ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Yanping Sun,Tong Shu,Jianxin Ma,Qiong Dai,Peiwen Peng,Ziping Zhou,Xiang Zhou,Lei Su,Xueji Zhang
The development of modern technologies has acclimatized biosensors to complicated applicable scenarios with integrated properties as a whole instead of the pursuit of a single-point breakthrough. Here, we targeted a few concerns in the development of enzyme-based biosensors, including stability, analyte enrichment, and signal transduction, and developed a general biosensing model utilizing enzymes, aggregation-induced emission (AIE) luminogens, and stimuli-responsive framework materials as the units. We propose such proof-of-concept of glucose biosensors by coencapsulating glucose oxidase and AIE-type gold nanoclusters into acid-sensitive zeolite imidazolate framework (ZIF)-8 nanocrystals. The acid-activated degradation of ZIF-8 bridges the molecular signals produced by the enzyme-catalytic reaction of glucose and the photon signals generated by ZIF-8-induced AIE effects of gold nanoclusters, resulting in the “turn-off” model nanoprobes for glucose detection with high selectivity. After embedding the nanoprobes into hollow-out tapes, the formed paper biosensors can conveniently detect glucose with the help of a smartphone.
研究领域:
生物化学
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材料科学
·
分析化学
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Fei Gao,Chang-Le Shi,Wen An,Xiao-Rui Du,Fang-Di Hu,Juan Chen,Xin-Yue Chen
This study designed targeted peptide sequences (KKWWWWKEREK, SSKWAWAWKL) based on the electronegativity of organophosphorus pesticides (OPs) and the structural characteristics of the acetylcholinesterase (AChE) catalytic active site. On this basis, the aggregation-induced emission (AIE) molecules Bis-pyrene (BP) and tetraphenylethylene (TPE) were introduced, which interacted electrostatically and covalently with the peptide sequences to induce peptide aggregation, restrict the molecular motion of AIE molecules, and trigger fluorescence enhancement. This sensing system has been successfully applied to the detection of real-world samples including Yellow River water, soil, and eluates from four types of Chinese medicinal herbs, thereby achieving enzyme-free detection of OPs. To enhance the convenience and intelligent capabilities of the detection process, a smartphone application with embedded intelligent algorithms and a portable rapid detection device have been developed. The post-reaction sample simply required placement within the device for imaging, after which the software automatically performed image analysis and concentration calculation. The entire process was completed within several minutes, with user-friendly operation and good potential for practical application. This method offered a novel approach for constructing enzyme-free, visual, and on-site rapid detection systems for OPs.
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Polymers
·
2026
·Vol. 18
·期 10
·1202
·
IF 5.8
Liangcong Fan,Peisen Xu,Hongyu Wang,Zhifeng Cai,Juan Zuo,Cong Liu,Xiaohang Tan,Fengxiong Long,Hao Luo,Qingqing Gao
A novel transition-metal-free alkyne–thiol click polymerization with 100% atom economy is reported. Using t BuOLi as a catalyst at 80 °C, the polymerization efficiently yields poly(vinyl sulfide)s (PVSs) with molecular weights up to 11,800 g/mol and yields up to 91%. These sulfur-rich polymers exhibit high thermal stability ( T d up to 293 °C) and high refractive indices (1.8375–1.6383) across the visible range. By integrating abundant sulfur coordination sites with aggregation-induced emission (AIE) properties, the PVS aggregates serve as high-performance fluorescent chemosensors. The sensor enables exclusive, sensitive trace detection of Pd 2+ and Au 3+ with remarkable anti-interference capability and pH robustness (pH 1–7). Notably, an ultrafast response (1–2 min) for Pd 2+ is achieved, with limits of detection (LOD) reaching 7.11 × 10 −7 M for Pd 2+ and 1.06 × 10 −6 M for Au 3+ , and corresponding limits of quantification (LOQ) reaching 2.37 × 10 −6 M and 3.53 × 10 −6 M, respectively. This methodology offers a sustainable route to heteroatom-rich macromolecules for next-generation optical engineering and environmental monitoring.
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TALANTA
·
2026
·
IF 6.7
Wei Zhang,Jinhui Wang,Jialu Xu,Yulong Xu,Haiyan Li,Yujun Jiang
The environmental persistence and inherent biodegradation resistance of pesticide residues pose a serious threat to ecosystems and human health, necessitating the development of efficient monitoring strategies. Herein, we decipher the fluorine-fluorine (F···F) interaction within an AIE-active, trifluoromethyl-functionalized covalent organic framework (PEFA-COF) and exploit this molecular recognition motif for the selective detection of trifluralin (TFR). Benefiting from abundant trifluoromethyl moieties and superior luminescence properties, the PEFA-COF enables specific TFR recognition through a synergistic interplay of electrostatic forces, hydrogen bonding, and F···F interactions. This recognition event triggers a pronounced fluorescence quenching response via the internal filtration effect (IFE), facilitating highly sensitive and selective TFR quantification. The constructed PEFA-COF-based fluorescent sensing platform was successfully validated in complex water and milk matrices, achieving an excellent fluorescence quenching coefficient and a detection limit as low as 0.06 μmol/L. Collectively, this work not only deciphers the critical role of F···F interaction in pesticide recognition but also advances the function-led design of AIE-active COFs toward practical and robust pesticide residue monitoring in food supply chains.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Peiyao Wang,Xiaoluan Yang,Shuoze Geng,Lei Guo,Guiying Li
The development of integrated platform for the simultaneous detection and removal of heavy metal ions remains critical challenge in environmental monitoring. Herein, tetraphenylethylene-modified mesoporous silica nanoparticles (MSN-TPE) were fabricated via Schiff base reaction, and then incorporated into sodium alginate (SA) hydrogel for simultaneous detection and adsorption of Fe 3+ . The as-prepared hydrogel and MSN-TPE probe exhibited strong aggregation-induced emission (AIE) fluorescence, excellent stability against long-term storage, varied pH and temperatures. The hydrogel achieved sensitive and selective fluorescence quenching response to Fe 3+ , with a detection limit as low as 0.460 μM. Thanks to its porous network structure and abundant active sites, the hydrogel also demonstrated significant adsorption capacity for Fe 3+ , with the maximum theoretical adsorption capacity of 383.06 mg/g. Mechanism analysis indicated that Fe 3+ quenched the fluorescence of probe through static quenching, and the adsorption process was mainly driven by the coordination and electrostatic interactions between Fe 3+ and the nitrogen/oxygen functional groups in hydrogel. Combined with simple preparation and excellent anti-interference ability, this dual-functional hydrogel shows broad application prospects in water quality monitoring and heavy metal purification.
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高影响因子
JOURNAL OF FLUORESCENCE
·
2023
·Vol. 34
·期 4
·1603-1615
·
IF 2.7
Yang Yun-Shang,Yuan Yi-Zhen,Zhang Ying-Peng,Guo Hui-Chen,Xue Ji-Jun
Widely utilized in the chemical industry and agriculture, hydrazine is easily absorbed by living things and can cause physical harm when in touch for an extended period of time. As a result, a novel cinnamaldehyde chalcone C5 was produced by Friedel Crafts process and aldol condensation reaction. Triphenylamine was used as the raw material for hydrazine determination in both reactions. Chalcone C5 exhibits significant AIE behavior in a mixed mixture of ethanol and water in addition to having great selectivity and a low detection limit (0.119 nm) for hydrazine. The solvent effect test revealed a linear relationship between the Stokes shift of C5 in the solvent and the rise in solvent orientation polarization. It is important to note that C5 is not harmful to MCF-7 cells, mouse kidney cells, or pig kidney cells. Furthermore, research on cell imaging has demonstrated that probe C5 may be utilized to image the fluorescence of hydrazine in active MCF-7 cells.
研究领域:
化学
·
生物医学
·
材料科学
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Journal of Materials Chemistry C
·
2019
·Vol. 7
·期 30
·9308-9315
·
IF 6.641
Ningwei Sun,Kaixin Su,Ziwei Zhou,Xuzhou Tian,Daming Wang,Nicole Vilbrandt,Andreas Fery,Franziska Lissel,Xiaogang Zhao,Chunhai Chen
Switchable fluorescent materials have gained great attention due to their promising applications in sensors, memory devices and displays. However, further progress is hindered by the low fluorescence contrast, modest response speed and inferior long-term cycling stability. Based on a rational design strategy by combining a highly conjugated tetraphenyl-p-phenylenediamine (TPPA) unit and an aggregation induced emission (AIE)-active tetraphenylethylene (TPE) unit, we synthesized a novel diamine “N,N′-bis(4-aminophenyl)-N,N′-di(4-(1,2,2-triphenylethenyl)phenyl)-1,4-phenylenediamine” to construct an electro- and AIE-active polymer. In addition to the high efficiency solid-state fluorescence and the extremely stable redox properties, the resulting polymer TPE-TPPA-PA realized highly integrated emission/color dual-switchable properties, including multistage color-changing, high fluorescence on/off contrast up to 252, impressively rapid response rate (1.3/0.5 s for EC and 0.7/2.1 s for EFC processes) and excellent cycling stability over 10 000 s. The demonstrated synergistic effect between stable electroactive TPPA and AIE-active TPE may provide a new pathway for further molecular design to realize high-performance emission/color dual-switchable materials.
研究领域:
材料科学
·
高分子化学
·
光电子器件
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智能材料
·
电化学
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DOI
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Rui Jiang,Song Zhao,Langkun Chen,Maoyu Zhao,Wenjing Qi,Wensheng Fu,Lianzhe Hu,Yan Zhang
In this research, a new DSA (Distyryl-anthracene) derivative with four carboxyl groups was designed and synthesized. This molecule exhibits aggregation-induced emission property (AIE). With the AIE character, a convenient and sensitive fluorescent probe for the detection of protamine , heparin and heparinase has been developed. The protamine can directly induce the aggregation of probe, which caused by electrostatic attraction. In this way, the turn-on detection of protamine is achieved, and the detection limit is as low as 30 ng mL −1 . When heparin appears, the probes will be redisperse in solution, which causes a decrease in fluorescence intensity. Besides, this method also shows good selectivity and sensitivity, and the linear range of heparin is from 0.08 to 8 μg mL −1 with detection limit of 37 ng mL −1 . After hydrolyzing heparin by heparinase, the probes rebind with protamine and the fluorescence enhance. The fluorescence enhancement was linearly related to the concentration of heparinase in the range of 0.02–2.0 μg mL −1 and detection limit as low as 143.7 ng mL −1 . In addition, the results exhibited that the recovery percentage of heparinase in bovine samples reached to 96–101%.
研究领域:
生物化学
·
分析化学
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DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Xinhui Hou,Yifan Song,Yupeng Lv,Peiyao Wang,Kun Chen,Guiying Li,Lei Guo
Temperature-responsive nanomicelles with aggregation induced emission (AIE) property were prepared by the host–guest complexation of ferrocene functionalized tetraphenyl (TPE-Fc) and β-cyclodextrin-poly ( N -isopropylacrylamide) (β-CD-(PNIPAM) 7 ). The AIE chromophore TPE-Fc bound to the hydrophobic cavity of cyclodextrin serves as the core of micelles, and temperature sensitive PNIPAM serves as the shell to give the micelles good solubility. The size of the nanomicelles is about 100 nm. At the excitation wavelength of 340 nm, the strongest fluorescent emission peak was 421 nm. The introduction of cyclodextrin star polymer increased the fluorescence intensity of nanomicelles, thus improving the recognition of probe to Fe 3+ and Fe 2+ . The fluorescent probe can quickly detect Fe 3+ and Fe 2+ in water within 5 min even in the presence of various interfering ions. The detection limits of Fe 3+ and Fe 2+ were 1.04 μM and 0.78 μM, respectively in the range of 10–90 μM. The formation of complex between the probe and Fe 3+ /Fe 2+ was supported by Job’s plot. The probe was successfully applied to the detection of Fe 3+ and Fe 2+ in actual water sample with a good recovery. In addition, a possible sensing mechanism for the interaction of iron ions with amide bond groups of nanomicelles was proposed.
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ACS Applied Polymer Materials
·
2023
·
IF 5
Siyi Li,Na Liang,Jiyang Liu,Yuecong Shi,Pengfei Yan,Shaoping Sun
An aggregation-induced emission (AIE)-featured amphiphilic polymer was synthesized by linking hyaluronic acid (HA) with a tetraphenylethene (TPE) derivative via hydrazone bonds (HA-hyd-TPE). The polymer exhibited a powerful AIE effect and could self-assemble to form polymeric micelles. The paclitaxel (PTX)-loaded micelles had a mean size as low as 82.2 nm, with a drug loading capacity of 10.7% and an entrapment efficiency of 79.8%. According to in vitro drug release testing, the micelles exhibited a rapid release of PTX under acidic conditions. In vitro cell viability experiments indicated the significant inhibition ability of the micelles on the growth and proliferation of MCF-7 cells. Cellular uptake assessment confirmed the excellent cellular imaging capability of HA-hyd-TPE micelles, and the micelles could be specifically internalized by MCF-7 cells. Furthermore, the superior antitumor activity and negligible systemic toxicity of the micelles were demonstrated by an in vivo antitumor test. All results suggested that HA-hyd-TPE micelles might be promising carriers for both bioimaging and efficient cancer treatment.
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Polymer Chemistry
·
2022
·Vol. 13
·期 37
·5412-5421
·
IF 5.364
Jing-Han Gao,Baoquan Wan,Ming-Sheng Zheng,Jun-Wei Zha
Polysiloxane plays an irreplaceable role in aviation, automobile, flexible electronic devices, electrical engineering, etc. However, the poor mechanical strength makes it prone to damage during the working process. Therefore, it is of great significance to develop self-healing polysiloxane material. In this work, we prepared a silicon elastomer (CA-PDMS) by introducing citric acid (CA) and urea-group into the polydimethylsiloxane polymer chains, which featured a dynamic cross-linking network of multiple types of hydrogen bond synergies. The elastomer was mechanically tunable by adjustment of the ratio of the hydrogen bonds between the two parts. With an increase in the CA ratio, the elastomers showed a trend from “hard” to “soft”. The maximum elongation at break achieved was 1076.3%, revealing excellent stretchability. Due to the dynamic reversibility of hydrogen bonds, CA-PDMS showed conspicuous self-healing capability and CA had a positive impact on self-healing. Self-healing efficiency was >95% at 60 °C, while the self-healing efficiency reached 81.4% at room temperature. Compared with PDMS-0 without CA, the improvement was respectively about one and seven times. What's more, CA is commonly prepared as carbon quantum dots, compounding with polymer to obtain luminescent materials. Unlike previous research, this study introduced CA into the PDMS polymer chains through polymerization, generating untraditional light-emitting amide groups to achieve luminescence. As far as we know, this is the first time that CA has been reported to improve self-healing and ductility and realize AIE emission by co-polymerization with PDMS.
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Nanomaterials
·
2022
·Vol. 12
·期 4
·641
·
IF 5.719
Yu-Wen Wei,Sayed Mir Sayed,Wei-Wen Zhu,Ke-Fei Xu,Fu-Gen Wu,Jing Xu,He-Peng Nie,Yu-Li Wang,Xiao-Lin Lu,Qian Ma
This study aimed to add two functional components—antibacterial 45S5BGs particles and AIE nanoparticles (TPE-NIM+) with bioprobe characteristics—to the guided tissue regeneration (GTR) membrane, to optimize the performance. The PLGA/BG/TPE-NIM+membrane was synthesized. The static water contact angle, morphologies, and surface element analysis of the membrane were then characterized. In vitro biocompatibility was tested with MC3T3-E1 cells using CCK-8 assay, and antibacterial property was evaluated withStreptococcus mutansandPorphyromonas gingivalisby the LIVE/DEAD bacterial staining and dilution plating procedure. The fluorescence staining of bacteria was observed by Laser Scanning Confocal Microscope. The results showed that the average water contact angle was 46°. In the cytotoxicity test, except for the positive control group, there was no significant difference among the groups (p> 0.05). The antibacterial effect in the PLGA/BG/TPE-NIM+group was significantly (p< 0.01), while the sterilization rate was 99.99%, better than that in the PLGA/BG group (98.62%) (p< 0.01). Confocal images showed that the membrane efficiently distinguished G+bacteria from G−bacteria. This study demonstrated that the PLGA/BG/TPE-NIM+membrane showed good biocompatibility, efficient sterilization performance, and surface mineralization ability and could be used to detect pathogens in a simple, fast, and wash-free protocol.Keywords:aggregation-induced emission nanoparticles;antibacterial;antibacterial differentiation;bioactive glass;bioprobe;guided tissue regeneration (GTR)
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