MARINE ENVIRONMENTAL RESEARCH
·
2025
·
IF 3.2
Peipei Liu,Qichao Fan,Jingjing Miao,Lu Wang,Shanshan Jiang,Luqing Pan
The contamination of marine sediments by endocrine-disruptive contaminants (EDCs) represents a global threat to marine ecosystems. Among these pollutants, 4-nonylphenol (4-NP) and 17β-estradiol (E2) are particularly noted for their potent endocrine-disrupting effects in aquatic organisms. This study employed juvenile Manila clams ( Ruditapes philippinarum ), with genetically determined sexes, as model organisms in a 14-day exposure experiment. The clams were exposed to 4-NP and E2 at concentrations of 0 (control), 0.1, 1, and 10 μg/L. We primarily investigated the effects on steroidogenesis and vitellogenin ( VTG ) expression, which are key factors in assessing endocrine disruption. Results showed that 4-NP inhibited shell growth at all tested concentrations, and increased free E2 in tissues levels were observed in clams exposed to 0.1 μg/L of 4-NP on both the 7th and 14th days. Conversely, E2 did not significantly affect free E2 in tissues levels. Notably, exposure to 1 μg/L 4-NP significantly upregulated mRNA expression of genes involved in the steroidogenesis pathway ( GnRH , CYP17 , and 17β-HSD ) in genetically female juveniles. Both male and female juveniles showed increased VTG mRNA expression after 4-NP exposure. These findings confirm the endocrine-disrupting potential of 4-NP, particularly affecting genetically female juveniles. The alterations in key genes involved in steroidogenesis and the upregulation of VTG expression highlight the vulnerability of bivalves to EDCs. This study underscores the importance of VTG expression as a reliable biomarker for assessing the estrogenic impacts and action mechanisms of EDCs in juvenile bivalves.
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
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2025
·
IF 4.2
Dejian Chen,Yu Wang,Xiaomin Wang,Xiaosa Si,Yajing Weng,Shengbing Liu,Weiwei Pan,Ying Xu,Yong Wang,Yaling Zhang
Ferroptosis is a type of cell death caused by iron-dependent lipid peroxidation and excessive production of reactive oxygen species (ROS). Hyperandrogen exposure can induce ovarian ferroptosis in polycystic ovary syndrome (PCOS). However, there is not enough direct evidence regarding ovarian ferroptosis in PCOS to prove the role of ferroptosis in PCOS and the underlying mechanism. Nuclear receptor coactivator 4 (NCOA4) expression in ovarian granulosa cells and its mechanism of mediating ferroptosis have not been studied. In this study, we aimed to investigate how iron overload in ovarian granulosa cells and hyperandrogen exposure-induced ferroptosis affect ovarian development in a PCOS model. Increased ferroptosis was observed in hyperandrogenic mice with PCOS and in 5α-dihydrotestosterone (DHT)-induced primary granulosa cells. Iron deposition increased significantly, followed by increased cellular Fe 2+ concentration, whereas ROS accumulation, malondialdehyde (MDA), glutathione (GSH), and the glutathione/oxidized glutathione (GSH/GSSG) ratio decreased. NCOA4 and transferrin receptor expression increased; however, ferritin heavy chain 1 expression decreased in ovarian tissues. Androgen receptor and NCOA4 showed increased colocalization in the ovarian granulosa cell layer. Notably, DHT induced ferroptosis by activating NOCA4-dependent ferritin autophagy. However, deferoxamine mesylate inhibited ferroptosis in the ovarian granulosa mice cells, ameliorating the PCOS phenotype. Steroid hormone biosynthesis, arachidonic acid metabolism, and unsaturated fatty acid pathways were most significantly affected, providing a reference for PCOS diagnosis and treatment and corresponding drug development.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2026
·
IF 7.1
Axue Wang,Bingbing Lai,Xiaobo Wang,Huaigang Su,Wenjing Lou,Shengmao Zhang
Biobased lubricants have garnered significant attention due to their environmentally friendly characteristics. In this study, poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB) was employed as a thickener to successfully prepare four biobased greases with identical NLGI consistency grades. Scanning electron microscopy (SEM) characterization revealed that the P34HB thickener formed a three-dimensional lamellar network microstructure, elucidating the grease formation mechanism of the P34HB thickener. Rheological tests demonstrated that this grease system exhibited typical non-Newtonian fluid behavior and pronounced shear-thinning effects. Tribological performance evaluation indicated that the grease formulated with acetyl triethyl citrate (ATEC) as base oil displayed optimal friction-reducing and anti-wear properties. This research provided expanded base oil options for developing eco-friendly lubricants, extended the application scope of biobased materials in grease technology, and held substantial engineering value for promoting innovative development in green lubrication technologies
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DALTON TRANSACTIONS
·
2026
·
IF 3.3
Yun Lv,Yanhong Wang,Nian Shi,Keke Huang,Jinkui Tang,Hongcheng Lu
The synthesis of novel two-dimensional (2D) triangular frustrated compounds are important for providing various platforms to investigate exotic quantum magnetism. Here, we successfully synthesised a series of RE-based magnetic compounds Ba3BiPbREO(BO3)4 (RE = Pr, Nd, Gd, Dy) with a geometrically-perfect 2D triangular lattice directed by triangular BO3 unit. These compounds stabilise 2D layered structures in the hexagonal (P63/mmc) crystal system, where magnetic ions are linked by BO3 to form a perfect triangular frustrated lattice. The magnetisation susceptibility results show that all synthesised compounds Ba3BiPbREO(BO3)4 exhibit dominant antiferromagnetic (AFM) interactions, with no long-range order (LRO) down to 2 K, which is further confirmed by specific heat measurements. Additionally, their thermal stability, attenuated total reflectance Fourier-transform infrared (ATR-FTIR) and Ultraviolet−visible-near-infrared (UV−Vis−NIR) diffuse reflectance spectra are also reported. This work provides a series of RE-based magnetic compounds with a two-dimensional triangular frustrated lattice, offering novel model materials for further investigation on rare-earth-based frustrated magnetism.
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JOURNAL OF ORGANIC CHEMISTRY
·
2023
·
IF 3.6
Yuhang Xue,Chengjun Wu,Haiwen Li,Cunde Wang
Acetic acid-catalyzed (3 + 2) cyclization reaction of substituted 2-aroyl-3-aryl-1,1-dicyanocyclopropanes with arylhydrazines was investigated for the efficient synthesis of 4-dicyanomethyl-1,3,5-triaryl-4,5-dihydropyrazoles in good yields, in which 4,5-double substituents are predominantly trans selective. This approach included the consecutive condensation, ring opening, and double nucleophilic cyclization reaction.
研究领域:
有机化学
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合成方法学
·
杂环化学
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Lingzhi Chen,Meng Peng,Hualiang Huang
The corrosion inhibition behavior and mechanism of disodium 4-dodecyl-2,4′-oxydibenzenesulfonate (DDPBDS) on copper in ammonia water were examined through both experimental methodologies and theoretical computations. The findings indicated that DDPBDS exhibited the capability to concurrently suppress the electrochemical corrosion reactions of copper and was an efficient, durable corrosion inhibitor . At the concentration of 0.1 g/L, DDPBDS demonstrated an impressive corrosion inhibition efficiency of 99.92 % on copper during the initial soaking period, and after soaking for 15 days, its corrosion inhibition efficiency still reached 99.89 %. DDPBDS formed a uniform, dense and hydrophobic protective layer on the copper surface through physicochemical mixed adsorption, which exhibited an adsorption arrangement resembling a skateboard configuration, hindering the copper corrosion .
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Wendi Xiao,Jiale Chen,Siting Peng,Dingfeng Wang,Junyuan Shi,Liwei Gao,Ting Zhang,Jiong Cheng,Da Chen
The widespread use of 4-nitrophenol (4-NP) and curcumin, although beneficial across numerous industries, poses potential risks to human health and the environment. Thus, creating a sensitive and straightforward detection strategy is crucial for the rapid monitoring of these pollutants. Herein, a nitrogen-doped carbon dots (N-CDs)-based dual-excitation ratiometric fluorescent probe is developed, capable of detecting 4-NP and curcumin. The N-CDs are prepared from tris (hydroxymethyl) aminomethane (Tris) and phloroglucinol via a facile hydrothermal method, exhibiting a strong cyan fluorescence centered at 497 nm under excitation at 399 nm and 469 nm. In the presence of 4-NP, the fluorescence excited at 399 nm is significantly quenched compared to that excited at 469 nm due to the inner filter effect (IFE) and static quenching, achieving a limit of detection (LOD) of 76 nM within a linear range of 0.076–110 μM. In contrast, curcumin induces nearly complete fluorescence quenching at both excitation wavelengths, resulting from the quenching mechanism of dominant IFE and partial fluorescence resonance energy transfer. This response allows for curcumin detection over a concentration range of 0.081–90 μM with a low LOD of 81 nM. Furthermore, a smartphone-assisted sensing platform is constructed for the visual detection of 4-NP and curcumin in actual samples, achieving LODs as low as 117 nM and 123 nM, respectively. Therefore, this work enhances the capability for multi-analyte monitoring in complex systems and provides a practical and instructive strategy for detecting 4-NP and curcumin.
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ENVIRONMENTAL TOXICOLOGY
·
2023
·
IF 4.5
You Xiao,Yuanyuan He,Chongsi Xu,Mei Li,Fan Hu,Wei Wang,Zhenquan Wang,Yi Cao
MoS 2 nanosheets (NSs) are novel 2D nanomaterials (NMs) being used in many important fields. Recently, we proposed the need to evaluate the influences of NMs on Kruppel-like factors (KLFs) even if these materials are relatively biocompatible. In this study, we investigated the influences of MoS 2 NSs or bulk on KLF4 signaling pathway in 3D Caco-2 spheroids in vitro and mouse intestines in vivo. Through the analysis of our previous RNA-sequencing data, we found that exposure to MoS 2 NSs or bulk activated KLF4 expression in 3D Caco-2 spheroids. Consistently, these materials also activated KLF4-related gene ontology (GO) terms and down-regulated a panel of KLF4-downstream genes. To verify these findings, we repeatedly exposed mice to MoS 2 NSs or bulk materials via intragastrical administration (1 mg/kg bodyweight, once a day, for 4 days). It was shown that oral exposure to these materials decreased bodyweight, leading to relatively higher organ coefficients. As expected, exposure to both types of materials increased Mo elements as well as other trace elements, such as Zn, Fe, and Mn in mouse intestines. The exposure also induced morphological changes of intestines, such as shortening of intestinal villi and decreased crypt depth, which may result in decreased intestinal lipid staining. Consistent with RNA-sequencing data, we found that material exposure increased KLF4 protein staining in mouse intestines and decreased two KLF4 downstream proteins, namely extracellular signal-regulated kinase (ERK) and serine/threonine kinase (AKT). We concluded that MoS 2 materials were capable to activate KLF4-signaling pathway in intestines both in vivo and in vitro.
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JOURNAL OF VIROLOGICAL METHODS
·
2023
·
IF 3.1
Shuzhen Chen,Qingdong Luan,Shimei Qiu,Yue Zhao,Yanjin Lu,Shufang Sun,Jianlin Wang,Yanbo Yin
To detect the antibody against fowl adenovirus serotype 4 (FAdV-4) in clinical practice, the latex agglutination test (LAT) was developed by using the Fiber-2 protein of FAdV-4 as an antigen bound to sensitized latex microspheres . The concentration, time, and temperature of sensitization latex microspheres by the Fiber-2 protein were studied and optimized; the specificity, sensitivity, and repeatability of LAT were tested; and the method developed in the study was applied. The results showed that the optimum sensitization concentration of Fiber-2 protein was 0.8 mg/mL, the time was 120 min, and the temperature was 37 ℃. Except for antiserum against FAdV-4 and FAdV-10, LAT developed in the study could not agglutinate antisera against FAdV-1, FAdV-2, FAdV-3, FAdV-4, FAdV-5, FAdV-6, FAdV-8a, FAdV-8b, FAdV-11, Newcastle disease virus , infectious bronchitis virus , egg drop syndrome virus and Clostridium perfringens . Compared with the commercial FAdV-4 ELISA Kit, the titers in 21 clinical samples were low when tested by the developed LAT method, but there was no significant difference. The coefficients of variation among different batches and the same batch of latex-sensitized particles were between 0 % and 13.3 % and 0–8.7 %, respectively. The critical value of immune protective antibody against FAdV-4 was 2 5 , and the titers in 40.9 % of clinical samples were higher than the immune critical point. The results showed that the Fiber-2-based LAT developed in the study has the characteristics of high specificity, sensitivity and repeatability, has the advantages of free equipment, long shelf life, and fast and easy operation, and is an effective and convenient method for serological diagnosis of FAdV-4 infection and evaluating the efficacy of vaccines.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Jia Sun,Yinsheng Gu,Yingwei Lu,Juntao Hu,Tao Chen,Changfei Zhu,Paifeng Luo
Nowadays, the MA-FA mixed-cation perovskite solar cells (PSCs), demonstrating much higher stability than that of single-cation MAPbI 3 or FAPbI 3 , are still encountering a low-efficiency issue. The main reason is that there existing a lot of defects in SnO 2 electron transport layers (ETLs) and perovskite absorbers. Herein, we develop a synergistic strategy of Rubidium Chloride (RbCl) doping and 4- tert -butylbenzylammonium iodide (tBBAI) passivation to fabricate high-performance MA x FA 1-x PbI 3 mixed-cation PSCs. The alkali halide RbCl is first selected as a novel doping additive to regulate the film properties of SnO 2 and perovskites. Research shows that the negative Cl - ions can combine with uncoordinated Sn 4+ ions due to their strong bonding ability, which can passivate the oxygen-vacancy-related defects and enhance the charge transport of SnO 2 ETLs. Meanwhile, the doped Rb + and Cl - ions may diffuse into perovskite lattices to promote grain growth and reduce the defects of perovskites. Besides, we employ an organic halide salt tBBAI to passivate perovskites and suppress surface defects. Results of deep level transient spectroscopy (DLTS) indicate that SnO 2 and SnO 2 -RbCl based devices have deeper hole traps and large trap densities (Δ E = 0.92 eV, N T = 1.10 × 10 16 cm −3 ; ΔE = 0.93 eV, N T = 2.16 × 10 15 cm −3 ); while tBBAI-treated SnO 2 -RbCl-based devices own a shallower hole trap and a smaller trap density ( ΔE = 0.72 eV, N T = 2.44 × 10 13 cm −3 ); and the corresponding I Pb and I (MA/FA) antisite defeats are also identified. Therefore, our synergistic strategy is effectively able to reduce the defect density and suppress the non-radiative recombination. Consequently, the best-performance MA 0.85 FA 0.15 PbI 3 PSCs achieve an impressive power conversion efficiency (PCE) of 22.54% with a large open circuit voltage ( V oc ) of 1.16 V, which are by far the highest values of MA 0.85 FA 0.15 PbI 3 mixed-cation PSCs.
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JOURNAL OF SOLUTION CHEMISTRY
·
2023
·Vol. 52
·期 7
·762-789
·
IF 1.2
Li Min,Zhang Xiaocheng,Yu Yingmin,Liu Lanmu
The extractive distillation was used to separate ethylbenzene and m-xylene. After the solvent screening, 1,2,4-trichlorobenzene was chosen as the extractive solvent. The vapor–liquid equilibrium (VLE) of binary mixtures of m-xylene, ethylbenzene, and 1,2,4-trichlorobenzene was measured at 101.33 kPa. The measurements were taken with a modified Rose equilibrium still. The Wisniak’s test was used to assess the thermodynamic consistency of the VLE experimental results. To obtain the binary interaction parameters, the binary VLE experimental data were correlated with the NRTL, Wilson, and UNIQUAC activity coefficient models. The results showed that three models all fit the experimental values of three binary systems well, and the ternary VLE data of m-xylene + ethylbenzene + 1,2,4-trichlorobenzene were estimated using Aspen Plus V11 based on these model parameters. The experimental data agree well with the estimation values generated from three models. Finally, the effect of 1,2,4-trichlorobenzene as an extractant was analyzed, and it is proved to have a good influence on the separation of ethylbenzene from mixed xylenes by extractive distillation.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Guoqiang Guo,Tingting Li,Ziyi Liu,Xinyu Luo,Ting Zhang,Siyuan Tang,Xu Wang,Da Chen
Recently, converting bio-waste into bio-asset and implementing a portable sensing instrument for pollutant monitoring has been highly desirable and challenging. Herein, biomass-derived nitrogen-doped carbon dots (CDs) are prepared hydrothermally and emit blue fluorescence (470 nm) with a high quantum yield of 23.2%. Significantly, CDs can serve as a pH-modulated fluorescence switching nano-sensor to detect 4-NP from 0.054 to 68 μM with low detection limit (LOD, 54 nM) and limit of quantification (LOQ, 181 nM) based on inner filter effect. Moreover, the satisfactory recovery of 101.8–107.5% is gained in practical sample monitoring. Furthermore, a smartphone-integrated optosensing device with CDs-based film is developed for detecting 4-NP with LOD and LOQ of 0.110 μM and 0.350 μM. Concomitantly, the practicability of this device is further validated in several crop samples with satisfactory recovery rates of 101.6–108.6%. Therefore, this work provides a reliable way and a prospective application for on-site 4-NP monitoring in food.
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