Water
·
2022
·Vol. 14
·期 14
·2260
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IF 3.53
Md. Nahid Pervez,Shengjia Ma,Siqi Huang,Vincenzo Naddeo,Yaping Zhao
In the current work, novel graphene quantum dots (GQDs)-doped goethite (α-FeOOH) nanocomposites (GQDs/α-FeOOH) were prepared by following a feasible hydrolysis method and applied for ciprofloxacin (CIP) removal. Results showed that the CIP degradation efficiency was significant (93.73%, 0.0566 min−1) in the GQDs/α-FeOOH + H2O2+ Vis system using much lower amounts of H2O2(0.50 mM), which is 3.9 times the α-FeOOH + H2O2+ Vis system. It was found that •OH,O2•−, and1O2were mainly responsible for CIP degradation in the GQDs/α-FeOOH photo-Fenton system. GQDs/α-FeOOH demonstrated broad-spectrum UV–vis-IR responsiveness in the degradation of ciprofloxacin as a function of the doping of GQDs. Additionally, GQDs/α-FeOOH showed outstanding durability (recyclability up to 3 cycles with a lower iron leaking amount, 0.020 mg L−1), a broad range of application pH, and a pretty acceptable catalytic efficacy in a variety of surface water matrices. Overall, GQDs/α-FeOOH have been shown to be an effective photocatalyst for the remediation of emerging contaminants via the workable exploitation of solar energy.Keywords:GQDs;goethite;emerging contaminants;photo-Fenton-like reaction;water pollution
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2023
·
IF 6.7
Zhan Cui,Fang-Yan Guo,Li Li,Fuping Lu,Cheng-Hua Jin,Xiangming Wang,Fufeng Liu
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the accumulation of α-synuclein (α-Syn) aggregates. However, there are currently no effective therapies for PD. Brazilin, an inhibitor of α-Syn aggregation, is unstable and toxic. Therefore, we have developed and synthesized derivatives of brazilin. One of these derivatives, called brazilin-7-acetate (B-7-A), has shown reduced toxicity and a stronger effect on inhibit α-Syn aggregation. It showed that B-7-A prevented the formation of α-Syn fibers and disrupted existing fibers in a dosage-dependent manner. Additionally, B-7-A significantly reduced the cytotoxicity of α-Syn aggregates and alleviated oxidative stress in PC12 cells. The beneficial effects of B-7-A were also confirmed using the Caenorhabditis elegans model. These effects included preventing the accumulation of α-Syn clumps, improving behavior disorder, increasing lifespan, reducing oxidative stress, and protecting against lipid oxidation and loss. Finally, B-7-A showed good ADMET properties in silico. Based on these findings, B-7-A exhibits potential as a prospective treatment for PD.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Tianlie Luo,Yueyu Ran,Yaling Li,Xi Ren,Dian Liu,Shuya Guo,Zhongyu Guo,Guo Liu,Yihua Li,Willie J.G.M. Peijnenburg
Dissolved black carbon (DBC) plays a critical but poorly understood role in the photochemical transformation of organic pollutants. Its structural heterogeneity, determined by biomass source and pyrolysis temperature, strongly influences its photosensitization efficiency. This study systematically investigated the molecular characteristics of DBC derived from rice, wheat and corn straw and examined their effects on the photodegradation kinetics and pathways of α-nitroso-β-naphthol (αNβN). Fourier transform ion cyclotron resonance mass spectrometry analysis revealed that DBC primarily comprises CHO compounds with lignin-derived and fused-ring aromatic structures. With increasing pyrolysis temperature, lignin transforms into highly condensed polycyclic aromatic frameworks characterized by enhanced unsaturation and aromaticity. This molecular transformation directly governs the photochemical activity of DBC, as evidenced by linear correlations between the molecular features of DBC (i.e., unsaturation and aromaticity) and its optical properties, steady-state concentrations of reactive intermediates (RIs) and αNβN photolysis rates. Mechanistic studies identified the triplet-excited state of DBC ( 3 DBC ⁎ ) as the dominant RI responsible for αNβN degradation via dehydrogenation, condensation and redox reactions. While most photoproducts exhibit lower ecotoxicity than αNβN, exceptions such as 2-nitro-1-naphthol and coumarin underscore source-dependent risk variations. These findings advance the molecular-level understanding of the environmental implications of DBC, emphasizing its dual function as both a photochemical promoter and a modulator of pollutant behavior.
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TETRAHEDRON
·
2017
·
IF 2.651
Zhenyu Tian,Kun Meng,Yanhong Shi,Naixia Zhang,Xuehui Liu,Hongwei Jin,Yongmin Zhang,Lihe Zhang,Demin Zhou,Sulong Xiao
A newly synthesized hexavalent oleanolic acid/per- O -methylated α -cyclodextrin conjugate shows significant differences in NMR spectra with previously synthesized analogs. Characterization of the product by 1 H NMR, 13 C NMR, COSY, HSQC , HMBC , TOCSY , NOE, and ROESY experiments were performed. Detailed investigations revealed that the compound has two conformations in solution and the ratio of them was 1:1. Further variable-temperature NMR study revealed that the two conformations were stable at temperature range of 273–323 K in CDCl 3 solution.
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Journal of Essential Oil Bearing Plants
·
2020
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IF 0.824
Yu Chen,Lejing Chi,Xiaoxin Liang,Yaohui Shi,Tongyun Wu,Mao Ye,Ping Han,Li Lin,Lanyue Zhang,Peng Xu,Zhiyun Du
Cedrus deodara is a cedar plant from the Pinaceae family. Because Cedrus is widely used in health care products, cosmetics, medicine, and insecticides, the essential oils of Cedrus deodara (CDEOs) are gaining increasing levels of attention. However, there have only been a few studies on the anti-inflammatory effects of CDEOs. This study aimed to systematically study the composition and biological effects of CDEOs, in line with this, the study assessed the chemical composition of CDEOs and evaluated their anti-inflammatory mechanisms in mice. Gas chromatography-mass spectrometry (GC-MS) was used to determine and analyze a total of 41 compounds from CDEOs. It was found that the major components of CDEOs are thujopsene (28.23%), α-cedrene (17.01%), and cedrol (15.55%); moreover, our results showed that the active ingredients in CDEOs have anti-inflammatory and antioxidant effects and that the active ingredients in CDEOs can be used as an antioxidant, as an important biological resource in functional food, and as ingredients in cosmetics and pharmaceuticals. Taken together, these CDEOs serve as ideal additives for anti-inflammatory drugs.
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Frontiers in Microbiology
·
2021
·
IF 5.64
Luo Xudong,Ye Xiangdong,Ding Li,Zhu Wen,Yi Pengcheng,Zhao Zhiwen,Gao Huanhuan,Shu Zhan,Li Shan,Sang Ming,Wang Jue,Zhong Weihua,Chen Zongyun
Antibiotic-resistant ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) has become a serious threat to public health worldwide. Cationic α-helical antimicrobial peptides (CαAMPs) have attracted much attention as promising solutions in post-antibiotic era. However, strong hemolytic activity and in vivo inefficacy have hindered their pharmaceutical development. Here, we attempt to address these obstacles by investigating BmKn2 and BmKn2-7, two scorpion-derived CαAMPs with the same hydrophobic face and a distinct hydrophilic face. Through structural comparison, mutant design and functional analyses, we found that while keeping the hydrophobic face unchanged, increasing the number of alkaline residues (i.e., Lys + Arg residues) on the hydrophilic face of BmKn2 reduces the hemolytic activity and broadens the antimicrobial spectrum. Strikingly, when keeping the total number of alkaline residues constant, increasing the number of Lys residues on the hydrophilic face of BmKn2-7 significantly reduces the hemolytic activity but does not influence the antimicrobial activity. BmKn2-7K, a mutant of BmKn2-7 in which all of the Arg residues on the hydrophilic face were replaced with Lys, showed the lowest hemolytic activity and potent antimicrobial activity against antibiotic-resistant ESKAPE pathogens. Moreover, in vivo experiments indicate that BmKn2-7K displays potent antimicrobial efficacy against both the penicillin-resistant S. aureus and the carbapenem- and multidrug-resistant A. baumannii, and is non-toxic at the antimicrobial dosages. Taken together, our work highlights the significant functional disparity of Lys vs Arg in the scorpion-derived antimicrobial peptide BmKn2-7, and provides a promising lead molecule for drug development against ESKAPE pathogens.
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CARBOHYDRATE RESEARCH
·
2025
·
IF 2.5
Lin Ge,Ruobing Jia,Yingying Liu,Lingling Zhan
Soybean contains anti-nutritional factor raffinose oligosaccharide (RFOs), which can cause flatulence, gastrointestinal dysfunction and low feed utilization rate. However, α-galactosidase can hydrolyze raffinose oligosaccharides (RFOs). Therefore, in this study, a novel α-galactosidase from Thermoclostridium stercorarium subsp. thermolacticum DSM 2910 (TstGal) which can hydrolyze raffinose was cloned, expressed, purified, and characterized. The gene fragment size is 2208 bp, and the enzyme TstGal consists of 736 amino acids. Under the optimum culture conditions, the maximum enzyme activity of the target protein TstGal was 23.8 U/mL. The enzyme was purified 11.3-fold by Ni-NTA agarose resin with an overall recovery of 51.4 % and specific activity of 9.0 U/mg, and its relative molecular weight was about 85 kDa. The optimal temperature of TstGal was 70 °C, and it exhibited excellent thermal stability at 60 °C. Furthermore, The TstGal had the highest activity at pH 6.5 and good pH stability at pH 5.0–7.5. Besides, the enzyme has a good sugar tolerance to galactose and sucrose. In addition, K + and Fe 2+ could significantly enhance the enzyme activity at a concentration of 5 mM. The values of K M , V max , k cat , and k cat /K M for p NPGal were found to be 0.507 mM, 13.979 U/mg, 19.735 s −1 , and 38.895 s −1 mM −1 , respectively. Under the optimum conditions, the maximum hydrolysis rate of raffinose by TstGal reached 99.8 %, which shows that the enzyme had potential application value in food and feed industry.
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CHINESE JOURNAL OF CATALYSIS
·
2024
·
IF 15.7
Zhounan Yu,Leilei Zhang,Yuanlong Tan,Rizheng Jing,Hongchen Cao,Caiyi Lou,Rile Ge,Junhu Wang,Aiqin Wang,Tao Zhang
Rh-P complexes have been widely used as catalysts for hydroformylation reactions. The extremely high price of Rh and its scarce reserves have prompted the exploration of the alternatives. In this study, we reported that Pt/PS-PPh 2 single-atom catalysts promoted by SnCl 2 were highly efficient and selective for the hydroformylation of higher α-alkenes. A broad scope of substrates (i.e., C 6 –C 12 ) were smoothly converted to the corresponding linear aldehydes with high yields under reaction conditions of 90–120 °C and 4–6 MPa syngas . The turnover frequency (TOF) was comparable to homogeneous Pt-Sn catalysts, and the linear/branched ratio reached as high as > 20. In addition, the catalyst could be reused with the extra addition of SnCl 2 . The promotional role of SnCl 2 was elucidated by quasi- in situ X-ray adsorption fine structure, Fourier transform infrared, and Mössbauer spectroscopy . It was discovered that SnCl 2 was transformed into Sn(dioxane)Cl 3 − species coordinated to Pt as a moderately electron-donating ligand, which, together with the phosphine group, stabilized mononuclear Pt (I) species against reduction and aggregation.
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FOOD RESEARCH INTERNATIONAL
·
2024
·
IF 7
Rong Liu,Lingxuan Huang,Xuan Feng,Di Wang,Rasika Gunarathne,QingJun Kong,Jun Lu,Xueyan Ren
Aspergillus carbonarius , a common food-contaminating fungus, produces ochratoxin A (OTA) and poses a risk to human health. This study aimed to assess the inhibitory activity of tea tree essential oil and its main components, Terpene-4-ol (T4), α-terpineol (αS), and 3-carene (3C) against A. carbonarius . The study showed αS and T4 were the main antifungal components of tea tree essential oil, which primarily inhibit A. carbonarius growth through cell membrane disruption, reducing antioxidant enzyme activities (catalase, peroxidase, superoxide dismutase) and interrupting the tricarboxylic acid cycle. Furthermore, αS and T4 interacted with enzymes related to OTA biosynthesis. Molecular docking and molecular dynamics show that they bound mainly to P450 with a minimum binding energy of −7.232 kcal/mol, we infered that blocking the synthesis of OTA precursor OTβ. Our hypothesis was preliminarily verified by the detection of key substances in the OTA synthesis pathway. The results of UHPLC-QTOF-MS 2 analysis demonstrated that T4 achieved a degradation rate of 43 % for OTA, while αS reached 29.6 %, resulting in final breakdown products such as OTα and phenylalanine. These results indicated that α-terpinol and Terpene-4-ol have the potential to be used as naturally safe and efficient preservatives or active packaging to prevent OTA contamination.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2026
·
IF 3.3
Shang Suhui,Wang Xiao,Wang Xiaoyu,Li Yutong,Lu Xiang,Liu Zuguang
In this work, a composite carbon-based solid acid (CCSA) was prepared by one-step hydrothermal method via using glucose as carbon resource and concentrated sulfuric acid as a sulfonating agent, along with doped p -toluenesulfonic acid (PT) as a co-sulfonating agent and boric acid (BA) as a synthetic additive. The CCSA obtained was used to catalyze esterification reaction of α -pinene with glacial acetic acid. The results indicate that the addition of PT and BA can improve sulfonic acid groups significantly and show excellent catalytic performance due to the complementary and synergistic effect of incorporated PT and BA, achieving the conversion of α -pinene up to 99.5%, and the selectivity of total esters as high as 56.9%, which is superior to previous report, under the optimized conditions of reaction temperature of 70 °C, reaction time of 7.5 h, and catalyst dosage of 7 wt% (based on the total mass of raw materials). This is because doped PT as a sulfonating agent can increase sulfonic acid groups and also promotes the graphitization of carbon, which in turn limits the sulfonation and the introduction of more sulfonic acid groups. In contrast, doped BA can reduce the graphitization of carbon and is beneficial to the introduction of more sulfonic acid groups. The catalyst also has excellent reusability, still achieving 100% conversion and 32% total ester selectivity after four times recycling. This work provides a novel strategy for producing a composite carbon-based solid acid with excellent catalytic performance, a low cost and simple procedure.
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INDUSTRIAL CROPS AND PRODUCTS
·
2026
·
IF 6.4
Jiaxi Wang,Xiaoke Qi,Xinguang Qin,Haizhi Zhang,Liang Liu,Gang Liu
Natural α-Amylase (α-Amy) encounters limitation of poor operational stability because of its susceptibility to extreme temperature and pH. Here, in situ assembly of metal-organic framework (MOF) film on hydrogen-bonded organic framework (HOF) was reported as an effective encapsulation carrier for α-Amy to enhance its stability. α-Amy was firstly immobilized in HOF-101 through in situ encapsulation strategy. Then, by using HOF-101@α-Amy as core, ZIF-67 shell was synthesized through the assembly of Co 2 + and 2-methylimidazole, forming enzyme-MOF@HOF composite, ZIF-67@HOF-101@α-Amy (ZHA). In terms of characterization, the morphology and chemical structure of ZHA were investigated. Catalytic activities of immobilized α-Amy and free α-Amy were comparatively studied. In addition, the reusability and storage stability of ZHA were examined to confirm its enhanced stability. When applied in the liquefaction of starch derived from energy corn, ZHA efficiently reduced the viscosity of reaction system and produced a high yield of reducing sugars, demonstrating its great potential as a robust biocatalyst for industrial starch conversion in biorefineries.
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Journal of the Taiwan Institute of Chemical Engineers
·
2026
·
IF 6.9
Xilin Wang,Boxiang Zhang,Longfei Xia,Ping Dai,Yuqing Zhao,Liang Zhou,Dongyan Xu
Background Red mud is the world’s most extensively generated waste in the non-ferrous metal industry, posing significant environmental risks due to its strong alkalinity and lack of effective disposal methods. It is urgent to find a reasonable and effective strategy to transform red mud into a Heterogeneous catalyst for environmental remediation. Methods α-MnO 2 nanorods were anchored on biochar-modified red mud composite (RMBC) via the hydrothermal method and utilized as a catalyst to activate PMS for the degradation of Rhodamine B (RhB). Reactive oxygen species generated during the catalytic process was identified through EPR, XPS, and Raman spectroscopy measurements. Degradation intermediates of RhB were identified using LC-MS. Furthermore, the ecotoxicity of RhB and its transformation products was evaluated using the ecological structure-activity relationship (ECOSAR) prediction model. Significant findings The as-prepared α-MnO 2 /RMBC achieves a remarkable RhB degradation efficiency of 98.6 % within 30 min, significantly outperforming control samples including α-MnO 2 /RM, α-MnO 2 /BC, and the mixture of α-MnO 2 /RM and α-MnO 2 /BC, suggesting a pronounced synergistic interaction between α-MnO 2 and RMBC. Mechanistic analysis reveals that RhB degradation is predominantly governed by an activated surface-PMS inner-sphere complex, signified as Mn III (s) -(O)OSO– 3. Furthermore, the Fe II species inherent to RM facilitates the redox-mediated reduction of Mn IV to Mn III , thereby sustaining the catalytic activity of active Mn III sites and enabling robust recyclability and reusability of the α-MnO 2 /RMBC catalyst.
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