ChemCatChem
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2025
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IF 3.9
KunShan Ouyang,Mengyuan Qu,Liyan Xie,Zhishan Luo,Jianqin Chen,Jianhui Huang
CdIn 2 S 4 /In(OH) 3 heterojunctions were constructed via a scalable ultrasonic spray pyrolysis method combined with H 2 O 2 -enabled in situ etching, in order to address the issues of photocorrosion, scarce active sites, and rapid charge recombination observed in pristine CdIn 2 S 4 . The optimized heterojunction, achieved using 50 µL of H 2 O 2 , demonstrates a significantly enhanced H 2 evolution rate of 736 µmol g −1 h −1 , which is 12 times greater than that of pristine CdIn 2 S 4 , along with stable performance throughout three consecutive catalytic cycles. Structural and chemical analyses verify the formation of a closely integrated heterojunction interface, which facilitates improved charge separation and efficient electron transfer from CdIn 2 S 4 to In(OH) 3 , as further corroborated by electrochemical and photoluminescence studies. A possible mechanism for hydrogen evolution is also proposed. Graphical Constructing CdIn 2 S 4 /In(OH) 3 heterojunctions via in situ etching achieves a 12-fold enhancement in photocatalytic H 2 evolution with excellent stability, by enabling efficient electron transfer and charge separation.
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高影响因子
BRITISH JOURNAL OF PHARMACOLOGY
·
2022
·Vol. 179
·期 12
·3078-3095
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IF 9.473
Senlin Li,Hong Zhou,Mengyuan Xie,Zijun Zhang,Jing Gou,Jian Yang,Cheng Tian,Kun Ma,Cong-Yi Wang,Yi Lu,Qing Li,Wen Peng,Ming Xiang
Background and Purpose Tacrolimus a first-line medication used after transplantation can induce β-cell dysfunction, causing new-onset diabetes mellitus (NODM). Regenerating islet-derived protein 3 gamma (Reg3g), a member of the pancreatic regenerative gene family, has been reported to improve type 1 diabetes by promoting β-cell regeneration. We aim to investigate the role of Reg3g in reversing tacrolimus-induced β-cell dysfunction and NODM in mice. Experimental Approach Circulating REG3A (the human homologue of mouse Reg3g) in heart transplantation patients treated with tacrolimus was detected. The glucose-stimulated insulin secretion and mitochondrial functions, including mitochondria membrane potential (MMP), mitochondria calcium, ATP production, oxygen consumption rate and mitochondrial morphology were investigated in β-cells. Additionally, effects of Reg3g on tacrolimus-induced NODM in mice were analysed. Key Results Circulating REG3A level in heart transplantation patients with NODM significantly decreased compared with those without diabetes. Tacrolimus down-regulated Reg3g via inhibiting STAT3-mediated transcription activation. Moreover, Reg3g restored glucose-stimulated insulin secretion suppressed by tacrolimus in β-cells by improving mitochondrial functions, including increased MMP, mitochondria calcium uptake, ATP production, oxygen consumption rate and contributing to an intact mitochondrial morphology. Mechanistically, Reg3g increased accumulation of pSTAT3(Ser727) in mitochondria by activating ERK1/2-STAT3 signalling pathway, leading to restoration of tacrolimus-induced mitochondrial impairment. Reg3g overexpression also effectively mitigated tacrolimus-induced NODM in mice. Conclusion and Implications Reg3g can significantly ameliorate tacrolimus-induced β-cell dysfunction by restoring mitochondrial function in a pSTAT3(Ser727)-dependent manner. Our observations identify a novel Reg3g-mediated mechanism that is involved in tacrolimus-induced NODM and establish the novel role of Reg3g in reversing tacrolimus-induced β-cell dysfunction. Graphical
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PubMed
高影响因子
Journal of Functional Foods
·
2021
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IF 4.451
Yaozhong Hu,Jiaxin Gu,Jing Lin,Yi Wang,Feier Yang,Jia Yin,Zhenting Yu,Sihao Wu,Huan Lv,Xuemeng Ji,Shuo Wang
The intervention of EGCG on M1/M2 macrophage polarization was still unclear and should be studied comprehensively. In this context, the intervention of EGCG on macrophage polarization has been investigated to reveal that EGCG promoted M2 polarization of RAW264.7 upon treating with EGCG. A significant inhibitory effect of EGCG on M1 polarization was observed upon stimulating with LPS and IFN-γ. The expression of macrophage phenotype related marker genes (iNOS, COX-2, IL-1β for M1; Arg-1, Ym-1, IL-10 for M2) demonstrated the suppression of M1 polarization and the promotion of M2 polarization in liver, colon, spleen, and brain. Further analysis against peritoneal macrophages verified the increased M2 phenotypes and decreased M1 macrophages, and the similar variation in liver were confirmed by immunohistochemistry (IHC). No significant variation of spleen macrophages was observed with the general macrophages in declined tendency. Bio-distribution of EGCG and its metabolites (EGC, GA) in different organs has been further determined.
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高影响因子
ACS Chemical Neuroscience
·
2022
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IF 5.78
Qianlei Zhao,Tingting Chen,Chao Ni,Yingying Hu,Yan Nan,Wei Lin,Yanli Liu,Feixia Zheng,Xulai Shi,Zhongdong Lin,Jianghu Zhu,Zhenlang Lin
The blood–brain barrier (BBB) is an important physiological barrier of the human body contributing to maintaining brain homeostasis and normal function. Hypoxic-ischemic (HI)-related brain injury is one of the main causes of neonatal acute morbidity and chronic disability. The previous research of our group confirmed that there was serious BBB destruction during HI brain injury. However, at present, the protection strategy of BBB is very limited, and further research on the protection mechanism is warranted. Indole-3-propionic acid (IPA) is a bacterial metabolism with anti-inflammatory and antioxidant properties, having neuroprotective effects and protective effects on the mucosal barrier. However, the role of IPA in BBB is not clear. In this research, we demonstrated the protective effect of IPA on BBB disruption from HI brain injury and hypothesized that it involves the amelioration of inflammation, oxidative stress, and MMP activation, thereby inhibiting apoptosis of rat brain microvascular endothelial cells (rBMECs). We demonstrated that expression levels of several inflammatory markers, including iNOS, TNF-α, IL-6, and IL-1β, were significantly increased from HI damage or OGD injury. However, IPA treatment inhibited the increase significantly. Moreover, we demonstrated that IPA reduced intracellular ROS levels and MMP activation in rBMECs from OGD injury. Further research on the underlying detailed molecular mechanisms suggested that IPA attenuates inflammation by inhibiting NF-κB signaling. Finally, we investigated the mechanism of the relationship between PXR activation and NF-κB inhibition. The results suggested overexpression of PXR in rBMECs could significantly counteract the decrease of junction proteins and downregulate the increased p-IκB-α and p-NF-κB from OGD injury. However, the protective effects of IPA were reversed by antagonists of the PXR. Taken together, IPA might mitigate HI-induced damage of the BBB and the protective effect may be exerted through modulating the PXR signaling pathway.
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PubMed
高影响因子
ACS Applied Optical Materials
·
2025
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IF 3.8
Huan Zhou,Meng Cheng,Zhihua Yang,Shilie Pan
Birefringent materials are crucial optical materials that enable the control of polarized light in optical technologies, yet achieving high birefringence in systems dominated by non-π-conjugated units in the deep-ultraviolet (UV) region remains a significant challenge. Herein, a birefringent material, [C(NH2)3]2PO3(OH), was successfully synthesized by integrating π-conjugated [C(NH2)3] units and heteroleptic tetrahedra [PO3(OH)]. The short UV cutoff edge (<200 nm) and large birefringence (0.086 @ 546 nm) make [C(NH2)3]2PO3(OH) a potential deep-UV birefringent crystal. This study provides the experience for the design of deep-UV optical crystals.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Qian Zhang,Qianrui Yang,Tianci Liu,Yuchen Yue,Jingran Zhang,Guifu Zuo
In this work, a novel Faraday cage-type electrochemiluminescence (ECL) biosensor was constructed for the ultrasensitive "turn on" detection of CEA. The capture unit was prepared by immobilizing the Carcinoembryonic antibody Ab 1 onto the functionalized magnetic Fe 3 O 4 nanoparticles, while the detection unit consisted of modified g-C 3 N 4 labeled with antibody Ab 2 . The recognition scaffold was assembled as follows: the capture unit was first fixed onto the magnetic electrode surface; the target CEA was then captured; followed by further hybridized with the detection unit; ultimately forming the Faradaycage biosensor structure. In this configuration, the signal unit became part of the electrode surface, enabling all electrochemiluminophores in the signal unit to participate in the electrode reaction, thereby significantly enhancing the detection sensitivity. Utilizing the proposed Faraday-cage cascade, the ECL intensity increased with the rising CEA concentration. The linear range was from 0.01 to 100 ng/mL, with a detection limit of 0.35 pg/mL. The sensor was validated for its selectivity, stability, reproducibility, precision, and application potential. This Faraday cage-type ECL biosensor shows promising prospects for clinical CEA detection.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 36
·2307
·
IF 2.8
Zhang Huayushuo,Ma Qian,Gao Pan,Li Bolong,Yang Xiaoxia,Li Chao,Song Mingming,Hou Zhiwei,Jiang Xiaomei
X-ray detection has extensive applications in medical imaging, scientific research, and security inspection. Despite the superior radiation detection properties of lead-based perovskites, including high carrier mobility and superior attenuation efficiency, their toxicity and instability arising from ion migration hinders further development. To address these challenges, a series of halogen-tuned lead-free 3-methylpiperidine bismuth halides, (C 6 H 14 N) 3 Bi 2 I 9 , (C 6 H 14 N) 2 BiBr 5 and (C 6 H 14 N) 2 BiCl 5 (C 6 H 14 N = 3-methylpiperidine) single crystals were grown and systematically characterized. 3-methylpiperidine was selected for its steric effect stabilizing the lattice, and the synergistic tuning through halogen variation enabled a structural transition along with modulation of their properties. Notably, the lateral-structured (C 6 H 14 N) 3 Bi 2 I 9 single-crystal X-ray detector exhibits a sensitivity of 388.05 μC Gy −1 cm −2 , a low detection limit of 71.05 nGy s −1 , and a small dark current drift of 2.16 × 10 –8 nA cm −1 s −1 V −1 . Importantly, this material retains its original morphology after 8 months of storage in ambient conditions. Furthermore, flexible X-ray devices fabricated via spin-coating (C 6 H 14 N) 3 Bi 2 I 9 exhibited a favorable X-ray response with a sensitivity of 121.48 μC Gy −1 cm −2 , as well as excellent mechanical stability. This work reveals that halogen tuning effectively optimizes the structure and performance of Bi-based perovskites, providing valuable insights for advancing them in X-ray detection applications.
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高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2025
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IF 1.6
Zhao Fan,Zhang Wei,Chen Yuantao
The zinc-based metal–organic framework (IRMOF-3) was assembled on the surface of Galdieria sulfuraria (Gs) via a one-pot method to fabricate the composite adsorbent Gs/IRMOF-3. Results show that the material achieves optimal adsorption performance at pH = 6. The adsorption process follows the Freundlich isotherm model and pseudo-second-order kinetic model, demonstrating that it is dominated by multi-molecular layer chemical adsorption and represents a spontaneous endothermic process. This study provides a novel strategy for developing efficient and eco-friendly uranyl adsorption materials.
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高影响因子
Journal of Materials Chemistry A
·
2025
·Vol. 13
·期 35
·29450-29460
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IF 9.5
Yushen Qian,Mengxue Wu,Anyu Hu,Honghao Deng,Nawal K. Almaymoni,Abdullah N. Alodhayb,Jie Li,Jiahong Pan,Ping Chen,Zhicong Shi
Sodium iron sulfate (Na2+2xFe2−x(SO4)3, NFS) is a promising cathode material for sodium-ion batteries (SIBs) for large-scale energy storage systems due to its low cost and long life. However, NFS is an insulator and cannot reversibly store sodium ions to a large extent. To address this problem, an NFS material integrated with carbon nanotubes (CNTs) is developed in this work. The incorporation of CNTs effectively converts NFS from an insulator to a semiconductor, thereby significantly enhancing the electrochemical performance. The NFS@CNTs material incorporates an alluaudite-type framework that improves electronic conductivity, thereby enhancing rate capability and cycling life. By introducing 10 wt% CNTs, the NFS@CNTs composite achieves a high working voltage of 3.8 V (vs. Na/Na+) and an impressive high-rate specific capacity of 80 mA h g−1 at a rate of 20C. Furthermore, it can retain 81.4% of the initial specific capacity after 20 000 cycles at a rate of 50C, demonstrating an outstanding cycling stability. This work not only provides an in-depth understanding of the potential of NES to be used as a high-rate, long-lasting cathode material for SIBs but also lays the foundation for SIBs in large-scale energy storage applications.
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2017
·
IF 3.615
Xingzhong Guo,Pengan Yin,Hui Yang
Hierarchically porous composites constructed by ZnAl-Cl type layered double hydroxides (LDH) nanosheets and amorphous Al(OH) 3 nanosheets were synthesized via a facile sol-gel route for the adsorption of two typical anionic dyes Methyl Orange (MO) and Congo Red (CR) from aqueous solutions. The micro-macrostructure and adsorption properties of hierarchically porous ZnAl-LDH/Al(OH) 3 composites before and after calcination were investigated in detail. The adsorption mechanism and adsorption–desorption cycles were also discussed. Materials characterization confirm that the resultant hierarchically porous composites possess three-dimensional macrostructure with interconnected macropores and co-continuous skeletons constructed by ZnAl-LDH and Al(OH) 3 nanosheets . Calcination at 500 °C allows the transformation from LDH composite to layered double metal oxides (LDO), while the macrostructure is basically maintained with a macropore size of 0.5 μm, a porosity of 53.1% and a BET surface area as high as 122 m 2 g −1 . Adsorption performances show that hierarchically porous composites exhibit ultrafast adsorption rates and high adsorption capacities in the removal of anionic dyes CR and MO. The maximum adsorption capacities of hierarchically porous LDH-based composites and LDO composites via calcination at 500 °C are 2348.3 and 1574.4 mg g −1 for CR and 1013.5 and 1015.1 mg g −1 for MO, respectively. XRD and FTIR results after the dyes adsorption indicate that the intercalation of MO − and CR − anions into the LDH structure via ion exchange with the pristine chloride ions group and the attachment on the external Al(OH) 3 surface determine the adsorption behavior , thus leading to an expansion of the interlayer space . And the calcined products LDO-based composites can be reversibly transformed back into the LDH structure via reconstruction procedure in the presence of dyes aqueous solution. Furthermore, the adsorption–desorption cycles confirm that the as-prepared hierarchically porous composites own excellent recyclable properties and the removal efficiency for CR and MO are 80.2% and 73.7% even after five cycles, respectively.
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高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 13
·130517
·
IF 3.721
Zhaoyu Wang,Lihua Jiang,Chen Liang,Chunpeng Zhao,Zesen Wei,Qingsong Wang
The overcharge issue still occupies a high safety risk for NCM cathode materials with less stable structure. In this work, an original overcharge protection electrolyte additive named as 3-fluoroanisol (3FA) is recommended for NCM 622. The anti-overcharge effect of 3FA was verified in detail by cycle voltammetry, constant-current overcharge and discharge, AC impendence and scanning electron microscopy measurement. The electrolyte conductivity and long-term cycle performance tests were conducted to evaluate the impact of 3FA on the cell system operated in conventional voltage range. The 3FA is electro-polymerized at about 4.4 V and the time from upper cut-off voltage to overcharge state is extended from 5.46 h to 11.82 h in CR2032 cell, no adverse effects are shown during normal use at the same time under the additive amount of no more than 5 wt.%. Moreover, C80 micro-calorimeter test shows that 3FA increases thermal stability of electrolyte and NCM 622 cathode system. The heat production during overcharge was measured further. With the increase of the amount of 3FA added, the heat production during overcharge increases and the peak heat release rate occurs near 4.4 V, which further proves the effect of overcharge protection of 3FA. Thus, 3FA enhances overcharge endurance and thermal stability of lithium-ion battery with NCM 622 cathode.
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高影响因子
Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 32
·10828-10833
·
IF 6.4
Dandan Wang,Xinyuan Zhang,Pifu Gong,Zheshuai Lin,Zhanggui Hu,Yicheng Wu
The balance between band gap and second harmonic generation (SHG) response, which are usually inversely related, is the key factor for achieving good performance in a mid-infrared (mid-IR) nonlinear optical (NLO) crystal. Still it remains a challenge to achieve this balance, which strongly hinders the development of mid-IR solid-state lasers. In this work, utilizing an aliovalent substitution strategy of functional units, we successfully realize mid-IR NLO balanced performance in a chiral iodate, Ga(IO3)3, which simultaneously exhibits a strong SHG response (13 × KDP) and a wide optical band gap (3.94 eV). The first-principles calculation is also performed to elucidate its NLO origin. Combining the experimental measurements and theoretical calculations, it is clear that Ga(IO3)3 possesses excellent comprehensive NLO performance including a strong SHG effect, a wide band gap, good thermal stability (450 °C), and a large birefringence, indicating its potential applications as a mid-IR NLO crystal.
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高影响因子
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