JOURNAL OF CATALYSIS
·
2026
·
IF 6
Jian Shi,Xiao Liang,Qian Zhang,Yaowei Xu,Xiyang Yu,Bing Tang,Donghuai Tu,Hui Ma,Wei Mao,Jianming Yang,Chunran Chang,Jian Lu,Yadong Li
The heterogeneous catalysis of HCl oxidation over Ru-based catalysts is a green and low-carbon chemistry route to recover high-purity Cl 2 from HCl byproduct for industrial practice. Herein, we report a facile fluorination strategy to fabricate durable supported Ru/Ti oxide catalysts for efficient HCl oxidation. The space–time yield by Ru/Ti-hf can reach up to 26.9 g Cl2 ·g cat −1 ·h −1 with an ultrahigh HCl TOF of 1.5 × 10 4 h −1 . After 24-h accelerated deactivation, this catalyst exhibits over 60% higher activity compared to the conventional Ru/Ti-r. This method allows for establishing highly dispersed and sintering-resistant RuO x species. The fluorine incorporation on TiO 2 surface generates abundant oxygen vacancies and Ru active sites, enhancing the activation capabilities for oxygen. Mechanistic calculations further suggest that the Cl-atom recombination step demanding the highest activation energy is facilitated with a lower energy barrier, due to the accumulation of electrons at the 4 d orbital of Ru sites and the transfer of electron to the antibonding orbital of Ru-Cl by moderate fluorine incorporation. These findings provide a nimble approach to fabricating efficient and durable catalysts promising for HCl oxidation in industry.
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ACS Synthetic Biology
·
2026
·
IF 4.5
Ruiying Zhu,Zehua Bao
Genetic diversification serves as the foundation for in vivo molecular evolution. The fusion of a cytidine deaminase with T7 RNA polymerase (MutaT7) enables efficient diversification of DNA sequences downstream of the T7 promoter in model microbial hosts E. coli and S. cerevisiae. Vibrio natriegens, currently the fastest-growing nonpathogenic bacterium with a doubling time half that of E. coli, emerged as a promising alternative chassis for synthetic biology. Here, we report the establishment of MutaT7 in V. natriegens (dubbed VnMutaT7), achieving rapid evolution of the model protein TEM-1 to confer high-level ceftazidime resistance in just 36 h. This work establishes the potential of V. natriegens as an accelerated platform for protein engineering.
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高影响因子
CHEMPHYSCHEM
·
2026
·Vol. 27
·期 12
·e202500912
·
IF 2.4
Ruipeng Hao,Fangyuan He,Wanyu Xie,Ming Wei,Xuwen Gao,Wenbo Lu
Rapid and efficient detection of dopamine is crucial for disease prevention and clinical diagnosis. Herein, ZnCoP nanopolyhedra synthesized via a metal–organic framework (MOF)-derived phosphidation route are employed as an electrocatalyst for electrochemical dopamine sensing. The constructed sensor exhibits outstanding analytical performance, featuring a wide linear range (0.5–1500 μM), high sensitivity (1038 μA mM −1 cm −2 ), and a low detection limit of 0.19 μM. Additionally, the sensor demonstrates excellent selectivity, long-term stability, and reliable repeatability. The superior performance is attributed to the well-defined polyhedral architecture inherited from the MOF precursor, which offers abundant electroactive sites and facilitates efficient electron transfer. These results establish ZnCoP nanopolyhedra as a promising sensing platform for dopamine detection, with strong potential for applications in medical diagnostics and bioanalytical monitoring. Graphical Metal–organic framework (MOF)-derived ZnCoP nanopolyhedra are synthesized via a direct phosphidation strategy and serve as an efficient electrocatalyst for dopamine detection. The material retains the polyhedral morphology of the MOF precursor with a roughened surface, providing abundant active sites and enhanced conductivity. Benefiting from these features, the electrochemical sensor delivers a wide linear range (0.5–1500 μM), a low detection limit (0.19 μM), and high sensitivity (1038 μA mM −1 cm −2 ), along with excellent selectivity, stability, and reproducibility.
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NATURE BIOTECHNOLOGY
·
2025
·
IF 41.7
Li Guangye,Chen Guo,Yuan Guo-Hua,Wei Jia,Ni Qingyang,Wu Jing,Yang Bei,Yang Li,Chen Jia
RNA editing can be a promising therapeutic approach. However, ectopic expression of RNA editing enzymes has been shown to trigger off-target editing. Here we identified adenosine deaminase acting on RNA (ADAR) inhibitors (ADIs) that suppress the activity of the fused ADAR2 deamination domain (ADAR2 DD ). Using these specific ADIs, we develop an RNA transformer adenosine base editor (RtABE) with high specificity. Fusing ADI to ADAR2 DD , RtABE remains inactive until it binds to its target site. After binding to the target site, ADI is cleaved from ADAR2 DD , and RtABE becomes active. RtABE can induce efficient editing in broad sequence contexts, including UAN, AAN, CAN and GAN. Using an adeno-associated virus for delivery of RtABE enables therapeutic RNA correction and restoration of α- l -iduronidase activity in Hurler syndrome mice with no substantial off-target editing. RtABE is a specific and efficient RNA editing system with a broad scope that may be a better alternative to existing RNA editing tools.
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Processes
·
2026
·Vol. 14
·期 8
·1242
·
IF 3.4
Jun Zhang,Sheng Fan,Zhong He,Xin Zheng,Shifeng Zhang
To overcome polymer-based plugging materials’ disadvantage of being prone to degradation and failure under hydrothermal conditions, an epoxy resin plugging particle with a high-pressure-bearing capacity under high temperatures was prepared by optimizing the curing process. Bisphenol A Epoxy Resin E51 and Diethyltoluenediamine (DETDA) were selected as raw materials for sample preparation. Due to the high viscosity of the system, 1,2-cyclohexanediol diglycidyl ether was introduced as a diluent, and an optimal concentration of 20% was determined through experimental optimization. Non-isothermal differential scanning calorimetry, bottle testing, and infrared spectroscopy were employed to investigate the variation laws of curing temperature, curing time and curing degree during the epoxy resin curing process via one-step and multi-step methods. The compressive strength of the epoxy resin prepared using the two processes was evaluated. After comprehensively comparing the preparation time, process complexity, and compressive strength of the final samples of the one-step and two-step curing methods, the one-step process (90 °C/5 h) was determined to be superior. In addition, the results of the fracture plugging experiment showed that after the bulk epoxy resin prepared using the optimized process was made into particles through a mechanical method and treated under hydrothermal conditions at 120 °C, the maximum breakthrough pressure reached 4.2 MPa, which was 950% and 135.96% higher than that of Particle 1 (Poly(2-acrylamido-2-methylpropanesulfonic acid)/acrylamide (PAMPS/AM) gel) and Particle 2 (PAMPS/AM gel treated with Polyethylene glycol (PEG)), respectively, which were used as control groups. This result indicates that epoxy resin can be used as a high-temperature-resistant plugging material and should be further researched.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Xi Gao,Xinyun Pu,Xu Peng,Shaoxiong Feng,Xu Wei,LianjunTang,Xixun Yu
The longevity and applicability of glutaraldehyde cross-linked commercial bioprosthetic heart valves (BHVs) that are the first choice for the transcatheter heart valve replacement (THVR) remain limited due to thrombus accumulation, calcification, inflammatory reactions and poor endothelialization. In this study, we first performed the prefunctionalization treatment of dual crosslinking by carboxymethylated λ-carrageenan and 4-pentenoic acid on decellularized bovine pericardium; subsequently, we conducted a post-functionalization treatment by dual modification of immobilizing the cyclodextrin (CD)/rutin and organic selenium onto above-mentioned doubly cross-linked (DC) bovine pericardium through the amidation reaction; finally, we obtained the anticipated bioprosthetic heart valve with multiple functions (DC + CD/Rutin+Se-BP). Uniaxial tensile tests demonstrated that this doubly cross-linked BHV exhibited superior mechanical properties compared with glutaraldehyde-treated bovine pericardium, which is expected to increase its structural stability and service life. By introducing the CD/Rutin complex and organic selenium, DC + CD/Rutin+Se-BP not only exhibited the ability to inhibit the adsorption of plasma proteins, platelet aggregation and thrombosis but also presented the excellent anti-inflammatory and anti-calcification characteristics both in vitro and in vivo. Furthermore, DC + CD/Rutin+Se-BP also exhibited stable in situ nitric oxide (NO) catalytic release ability due to the immobilization of organic selenium, which endowed bioprosthetic heart valve with excellent compatibility with human umbilical vein endothelial cells (HUVECs) and facilitated the long-term promotion of its endothelialization process. In summary, this approach combining dual cross-linking and dual modification provides a promising strategy for future design of BHVs, and DC + CD/Rutin+Se-BP exhibits a bright prospect in the clinical applications of BHVs.
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CHEMISTRY-A EUROPEAN JOURNAL
·
2026
·
IF 3.6
Yuying Zhang,Jianfang Qin,Mengxi Zhang,Lijuan Jia,Fenglin Zhang,Tong Chang,Haiying Yang,Xu Liu,Yan Zhu
Exploiting atomic-precision metal nanoclusters as an electrochemical sensor for environmental detection is a significant application in the field of cluster chemistry. However, the development of cluster-based sensors is still in its infancy. Herein, we successfully fabricate a three-layer KBE-CS/Au 25 @MLG/GC electrode (KBE = kidney bean enzyme, CS = chitosan, MLG = multilayer graphene, GC = glassy carbon), in which Au 25 @MLG and CS serve to adsorb and protect the plant esterase of KBE, respectively. The optimized Au 25 -based sensor demonstrates an excellent linear relationship between the mass concentration of profenofos (lgC) and the inhibition rate (Inh %) within the range of 1∼2000 µg/L with a detection limit of 0.137 µg/L. Furthermore, this biosensor presents excellent reproducibility, anti-interference, and stability for the detection of profenofos in real samples. This study paves an avenue to construct a cluster-based detection platform with high performance in electrochemical sensing, facilitating the practical application of metal nanoclusters in pesticide detection. Graphical A three-layer electrochemical sensor is constructed based on an enzyme inhibition mechanism, in which atomically precise Au 25 nanoclusters serve as an electrocatalyst for the conversion of 1-naphthyl acetate to 1-naphthol that can be efficiently recognized in the enzymatic reaction. This novel biosensor exhibits outstanding reproducibility, anti-interference, and stability for the detection of profenofos with a low limit of 0.137 µg/L.
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Advanced Materials Technologies
·
2026
·
IF 6
Cheng Liu,Dan Liu,Shiman Yang,Weiqi Luo,Wenhui Xu,Xiaoqing Liu,Jianyu Wang,Yan Wang,Li Wang,Yichun Ding
Flexible pressure sensors are pivotal for next-generation applications in health monitoring, electronic skin, and human-machine interaction. While iontronic sensors are prized for their high sensitivity, conventional methods to optimize the dielectric layer often involve complex and costly microfabrication. This work presents a high-sensitivity iontronic sensor created from an ionic asymmetric fiber mat (i-AFM) dielectric, fabricated by a simple sequential electrospinning process. This ionic-asymmetric and fibrous design synergistically minimizes initial capacitance while maximizing the pressure-induced interfacial contact area change. The resulting device achieves an ultra-high sensitivity of 47.27 kPa −1 , a wide linear range up to 750 kPa, an ultra-low detection limit of 0.86 Pa, and a fast response/recovery time of 1.92/7.06 ms. The sensor accurately monitors tiny pressures and various physiological signals, including pulse, breathing, swallowing vibration, and joint bending. Furthermore, a 4 × 4 sensor array enables spatial pressure mapping, and integration with a machine learning model achieves >95.00% accuracy in speech recognition. This versatile, high-performance sensing platform holds significant promise for wearable healthcare, soft robotics, and human-machine interaction.
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ACS Nano
·
2026
·
IF 17.3
Junhui Zhang,Chunrong Ma,Guangshuai Han,Zhezheng Ding,Yan Wang,Daqian Wang,Jinnuo Li,Bing Sun,Timing Fang,Xiaomin Liu,Xiao Tang
The development of high-energy lithium-ion batteries is crucial for next-generation energy storage and electric vehicle/aircraft technologies; however, their development is hindered by conventional electrolyte designs, which perform poorly across wide temperature ranges. Herein, entropy-enhanced electrolytes have been developed for graphite||LiNi0.9Co0.05Mn0.05O2 (NCM955) cells by a data-driven approach. Entropy-enhanced electrolytes feature diversified solvation structures that significantly improve thermodynamic stability and ionic kinetics. Furthermore, the film-forming ability of both the anodes and cathodes under various conditions is systematically investigated. One formulation with a moderate entropy value proves particularly effective, facilitating the formation of stable electrode/electrolyte interphases, which enables graphite||NCM955 cells with superior cycling stability across a wide temperature range. Consequently, the as-assembled graphite||NCM955 cells with the entropy-enhanced electrolyte can deliver a remarkable long-term lifespan (>1500 cycles) with a high energy density, maintaining high capacity retention from −30 to 70 °C. This work provides strategic insights for developing next-generation electrolytes for high-energy-density and all-climate-adaptive lithium-ion batteries.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Lulu Zhang,Zehao Li,Wanying Wang,Yingjie Feng,Jinchu Yang,Yongming Xu,Zhenzhen Huang,Nannan Wang,Kaijing Yin
Dihydrocarvone is an important flavor compound and chiral building block obtained through the ene reductase (ER)-mediated reduction of carvone. In this study, a new ER, KlebER1, from Klebsiella sp. O852 was identified and characterized. Optimal enzyme activity occurred at 40 °C and pH 7, with approximately 80% activity retained after incubation at 20–40 °C for 3 h. Based on sequence alignment, alanine scanning, and molecular docking analyses, a site-directed mutation (A303N) was introduced, resulting in a 1.73-fold enhancement in activity. Finally, an enzymatic cascade system incorporating the A303N mutant and glucose dehydrogenase for coenzyme regeneration was constructed both in vivo and in vitro for dihydrocarvone production. This biocatalytic system achieved a dihydrocarvone concentration of 5.88 mmol/L and a conversion rate of 99%, representing a significant improvement compared to the single use of A303N mutant. This study lays the foundation for investigating the function and modification of ERs and promoting the efficient biosynthesis of dihydrocarvone.
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ACS Applied Nano Materials
·
2026
·
IF 5.8
Qingjie Yang,Qirong Zhu,Xueting Liu,Qingxiu Yang,Mingzhe Li,Siwen Yu,Jianjun Guo,Dingyi Tong,Aihua Sun,Yuchuan Cheng
Current CMP processes still face significant challenges in minimizing or eliminating the use of additional oxidants and/or external energy inputs. In this work, we present a green and highly efficient CMP strategy that ingeniously harnesses the piezoelectric effect of barium titanate (BaTiO3) to enhance the polishing process. A five-factor orthogonal experimental design was employed to systematically investigate the influence of key process parameters on the material removal rate (MRR) during silicon wafer polishing. Through parameter optimization, the process achieved an exceptionally high MRR of 436 nm·min–1, accompanied by an ultralow surface roughness (Ra = 0.253 nm). Under the applied polishing pressure, tetragonal-phase BaTiO3 particles generate reactive oxygen species (ROS) in situ. The addition of a small amount of hydrogen peroxide (H2O2) further amplifies this effect: H2O2 acts not only as a catalytic substrate but also as an electron scavenger, significantly accelerating the formation of a soft and easily removable silicate oxide layer on the silicon surface. Simultaneously, the BaTiO3 particles serve as abrasives, mechanically removing this oxide layer and thereby establishing a synergistic “oxidation–abrasion” mechanism. The mechanism was confirmed by ESR and XPS characterization. Notably, the entire polishing process requires no additional energy input such as heating, light irradiation, or external electric fields and operates efficiently using only the standard mechanical action of conventional CMP equipment. This approach thus offers an innovative, environmentally sustainable, and highly effective solution for global silicon wafer planarization.
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Nature Communications
·
2026
·
IF 18.1
Jia Junqi,Liu Yu,Yu Jiamin,Wang Jingwei,Zhang Yiting,Fang Yuan,Yu Ying,Sun Zhongxing,Li Zhuoning,Tang Yin,Shao Juejia,Zhang Yanjun,Song Hai,Ulianov Sergey V.,Huang Jing,Fang Dong
Histone H3 lysine 36 dimethylation (H3K36me2) plays a key role in transcriptional elongation and chromatin organization, yet how its deposition is spatially controlled across the genome remains unclear. Here, we identify TOP1 as a critical recruiter of the H3K36me2 methyltransferase NSD2 to gene bodies. Disruption of the TOP1–NSD2 interaction reduces H3K36me2 at gene bodies, impairs RNA polymerase II release, and represses transcription. Remarkably, loss of this recruitment increases H3K36me2 at repetitive sequences, licensing their aberrant transcriptional activation. We show that NSD2 is primarily responsible for depositing H3K36me2 at these loci. We further identify MTA1 as a recruiter of NSD2 to repetitive elements via recognition of the GATC consensus sequence. Together, TOP1 and MTA1 spatially partition NSD2 across the genome, enabling H3K36me2 to serve dual roles in regulating canonical gene expression and acting as an active mark for the transcriptional activation of repetitive sequences.
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