TENSIDE SURFACTANTS DETERGENTS
·
2024
·Vol. 61
·期 6
·555-567
·
IF 1.2
Wenrui Zheng,Yue Lei,Yuheng Li,Haiyan Gao,Liangliang Lin,Hujun Xu
A triethanolamine-modified poloxamer temperature-sensitive hair care gel was formulated in order to reduce the adverse health effects associated with sodium thioglycolate (TGA(Na)), the active component in hair treatment agents, while maintaining excellent efficacy. It was found that TEA-3 gelled at 32 °C with a triethanolamine concentration of 3 %. This formulation exhibited a reversible phase transition, transitioning to a solid state upon contact with the scalp (>32 °C) and reverting to a liquid state when in contact with hair (<32 °C). The release behavior of TGA(Na) from the gel was assessed by both in vitro release studies and transdermal experiments. In addition, it was observed that the triethanolamine-modified poloxamer gel exhibited improved hair care efficiency compared to conventional hair care agents. These results suggest that the triethanolamine-modified poloxamer gel is a promising alternative to conventional hair care products, offering improved efficacy while minimizing potential adverse health effects.
研究领域:
材料科学
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药剂学
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化妆品科学
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·Vol. 141
·期 32
·e55747
·
IF 2.7
Yuhang Wang,Mingyang Liu,Zhengsheng Hu,Hanlin Lv,Yanjun Chen,Yifeng Wang
As an efficient means of material carrying, multilayer capsules are widely used in medicine, agriculture, food safety and other fields. Here, we report a kind of temperature-triggered multilayer capsule with chitosan-sodium dodecyl benzene sulfonate (CS-SDBS) as the shell and gelatin bead containing α-cyclodextrin (α-CD@gelatin) as the core. The α-CD@gelatin/CS-SDBS multilayer capsules can simultaneously encapsulate various substances, such as drugs, fluorescent materials, and nanoparticles. The encapsulated substances do not interfere with each other because they are located in different layers. Both the temperature-sensitive property of gelatin and the host-guest interaction between α-CD and SDBS are utilized to achieve temperature-controlled release of substances in the multilayer capsules. The release rate can be adjusted by the α-CD amount in the gelatin beads. The controlled drug release and chemical detection of the multilayer capsules are studied with sodium salicylate, iodine, and purple cabbage pigment as the carriers. The results show that the α-CD@gelatin/CS-SDBS multilayer capsules have excellent capabilities of encapsulation and controlled release, which are beneficial for their application in the fields of substance encapsulation, drug-controlled release, and chemical detection.
研究领域:
材料科学
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医药学
·
化学工程
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产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2024
·
IF 10.5
Xi Tan,Jing Zhang,Yongyuan Heng,Lin Chen,Yi Wang,Shaojun Wu,Xiaoli Liu,Biao Xu,Ziyi Yu,Rong Gu
Compared with stem cells, exosomes as a kind of nanoscale carriers intrinsically loaded with diverse bioactive molecules, which had the advantages of high safety, small size, and ethical considerations in the treatment of myocardial infarction, but there are still problems such as impaired stability and rapid dissipation. Here, we introduce a bioengineered injectable hyaluronic acid hydrogel designed to optimize local delivery efficiency of trophoblast stem cells derived-exosomes. Its hyaluronan components adeptly emulates the composition and modulus of pericardial fluid, meanwhile preserving the bioactivity of nanoscale exosomes. Additionally, a meticulously designed hyperbranched polymeric cross-linker facilitates a gentle cross-linking process among hyaluronic acid molecules, with disulfide bonds in its molecular framework enhancing biodegradability and conferring a unique controlled release capability. This innovative hydrogel offers the added advantage of minimal invasiveness during administration into the pericardial space, greatly extending the retention of exosomes within the myocardial region. In vivo, this hydrogel has consistently demonstrated its efficacy in promoting cardiac recovery, inducing anti-fibrotic, anti-inflammatory, angiogenic, and anti-remodeling effects, ultimately leading to a substantial improvement in cardiac function. Furthermore, the implementation of single-cell RNA sequencing has elucidated that the pivotal mechanism underlying enhanced cardiac function primarily results from the promoted clearance of apoptotic cells by myocardial fibroblasts.
研究领域:
生物医学工程
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心脏病学
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组织工程
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纳米技术
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再生医学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2024
·Vol. 12
·期 46
·31982-31992
·
IF 10.7
Yizhe Liu,Xiaoxiang Li,Yangzhe Xu,Benwei Fu,Chengyi Song,Wen Shang,Peng Tao,Tao Deng
Seasonal storage of solar-thermal energy within salt hydrate phase change materials (PCMs), which are known for their large latent heat capacity, suitable phase change temperature range and cost-effectiveness, has garnered tremendous attention. Salt hydrates, however, suffer from poor phase change and physical stability, low solar absorptance, and leakage issues after melting. In this work, we report impregnating sodium acetate trihydrate (SAT) within polyacrylamide hydrogel networks decorated with solar-absorbing polydopamine particles, and explore their applications for direct harvesting, long-term storage and controllable release of solar-thermal energy. Owing to the formation of intermolecular hydrogen bonding, the hydrogel-impregnated SAT composites retain their stable supercooling during both long-term heat storage at room temperature for 2 years and repeated heating/cooling cycles. Through applying electrical pulses, the crystallization of supercooled PCM composites and the release of latent heat can be triggered in a programmable manner. The hydrogel networks also prevent phase separation and leakage of melted SATs while retaining a latent heat enthalpy higher than 180 J g−1. We demonstrate that such flexible, self-adhesive, leakage-proof, supercooled PCM composites could not only enable seasonal harvesting of renewable solar-thermal energy and provide intelligent thermal regulation for both buildings and the human body, but also have the potential to facilitate widespread terminal usage of thermal storage technology.
研究领域:
材料科学
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能源技术
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环境科学
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产品关联
DOI
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 50
·32355-32364
·
IF 4.036
Rui Liu,Baofeng Xu,Zhifang Ma,Hongbo Ye,Xinghua Guan,Yue Ke,Zehong Xiang,Qiang Shi
Platelets activation and hypercoagulation induced by tumor cell-specific thrombotic secretions such as tissue factor (TF) and cancer procoagulant (CP), microparticles (MPs), and cytokines not only increase cancer-associated thrombosis but also accelerate cancer progress. In addition, the tumor heterogeneity such avascular areas, vascular occlusion and interstitial fluid pressure still challenges efficient drug delivery into tumor tissue. To overcome these adversities, we herein present an antiplatelet strategy based on a proteinic nanoparticles co-assembly of L-arginine (LA) and photosensitizer IR783 for local NO release to inhibit the activation of tumor-associated platelets and normalize angiogenesis, suppressing thrombosis and increasing tumoral accumulation of the nanoagent. In addition, NIR-controlled release localizes the NO spatiotemporally to tumor-associated platelets and prevents undesirable systemic bleeding substantially. Moreover, NO can transform to more cytotoxic peroxynitrite to destroy cancer cells. Our study describes an antiplatelet-directed cancer treatment, which represents a promising area of targeted cancer therapy.
研究领域:
肿瘤学
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药理学
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治疗学
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生物医学工程
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分子生物学
✓ 已验证
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2017
·
IF 4.3
Yang Liu,Dan Li,Xinhong Guo,Haiwei Xu,Zhi Li,Yanling Zhang,Chuanjun Song,Ruhan Fan,Xing Tang,Zhenzhong Zhang
We synthesized a pH-responsive conjugate of 10-hydroxycamptothecin-thiosemicarbazide-linear polyethylene glycol 2000 (PEG2000). The conjugate was confirmed by matrix-assisted laser desorption time of flight mass spectrometry, 1 H NMR, and 13 C NMR. The water solubility of the prodrug was increased by over 3,000 times; much longer body circulation time, higher tumor-targeting ability, and reduced toxicity were observed, compared with commercial 10-HCPT injection. The linker contains a pH-sensitive hydrazone bond, which breaks under low pH conditions in the tumor microenvironment. The conjugates showed good stability in phosphate-buffered saline (pH 7.4) and rat plasma. This amphiphilic conjugate could self-assemble into nanosized micelles of 80–100 nm. Cytotoxicity assay results indicate significantly higher efficacy of the conjugate (IC 50 [half maximal inhibitory concentration] =0.117 µM on SW180 cells) than 10-HCPT solution (IC 50 =0.241 µM on SW480 cells). Cellular uptake analysis suggested its rapid internalization and nuclear transport. Pharmacokinetic analysis of the conjugates demonstrated that the conjugate circulated for a longer time in the blood circulation system ( T 2/1 =10.516±1.158 h) than did 10-HCPT solution ( T 2/1 =1.859±1.385 h), and that it also enhanced the targeting and mean residence time (MRT 0–inf =39.873±4.549 h) in the tumor site, compared with 10-HCPT (MRT 0–inf =9.247±1.026 h). Finally, the conjugate demonstrated an increased tumor growth inhibition effect (TIR =82.66%±7.175%) in vivo and lower side effects than 10-HCPT (TIR =63.85%±5.233%). This prodrug holds great promise in improving therapeutic efficacy and overcoming multidrug resistance.
研究领域:
药学
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药物递送系统
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癌症治疗
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纳米技术
✓ 已验证
DOI
PubMed
高影响因子
APPLIED CLAY SCIENCE
·
2020
·
IF 4.605
Huiqiong Yan,Pan Zhang,Xiuqiong Chen,Chaoling Bao,Rui Zhao,Jisen Hu,Chang Liu,Qiang Lin
To fabricate a hydrophobic pharmaceutical formulation with the use of montmorillonite (MMT), the strong polarity and structural properties of montmorillonite were modified by via simple and convenient wet ball-milling method using the nonionic surfactant , octyl phenyl polyoxyethylene ether , as the modifier, to improve the MMT's affinity to hydrophobic organic drug, ibuprofen . The resultant organo-montmorillonite (OPP-MMT) was characterized by the means of scanning electron microscopy, dynamic light scattering , Fourier transform infrared spectroscopy , X-ray diffraction, transmission electron microscopy , thermogravimetric analyzer, BET-specific surface area measurements, drug adsorption and in vitro release experiments, and in vitro cell viability assay . Experimental results showed that octyl phenyl polyoxyethylene ether was successfully inserted into the interlayer of the raw Na-MMT during the wet ball-milling process. The adsorption and intercalation modification of octyl phenyl polyoxyethylene ether destroyed the rigid structure of Na-MMT, enlarged the interlayer spacing of Na-MMT, and enhanced its specific surface area, pore volume and mean mesopore size, which made it be more conducive to the loading of hydrophobic organic drugs. The adsorption analysis of OPP-MMT on ibuprofen showed that the affinity of OPP-MMT to hydrophobic drugs was better than that of Na-MMT, which was beneficial to the loading of ibuprofen. Moreover, the good affinity of OPP-MMT to hydrophobic drug allowed it to exhibit good controlled release properties for the drug delivery.
研究领域:
材料科学
·
药学
✓ 已验证
DOI
高影响因子
Food Frontiers
·
2026
·Vol. 7
·期 2
·e70257
·
IF 6.3
Wei Li,Kai-ni Jing,Xiao-mei Yang,Zi-yang Ding,Zhi-fei He,Liang Zou,Hong-jun Li
Tributyrin (TB), a stable triglyceride prodrug of butyrate, holds immense potential for modulating gut health and managing ulcerative colitis (UC) via dietary intervention. However, its application in functional foods is restricted by its hydrophobicity, gastric instability, and rapid absorption in the upper gastrointestinal tract (GIT). To address these challenges, this study engineered a food-grade, colon-specific delivery system based on hierarchical emulsion-filled hydrogel microbeads. TB was initially stabilized by octenyl succinic anhydride (OSA)-modified Tartary buckwheat starch to form robust Pickering emulsions (OSP), which were subsequently embedded within a pH-responsive sodium alginate (SA)/carboxymethyl chitosan (CMCS) composite matrix. The intermolecular polyelectrolyte complexation between SA and CMCS, reinforced by Ca 2+ -mediated crosslinking, significantly enhanced the structural integrity and encapsulation efficiency (∼64%) of the microbeads (TB-OSP@C/S). In vitro digestion kinetics demonstrated that this multi-compartment architecture acted as an effective diffusion barrier, suppressing gastric release (< 20%) while facilitating sustained release in the simulated colonic environment driven by pH-dependent swelling and the enzymatic degradation of the protective starch shell. In a DSS-induced murine colitis model, oral administration of TB-OSP@C/S microbeads markedly improved the disease activity index, alleviated colonic tissue damage, and exhibited superior anti-inflammatory efficacy compared to free TB. This work presents a facile, surfactant-free strategy for the precise delivery of hydrophobic nutraceuticals, offering a promising paradigm for developing precision nutrition products targeting intestinal inflammation.
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产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2026
·
IF 2.9
Yang Chengcheng,Tan Wentao,Wu Junxi,Lu Yizhen,Zhu Jinge,Guo Xianyu,Wang Ling,Yang Fengrui,Li Hui
As a PI3K enzyme inhibitor, quercetin is of great potential in cancer treatment. Development of a drug carrier for quercetin with higher loading capacity and controlled release performance is helpful to implement targeted and precise treatment and to improve the drug efficacy. For this purpose, a molecularly imprinted drug carrier for quercetin (MIDC-Q) was prepared successfully by surface imprinting on a ZIF-67@oc-poss@p-VPBA matrix using para-vinylphenylboronic acid (p-VPBA), N-isopropylacrylamide (NIPAAM), and acrylamide (AAM) as complex functional monomers and ethylene glycol dimethacrylate (EGDMA) as the cross-linker. Optimization of preparation conditions was performed by using an L 9 ( 3 4 ) orthogonal factor design method, and structural characterization for the carrier was done by Fourier Transform infrared spectroscopy (FTIR), Scanning Electron Microscope (SEM), X-Ray Diffraction (XRD), X-ray Photoelectron Spectroscopy (XPS), and Brunauer-Emmet-Teller (BET) analysis. The carrier MIDC-Q10 obtained under the optimized conditions has been proven to have a higher loading capacity (98.65 mg g⁻¹) toward the drug quercetin and possesses two main types of binding sites. When this quercetin-loaded carrier was used to perform a release behavior test in vitro, the release rate for quercetin could be controlled by adjusting media pH value, temperature, and/or ionic strength. The carrier showed significantly reduced release dynamics at 303 K in pH 7.2 media, needing about 84 h to reach 94.58% cumulative release. This controlled release behavior for this imprinted drug carrier might result from such chemical interactions as covalent bond, hydrogen bond, coordination interactions, and even ionic bonds between the molecular imprinting sites and the target molecules. The present work developed a novel and promising drug carrier for quercetin with controlled release performance.
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产品关联
DOI
高影响因子
Materials Today Chemistry
·
2024
·
IF 6.7
Hongchun Li,Jie Xu,Yongsheng Niu
The pH-responsive pesticide delivery system can enhance utilization efficiency of pesticides and reduce environmental pollution. Herein, an environmental and amphiphilic carbon dioxide-based copolymer , poly(propylene oxide-co-carbon dioxide-co-allyl glycidyl ether)-poly(polyacrylic acid)-methoxy poly(ethylene glycol) (PPAG-PAA-mPEG), was synthesized to fabricate a pH-responsive pesticide delivery system. The avermectin (AVE) was selected as a model drug to show PPAG-PAA-mPEG potential as a controlled-release pesticide system. The entrapment efficiency and the loading content of the AVE-loaded micelles was 88.6 % and 36.98 %, respectively. The AVE-loaded micelles were stable. The release rate of AVE gradually increased with the increase of pH. Pot trial showed that the AVE-loaded micelles showed a good pesticidal efficacy. Because of CO 2 as raw materials, and excellent pH-responsive controlled-release performance, these on-demand pesticide delivery systems might have significant potential in improving the utilization efficiency of pesticides in modern agriculture.
研究领域:
农业化学
·
高分子科学
·
药物递送系统
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Fan Yang,Jincheng Wang,Shiqiang Song,Pinhua Rao,Runkai Wang,Shihui Liu,Liqi Xu,Feng Zhang
A novel type of temperature and pH dual-stimuli-responsive microspheric soil conditioner was prepared for the controlled release of urea. First, poly(N-isopropylacrylamide-co-methacrylic acid) [P(NIPAM-co-MAA)] was synthesized, and the microspheric soil conditioner was prepared on the basis of chitosan-coated P(NIPAM-co-MAA) via the emulsion cross-linking method. The structure and morphology of the microsphere were characterized by Fourier transform infrared spectroscopy, hydrogen nuclear magnetic resonance, polarization optical microscopy, and scanning electron microscopy. The microsphere showed controlled release behavior in different temperature and pH conditions, indicating good stimuli responsiveness. The plant experiment revealed that the microsphere can effectively promote plant growth in acidified soil and high-temperature conditions, and the pH value of acidified soil could be improved. In addition, the microsphere possessed good biodegradation property in the soil. Therefore, the multi-responsive microspheric soil conditioner owns a great potential value to amend soil conditions and promote plant growth in agriculture applications.
研究领域:
农业科学
·
土壤学
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2016
·
IF 4.179
Xiaolei Zhu,Hongwei Zhang,Jun Nie,Guiping Ma
pH-sensitive drug loaded core shell fibers were fabricated by a combination of electrospinning and UV photo-polymerization. Combretastatin A4 (CA4) was selected as the model drug loaded in PLA to test the pH-sensitivity property of the core shell fibers. The morphology of the fibers was studied by scanning electron microscopy (SEM), and the core shell structure of the fibers was confirmed by transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS). The drug release assay was tested via the UV–vis spectrophotometer, and the pH-sensitivity of core shell fibers was tested by drug release assay under pH 5.0 and 7.4.
研究领域:
材料科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）