Toxics
·
2025
·Vol. 13
·期 4
·285
·
IF 4.1
Yonggang Zhao,Mo Peng,Honglei Liu,Xiaoyu Zhang,Dan Fu
Tris(2-chloroethyl) phosphate (TCEP) is a representative chlorinated organophosphate flame retardant (OPFR) that demonstrates greater persistence than other non-halogenated alkyl or aryl OPFRs. Although TCEP has been shown to accumulate significantly in the environment and contribute to testicular toxicity and spermatogenic dysfunction, the precise underlying factors and mechanisms of action remain unclear. Herein, male ICR mice were gavaged with corn oil, 50 mg/kg body weight (bw) TCEP, or 100 mg/kg bw TCEP from postnatal day (PND) 22 to PND 35. TCEP exposure resulted in the disruption of blood-testis barrier (BTB) integrity and in abnormal testicular development. Considering that Sertoli cells constitute the primary target of toxicants and that TCEP induces oxidative stress in the testis and other organs, we focused on ferroptosis in Sertoli cells. Our findings revealed a significant increase in ferroptosis in the testes and Sertoli cells following TCEP exposure, and we observed functional restoration of Sertoli cell junctions upon treatment with the ferroptosis inhibitor ferrostatin-1. Furthermore, ferritin heavy chain 1 (FTH1) was markedly reduced in TCEP-exposed testes and Sertoli cells. Since nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy is essential for the degradation of FTH1, we assessed ferritinophagic activity and found significant upregulation of NCOA4, ATG5, ATG7, and LC3B II/I in TCEP-exposed testes and Sertoli cells. These results strongly suggest that TCEP triggers Sertoli cell ferroptosis by activating ferritinophagy that leads to reduced expression of BTB-associated proteins, ultimately causing BTB disruption and testicular developmental toxicity.
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 11
·1-15
·
IF 2.8
Zheng Lingling,Wen Juanjuan,Wu Jiayi,Deng Huajuan
This research involved the synthesis of a series of single-phase oxyapatite-type phosphors, Ba 2 La 3 (SiO 4 ) 2 (PO 4 )O:Dy 3+ through a high-temperature solid-state reaction methodology. A comprehensive examination was undertaken to elucidate their crystallographic structure, phase homogeneity, morphological features, photoluminescence (PL) properties, and thermal stability. Phase purity was meticulously assessed via X-ray diffraction (XRD) analysis, confirming the hexagonal crystal system alignment with space group P 6 3 / m (No.176) for the Ba 2 La 3 (SiO 4 ) 2 (PO 4 )O:Dy 3+ phosphors. Excitation at 349 nm revealed a triplet of distinguished emission peaks situated at wavelengths of 480 nm (attributed to the 4 F 9/2 - 6 H 15/2 transition), 572 nm (corresponding to 4 F 9/2 - 6 H 13/2 ), and 664 nm (stemming from 4 F 9/2 - 6 H 11/2 transitions). The investigation pinpointed a 0.05 mol concentration of Dy 3+ as the optimum doping level within the Ba 2 La 3 (SiO 4 ) 2 (PO 4 )O matrix for maximized luminescence. Of note, these phosphors exhibit an abnormal thermal quenching behavior alongside a substantial activation energy barrier E a = 0.37 eV, underscoring their robustness at elevated temperatures. The exhaustive findings from this study for advocating the application of these phosphors in light-emitting devices.
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DOI
高影响因子
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2019
·
IF 1.479
Jialiang Chen,Lirong Fu,Yan Li,Xiaodeng Yang,Beibei Wang,Chunlin Xu,Tianduo Li
To illuminate the interactions in N-[(2-hydroxyl)-propyl-3-trimethyl ammonium] chitosan chloride (HTCC)/sodium carboxymethyl cellulose (CMC) based films, the film-forming solutions were studied by rheology, and HTCC/CMC based films were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy and thermogravimetric analysis. The HTCC/CMC based film-forming solutions with glycerol (polyvinyl alcohol (PVA) and anthocyanin) showed shear-thinning behavior. The apparent viscosity of the HTCC/CMC/glycerol (PVA and anthocyanin) film-forming solutions decreased slower than that of HTCC/CMC film-forming solution, due to the electrostatic interaction between HTCC and CMC, and hydrogen bonding interaction between the two biomacromolecules and glycerol, PVA and anthocyanin, which resulted in the formation of three-dimensional networks. The anthocyanin with rigid molecular structure formed different three-dimensional matrix with HTCC/CMC, resulted in viscosity dominated film-forming solution. The pH affected the electrostatic interaction between HTCC, CMC, and anthocyanin through neutralizing –COO− groups, and temperature showed a synergistic effect on both electrostatic interaction and hydrogen bonding. The inter-molecular interactions resulted in the red-shift of typical absorption peaks, and the increase of initial decomposition temperature and decomposition enthalpy of HTCC/CMC based films. The homogenous and smooth surface, and the compact texture of HTCC/CMC based films confirmed the intermolecular interaction between HTCC, CMC, and PVA (glycerol and anthocyanin).
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高影响因子
JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Guo Shanshan,Li Hua
Diabetes, particularly Type 2 Diabetes Mellitus (T 2 DM), is a chronic metabolic disorder with high and increasing global prevalence, characterized by insulin resistance and inadequate insulin secretion. Despite advancements in novel drug delivery systems, widespread and systematic treatment of advanced glycation end products (AGEs) remains challenging due to issues like drug toxicity, low water solubility, and uncontrolled release. Thus, developing nanoplatforms with controlled release capabilities has become a major research focus. Due to its excellent biocompatibility and drug delivery properties, chitosan has attracted considerable attention as a typical biopolymer. In this study, we designed and synthesized an intelligent fluorescence-pH sensitive nanopolymer material using chitosan. We loaded drug 1 and chromium phthalocyanine (CrPc) into folic acid-conjugated carboxymethyl chitosan (FA-CMCS) nanocarriers, forming FA-CMCS@1-CrPc. Comprehensive characterization of FA-CMCS@1-CrPc was conducted using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), and gas adsorption analysis (BET). The results indicate that the nanomaterial was successfully synthesized and exhibits excellent specific surface area, biocompatibility, and fluorescence response. Further research revealed that FA-CMCS@1-CrPc not only achieved controlled drug release but also could regulate drug release by adjusting pH. Additionally, due to its strong fluorescence performance, the nanomaterial demonstrated higher detection sensitivity, especially for monitoring the release of 5% trace drugs. An in vitro model of insulin-resistant cells was established to evaluate the effects of the drug delivery system on glucose degradation and AGE-RAGE regulation, providing a foundation for the development of new T 2 DM drugs. Graphical Abstract
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DOI
PubMed
高影响因子
FUEL
·
2019
·
IF 5.128
Weijie Geng,Wenxiu Li,Lin Liu,Junhai Liu,Liying Liu,Xiangjin Kong
The hydrodeoxygenation of furfural to 2-methylfuran is of great significance for biomass valorization. However, the design of efficient catalysts based on non-noble metals is still a huge challenge for this transformation. In this work, a uniformly dispersed Cu-Cu 2 O/N-RGO nanocomposite was assembled via microwave assisted reduction and ammonia evaporation synthetic strategy. Under the optimum conditions, the yield of 2-methylfuran reached 95.5%, and there was no catalyst deactivation was observed within 5 cycles. The characterization results confirmed that the activity of the catalyst was mainly attributed to the synergistic effects of surface Cu 0 and Cu + species in catalyst, which were originated from partial reduction of CuO species due to the strong interaction between Cu precursors and support. Furthermore, this strong interaction also promised stability of the catalyst which could immobilize copper particles to resist leaching.
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高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2022
·Vol. 52
·期 1
·547-558
·
IF 2.047
Zhou Jian,Ren Sili
The phosphor-converted white light-emitting diode (WLED) has received tremendous attention as a promising alternative to traditional light sources in lighting and displays. Herein, a novel broadband red emitter Ca 2 Sr(PO 4 ) 2 :Mn 2+ was successfully designed and synthesized based on the Sr-alloying and Mn-doping of Ca 3 (PO 4 ) 2 . The phase purity of the materials was verified by x-ray diffraction (XRD) analyses, while a scanning electron microscope (SEM) coupled with an energy-dispersive spectrometer (EDS) was employed to confirm the uniform dopant distribution. XRD Rietveld refinements were further performed to clarify the site occupation of alloying Sr and the Mn dopants. Effective site engineering confined the Mn dopants in a highly symmetric Ca5 site and excluded the immersion of Sr, leading to an extraordinarily long fluorescence lifetime. Density functional theory (DFT) simulations also revealed the good potential of the materials as host matrices for activators such as Mn 2+ . Finally, Ca 2 Sr(PO 4 ) 2 :Mn 2+ was used to fabricate a WLED prototype based on a near-ultraviolet (n-UV) commercial LED chip, which realized a warm white-light emission and high color rendering index (Ra) of 82.9. This WLED was able to survive the long-term stability test while maintaining high luminous efficacy of ~ 60 lm/W within 20 h, showing its great potential in practical applications.
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高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2021
·Vol. 222
·期 23
·2100284
·
IF 2.527
Da Zhang,Jinxin Zheng,Pengfei Zhang,Ronghui Zhao,Zhuo Chen,Meng Wang,Kuilin Deng
In the synthesis of traditional AIE-active polymers with conjugate or multi-benzene system, the troublesome process is still faced such as consuming time, high temperature, catalysis, no water or vacuum, and so on. In this study, the polydihydropyrimidone derivatives (PDPMDs) with AIE properties are facilely synthesized by the introduction of 4-dihydropyrimidone rings onto non-AIE-active intermediate polyureas (PUs) in Biginelli reaction. It is found that the unsymmetrical L- lysine ethyl diisocyanate and butylenediamine played a very important role in the smooth preparation and fluorescence enhancement of PDPMDs. Compared with the intermediate PUs, the fluorescence of PDPMDs is significantly enhanced (35-fold increase), which is mainly due to the intramolecular aggregation of dihydropyrimidone rings on PUs chains. At the same time, with the increase of the content of dihydropyrimidone rings, the fluorescence intensity of PDPMDs also increases, and the emission wavelength shows an obvious red shift. The fluorescence of PDPMDs also showed obvious dependence on excitation wavelength, which further reveals the clusterization-triggering emission (CTE) mechanism. In summary, the strategy of endowing AIE properties to non-AIE active polymer by introducing heterocycles into the backbone through multi-component reaction provides useful guidance for AIE functionalization of other non-AIE materials.
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高影响因子
Journal of Materiomics
·
2019
·
IF 0
Pengyuan Fan,Yangyang Zhang,Shan-Tao Zhang,Bing Xie,Yiwei Zhu,Mohsin Ali Marwat,Weigang Ma,Kai Liu,Liang Shu,Haibo Zhang
Low-temperature sintered (Na 1/2 Bi 1/2 ) 0.935 Ba 0.065 Ti 0.975 (Fe 1/2 Nb 1/2 ) 0.025 O 3 (NBT-BT-0.025FN) lead-free incipient piezoceramics were investigated using high-purity Li 2 CO 3 as sintering aids. With the ≤0.5 wt% Li 2 CO 3 addition, the introduced Li + cations precede to enter the A-sites of the perovskite lattice to compensate for the A-site deficiencies. Once the addition exceeds 0.5 wt%, the excess Li + cations will occupy B-sites and give rise to the generation of oxygen vacancies, which accelerate the mass transport and thus lower the sintering temperature effectively from 1100 °C down to 925 °C. It was also found that a small amount of Li + addition has little effect on the phase structure and electromechanical properties of the system, but overweight seriously disturbs these characteristics because of the large lattice distortion. The sintered NBT-BT-0.025FN incipient piezoceramics with 1.25 wt% Li 2 CO 3 addition at 925 °C provides a large strain of 0.33% and a corresponding large signal piezoelectric coefficient d * 33 of 550 pm/V at 60 kV/cm, indicating this system is a very promising candidate for lead-free co-fired multilayer actuator application.
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DOI
APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Shuaipeng Wang,Li Xu,Weixin Lu
Non-noble metal catalysts with high-performance are intensively exploited toward water electrolysis. Herein, we fabricate a novel Ni 3 S 2 @Co(OH) 2 heterostructure with a tentative method combining hydrothermal method with electrodeposition, in which the Ni 3 S 2 nanosheets are evenly integrated with Co(OH) 2 nanoparticles. Electrochemical tests reveal preeminent catalytic activities and durability on this heterostructure for both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). It presents high catalytic activities of 110 and 257 mV at 10 mA cm −2 for HER and OER, respectively, in 1.0 M KOH solution. Moreover this bifunctional electrode requires only 1.61 V to reach 10 mA cm −2 and shows excellent durability when assembled as an electrolyzer, superior than that of Pt-C||IrO 2 . The promoted activities are benefited from the interfacial cooperation and synergistic effect between Ni 3 S 2 and Co(OH) 2 , because of which the charge-transfer ability is enhanced and surface reactivity is of furtherance. This work is of very profound significance on electrocatalysts for water splitting, specific performances: (1) This heterostructure is synthesized based on interface engineering. (2) The promoted performance is due to the synergistic effect of two onefold-components. (3) The catalysis activities for HER and OER can synchronously reach ideal states when it is used as bifunctional catalyst.
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高影响因子
CORROSION SCIENCE
·
2021
·
IF 7.205
Hao Li,Yujie Qiang,Wenjie Zhao,Shengtao Zhang
2-Mercaptobenzimidazole (M) was successfully inbuilt in zeolitic imidazolate framework-8 (ZIF-8) on GO nanosheets and then imbedded into epoxy coating to prepare composite coating with pH-responsive and self-healing performances. Results showed that M-ZIF-8/GO possessed remarkable pH-triggered activity. The excellent self-healing behavior of M-ZIF-8/GO/EP coating was demonstrated by local electrochemical impedance spectroscopy, which was attributed to the release of corrosion inhibitors that could form a compact protective film on the metal. The anti-corrosion performance of matrix coating was also enhanced effectively because M-ZIF-8/GO could react with epoxy resin which greatly increased the compatibility of M-ZIF-8/GO and the crosslinking density of epoxy coating.
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高影响因子
Journal of Materials Chemistry C
·
2022
·Vol. 10
·期 15
·5905-5913
·
IF 8.067
Jiawei Lin,Zhongnan Guo,Niu Sun,Kunjie Liu,Xin Chen,Jing Zhao,Quanlin Liu,Wenxia Yuan
Organic–inorganic metal halides (OIMHs) exhibit various crystal structures and strong broadband emission, showing enormous potential for solid-state lighting and displays. In this work, we report a new lead-free OIMH (C11H24N2)2[InBr6][InBr4], which adopts a typical zero dimensional (0D) structure with the inorganic polyhedra separated by the large organic cations. Different from the general 0D In-based OIMHs with single octahedral [InBr6]3− units, (C11H24N2)2[InBr6][InBr4] contains both [InBr6]3− octahedra and [InBr4]− tetrahedra. It shows a large optical bandgap of 3.95 eV and excellent ambient stability. In addition, Sb dopants can be included in the structure, and an obvious preference for substituting the In atoms in the [InBr6]3− octahedra has been determined by analyzing the related bond lengths and polyhedral distortion. (C11H24N2)2[InBr6][InBr4] exhibits a broadband red emission (660 nm) that is ascribed to self-trapped excitons (STEs) in octahedral [InBr6]3−, and the photoluminescence quantum yield (PLQY) can be significantly enhanced from 8% to 61% upon Sb doping, mainly as a result of the extra photo-induced excitons from [SbBr6]3−. Density functional calculations reveal the direct bandgap nature of (C11H24N2)2[InBr6][InBr4], which is transferred to an indirect band gap after Sb doping due to the formation of the intra-gap band. A white light-emitting diode (WLED) was fabricated by combining the red emissive (C11H24N2)2[InBr6][InBr4]:Sb3+ and commercial green and blue phosphors, exhibiting a high color-rendering index of 88.7. Our work reports high-efficiency red photoluminescence (PL) in this special 0D double-inorganic-unit system, and demonstrates its potential applications for solid-state lighting.
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高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2022
·
IF 6.364
Pengbin Wang,Qinghu Guo,Fei Li,Fangquan Xia,Hua Hao,Huajun Sun,Hanxing Liu,Shujun Zhang
The development of ferroelectric ceramics with both large piezoelectric responses and broad service temperature range is still a key challenge for practical applications due to the so-called d 33 - T C trade-off. Here we report the strategy to utilize the synergistic contribution of morphotropic phase boundary and enhanced local structural heterogeneity, in which an excellent piezoelectric coefficient d 33 of 680 pC/N and a high Curie temperature of 330 ℃ are simultaneously achieved in Sm modified 0.25PIN-0.325PZ-0.425PT ceramics. The underlying mechanism responsible for the high dielectric and piezoelectric properties is studied based on cryogenic dielectric measurement and Rayleigh analysis. Of particular interest is that, a high field-induced strain of 0.19% is achieved in 0.25PIN-0.32PZ-0.43PT at electric field of 20 kV/cm, corresponding to a piezoelectric d 33 * of 945 pm/V, showing an excellent temperature stability with minimal variation of 7% up to 310 °C. This work demonstrates the introduction of high temperature end members and rare earth doping are conducive to ferroelectric solid solutions with desired broad usage temperature range and superior piezoelectric properties , which will greatly benefit high temperature actuator applications.
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高影响因子
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