Microsystems & Nanoengineering
·
2024
·Vol. 10
·期 1
·1-9
·
IF 7.3
Li Fuwang,Wei Jian,Qin Xiaomei,Chen Xue,Chen Dawei,Zhang Wentao,Han Jiaguang,Yuan Libo,Deng Hongchang
Field-controlled micromanipulation represents a pivotal technique for handling microparticles, yet conventional methods often risk physical damage to targets. Here, we discovered a completely new mechanism for true noncontact manipulation through photothermal effects, called thermal-optical tweezers. We employ a laser self-assembly photothermal waveguide (PTW) for dynamic microparticle manipulation. This waveguide demonstrates superior photothermal conversion and precision control, generating a nonisothermal temperature field. The interaction of thermal convection and thermophoresis within this field creates a microfluidic potential well, enabling noncontact and nondestructive particle manipulation. By varying the path of PTWs in lithography and manipulating laser loading modes, diverse manipulation strategies, such as Z-shaped migration, periodic oscillation, and directional transport, are achievable. Our innovative noninvasive micromanipulation technology minimizes not only physical damage to target objects but also enables precise and diverse manipulation of micro entities, opening up new avenues for the photothermal control of cells and biomolecules.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-19
·
IF 10.6
Ye Yan,Zhong Wenzhen,Luo Ruifeng,Wen Hongzhi,Ma Ziyang,Qi Shanshan,Han Xiaoqin,Nie Wenbiao,Chang Degui,Xu Runchun,Ye Naijing,Gao Fei,Zhang Peihai
Background The complex etiology and pathogenesis underlying Chronic Non-Bacterial Prostatitis (CNP), coupled with the existence of a Blood Prostate Barrier (BPB), contribute to a lack of specificity and poor penetration of most drugs. Emodin (EMO), a potential natural compound for CNP treatment, exhibits commendable anti-inflammatory, anti-oxidant, and anti-fibrosis properties but suffers from the same problems as other drugs.Methods By exploiting the recognition properties of lactoferrin (LF) receptors that target intestinal epithelial cells (NCM-460) and prostate epithelial cells (RWPE-1), a pathway is established for the transrectal absorption of EMO to effectively reach the prostate. Additionally, hyaluronic acid (HA) is employed, recognizing CD44 receptors which target macrophages within the inflamed prostate. This interaction facilitates the intraprostatic delivery of EMO, leading to its pronounced anti-inflammatory effects. A thermosensitive hydrogel (CS-Gel) prepared from chitosan (CS) and β-glycerophosphate disodium salt (β-GP) was used for rectal drug delivery with strong adhesion to achieve effective drug retention and sustained slow release. Thus, we developed a triple-targeted nanoparticle (NPs)/thermosensitive hydrogel (Gel) rectal drug delivery system. In this process, LF, with its positive charge, was utilized to load EMO through dialysis, producing LF@EMO-NPs. Subsequently, HA was employed to encapsulate EMO-loaded LF nanoparticles via electrostatic adsorption, yielding HA/LF@EMO-NPs. Finally, HA/LF@EMO-NPs lyophilized powder was added to CS-Gel (HA/LF@EMO-NPs Gel).Results Cellular assays indicated that NCM-460 and RWPE-1 cells showed high uptake of both LF@EMO-NPs and HA/LF@EMO-NPs, while Raw 264.7 cells exhibited substantial uptake of HA/LF@EMO-NPs. For LPS-induced Raw 264.7 cells, HA/LF@EMO-NPs can reduce the inflammatory responses by modulating TLR4/NF-κB signaling pathways. Tissue imaging corroborated the capacity of HA/LF-modified formulations to breach the BPB, accumulating within the gland's lumen. Animal experiments showed that rectal administration of HA/LF@EMO-NPs Gel significantly reduced inflammatory cytokine expression, oxidative stress levels and fibrosis in the CNP rats, in addition to exerting anti-inflammatory effects by inhibiting the NF-κB signaling pathway without obvious toxicity.Conclusion This triple-targeted NPs/Gel rectal delivery system with slow-release anti-inflammatory, anti-oxidant, and anti-fibrosis properties shows great potential for the effective treatment of CNP.Graphical Abstract
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Nature Energy
·
2025
·
IF 60.1
Yang Chao,Hu Wenxi,Zheng Mengting,Zhou Xing,Liu Xiaowei,Yang Jingting,Xu Dawei,Wang Meilong,Zhang Youcai,Chen Wen,Lu Jun,You Ya
Short circuits in lithium metal batteries caused by separator failure at elevated temperatures present a critical thermal safety challenge. Smart, temperature-responsive materials offer a promising way to prevent short circuits, yet practical systems with sufficiently fast response times have not been realized. Here we propose a thermo-responsive electrolyte that undergoes a rapid liquid-to-solid phase transition upon heating, offering a highly effective strategy to enhance lithium metal battery safety. The electrolyte leverages LiPF 6 to initiate cationic polymerization, enabling solidification within seconds at a temperature threshold near the separator’s melting point. This fast phase change forms an effective heat shield that prevents internal short circuits and thermal runaway. Demonstrated in LiFePO 4 ||Li pouch cells, the electrolyte ensures stable operation up to 90 °C and completely suppresses thermal runaway. Notably, the transition temperature can be tuned between 100 °C and 150 °C, allowing compatibility with various commercial separators. This ultrafast thermo-responsive electrolyte offers a pathway towards the design of intrinsically safe lithium metal batteries.
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Signal Transduction and Targeted Therapy
·
2025
·Vol. 10
·期 1
·1-18
·
IF 52.7
Xiao Xina,Hu Meng,Gao Li,Yuan Huan,Chong Baochen,Liu Yu,Zhang Rou,Gong Yanqiu,Du Dan,Zhang Yong,Yang Hao,Liu Xiaohui,Zhang Yan,Zhang Huiyuan,Xu Heng,Zhao Yi,Meng Wenbo,Xie Dan,Lei Peng,Qi Shiqian,Peng Yong,Tan Tao,Yu Yang,Hu Hongbo,Dong Biao,Dai Lunzhi
Oxidative stress plays a crucial role in organ aging and related diseases, yet the endogenous regulators involved remain largely unknown. This work highlights the importance of metabolic homeostasis in protecting against oxidative stress in the large intestine. By developing a low-input and user-friendly pipeline for the simultaneous profiling of five distinct cysteine (Cys) states, including free SH, total Cys oxidation (Sto), sulfenic acid (SOH), S -nitrosylation (SNO), and S -glutathionylation (SSG), we shed light on Cys redox modification stoichiometries and signaling with regional resolution in the aging gut of monkeys. Notably, the proteins modified by SOH and SSG were associated primarily with cell adhesion. In contrast, SNO-modified proteins were involved in immunity. Interestingly, we observed that the Sto levels ranged from 0.97% to 99.88%, exhibiting two distinct peaks and increasing with age. Crosstalk analysis revealed numerous age-related metabolites potentially involved in modulating oxidative stress and Cys modifications. Notably, we elucidated the role of fumarate in alleviating intestinal oxidative stress in a dextran sulfate sodium (DSS)-induced colitis mouse model. Our findings showed that fumarate treatment promotes the recovery of several cell types, signaling pathways, and genes involved in oxidative stress regulation. Calorie restriction (CR) is a known strategy for alleviating oxidative stress. Two-month CR intervention led to the recovery of many antioxidative metabolites and reshaped the Cys redoxome. This work decodes the complexities of redoxomics during the gut aging of non-human primates and identifies key metabolic regulators of oxidative stress and redox signaling.
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Signal Transduction and Targeted Therapy
·
2025
·Vol. 10
·期 1
·395
·
IF 52.7
Liu Yue,Wang Huirui,Zhan Jie,Sun Jiabo,Sun Yan,Fu Xiaojie,Lv Dongxue,Li Xiuyun,Dong Ting,Lou Hongxiang
The widespread clinical application of paclitaxel (PTX) in cancer treatment has been significantly limited by the emergence of drug resistance and the presence of drug-tolerant persister cells. To systematically identify key regulators of this resistance, we conducted a genome-wide CRISPR/Cas9 knockout screen, which revealed that cell division cycle 6 (CDC6) is a critical determinant of cell adhesion-mediated PTX resistance. Furthermore, our results illustrate that CDC6, an essential DNA replication licensing factor, functions through a pathway distinct from previously well-characterized resistance mechanisms. Genetic depletion of CDC6 considerably sensitizes cells, markedly increasing PTX-induced cell death. In addition to its established role in chromosome stability, CDC6 physically interacts with tropomodulin-3 (Tmod3) in the cytoplasmic compartment. This interaction enhances CDC6 protein stability and drives drug resistance phenotypes through the regulation of actin cytoskeleton remodeling and facilitating focal adhesion assembly. In addition, combination treatment with PTX and actin filament inhibitors synergistically enhanced the antitumor efficacy both in vitro and in vivo. Overall, our studies elucidate the mechanisms through which CDC6 functions as a key regulator of PTX resistance and provide a potential therapeutic strategy to increase PTX efficacy through the modulation of the cytoskeletal-adhesion axis.
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NATURE
·
2025
·Vol. 646
·期 8083
·102-107
·
IF 48.5
Liu Xiangsi,Li Shuyang,Yuan Chen,Zheng Bizhu,Cheng Gangya,Chen Yufan,Lu Xingyu,Gu Danyu,Lv Baijiang,Li Hao,Yan Zihan,Qian Hui,Zhu Yizhou,Sun Dalin,Song Yun,Xiang Yuxuan
The electrolyte–electrode interface serves as the foundation for a myriad of chemical and physical processes. In battery chemistry, the formation of a well-known solid–electrolyte interphase (SEI) plays a pivotal role in ensuring the reversible operations of rechargeable lithium-ion batteries (LIBs) 1 , 2 . However, characterizing the precise chemical composition of the low crystallinity and highly sensitive SEI presents a formidable challenge 3 . Here, taking lithium fluoride (LiF)—a widely studied and considered crucial SEI component 4 , 5 , 6 , 7 —as an example, we use 19 F solid-state nuclear magnetic resonance (NMR) and identify that LiF formed in SEI (LiF SEI ) has fruitful spectroscopy features that originated from the formation of limited LiF–LiH solid solutions: H-rich phase (LiH 1 − y F y ) and F-rich phase (LiF 1 − x H x ), which is further validated by 6 Li isotope NMR, synchrotron X-ray diffraction and cryo-electron microscopy (cryo-EM). By characterizing SEI formed in various electrolytes, we confirm the dominance of LiH 1 − y F y in high-coulombic-efficiency electrolyte, which can be rationalized by the fact that LiF–LiH solid solution shows improved ionic conductivity over LiF. As a proof of concept, we demonstrate that LiH 1− y F y -rich coating layer presents obvious advantages compared with LiF-rich coating layer in lithium-metal batteries. This revised understanding of the heterogeneous nature of SEI components would provide new insights for electrode–electrolyte interface design.
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NATURE
·
2025
·Vol. 637
·期 8048
·1104-1110
·
IF 48.5
Yang Bingbing,Liu Yiqian,Jiang Ru-Jian,Lan Shun,Liu Su-Zhen,Zhou Zhifang,Dou Lvye,Zhang Min,Huang Houbing,Chen Long-Qing,Zhu Yin-Lian,Zhang Shujun,Ma Xiu-Liang,Nan Ce-Wen,Lin Yuan-Hua
Dielectric-based energy storage capacitors characterized with fast charging and discharging speed and reliability 1 , 2 , 3 , 4 play a vital role in cutting-edge electrical and electronic equipment. In pursuit of capacitor miniaturization and integration, dielectrics must offer high energy density and efficiency 5 . Antiferroelectrics with antiparallel dipole configurations have been of significant interest for high-performance energy storage due to their negligible remanent polarization and high maximum polarization in the field-induced ferroelectric state 6 , 7 , 8 . However, the low antiferroelectric–ferroelectric phase-transition field and accompanying large hysteresis loss deteriorate energy density and reliability. Here, guided by phase-field simulations, we propose a new strategy to frustrate antipolar ordering in antiferroelectrics by incorporating non-polar or polar components. Our experiments demonstrate that this approach effectively tunes the antiferroelectric–ferroelectric phase-transition fields and simultaneously reduces hysteresis loss. In PbZrO 3 -based films, we hence realized a record high energy density among all antiferroelectrics of 189 J cm −3 along with a high efficiency of 81% at an electric field of 5.51 MV cm −1 , which rivals the most state-of-the-art energy storage dielectrics 9 , 10 , 11 , 12 . Atomic-scale characterization by scanning transmission electron microscopy directly revealed that the dispersed non-polar regions frustrate the long-range antipolar ordering, which contributes to the improved performance. This strategy presents new opportunities to manipulate polarization profiles and enhance energy storage performances in antiferroelectrics.
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Nature Catalysis
·
2025
·
IF 44.6
Zhao Kuang-Min,Wu Dao-Xiong,Wu Wen-Kun,Nie Jia-Bao,Geng Fu-Shan,Li Guang,Shi Hai-Yan,Huang Sheng-Chao,Huang Huan,Zhang Jing,Zhou Zhi-You,Wang Yu-Cheng,Sun Shi-Gang
Fe–N–C catalysts are the most promising alternative to Pt for the acidic oxygen reduction reaction (ORR), yet the electronic structure of their active centres remains elusive. Here we synthesize and characterize a conjugate-bridged iron phthalocyanine (FePc) dimer model catalyst with identical Fe sites and catalytic activity comparable to actual catalysts. A high-spin trivalent FeN 4 with an axial hydroxyl ligand, denoted as OH–Fe 3+ N 4 ( S = 5/2), is identified as the active state. By contrast, monomer and non-conjugated dimer manifest the OH–Fe 3+ N 4 ( S = 3/2) state with an excessive adsorption energy of ORR intermediates. Polymerized FePc is composed of 35% of the S = 5/2 state and 65% of the Fe 2+ N 4 ( S = 0 or 1) state, showing a general weaker adsorption energy. Both overly strong and weak adsorption energy hinder the ORR. Theoretical calculations indicate that π– d interaction between Fe and the conjugated carbon plane dictates the spin state. This study will help to precisely design Fe-based ORR catalysts.
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Nature Biomedical Engineering
·
2025
·
IF 26.6
Li Cuifeng,Li Yuxin,Zhou Bini,Li Tong,Wei Xiaohui,Chen Kun,Chen Wenlong,Shi Ziwei,Dai Xiaobin,Zhang Jiachen,Yang Chen,Ji Zhenglin,Sun Wenbo,Gao Ji,Wu Jing,Zhao Binbin,Min Xin,Li Yujie,Lin Lin,Yang Wei,Wang Min,Liu Zezhong,Liu Yaping,Zhu Chenyou,Yang Bo,Xu Jiang-Fei,Yan Li-Tang,Shi Yi,Lu Lu,Zhang Linqi,Ding Qiang,Xue Jing,Hou Baidong,Qi Hai,Liu Jiangning,Yang Yuhe R.,Liu Dongsheng,Liu Wanli
The emergence of novel infectious disease has intensified demand for more advanced vaccine development and more potent adjuvants to enhance immunogenicity. Here we introduce a dynamic DNA supramolecular matrix assembled from five unmodified, short DNA single strands, serving as a safe, multifaceted adjuvant platform. This DNA matrix elicits a robust humoral response with minimal adverse effects, generating potent neutralizing antibodies and conferring robust protection against SARS-CoV-2 and Streptococcus pneumoniae infections. Its dynamic colloidal feature prolongs the in vivo retention of both DNA and antigen, facilitating lymphatic-targeted transportation and presentation. This process leads to a robust pro-inflammatory response in both the vaccinated site and draining lymph node, which, in turn, promotes the recruitment and activation of immune cells, leading to a rapid, effective antigen-specific antibody response. The enhanced function of DNA matrix depends on the canonical TLR9–MyD88 signalling axis in dendritic cells. In addition, only right-handed, not left-handed, chirality of the DNA strands forms d -DNA matrix and promotes immune activations. Thus, this DNA matrix functions as an all-in-one adjuvant platform, opening promising avenues for future vaccine design.
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Nano-Micro Letters
·
2023
·Vol. 16
·期 1
·1-13
·
IF 26.6
Dai Huichao,Chen Yuan,Cao Yueyue,Fu Manli,Guan Linnan,Zhang Guoqun,Gong Lei,Tang Mi,Fan Kun,Wang Chengliang
The effect of small changes in isomers on electrochemical performance have not been focused in batteries and two isomers are reported for Zn-ion batteries here.
The isomer tetrathiafulvalene (TTF) could store two monovalent anions reversibly, showing remarkable performance that outperformed most of the reported organic electrode materials for zinc-ion batteries.
The isomer tetrathianaphthalene (TTN) could only reversibly store one monovalent anion and upon further oxidation, it would undergo an irreversible solid-state molecular rearrangement to TTF.
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Nano-Micro Letters
·
2022
·Vol. 14
·期 1
·1-14
·
IF 23.655
Yang Zijie,Lv Siyuan,Zhang Yueying,Wang Jing,Jiang Li,Jia Xiaoteng,Wang Chenguang,Yan Xu,Sun Peng,Duan Yu,Liu Fangmeng,Lu Geyu
3D porous crumpled MXene spheres were synthesized by ultrasonic spray pyrolysis technology.
All-MXene transient sensors utilizing porous crumpled MXene sphere as sensing material and MXene films as electrodes were developed, which achieved excellent gas/pressure sensing performance.
Both gas and pressure sensors can achieve rapid and controllable degradation in medical-grade H 2 O 2 (2%) within 6 h.
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Light-Science & Applications
·
2025
·Vol. 14
·期 1
·1-11
·
IF 23.4
Suo Hao,Wang Nan,Zhang Yu,Zhang Xin,Xiang Jinmeng,Wang Xiaojia,Xing Guansheng,Guo Dongxu,Chang Jiwen,Wang Yu,Li Panlai,Wang Zhijun,Zhang Yuhai,Chen Bing,Li Shuzhou,Guo Chongfeng,Wang Feng
Low-dimensional lead-free metal halide perovskites are highly attractive for cutting-edge optoelectronic applications. Herein, we report a class of scandium-based double perovskite crystals comprising antimony dopants that can generate multiexcitonic emissions in the ultraviolet, blue, and yellow spectral regions. Owing to the zero-dimensional nature of the crystal lattice that minimizes energy crosstalk, different excitonic states in the crystals can be selectively excited by ultraviolet light, X-ray irradiation, and mechanical action, enabling dynamic control of steady/transient-state spectral features by modulating the excitation modes. Remarkably, the transparent crystal exhibits highly efficient white photoluminescence (quantum yield >97%), X-ray excited blue emission with long afterglow (duration >9 h), and high-brightness self-reproducible violet-blue mechanoluminescence. These findings reveal the exceptional capability of low-dimensional perovskite crystals for integrating various excitonic luminescence, offering exciting opportunities for multi-level data encryption and all-in-one authentication technologies.
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危险品化学品经营许可证（带存储）