnetic (EM) environment becomes increasingly complex, single-function EM materials can hardly resist the increasing electromagnetic interference (EMI), and there is an urgent need to develop multifunctional EM materials. In this work, multifunctional WSe 2 /Co 3 C was prepared by simple hydrothermal methods. Its dielectric performance and EM response were investigated. Efficient absorption, shielding performance, and energy conversion devices were customized. By tailoring the loading content, WSe 2 /Co 3 C can switch between EM absorption and EMI shielding. The maximum shielding effectiveness (SE) of WSe 2 /Co 3 C reached 36 dB, and high reflection loss (RL) of −60.28 dB and wide effective absorption bandwidth (EAB) of 6.16 GHz can be obtained at low thickness. The multiple EM attenuation mechanisms brought by the combination of two-dimensional (2D) WSe 2 and magnetic Co 3 C are considered to be the main reason for the enhanced EM attenuation ability. The WSe 2 /Co 3 C composite provides a viable candidate for developing multifunctional EM materials in 2–18 GHz.
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JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 46
·17442-17458
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IF 4.5
Liu Han,Gao Nengwen,Wang Licheng,He Deqin
Catalytic membranes containing metal nano-catalyst are widely used in dye wastewater treatment. Comparing to the traditional catalyst loading methods, such as the co-precipitation, the surface grafting, and impregnation et al., hydrothermal method is simple, and the crystals obtained have a uniform distribution and high purity. In this study, CuO nano-catalysts is immobilized on ceramic substrate by hydrothermal method. The prepared membrane is used to activate persulfate (PMS) for the degradation of azo dyes. FTIR, XPS, XRD, and FESEM characterizations prove that CuO is successfully loaded onto the Al 2 O 3 substrate, the optimal loading amount is 0.03 g/cm 2 . Static degradation experiments show that the composite membrane could degrade 85% of the Congo red within 80 min. In the dynamic degradation process, the degradation efficiency is further improved to a maximum of 96.8% within 80 min, and the permeation flux of catalytic membrane is relatively stable during the degradation process. In long-term experiments, the degradation efficiency still remains at ~ 87% after 4 cycles, indicating good stability. Quenching experiment shows that the main oxidizing radicals are sulfate radical. In conclusion, the prepared membrane can activate PMS efficiently, which has a potential applications in dye wastewater treatment.
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BMC Chemistry
·
2023
·Vol. 17
·期 1
·1-13
·
IF 4.6
Li Yuanlin,Chen Hongqin,Yan Heng,Xu Yangyong,Tang Jinwen,Wang Runsen,Yan Mengru,Dai Yuqiao,Huang Yongguang,Liu Xiongmin
Biofuels are renewable alternatives to fossil fuels. Levopimaric acid‒base biofuels have attracted increasing attention. However, their stability remains a critical issue in practice. Thus, there is a strong impetus to evaluate the thermal stability of levopimaric acid. Through thermogravimetry (TG) and a custom-designed mini closed pressure vessel test (MCPVT) operating under isothermal and stepped temperature conditions, we investigated thermal oxidation characteristics of levopimaric acid under oxygen atmosphere. Thin-layer chromatography (TLC) and iodimetry were used to measure the hydrogen peroxides generated by levopimaric acid oxidation. A high pressure differential scanning calorimeter (HPDSC) was used to assess hydroperoxide thermal decomposition characteristics. Gas chromatography-mass spectrometry (GC-MS) was used to characterize the oxidation products. The thermal decomposition kinetics of levopimaric acid were thus elucidated, and a high peroxide value was detected in the levopimaric acid. The decomposition heat (Q DSC ) and exothermic onset temperature (T onset ) of hydroperoxides were 338.75 J g −1 and 375.37 K, respectively. Finally, levopimaric acid underwent a second-stage oxidation process at its melt point (423.15 K), resulting in complex oxidation products. Thermal oxidation of levopimaric acid could yield potential thermal hazards, indicating that antioxidants must be added during levopimaric acid application to protect against such hazardous effects.
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PubMed
高影响因子
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
·
2023
·
IF 2.3
Liu Yurong,Zhang Rui,Jing Hongling,Yu Daheng,Pan Renming,Chen Ruiyu
The macroscopic and microscopic surface morphology, products, kinetics, and reaction mechanism of one typical aero-engine material 0Cr18Ni9 in the cases of high-temperature oxidation and hot corrosion by a novel superhydrophobic and oleophobic ultrafine dry powder extinguishing agent (SHOU DPEA) are studied in a simulated aircraft engine compartment working environment. The results demonstrate that the oxidation and corrosion products both contain FeCr 2 O 4 , Fe 2 O 3 , and Fe 3 O 4 . However, the presence of SHOU DPEA accelerates the corrosion within the alloy. The 0Cr18Ni9 substrate shows a L-shaped segregation phenomenon and a chromium-poor layer. Furthermore, the oxidation and corrosion kinetic curves of 0Cr18Ni9 are both parabolic. In particular, the high-temperature oxidation behavior of 0Cr18Ni9 can be divided into two stages: a rapid oxidation stage (0-96 hours) and an oxidation equilibrium stage (96-192 hours), and the hot corrosion process can be divided into two stages: an initial slow incubation stage from 0 to 48 hours, and an accelerated corrosion stage from 48 to 192 hours. Additionally, the chemical reaction mechanisms for oxidation/corrosion are illustrated. Graphical Abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 34
·1-10
·
IF 2.8
Huang Chu,Meng Yingzhi,Li Chenlin,Wang Dawei,Chen Xue,Sun Lixian,Peng Biaolin,Lei Xiuyun,Shen Yufang,Liu Laijun
High-performance colossal permittivity ( ε′ > 10 4 ) plays an indispensable role in the development of electronic field. In this work, ultra-high dielectric permittivity ( ε′ > 237, 294 @1 kHz) and low dielectric loss (0.012 @1 kHz) were simultaneously achieved in Ta-doped BaTi 0.995 Ta 0.005 O 3 ceramics. Importantly, the dielectric permittivity changes less than 15% between − 55 and 200 °C, and the dielectric loss is less than 0.04. The excellent giant dielectric performance is related to the defect dipoles of electronic pins associated with electrons/oxygen vacancies/Ti 3+ , which are generated by B-site donor. And the thermal-activated short-range hopping of electrons is conformed to be the origin of low dielectric losses and excellent thermal stability. This work provides a strategy for achieving ultra-high dielectric permittivity, low dielectric loss, and excellent temperature stability of Ta-doped BaTiO 3 simultaneously through B-site defect engineering.
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Scientific Reports
·
2023
·Vol. 13
·期 1
·1-9
·
IF 4.6
Wu Yalin,Yin Yuanjian,Chen Xin,Zhou Yeping,Jiang Shan,Zhang Mingming,Cai Guangcheng,Gao Quan
Fusarium head blight (FHB) is a critical fungal disease causes serious grain yield losses and mycotoxin contaminations. Currently, utilization of chemical fungicides is the main control method which has led to serious resistance. Development of novel synergist is an important strategy to reduce the usage of chemical fungicides and postpone the development of resistance, while natural components are interesting resources. In this study, the synergistic effect of Taxodium 'zhongshansha' essential oil (TZEO) was determined and the best synergistic ratio (SR) of 3.96 in laboratory which was observed when the weight ratio of TZEO and prothioconazole was 1 : 1 with the corresponding EC 50 (half maximal effective concentration) value of Fusarium graminearum was 0.280 mg L −1 . Subsequently, an increase of 6.31% on the control effect to FHB index in field test was observed when compared to the treatment with prothioconazole alone, though there was no significant difference between these treatments. Furthermore, we established an effective method to detect the mycotoxin contaminations in wheat grain with the limits of quantifications (LOQs) value of 5 µg kg −1 (DON, ZEN, 3-DON, and 15-DON) and 1 µg kg −1 (OTA) and the contents were less to the maximum residue limit (MRL) values. It was also shown that the application of 20% TZEO EW led to a 20% reduction in the use of prothioconazole, which was calculated based on the control effect values of 86.41% and 90.20% between the treatments of 30% prothioconazole OD (225 g a.i ha −1 , recommend dosage) and 30% prothioconazole OD (180 g a.i ha −1 ) + 20% TZEO EW (225 mL ha −1 ), significantly. The initial residue of prothioconazole and prothioconazole-desthio was increased in the treatment with TZEO, which may play an important role in the synergistic effect on FHB. Moreover, none of the treatments posed a prothioconazole residue risk in the wheat grain and the environment. In addition, the essential oil has no any negative influence on wheat growth, which was revealed by a study of the chlorophyll content. These results provide an important botanical synergist for use with prothioconazole to control Fusarium head blight, and in-depth study to the synergistic mechanism of this oil is necessary in our future research.
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PubMed
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CELLULOSE
·
2023
·Vol. 30
·期 18
·11425-11437
·
IF 5.7
Ruan Hong,Chen Xin,Lv Chunzi,Gu Xingshuai,Zhou Zhijian,Lu Shaorong,Li Yuqi
Cellulose-based composites typically have poor water resistance because they are cross-linked through non-covalent bonds, such as hydrogen bonds. Herein, furan group was grafted onto sisal microcrystalline cellulose fiber (F-MSF) and a dynamic thermally reversible cross-linked network structure was formed with maleimide modified CaCu 3 Ti 4 O 12 (D-CCTO) to obtain recyclable D-CCTO/F-MSF composites (DFF) through the Diels-Alder reaction. The results showed that the mechanical properties of DFF composites were improved due to the improvement of the cross-linked structure between D-CCTO and F-MSF. At 1 wt% D-CCTO content, the tensile strength of DFF was 5.53 MPa, which increased by 346% compared with that of pure MSF. At 5 wt% D-CCTO content, the short-circuit current, open circuit voltage, transferred charge of DFF-based triboelectric nanogenerators (DF-TENG) were 3.2 µA, 85 V and 26 nC, respectively. Additionally, the DF-TENG was able to maintain its electrical performance of more than 60% at an ambient humidity of 90% and was able to light up more than 30 LED bulbs. This research provides new insights into addressing the challenge of poor water resistance in conventional cellulose-based composites, while also designing a recyclable TENG device that can harvest energy in high humidity environments. Graphical abstract
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CABI Agriculture & Bioscience
·
2023
·Vol. 4
·期 1
·1-8
·
IF 3.9
Huang Hexi,Di Ning,Wang Jie,Wang Yuxing,Zhu Zhengyang,Lu Caige,Wang Su,Zang Liansheng
The heavy metal, cadmium (Cd), causing growth retardation and yield reduction on rice and impacting the fitness of organisms inhabiting on rice through bottom-up effects, has become a great challenge to rice production. However, the effect of Cd-exposure on the development of an economically important and destructive rice pest, Chilo suppressalis remains unexplored. By exposing the larvae of C. suppressalis to different Cd-exposed artificial diets (0, 0.2, 1.0, 2.5, 5.0, and 10.0 mg/kg), we found that Cd exposure did not affect the larval duration or pupation rate of C. suppressalis , but caused negative effects on pupal weight at high Cd levels (5.0 and 10.0 mg/kg) and on adult deformity rate from 2.5 and 5.0 mg/kg treatments. Although Cd significantly increased the female pupae ratio, C. suppressalis did not oviposit when Cd treatment was more than 2.5 mg/kg. Meanwhile, Cd transferred to pupae, females, exuviae of pupa and eggs of C. suppressalis from Cd treated larvae, and exhibited a dose-dependent response on Cd accumulation. Our results indicated that Cd had a negative effect on rice stem borer and can be transferred to eggs of C. suppressalis , but more work is needed to further assess the bottom-up effect on third tropic levels in Cd-polluted fields.
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RARE METALS
·
2023
·
IF 8.8
Li Pei-Pei,Zhang Yu,Wang Chao,Wang Shu-Jie,Yan Wen-Qing,Xiao Dou-Xin,Kang Jing,Yang De-Zhi,Wu Hai-Xia,Dong Alideertu
Abstract Nanosilver has been regarded as a promising alternative to traditional antibiotics for fighting pathogen-associated infections due to its efficacy toward a broad spectrum of pathogens. However, bacterial resistance to nanosilver has emerged recently. In this contribution, a surface engineering strategy based on N-halamine chemistry to address bacterial resistance to nanosilver was proposed. Using 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) as an N-halamine source, AgCl nanodots were deposited on the surface of Ag nanowires (Ag NWs) via in situ redox reaction to prepare AgCl-on-Ag NWs. After in vitro and in vivo tests, AgCl-on-Ag NWs effectively inactivated two antibiotic-resistant bacteria, ampicillin-resistant Escherichia coli (AREC) and methicillin-resistant Staphylococcus aureus (MRSA) with the minimum bactericidal concentration (MBC) as low as 10 μg·ml −1 and exhibited good biosafety against normal cells. The experimental and theoretical tests demonstrated that AgCl-on-Ag NWs worked on AREC and MASA by generating high level of reactive oxygen species under visible light irradiation, coupled with the sustained Ag + ion release. Meanwhile, the antibacterial mechanism of AgCl-on-Ag NWs against MRSA was verified at the gene level by transcriptome analysis (RNA sequencing). Moreover, the full-thickness defect model verified that AgCl-on-Ag NWs reduced inflammatory cell infiltration and dramatically accelerated wound healing. This work provides a synergistic mechanism based on nanosilver surface engineering to eradicate the resistant bacteria that can alleviate drug resistance and develop an innovative approach for the treatment of bacterial infections.
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IONICS
·
2023
·
IF 2.8
Zeng Qinqin,Huang Qiannan,Luo Zihao,Liu Ao,Li Haoqin,Zhong Mingfeng,Zhang Zhijie
Silicon(Si) is one of the anode materials to replace graphite electrodes due to large specific capacity. However, the volume expansion of silicon anode material and instability of solid electrolyte interphase (SEI) layer greatly limits their practical applications. Herein, we demonstrate a novel sandwich network structure silicon-carbon anode composites and explored as electrode material for lithium-ion batteries (LIBs). The CBC/Si/NC composites were synthesized by using bacterial cellulose (BC) as the structural template and retains the three-dimensional network structure of BC and has a high specific surface area which ease the volume expansion of silicon during the charge-discharge process. Meanwhile, silicon nanoparticles covered with dopamine, the outer carbon, uniformly attached to the cellulose surface. The internal and external carbon layers improve the conductivity of the composite and can accelerate the diffusion and electronic transmission of lithium ions. The sandwich network structure composite anode demonstrates excellent cycle stability and a high reversible specific capacity of 889mAh·g −1 after 200 cycles at a current density of 0.5 A·g −1 .
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2023
·
IF 2.5
Feng Xingyi,Zeng Yingping,Yan Deen,Zou Hanbo,Yang Wei,Chen Shengzhou
Due to its high energy density and better safety performance, all-solid-state lithium batteries are regarded as important energy storage devices to replace the traditional liquid electrolyte Li-ion batteries. However, the problems of poor wettability of Li metal anode | solid-state electrolyte interface and easy growth of lithium dendrite have not been well solved. Here, we have constructed Fe-doped Li 7-3x Fe x La 3 Zr 2 O 12 (Fe-LLZO) and Li 6.5 La 3 Zr 1.5 Ta 0.5 O 12 (LLZTO) garnet-type double-layer solid electrolyte. The high density of Li 7-3x Fe x La 3 Zr 2 O 12 electrolyte and its interfacial wettability to Li metal not only effectively reduced the interface impedance between Li and solid electrolyte but also could stably cycle for more than 200 h without the growth of lithium dendrites at the rate of 0.1 mA cm −2 . In addition, the all-solid-state lithium battery (Li|Fe 0.1 -LLZO|LLZTO|LFP) with LiFePO 4 as a cathode also showed excellent cycle stability and C-rate performance.
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