ADVANCED FUNCTIONAL MATERIALS
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2025
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IF 19
Jiang Tan,Yongjin Fang,Kaicheng Wang,Miaomiao Wei,Zihan Zhang,Lei Wang,Shixuan Chen,Jingye Pan
Trauma from car accidents and other causes can result in severe bleeding and significant skin defects. Current biomaterials still face challenges in achieving rapid hemostasis to stabilize life-threatening conditions and subsequently promoting the complete repair of skin tissue. This study develops a carbon nanotube (CNT)-reinforced carbonized cellulose aerogel for managing fatal, uncontrolled bleeding and enhancing skin wound healing. These aerogels demonstrate high porosity with large pore sizes, appropriate hydrophilicity, and excellent shape recovery after compression. In vitro, the composite aerogels show good cytocompatibility and blood compatibility. Not only do they absorb substantial amounts of adhered red blood cells and platelets, but they also activate platelets. In vivo, the composite aerogels outperform clinically used gauze and gelatin sponges in hemostatic capacity in rat tail amputation and liver perforation hemorrhage models. Moreover, this work discovers that the photothermal effect of the composite aerogel could accelerate blood clot formation, enhance the mechanical properties of the formed clot. Additionally, they promote skin wound healing, achieving results comparable to the widely used commercial wound dressing, PELNAC. The appropriate temperature generated by the photothermal effect can promote the formation of a local blood supply. Overall, this composite aerogel presents a promising strategy for treating uncontrollable bleeding and promoting wound healing.
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产品关联
DOI
高影响因子
PROCESS BIOCHEMISTRY
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2022
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IF 4.885
Yatong Yu,Hangyu Shen,Xiaoying Wang,Magdi E. Gibril,Fangong Kong,Shoujuan Wang
Bacterial cellulose (BC) possesses good physical and mechanical properties for tissue engineering, but its negatively charged surface hinders cell adhesion . Here, the surface charge of BC was modulated with 2 −bromoethylamine hydrobromide (2 −BrEA) via a one-step synthesis method performed in alkaline aqueous solutions at room temperature. Positively charged spherical nanoparticles were thus formed in situ on BC. The amination degree of ethylamine-modified BC materials (BC−EAs) reached 2.80 mmol/g; whereas the crystallinity, fiber diameter, and water contact angle were 55.5 − 65.5%, 30 − 45 nm, and 32.5 − 44.9°, respectively. BC−EAs possess good antibacterial effectiveness against Escherichia coli and Staphylococcus aureus . The CCK− 8 and live/dead assays suggest that BC modified with 0.09 g/mL 2 −BrEA (BC−EA3) is biocompatible and possesses a high efficiency for promoting human neuroblastoma SH−SY5Y cell proliferation and differentiation. Its antibacterial ability is beneficial for preventing the formation of biofilms in the extracellular matrix during tissue and organoid formation, while the properties promoting SH−SY5Y cell proliferation and differentiation make BC−EA3 a good candidate for nerve- or other tissue engineering.
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DOI
高影响因子
ACS Sustainable Chemistry & Engineering
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2016
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IF 5.267
Yangyang Han,Xiaodong Wu,Xinxing Zhang,Zehang Zhou,Canhui Lu
A novel and straightforward synthetic strategy was developed to prepare silver nanoparticles-doped cellulose microgels (Ag NPs@CMG) nanohybrids at room temperature. Residual alkali (sodium hydroxide/urea) from a cellulose dissolving system was reused and acted as a functional accelerant, which made it possible for Ag+ to be reduced to Ag0 by CMG at room temperature, yielding Ag NPs decorated on CMG. The as-prepared Ag NPs@CMG nanohybrids exhibited excellent catalytic performance in reduction of 4-nitrophenol and organic dyes. Moreover, the Ag NPs@CMG nanohybrids were capable to form a desirable porous membrane for catalyzing and simultaneous product separation. Reactants passing through the membrane could be catalytically transformed to product, which is of great significance for water treatment. As a demonstration, three kinds of organic dye solutions were successfully decolorized by using a Ag NPs@CMG nanohybrids-based membrane. The simplicity, sustainability, and straightforwardness of this approach to prepare a highly efficient catalyst and functional membrane open up new possibilities for large-scale production and application of bioresources/noble metal nanohybrids in various fields.
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DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
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2022
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IF 6.449
Sudong Yang,Lin Chen,Shanshan Wang,Shuai Liu
Superhydrophilic textiles with underwater superoleophobicity have shown excellent separation performance for emulsified oil in wastewater, but their hierarchical structure and hydrophilic chemical design are complicated. Herein, a hydrophilic hierarchical layer of cellulose is constructed on commercial cotton fabrics surface through in-situ self dissolving and regenerating strategy. During the process, zinc chloride solution is used as solvent to dissolve cellulose, and sodium sulfate is used as pore forming agent to obtain open porous structure. The cellulose provides both hydrophilic surface and hierarchical structural foundation for the remodeled cotton fabrics (RCFs) without any further chemical modification. Based on the robust mechanical stability, superhydrophilicity, underwater superoleophobicity (θ oil > 150º), and anti-oil fouling property, the RCFs achieved a remarkable separation performance for oil-in-water emulsions with high separation efficiency (> 99.0%) and recyclable antifouling performance. The developed RCFs assembly strategy provides an excellent membrane for oil-in-water emulsion separation, and a new prospect for the convenient and universal construct of other superwetting cellulose-based materials.
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DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
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2022
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IF 6.449
Yanxia Chao,Huichang Gao,Xiang Zhu,Huibin Wang,Zhuohong Yang,Wuyi Zhou,Yaozong Li,Huangwei Chen,Yu Yang,Yang Hu
The multifunctional biocompatible hydrogels have attracted widespread attention in biomedical applications such as the fields of biomimetic tissues, wound dressings and biosensors. But it is a great challenge to facilely develop a hydrogel with favorable mechanical strength, adhesion performance, anti-swelling behavior, antibacterial activity and biocompatibility at the same time. Inspired by the mechanical reinforcement mechanism of double network and nanocomposite hydrogels as well as the adhesion mechanism of mussel, tannic acid-coated cellulose nanocrystals (TA@CNC)/pectin/polyacrylic acid nanocomposite hydrogels (TPP hydrogels) are reported in this work. The obtained TPP hydrogels exhibited high stretchability with the fracture strain of more than 1400%, and excellent elasticity and fatigue resistance. Additionally, the abundant catechol groups on TA@CNC nanoparticles endow TPP hydrogels with good adhesiveness and can adhere to various hydrophilic and hydrophobic substrates such as wood, glass, polytetrafluoroethylene and biological tissues. Moreover, TPP hydrogels also exhibited the significant anti-swelling properties expressed that the equilibrium swelling ratio of the tested TPP hydrogel was only 19.25% as much as that of the polyacrylic acid hydrogel. In addition, TPP hydrogels displayed favorable antibacterial properties against Escherichia coli and Staphylococcus aureus , and can effectively support the adhesion, growth and proliferation of mouse fibroblasts for showing cytocompatibility. All the results imply that TPP hydrogels have promising potential in biomedical application.
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Liping Yin,Wenhao Duan,Yanai Chen,Danyang Chen,Yong Wang,Shuai Guo,Jianglei Qin
Serious side effects of chemotherapy drugs greatly limited the anticancer performance, while targeted drug delivery could improve the therapeutic effect and reduce side effects. In this work, biodegradable hydrogel was fabricated from pectin hydrazide (pec-H) and oxidized carboxymethyl cellulose (DCMC) for localized Silibinin delivery in lung adenocarcinoma treatment. The self-healing pec-H/DCMC hydrogel showed blood compatibility and cell compatibility both in vitro and in vivo , and could be degraded by enzymes. The hydrogel also formed fast fit for injectable applications and showed sustained drug release characteristic sensitive to pH based on acylhydrzone bond cross-linked networks. The Silibinin, as a specific lung cancer inhibiting drug targets TMEM16A ion channel, was loaded into the pec-H/DCMC hydrogel to treat the lung cancer in mice model. The results showed that the hydrogel loaded Silibinin significantly enhanced the anti-tumor efficiency in vivo and greatly reduced the toxicity of the Silibinin. Based on the dual effect of improving efficacy and reducing side effects, the pec-H/DCMC hydrogel with Silibinin loading have broad application prospects to inhibit lung tumor growth in clinic.
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DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
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2022
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IF 10.723
Xuefeng Li,Huixia Lv,Fanli Shi,Jie Song,Zhenhai Zhang
In this study, high-substituted hydroxypropyl cellulose (HHPC) and low-substituted hydroxypropyl cellulose (LHPC) were orally administered (150 or 300 mg/kg) to investigate the inflammation inhibitory effects on DSS-induced colitis mice. In addition, the anti-inflammatory potential of HHPC in-vitro (RAW 264.7 cells) was evaluated. The result showed that HHPC could inhibit the excessive secretion of TNF-α, IL-6, and NO in RAW 264.7 cells induced by lipopolysaccharide . Oral administration of HHPC and LHPC could dose-dependently mitigate the pathological damage of colon tissue, suppressed spleen edema, preserved thymus index, reduced the serum level of inflammatory mediators (TNF-α, IL-6, IL-1β, and MPO), increased the secretion of sIgA in the colon, and restored the balance of the intestinal flora such as Rikenellaceae_RC9_gut_group, Lachnospiraceae_UCG-006, and Blautia . Overall, this study elucidated the therapeutic potential of LHPC and HHPC as a prebiotic to treat acute ulcerative colitis.
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Meisi Chen,Dandan Hao,Yuwen Shao,Tong Zhao,Chengyi Qiu,Xiemin Liu,Muhua Chen,Gang Zhang,Xinbao Zhu,Bo Fu
Cellulose directs Mg/Ni-MOF-74 growth on fiber surfaces. • Tuning Mg/Ni ratio optimizes pore structure and open metal site characteristics. • MNC-1 exhibits high CO 2 capacity and CO 2 /N 2 selectivity (>200). • Hierarchical porosity facilitates both CO 2 confinement and gas mass transfer. • Low isosteric heat of adsorption promotes easy regeneration. To overcome the poor dispersibility and limited gas mass transfer of MOF powders, a series of Mg/Ni-MOF-74/cellulose composites (MNC-x) were fabricated via cellulose interface directed in situ growth. The effects of the Mg/Ni ratio on the material structure and CO 2 /N 2 adsorption performance were investigated. Results showed that the introduction of Ni altered the local environment and crystal size, regulating the pore structure and adsorption sites of the MNC-x series materials. The optimal sample (MNC-1) achieved a static CO 2 adsorption capacity of 2.67 mmol·g −1 at 298 K and exhibiting superior cycling performance. IAST theoretical calculations indicated that MNC-1 possessed high CO 2 /N 2 selectivity, with an initial isosteric heat of adsorption of only 34.51 kJ·mol −1 , indicating that physical adsorption was predominant. Combined with DFT analysis, the excellent CO 2 adsorption performance of MNC-1 was mainly attributed to the interaction between the open metal sites of Mg/Ni and CO 2 , as well as the hierarchical pore structure formed by the microporous adsorption sites and mesoporous mass transfer channels. This study provides a feasible strategy for designing cellulose-supported, processable bimetallic MOF adsorbents for CO 2 adsorption. Download: Download high-res image (269KB) Download: Download full-size image
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DOI
高影响因子
CARBOHYDRATE POLYMERS
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2019
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IF 6.044
Ke Li,Xiao Zhang,Chen Du,Jinwan Yang,Bolang Wu,Zhiwei Guo,Conglin Dong,Ning Lin,Chengqing Yuan
With the increasing requirement of environmental protection, the development of lubricating materials with non-toxicity and good biodegradability becomes more and more significant. As the novel green nanomaterial derived from natural cellulose, cellulose nanocrystals (CNCs) in the present work were prepared from native cotton and added into polyalphaolefin (PAO) base oil as the lubricant additive. To improve the compatibility of CNCs with PAO, the surface of CNCs were grafted by stearoyl chains, which entangled with polyolefin chains and led to a good dispersibility and stability of the colloidal solution. This hybrid oil with the elevated viscosity improved the formation of lubricant film in the boundary lubrication regime. Combining with the mending effect of CNC particles on the surface roughness and scars, both the friction and the wear were dramatically reduced. Specifically, the introduction of 2 wt% modified nanocrystals (mCNC) in PAO base oil reduced the coefficient of friction (COF) by 30%. The results of this study suggest that cellulose nanocrystal is a promising ecofriendly and effective lubricant additive.
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DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
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2022
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IF 10.723
Weisheng Yang,Yang Song,Chang Li,Huiyang Bian,Hongqi Dai,Chaoquan Hu
Developing renewable and biodegradable materials derived from cellulose is an attractive strategy to replace petroleum-derived plastics. In this study, metal ions (Cu 2+ , Fe 3+ , and Al 3+ ) were added as a green binder into carboxymethyl cellulose (CMC) films to improve their mechanical properties and water resistance capacity. The tensile strengths of CMC Al 3+ films were 133 MPa and 99 MPa at 43 % and 97 % humidity, respectively, which were comparable to or greater than those of the majority of commercially available plastics. Additionally, we proposed an interfacial adhesion-assisted molding strategy for forming cellulose-based films, avoiding film wrinkles and unevenness during drying and metal-coordination formation. The resultant films exhibited high transparency, excellent mechanical properties, water resistance capacity, ultraviolet light (UV) shielding, and antibacterial activity . In summary, the biodegradable, eco-friendly, excellent application performance, and adaptability of CMC M n+ (M n+ : polyvalent metal ions) films open new prospects as a viable alternative to non-biodegradable plastics.
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DOI
PubMed
高影响因子
SOFT MATERIALS
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2022
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IF 1.619
Yan Bai,Shuaihang Bi,Weikang Wang,Ning Ding,Yuyuan Lu,Mengyue Jiang,Chengbo Ding,Weiwei Zhao,Ning Liu,Jing Bian,Shujuan Liu,Qiang Zhao
With the booming growth of flexible human-computer interactions and telecommunications, it is desirable to fabricate a high-sensitivity strain sensor to monitor human movement and develop an electromagnetic interference (EMI) shielding materials to protect modern microelectronics and humans from electromagnetic damage. Herein, the biocompatible, stretchable, and compressible cellulose/MXene hydrogel has been prepared to first realize the dual-functional applications in strain sensor and EMI shielding. Two-dimensional MXene nanosheets serve as conductive sensing materials and fillers to construct conductive networks. The hydrogen bond interaction between them enhances the mechanical property of hydrogel. Benefiting from the excellent electrical conductivity and good mechanical property of the cellulose/MXene hydrogel, the resultant strain sensor displays excellent tensile strain (~144.4%), high sensitivity (gauge factor ~ -6.97), adjustable detection range (0-68.7%), fast response time (~100 ms), and great stability (~1000 cycles). It can monitor human motion, including pulse beating, speech recognition, writing sensing and pressure distribution induction of 4 × 4 sensor array platform. Moreover, the cellulose/MXene hydrogel presents an absorption-predominant EMI shielding performance in the frequency of X-band. This work provides a new inspiration for the development of multifunctional hydrogel in artificial intelligence, human-computer interaction, and EMI shielding technique.
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Nan Sun,Zhaofeng Wang,Ying Xu,Jie Cong,Jia Li,Long Bai,Pengfei Huo,Zhiguo Li,Yang Liu
Inspired by the self-recoverability ability of organisms, various self-healing materials have been developed. However, most reinforced fillers are faced with the problem that mechanical strength and self-healing efficiency of materials cannot be improved simultaneously. Here we first prepared new polysiloxane-polyurea (PDMS-PU) and used it as matrix resin to prepare cellulose nanofiber (CNF)/PDMS-PU composite materials with high mechanical properties. CNFs increased the tensile strength of PDMS-PU by 38.87 % and CNF/PDMS-PU composite materials maintained the great bending resistance, transparency and reprocessing properties of PDMS-PU. Moreover, the introduction of CNFs did not reduce the self-healing efficiency of PDMS-PU, and PDMS-PU containing disulfide bonds with CNF content of 1 % (CNF/PDMS-IPDI-S-1 %) with healing efficiency of 95.58 %, and the tensile strength after three recycling processing was still as high as 92.55 % of the original. CNFs reinforced PDMS-PU composite materials are expected to replace PDMS materials in advanced engineering fields that require high strength durability and good formability.
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）