JOURNAL OF CHEMICAL RESEARCH
·
2018
·
IF 0.668
Xiaoyun Ma,Daqin He,Zhengjian Chen
A simple method for the preparation of nitriles in moderate to good yield has been achieved by treatment of aromatic and heterocyclic aldoximes with malononitrile in water at reflux in the presence of copper acetate as catalyst. Arylaldoximes with an electron-donating group showed the highest reactivity, their conversion being achievable at room temperature.
✓ 已验证
DOI
高影响因子
JOURNAL OF COORDINATION CHEMISTRY
·
2014
·
IF 2.212
Xiao-Li Tang,Ai-Qing Ma,Guo-Qiang Cai,Long-Guan Zhu
Three complexes with same components, PdII, 2-sulfobenzoate and 1,10-phenanthroline, [Pd(phen)2]⋅2(2-Hsb) (1), [Pd(phen)2](2-Hsb)⋅(2-Hsb)⋅2H2O (2), and [Pd(phen)2]⋅[Pd(phen)(2-sb)2]⋅6H2O (3), where 2-H2sb is 2-sulfobenzoic acid and phen is 1,10-phenanthroline, were synthesized and characterized by IR spectra, elemental analyses, thermogravimetric analyses, UV–vis absorption spectra and powder X-ray analysis. Single X-ray crystal structural analyses showed that 1 and 2 are ionic species, while 3 is a dimer through weak bonding interactions. In 1 and 2, 2-Hsb− ligands are partly deprotonated and it is fully deprotonated in 3. In 2 and 3 there are hydrogen bonds and π–π interactions. Extended hydrogen bonding structures for 2 and 3 are 1-D and 3-D architectures, respectively. The oxidation of methyl phenyl sulfide by 1-3 as homogeneous catalysts gave high conversion and selectivity in methanol. The addition of 2-sulfobenzoic acid in the catalytic reaction further promotes the conversion.
✓ 已验证
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2022
·
IF 10.753
Yingdong Chen,Rongze Sun,Wentao Yan,Mengyao Wu,Yong Zhou,CongJie Gao
In many important industries, such as the textile printing industry, a large amount of dye/salt wastewater is often discharged, which can destroy the ecological environment of the water body. Membrane technology has a great potential in the treatment of environmental problems caused by dye/salt wastewater. Polyvinyl alcohol (PVA) nanofiltration (NF) membrane has a bright future in dye/salt wastewater treatment , however, works on this are rare. Herein, antibacterial PVA NF membrane incorporated with Cu(OH) 2 nanowires for the dye/salt wastewater treatment is reported. The membrane was prepared via coating the solutions containing PVA, glutaraldehyde and Cu(OH) 2 nanowires on the polyethersulfone ultrafiltration membrane. Cu(OH) 2 nanowires has a diameter of 60 nm and was successfully introduced into the membrane. The introduction of nanowires improved the membrane hydrophilicity and roughness, which is conducive to the improvement of membrane flux. Membrane separation performance for one component solution and dye/salt solution were investigated. The introduction of Cu(OH) 2 increases the flux of the membrane obviously (the highest increase is 178.78% (from 21.49 to 38.42 L·m −2 ·h −1 ·bar −1 , for NaCl solution as the feed). Besides, the membrane doped with nanowires also possessed a high dye/salt selectivity . For one component solution, the dye removal rate was over 97.00% while the salt rejection was low (the lowest was 13.18% (NaCl)). For the dye/salt solution, the dye (Congo Red) rejection kept at a high level (98.91%) and the salt (NaCl) rejection was still low (13.71%), while the flux was also high (37.56 L·m −2 ·h −1 ·bar −1 ). The performance is superior to that of many membranes reported in previous works. Moreover, the Cu(OH) 2 nanowires endowed the membrane with an improved and high antibacterial property. The sterilization rate of Escherichia coli and Staphylococcus aureus reached more than 99.99%.
✓ 已验证
DOI
PubMed
高影响因子
Metabolites
·
2022
·Vol. 12
·期 7
·610
·
IF 5.581
Lin-Lin Cao,Yi Han,Lin Pei,Zhi-Hong Yue,Bo-Yu Liu,Jing-Wen Cui,Mei Jia,Hui Wang
Type 2 diabetes mellitus (T2DM) has been identified as an independent risk factor for hepatocellular cancer (HCC). However, there are no ideal biomarkers for the surveillance and early detection of HCC in the T2DM population at present. In this study, we aimed to explore novel metabolite biomarkers for T2DM-positive [T2DM(+)] HCC by metabolomic analysis. At first, many serum metabolites were found dysregulated in T2DM(+) HCC patients in untargeted metabolomic analyses. Targeted metabolite analyses confirmed that serum benzoic acid and citrulline were increased, and creatine was decreased in T2DM(+) HCC compared to the T2DM group. A metabolite classifier including benzoic acid, creatine, and citrulline was identified as a novel biomarker for the diagnosis of T2DM(+) HCC, with an area under the ROC curve (AUC) of 0.93 for discriminating T2DM(+) HCC patients from T2DM patients. In addition, the metabolite classifier detected small-size (AUC = 0.94), early-stage (AUC = 0.94), and AFP-negative (AUC = 0.96) tumors with high sensitivity and specificity. The combination of this metabolite classifier and AFP might be useful in the surveillance and early detection of HCC in the T2DM population. In conclusion, this study establishes a novel diagnostic tool for T2DM(+) HCC.Keywords:hepatocellular cancer;type 2 diabetes mellitus;metabolomics;metabolite classifier;benzoic acid;creatine;citrulline
✓ 已验证
DOI
PubMed
高影响因子
OPTICS LETTERS
·
2020
·Vol. 45
·期 5
·1047-1050
·
IF 3.714
Guoquan Qian,Wenlong Wang,Guowu Tang,Xianchao Guan,Wei Lin,Qi Qian,Dongdan Chen,Changsheng Yang,Jiantao Liu,Guiyao Zhou,Shanhui Xu,Zhongmin Yang
In this work, Tm:YAG (Tm:${{\rm Y}_3}{{\rm Al}_5}{{\rm O}_{12}}$) ceramic-derived multimaterial fiber was fabricated by using the molten core method, which has a high gain per unit length of 2.7 dB/cm at 1950 nm. To our knowledge, this is the highest gain per unit length at 2 µm band in similar Tm:YAG-derived multimaterial fibers. A distributed Bragg reflector (DBR) fiber laser was built based on a 10-cm-long as-drawn fiber. The achieved 1950 nm laser, which has a maximum output power of $\sim{240}\;{\rm mW}$ and a slope efficiency of 16.5%, was pumped by a self-developed 1610 nm fiber laser. What is more, an all-fiber-integrated passively mode-locked fiber laser based on the 10-cm-long as-drawn fiber was realized. The mode-locked pulses operate at 1950 nm with duration of $\sim{380}\;{\rm ps}$, and the repetition rate is 26.45 MHz. The results described here indicate that the Tm:YAG ceramic-derived multimaterial fiber with high gain per unit length has promising applications in 2 µm all-fiber fiber lasers.
✓ 已验证
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2018
·
IF 5.116
Cao Cui,Jingyun Wang,Zhenguo Luo,Jin Wang,Chunxia Li,Zhengquan Li
Cobalt hydroxide in α-form (α-Co(OH) 2 ) is an attractive electrocatalyst for oxygen evolution reaction (OER). Traditional preparation of α-Co(OH) 2 nanosheets often leads to a packing morphology after synthesis or post electrode fabrication, which severely limits the exposure of surface active sites. In this work, we report the synthesis of a self-supported 3D flower-like structure consisting of 2D α-Co(OH) 2 nanosheets through a metal-organic-framework (MOF)-mediated synthetic method. We found that the formation of MOF intermediates can produce dispersive α-Co(OH) 2 nanosheets with a stable 3D hierarchical structure which can effectively avoid the packing of individual nanosheets. The developed α-Co(OH) 2 nanosheets exhibit an obviously enhanced OER activity in comparison with the nanosheets prepared with traditional method. The prepared α-Co(OH) 2 nanosheets have been well characterized and their formation mechanism is proposed.
✓ 已验证
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2017
·
IF 3.154
Jian Zhang,Lei Zhao,Chun Zhu,Zengxue Wu,Guoping Zhang,Xiuhai Gan,Dengyue Liu,Jianke Pan,Deyu Hu,Baoan Song
A series of vanillin derivatives incorporating a bis(2-hydroxyethyl)dithioacetal moiety was designed and synthesized via a facile method. A plausible reaction pathway was proposed and verified by computational studies. Bioassay results demonstrated that target compounds possessed good to excellent activities against potato virus Y (PVY) and cucumber mosaic virus (CMV), of which, compound 6f incorporating a bis(2-hydroxyethyl)dithioacetal moiety, exhibited the best curative and protection activities against PVY and CMV in vivo, with 50% effective concentration values of 217.6, 205.7 μg/mL and 206.3, 186.2 μg/mL, respectively, better than those of ribavirin (848.0, 808.1 μg/mL and 858.2, 766.5 μg/mL, respectively), dufulin (462.6, 454.8 μg/mL and 471.2, 465.4 μg/mL, respectively), and ningnanmycin (440.5, 425.3 μg/mL and 426.1, 405.3 μg/mL, respectively). Current studies provide support for the application of vanillin derivatives incorporating bis(2-hydroxyethyl)dithioacetal as new antiviral agents.
✓ 已验证
DOI
PubMed
高影响因子
BIOORGANIC CHEMISTRY
·
2021
·
IF 5.275
Le-Yun Sun,Cheng Chen,Jianpeng Su,Jia-Qi Li,Zhihui Jiang,Han Gao,Jia-Zhu Chigan,Huan-Huan Ding,Le Zhai,Ke-Wu Yang
The emerging COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has raised a global catastrophe. To date, there is no specific antiviral drug available to combat this virus, except the vaccine. In this study, the main protease (M pro ) required for SARS-CoV-2 viral replication was expressed and purified. Thirty-six compounds were tested as inhibitors of SARS-CoV-2 M pro by fluorescence resonance energy transfer (FRET) technique. The half-maximal inhibitory concentration (IC 50 ) values of Ebselen and Ebsulfur analogs were obtained to be in the range of 0.074–0.91 μM. Notably, the molecules containing furane substituent displayed higher inhibition against M pro , followed by Ebselen 1i (IC 50 = 0.074 μM) and Ebsulfur 2k (IC 50 = 0.11 μM). The action mechanism of 1i and 2k were characterized by enzyme kinetics, pre-incubation and jump dilution assays, as well as fluorescent labeling experiments, which suggested that both compounds covalently and irreversibly bind to M pro , while molecular docking suggested that 2k formed an S S bond with the Cys145 at the enzymatic active site. This study provides two very potent scaffolds Ebsulfur and Ebselen for the development of covalent inhibitors of M pro to combat COVID-19.
✓ 已验证
DOI
PubMed
高影响因子
Bioresources and Bioprocessing
·
2019
·Vol. 6
·期 1
·1-12
·
IF 0
Zhang Can,Song Wei,Liu Jia,Chen Xiulai,Liu Liming
( R )- or ( S )-2-Hydroxy-4-(methylthio)butanoic acid (HMTBA) is used as a poultry nutritional supplement and to treat renal failure disease. Herein, we report an artificially designed biocatalytic cascade process, which uses l -methionine to synthesize ( R )- or ( S )-HMTBA. This biocatalysis cascade comprises a basic module and two different extender modules and operates in a modular assembly manner. The basic module responsible for the transformation of l -methionine to α-keto-γ-methylthiobutyric acid (KMTB) is comprised of the l -amino acid deaminase. Two different extender modules responsible for the transformation of KMTB to ( R )- or ( S )-HMTBA are comprised of the R/S-specific lactate dehydrogenase in combination with the formate dehydrogenase, respectively. Engineered Escherichia coli catalysts, one containing the basic module, the other containing the one of two different extender modules, produced 97.6 g L −1 ( R )-HMTBA and 96.4 g L −1 ( S )-HMTBA with a yield of 96.9% and 95.8% at the large scale (1 L) using a two-stage strategy in one pot, respectively. Therefore, this biocatalytic process lays the foundation for the industrial-scale conversion of low-cost l -amino acids to corresponding high-value enantiopure chiral 2-hydroxy acids.
✓ 已验证
DOI
FOOD HYDROCOLLOIDS
·
2021
·
IF 9.147
Yilun Luo,Wei Zheng,Qian Shen,Li Zhang,Cuie Tang,Rong Song,Shilin Liu,Bin Li,Yijie Chen
To investigate the adsorption kinetics and dilatational rheological properties of Pea Albumin-2 (PA-2) at the oil-water interface, recombinant PA-2 was expressed and purified. Our native-PAGE, SDS-PAGE, and homology modeling results indicated that PA-2, a kind of globular protein, could form dimers by non-covalent interactions rather than disulfide bonds. The TEM results showed that some PA-2 proteins could form aggregates with the size of around 2–3 μm. Unlike other globular proteins, PA-2 exhibited the non-monotonic kinetic dependency of the dynamic viscoelastic modulus (E). Besides, the rate of rearrangement ( k R ) of PA-2 was significantly higher than that of other typical food proteins. Our results demonstrated that PA-2 could adsorb to the oil-water interface in the form of aggregates. The addition of 2-ME (β-mercaptoethanol) would impact dilatational rheological properties of PA-2, leading to disaggregation and higher rearrangement of PA-2 protein aggregates at the oil-water interface. Our data offered more information on the interfacial dynamic properties of globular proteins, and provided a new insight to the conformational changes of globular proteins at the oil-water interface, basing on their dynamic viscoelastic behaviors.
✓ 已验证
DOI
高影响因子
ACS Omega
·
2018
·
IF 0
Yuanzi Wu,Chao Yan,Jian’an He,Wenli Xiong,Shuigen Wu,Shutao Liu,Zhen Cai
Capsid protein of porcine circovirus type 2 (PCV2) is an ideal subunit vaccine candidate for the postweaning multisystemic wasting syndrome. In this study, mannan-mediated targeting of PCV2ΔCap42-233 protein to antigen presenting cells (APCs) was investigated for the development of PCV2 vaccine. Mannan was attached to PCV2ΔCap42-233 protein via an acid sensitive Schiff base reaction. The mannosylated protein was endowed with the capacity to target the mannose receptor on APCs as well as the ability of controlled release of the antigen in the acidic condition of the lysosome. Finally, the immune response of mannosylated PCV2ΔCap42-233 protein in mice was evaluated. The mannosylated protein exhibited the ability to stimulate humoral immune response and enhance the immunity. Thus, acid-sensitive and APCs-targeting mannosylated PCV2ΔCap42-233 protein represents a promising candidate for the potential commercial application as an efficient vaccine against porcine circovirus.
✓ 已验证
DOI
CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Junwei Yao,Jingxia Liu,Heng Zhi,Hongbing Tao,Xiaobao Xie,Qingshan Shi
The primary purpose of this study was to develop an innovative chitosan (CS) modified polylactic acid (PLA) nanospheres for enhancing the bioavailability of 1, 2-benzisothiazolin-3-one (BIT). The cellular uptake efficiency was corresponded positively to the quantity of CS coated on BIT-PLA nanospheres against E. coli and S. aureus . The membrane potentials of E.coli and S. aureus treated with BIT-PLA, BIT-PLA-0.1%CS and BIT-PLA-0.5%CS were reduced with the extension of incubation time and the ratio of coated CS. The enhancement of CS modified on BIT-PLA nanospheres was reduced antioxidase activities and generated excessive reactive oxygen species . The lowest EC 50 value of the modified BIT-PLA-0.5%CS suggested that its toxicity index was around 2.95-fold and 2.11-fold that of non-modified BIT-PLA against E. coli and S. aureus , respectively. These results revealed that the CS modified BIT-PLA nanospheres had a bright prospect in antibacterial formulation delivery system and improving the bioavailability.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）