Biomaterials Science
·
2026
·
IF 6.1
Gui-Yuan Wang,Zhuo-Yue Li,Chao-Ran Li,Ya-Tao Wang,Pei-Pei Yang,Lei Wang,Hao Wang,Xu Cui,Litao Li
The treatment of fibrinogen deficiency-related bleeding disorders and acquired hypofibrinogenemia remains heavily reliant on blood-derived products such as fibrinogen concentrate, a mainstay therapy constrained by limited supply, viral contamination risks, and high cost. Inspired by the natural blood clotting mechanism, this study has designed an intelligent multifunctional biomimetic targeting and self-assembling peptide, I.e. SDGRG-C12-KLVFF-GRGDS (SC12FS). This peptide firstly self-assembled into nanoparticles mimicking fibrinogen to specifically target the activated platelet membrane glycoprotein GPIIb-IIIa receptor and induce platelet aggregation and form a loose primary hemostatic plug. Then the nanoparticles would transform into nanofibers and further formed interwoven fibrous networks with fibrin-like functionality by ligand-receptor induced fibrillogenesis. These networks effectively entrap platelet aggregates and red blood cells, leading to the formation of a stable secondary clot. The biomimetic peptide showed the recovered hemostatic functionality and biosafety for the hypofibrinogenemia model of rats and rabbits by intravenous injection. This study provides a novel biomimetic material for safe, accessible hemostatic therapy overcoming the dependence on human plasma sources for alleviating hypofibrinogenemia.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RESOURCES CONSERVATION AND RECYCLING
·
2026
·
IF 10.4
Tianshu Bao,Congcong Li,Chenye Wang,Huiquan Li,Liangbin Li,Zhenhua Sun,Lili Yu,Xinjuan Hou,Aiping Peng,Ming Ye
Global lithium demand has heightened interest in direct extraction from salt-lake brine. Mn-based ion sieves (HMOs) offer high capacity, fast kinetics, and low cost but suffer from Mn dissolution. This study reports a low-dissolution HMO@Hy sieve prepared via hydrothermal carbon coating. The oxygen-rich carbon layer curbs metal leaching without performance loss seen in amorphous carbon coatings, reducing Mn dissolution from 2.01% to 1.06%. The material exists as loose powder with a uniform 2–3 nm coating and adsorbs 21.1 mg/g from real brine within one hour. First-principles calculations show the carbon-doped coating raises surface Mn valence, reducing charge density and limiting dissolution during desorption. Granulation and cycling tests confirm practical potential: one ton of adsorbent processes 114 tons brine weekly, yielding 0.49 tons Li₂CO₃ and ¥42,800 economic benefit. This non-metallic coating strategy enhances HMO stability for sustainable lithium recovery.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2026
·
IF 5.1
Zhiwei Wang,Zihao Song,Wenqi Jiang,Jin Zhu,Xianfei Luo,Yuchen Li,Wenbin Zhu,Gan Jin,Hua-Yu Tang,Xing Gao,Xue-Li Liu
Amine intercalation is an efficient way to fine tune and enhance the properties of layered α-zirconium phosphate (α-ZrP), however, its impact on the proton conduction properties of α-ZrP has been rarely explored. In this contribution, a long-chain alkylamine, dodecylamine (DDA), was successfully intercalated into α-ZrP nanoplates. The intercalation was seen to exert both positive and negative impacts on the proton-transport capabilities of α-ZrP. When the intercalant concentration was low, the hydrophobic long-chain alkyl groups of anchored DDA molecules hindered the diffusion of water, causing suppressed proton conduction. With a high DDA concentration, enhanced proton conduction was observed in the intercalated α-ZrP, due to the existence of expanded interlayer spacing and free DDA, which facilitated the diffusion and accommodation of water molecules, leading to an increase in carrier concentration and the formation of hydrogen-bonding networks. The optimized DDA-intercalated α-ZrP (α-ZrP-DDA (1:4)) showed a proton conductivity of 1.11×10-4 S cm-1 at 303 K and 98% relative humidity (RH), which was one order of magnitude higher than that of α-ZrP. Moreover, a humidity sensor based on α-ZrP-DDA (1:4) was fabricated, which could distinguish deep, normal and fast breathing, indicating its potential for practical monitoring of human breath. Our work demonstrates that amine intercalation is an efficient strategy for modulating proton-transport behavior in α-ZrP, thereby broadening its potential applications.
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Haozhe Li,Yunbo Zhang,Jiang Huang
Low-energy electron beam (LEEB) curing enables precise surface modification, yet the microscopic energy deposition at heterogeneous interfaces remains poorly understood, often leading to suboptimal interfacial cross-linking or substrate damage. Herein, we establish a mechanism-driven interface engineering strategy by integrating Monte Carlo simulations (FLUKA, 50–250 keV) with experimental validation (up to 200 keV) using a PDMS model system. We elucidate the critical role of secondary particle cascades in determining surface properties and define a universal physical criterion for robust curing: aligning the peak cascade intensity precisely at the coating/substrate interface. Furthermore, we quantify the profound impact of substrate density. High-density substrates (e.g., steel) act as an “energy mirror,” significantly enhancing the localized interfacial dose via backscattering. Conversely, for low-density substrates lacking this effect, we reveal a necessary strategic crossover toward controlled over-penetration to secure sufficient interfacial adhesion. This work moves beyond empirical trial-and-error, providing a framework to balance bulk uniformity against interfacial over-irradiation risks for superior coating performance.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Jiaying Li,Chengcheng Yuan,Meichen Zhang,Yingchao Wang,Feng Xu,Fengshan Zhang,Zongwei Guo,Hao Ma,Xingxiang Ji
Driven by the principles of ecological sustainability, this study presents an integrated biorefinery strategy for the rapid deconstruction and integrated valorization of moso bamboo. A novel lactic acid-based ternary deep eutectic solvent (DES), composed of tetrabutylammonium chloride, lactic acid, and p- toluenesulfonic acid (TBAC/LA/PTSA), was developed to achieve rapid fractionation. Under optimized conditions (130 °C, 30 min), the ternary DES achieved a high removal efficiency of lignin (86.28%) and hemicellulose (95.23%), significantly reducing pretreatment time and energy consumption. The resulting cellulose-rich residue exhibited an exceptional enzymatic hydrolysis efficiency of 98.28%, maintaining a robust performance of 76.75% even after five DES recycling cycles. Structural characterization revealed that the isolated lignin possessed high purity, moderate molecular weight, and superior antioxidant activity (IC 50 = 0.66 mg/mL), outperforming the commercial antioxidant BHT (IC 50 = 0.96 mg/mL). Furthermore, the pretreatment liquid was directly transformed into a high-performance functional eutectogel via a seamless in situ gelation process. The resulting eutectogel displayed outstanding mechanical properties (747% tensile strain and 954 kPa compressive strength) and exceptional environmental adaptability across a wide temperature range (−70 to 65 °C). This integrated approach not only demonstrates the efficient deconstruction of bamboo biomass but also provides a sustainable pathway for synthesizing wearable flexible electronics, ensuring the comprehensive utilization of all lignocellulosic components.
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2026
·
IF 5.2
Hang Peng,Jingrui Yuan,Zehua Yang,Xing-Bao Wang,Yuanyuan Shan
Pickering emulsions stabilized by solid particles provide a well-defined interfacial environment for catalytic reactions. In this study, a continuous-flow Fenton oxidation system was developed using an oil-in-water Pickering emulsion stabilized by a nickel–aluminum layered double hydroxide/graphene composite. The material functions both as a solid emulsifier and a heterogeneous Fenton catalyst, forming a stable emulsion column under continuous operation. The system degraded over 97% of methyl orange within 8 h and maintained about 90% removal efficiency over 50 h of uninterrupted operation. In contrast, a conventional batch Fenton process achieved only ∼44% degradation under similar conditions. The enhanced performance is attributed to the coupled adsorption and catalytic oxidation at the oil–water interface. The emulsifier enriches methyl orange and activates H2O2 to generate reactive radicals. Even in the absence of externally added Fe2+, Ni2+ in the composite can activate H2O2, while the coexistence of Ni2+ and Fe2+ further promotes sustained radical generation. These results demonstrate that Pickering emulsion-based continuous reactors provide a robust and scalable strategy for the efficient removal of refractory organic pollutants.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHARMACEUTICAL SCIENCES
·
2026
·
IF 3.9
Dexue Liu,Sajid Asghar,Dan Gao,Wenrong Li,Haijuan Dong,Tingmei LYU,Zhipeng Chen,Yanyu Xiao
Combination therapy, which integrates diverse treatment modalities to induce synergistic anti-tumor effects, has emerged as a promising strategy in oncology. In this study, we developed a near-infrared (NIR) laser-triggered nitric oxide (NO)-releasing and enzyme-sensitive targeted drug delivery system BNN6/EPI-HA@HP-PDA) for the synergistic treatment of breast cancer via combined chemotherapy, NO gas therapy, and photothermal therapy. The system was constructed based on polydopamine (PDA) nanoparticles modified with hyaluronic acid (HA) and hydroxypropyl-β-cyclodextrin (HP-β-CD), co-loaded with epirubicin (EPI) and the NO donor BNN6 (N, N'-di-sec-butyl-N, N'-dinitroso-1,4-phenylenediamine). The resulting spherical nanoparticles exhibited a uniform size of 180.26 nm and a zeta potential of -27.69 mV, with high drug loading and encapsulation efficiencies of 12.04% and 98.10% for EPI and 46.91% and 88.14% for BNN6, respectively. In vitro release studies confirmed nanoparticles’ responsiveness to hyaluronidase, pH, and NIR irradiation. Cellular assays revealed significantly enhanced cytotoxicity of BNN6/EPI-HA@HP-PDA in both MCF-7 and MCF-7/ADR cells, attributable to the combined effects of PDA-mediated hyperthermia, EPI-induced chemotherapy, and NO-mediated gas therapy. Pharmacokinetic evaluation showed a 4.62-fold increase in the area under the curve of BNN6/EPI-HA@HP-PDA compared to free EPI solution. In vivo experiments further demonstrated potent tumor growth inhibition (96.71%) in MCF-7/ADR tumor-bearing Balb/c mice treated with BNN6/EPI-HA@HP-PDA plus laser irradiation, with no detectable systemic toxicity. In general, BNN6/EPI-HA@HP-PDA presents a combination strategy of photothermal/gas/chemotherapy for the synergistic therapy of breast cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Yu Su,Haobo Wen,Ke Hu,Cuiping Wen,Ping Wang,Lulu Zhao,Gang Zou,Wei Jiang,Yaxi Chen,Yunfei Zhao,Qiu Li
The multifaceted pathogenesis and multi-cellular involvement of diabetic nephropathy (DN) stand in stark contrast to the inadequacy of conventional single-target therapeutic strategies. This disparity underscores the urgent need for novel drugs with comprehensive targeting capabilities. Herein, the SREBP cleavage-activating protein/sterol regulatory element-binding proteins (SCAP/SREBPs) pathway was identified as a central driver in DN, where its activation in key renal parenchymal cells promotes lipid metabolic disorders and inflammation, thereby exacerbating renal injury. Guided by this discovery, we screened a 245-member nanoparticle library comprising SCAP inhibitors self-assembled with chitosan, and identified chitosan-lycorine nanoparticles (CLNPs) as the optimal candidate. Owing to its efficient intestinal absorption and significant accumulation in mesangial and proximal tubular epithelial cells, oral CLNPs strongly alleviated renal injury in a murine model of DN by counteracting lipid accumulation and inflammation, consistent with SCAP/SREBPs pathway inhibition. Critically, CLNPs prevented hepatotoxicity from free lycorine, which reduced mortality and enabled safer prolonged therapy. Together, our findings demonstrate the viability of CLNPs for DN, thereby offering a generalizable strategy for combating complex diseases through a single combinatorial agent that counters multiple co-existing pathological injuries.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2026
·Vol. 16
·期 6
·378
·
IF 4.8
Hao Li,Lin Zhang,You Long,Chao Shen,Song Zhang,Fang Chen,Nan Chen,Chenghong Huang
Paclitaxel is a first-line anticancer drug, but its low water solubility impedes bioavailability. The purpose of this study is to estalish a delivery strategy via carboxymethyl chitosan (CMCS)-encapsulated 6-deoxy-6-mercapto-β-cyclodextrins (dmβCDs)-modified concave cubic gold (CCGs) to achieve PTX release. CCGs were initially synthesized by the one-pot method and further modified by dmβCDs, the dmβCDs can effectively capture PTX molecules, followed by encapsulation with CMCS, and then prepare pH-responsive CMCS/dmβCDs/CCGs nanocarriers after lyophilization. Results indicated that desirable hexagonal CCGs with 50 ± 5 nm size can be obtained by adjusting H 2 O 2 and HClO concentration. FT-IR, Raman and XRD spectra had confirmed dmβCDs successfully grafted to the surface of CCGs. Drug loading experiments demonstrated that the nanocarrier encapsulated PTX in amorphous powder or molecular form have a capacity of 55.05 µg/mL. Drug release experiments revealed PTX release from CMCS/dmβCDs/CCGs nanocarriers carrying a typical pH-responsive profile and indicating earlier release in an acidic environment than in a neutral or alkaline environment. The proposed method can be utilized to effectually achieve high-efficiency solubilization and targeted release inside tumor cells of PTX.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Chunling Nie,Yefan Niu,Weina Guo,Pengrui Wu,Yijun Liu,Zhonghui Shen,Zhihong Song,Xindi Wei,Yanbo Wang,Hong Zeng,Jianguo Wang
Water-in-water (W/W) Pickering emulsions have aligned with the increasing consumer demands for health foods due to their entirely aqueous formulation with oil-free. In this work, Pullulan (PUL) and Hydroxypropyl methylcellulose (HPMC) were used to construct polysaccharide-based W/W Pickering emulsion system. PUL and HPMC concentrations played crucial roles in droplet sizes and phase behavior of PUL/HPMC Pickering emulsions. Cellulose nanocrystals (CNCs) and cellulose nanofibrils (CNFs) were used as stabilizers to prepare PUL/HPMC Pickering emulsions and the stabilization mechanisms were investigated. PUL/HPMC Pickering emulsions stabilized by CNCs with a rigid rod-like structure and strong interfacial adsorption capacity exhibited smaller and more uniform droplet morphology and higher storage stability, whereas the flexible fibrillar CNFs tended to form entangled networks in the continuous phase and bridge droplets, resulting in droplet deformation and coalescence. Furthermore, environmental stability of PUL/HPMC Pickering emulsions revealed that increasing CNCs concentration could significantly enhance their centrifugal and thermal stability. This work would provide a novel insight into the stabilization behavior of nanocellulose with different morphologies in W/W Pickering emulsions and broaden potential applications of W/W Pickering emulsions in functional food fields.
✓ 已验证
产品关联
DOI
高影响因子
FUEL
·
2026
·
IF 7.8
Bohan Zhang,Chang Wen,Zhaoxi Ye,Haozhuo Huang,Qingsong Hua,Ke Liu,Tianyu Liu,Zijian Zhou,Zhengkai Tu
Developing highly efficient and durable bifunctional electrocatalysts for both the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) in acidic environments is vital for advancing proton exchange membrane water electrolysis (PEMWE) technology. Herein, we report the design and synthesis of a three-dimensional Pt-RuO 2 -based catalyst supported on reduced graphene oxide (rGO), denoted as 3D Pt-RuO 2 /rGO, which exhibits outstanding bifunctional electrocatalytic activity by tuning its electronic structure and the binding strength of reaction intermediates. The 3D porous architecture not only facilitates fast charge transfer and mass transport of the catalysts but also increases the exposure of active sites. Remarkably, 3D Pt-RuO 2 /rGO delivers low overpotentials of only 200 mV for OER and 14 mV for HER at 10 mA cm −2 in 0.5 M H 2 SO 4 . It also enables overall water splitting (OWS) at a cell voltage as low as 1.48 V at 10 mA cm −2 , outperforming conventional noble metal-based materials (NMBs). Furthermore, a 3D Pt-RuO 2 /rGO||3D Pt-RuO 2 /rGO MEA delivered a low cell voltage of 1.549 V at 1 A cm −2 and maintained stable operation for 300 h in a PEM single-cell electrolyzer. Operando differential electrochemical mass spectrometry (DEMS) shows that the OER of 3D Pt-RuO 2 /rGO under acidic conditions follows the adsorption evolution mechanism (AEM). Density functional theory (DFT) calculations further reveal the synergistic interaction between oxygen vacancies and the metal/oxide heterointerface. This interface-vacancy synergy not only facilitates the exposure of abundant active sites, but also promotes electron transfer from Pt to RuO 2 , thereby optimizing the kinetics of water dissociation. This work provides valuable insight into the rational design of bifunctional electrocatalysts for high-efficiency acidic water electrolysis and highlights the potential of 3D heterostructured materials for future PEMWE systems.
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·
IF 3.9
Honghong Chen,Congcong Li,Youlei Tu,Shaoyun Guo,Jiabin Shen
Conventional polymer-based radiative cooling materials often exhibit limited functional integration and poor stability under complex environmental conditions, restricting their application in multifunctional practical scenarios. Here, a multifunctional anisotropic polytetrafluoroethylene (PTFE) based aerogel was fabricated by constructing a directional porous architecture via unidirectional freezing, combined with the incorporation of fluorosilane-modified silica (SiO2) nanoparticles. The tailored structure effectively suppressed shrinkage and deformation during sintering, enhanced porosity and surface hydrophobicity, and imparted excellent oleophilic absorption capacity. Benefiting from the high infrared emissivity of the Si–O–Si network in the atmospheric window (elevated to 94.5%) and the structure-induced solar reflectance (increased to 94%), the aerogel achieved all-day passive radiative cooling with temperature reductions of ∼10.1 °C during the daytime and ∼4.3 °C at night under outdoor conditions. The structural design strategy proposed in this work provides insights into developing highly stable and multifunctional radiative cooling materials, and also opens possibilities for multifunctional energy conservation applications of PTFE-based aerogels.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）