Materials Today Bio
·
2026
·
IF 11
Aiyang Tong,Yang Zhou,Yang Ding,Yuelin Zhao,Changna Han,Linlin Wei,Jian Zhao
PANoptosis, a newly characterized form of inflammatory programmed cell death that integrates multiple cell death modalities, offers distinct advantages in both potent tumor cell killing and activation of antitumor immunity. However, strategies that can effectively induce PANoptosis in tumor cells remain scarce. Herein, we constructed a tumor microenvironment-responsive nanoplatform (HA-MnO 2 -FTY720@CaO 2 , HMFC) comprising a CaO 2 core and a MnO 2 shell, loaded with fingolimod (FTY720) and surface-functionalized with hyaluronic acid (HA) for CD44-mediated targeting. Under the mildly acidic and glutathione (GSH)-rich conditions of the tumor microenvironment (TME), the MnO 2 shell degrades, liberating FTY720 and exposing the CaO 2 core. The CaO 2 subsequently decomposes to release Ca 2+ and H 2 O 2. FTY720 inhibits Transient Receptor Potential Melastatin 7 (TRPM7) channels, disrupting Ca 2+ /Mg 2+ homeostasis and thereby provoking severe calcium overload. Simultaneously, MnO 2 depletes GSH and, together with CaO 2 -derived H 2 O 2 , promotes a Fenton-like reaction that generates abundant reactive oxygen species (ROS), thereby disrupting intracellular redox homeostasis. In addition, Mn 2+ released from MnO 2 degradation activates the cGAS–STING pathway, further contributing to DC maturation and antitumor immunity. This orchestrated immune response markedly suppresses tumor growth and when combined with anti-PD-L1 therapy, induces a pronounced abscopal effect. Together, our results indicate that calcium overload, FTY720-mediated TRPM7 inhibition, and MnO 2 -induced redox imbalance can drive PANoptosis, offering a new concept for enhancing cancer immunotherapy.
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高影响因子
JOURNAL OF NON-CRYSTALLINE SOLIDS
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2026
·
IF 3.6
Zhitao Shan,Hong Wang,Shujiang Liu,Yanfei Zhang,Cheng Zuo,Qiuju Zheng,Haizheng Tao,Yuanzheng Yue
In this work, we investigated the structural and physical property evolutions induced by the substitution of Al 2 O 3 by Ga 2 O 3 in two series of CaO-Al 2 O 3 -Ga 2 O 3 (CAG) glasses. To suppress crystallization, glasses with compositions of (I) 50CaO• (50- x )Al 2 O 3 • x Ga 2 O 3 ( x = 0–50 mol%) and (II) 63CaO• (37- x )Al 2 O 3 • x Ga 2 O 3 ( x = 0–37 mol%) were prepared via containerless aerodynamic levitation technique. It was found that with increasing substitution of Al 2 O 3 by Ga 2 O 3 (i.e., increasing x ), both glass series exhibited monotonic decreases in hardness, glass transition temperature and thermal expansion coefficient. High-resolution XPS analyses revealed that the two glass series exhibited distinct compositional dependences in their local structural evolution. Specifically, in series I ([CaO]:[Al 2 O 3 +Ga 2 O 3 ] = 1:1), the coordination environments of O, Ga, and Al remained largely unchanged upon substitution. In contrast, Series II ([CaO]:[Al 2 O 3 +Ga 2 O 3 ] = 12:7) exhibited significant shifts in O and Al coordination, while the Ga environment was only minimally affected. Furthermore, XPS indicated that trace OH - species preferentially interact with Al/Ga-O bonds by non-bridging oxygens within [AlO 4 ] or [GaO 4 ] tetrahedra. These findings elucidate the critical roles of both [CaO]/[Al 2 O 3 +Ga 2 O 3 ] and [Al 2 O 3 ]/[Al 2 O 3 +Ga 2 O 3 ] ratios in tailoring the structure - property relationships of CAG glasses.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Jiankun Li,Shang Wu,Quanlu Yang,Huize Zhang,Chenxu Zhu,Xiaoyi Meng,Xiaojun Yang,Qiong Su,Shuhe Kang,Juzhen Kang,Wei Lan
HS-FeNi-BNC is synthesized via B-bridging, with hollow porous carbon and Fe-B-Ni diatomic sites. • Fe-B-Ni bridge enables p-d hybridization to tune metal sites' electronic structures. • HS-FeNi-BNC delivers exceptional ORR/OER/HER electrocatalysis in alkaline media. • HS-FeNi-BNC-based ZABs operate from −10 to 60 °C with 92.9% Zn utilization efficiency. Rechargeable zinc-air batteries (ZABs) require efficient electrocatalysts to boost the sluggish oxygen reduction reaction (ORR)/ oxygen evolution reaction (OER) kinetics at the air cathode. However, designing high-activity catalysts faces considerable challenges due to spatial and electronic constraints. Herein, a boron-doped hollow spherical porous carbon (HS-FeNi-BNC) anchored with Fe-B-Ni diatomic sites is prepared via a facile B-bridging strategy, realizing the regulated construction of heteroatom doping and diatomic active sites. HS-FeNi-BNC possesses abundant micropores/mesopores, uniformly dispersed Fe Ni diatomic centers (0.27 nm spacing) with a Fe-B-Ni bridge structure, and topological carbon defects induced by B/N co-doping. HS-FeNi-BNC exhibits exceptional trifunctional electrocatalytic performance in alkaline electrolytes, with an ORR E 1/2 of 0.864 V, an OER overpotential of 308 mV and a hydrogen evolution reaction (HER) overpotential of 301 mV at 10 mA cm −2 . HS-FeNi-BNC-based ZABs achieve an outstanding wide-temperature operating range of −10 °C to 60 °C, a specific capacity of 761.51 mAh g −1 and a Zn utilization efficiency of 92.9%, outperforming Pt/C + RuO 2 -based ZABs. Density functional theory (DFT) calculations reveal that the Fe-B-Ni bridge structure triggers p-d orbital hybridization, regulating metal site electronic structures, optimizing reaction intermediate adsorption and accelerating interfacial electron transfer. This work advances the development of high-efficiency heteroatom-modified non-noble metal multifunctional catalysts. Download: Download high-res image (207KB) Download: Download full-size image
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ACS Applied Bio Materials
·
2026
·Vol. 9
·期 15
·7094-7101
·
IF 5.6
Xing Ziyang,Hua Kailiang,Li Rui,Rong Xixi,Mi Li
Whole-cell biocatalysis of hydrophobic substrates is fundamentally constrained by low solubility and mass transfer limitations, which hinder effective coupling between substrate transport and intracellular metabolism. Herein, we report an interface-regulated nano–bio hybrid system that overcomes these limitations by enhancing substrate accessibility at the microorganism interface. By immobilizing Pseudomonas aeruginosa ( Pas ) onto a coordination-engineered dicopper material (DTD-Cu), a confined nano–bio interface ( Pas @DTD-Cu) is constructed, enabling localized enrichment of hydrophobic substrates and shortening diffusion distances. As a result, the catalysis efficiency of Pas @DTD-Cu is increased to over 200% of that of free bacteria, while maintaining stable activity across a broad pH range (1–11). The increments in ATP, total protein, NADH, and the NAD + /NADH ratio illustrate that the metabolic flux in Pas increases without altering the degradation pathways, suggesting that the performance improvement originates from interfacial regulation rather than pathway modification. This work establishes an interface-controlled strategy for efficient biocatalysis of hydrophobic substrates.
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ELECTROCHIMICA ACTA
·
2026
·
IF 5.8
Yingyuan Zhao,Anpeng Su,Panpan Li,Mengbing Liu,Hubing Yin,Lu Wang,Jingjing Zheng,Yu Xiao,Wei Du
A facile one-pot strategy synthesizes porous B-NiCo-LDH/Ti 3 C 2 2D/2D heterostructures. • B doping tunes electronic structure and strengthens NiCo-LDH/Ti 3 C 2 interfacial bond. • Composite shows enlarged surface area and optimal porous structure for ion transport. • This work offers a universal strategy for designing doped 2D heterostructures. MXenes and layered double hydroxides (LDHs) emerge as advanced electrode candidates for high-performance supercapacitors. Nevertheless, pure Ti 3 C 2 or LDH suffers from either self-stacking or low electronic conductivity and instability. In this work, porous B-doped NiCo-LDH (B-NiCo-LDH) anchored on Ti 3 C 2 nanosheets has been designed and fabricated via a one-pot co-precipitation reaction. Element doping, composite fabrication and structural regulation are realized simultaneously via a simple one-step synthetic strategy. The obtained 2D/2D B-NiCo-LDH/Ti 3 C 2 heterostructures combine the advantages of LDH, Ti 3 C 2 , element doping and porous structure. Boron incorporation diminishes interfacial binding energy in the B-NiCo-LDH/Ti 3 C 2 system, expedites electron movement across interfaces, and ameliorates the composite’s electrical conductivity. The optimal B-NiCo-LDH/Ti 3 C 2 -20 delivers a specific capacitance of 1581.66 F g −1 at 1.0 A g −1 , a rate capability with 82.73% capacitance retention at 20 A g −1 , and a cycling stability of 77.55% after 5000 cycles. An aqueous battery-type hybrid asymmetric supercapacitor (HASC, B-NiCo-LDH/Ti 3 C 2 -20//Bi 2 O 3 /Ti 3 C 2 ) exhibits an energy density of 87.28 Wh kg −1 at a power density of 753.86 W kg −1 . This work provides a feasible strategy for improving energy storage performance via the design of element-doped 2D heterostructures. Download: Download high-res image (379KB) Download: Download full-size image
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2026
·Vol. 46
·期 16
·118705
·
IF 6.3
Xingjie Su,Zepeng Cao,Qianbiao Du,Linzhao Ma,Hao Li
In this research, we successfully synthesized a novel Li 5 Mg 21 TiAl 3 O 30 ceramic via the traditional solid-state reaction. This ceramic, when sintered at 1360 °C, demonstrated favorable microwave dielectric properties (MDPs), characterized by an εᵣ of 10.73, a Q×f of 81,598 GHz (at 12.61 GHz), and a τ f of −27.65 ppm/°C. In addition, the Deep Deterministic Policy Gradient (DDPG) algorithm was employed to optimize a ceramic-based dielectric resonator antenna (DRA) intelligently. Through this approach, the antenna parameters were effectively optimized, achieving a design with a center frequency of 7.90 GHz, a low return loss (S 11 ) of –53.6 dB, and a wide bandwidth of 1050 MHz, and a radiation efficiency of 92.55%, aligning the requirements of the 6 G band. The innovative application of deep learning technology improved the DRA design optimization process, offering a new paradigm for the intelligent design of ceramic-based microwave communication devices.
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Food Bioscience
·
2026
·
IF 6.2
Hong Lu,Xuyang Ning,Qingwei He,Qianyun Lei,Ping Hu,Yingzhen Liang
To overcome the poor bioaccessibility of Coenzyme Q10 (CoQ10), we developed a polyethylene glycol-based dripping pill (DP) solid dispersion system. The optimized formulation achieved an amorphous state, resulting in uniform morphology, significantly accelerated dissolution, and enhanced oral bioavailability compared to crystalline CoQ10. In an isoproterenol-induced oxidative cardiac stress model, CoQ10 DPs showed demonstrated cardioprotective bioactivity by alleviating cardiac remodeling and oxidative injury. These protective effects were associated with reduced reactive oxygen species (ROS) accumulation, restored superoxide dismutase (SOD) activity, and decreased inflammatory marker levels. This study presents a robust formulation strategy to maximize the bioactivity of lipophilic nutrients for functional food applications.
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Small Methods
·
2026
·
IF 8.7
Mingyang Han,Xiao Yang,Rui Guo,Ya Gao,Hao Chen,Zhaoxu Li,Lishi Jiao,Shi Bai
Biomarkers for acute myocarditis (AM) are commonly used in clinical diagnosis, but their ultralow concentrations in blood are challenging to be detected in the early stage. This study presents a novel bowl-shaped surface-enhanced Raman scattering (SERS) substrate with high-performance, prepared via one-step hydrofluoric acid etching of SiO 2 microspheres, 515 nm femtosecond-laser reduction of gold ions, and nanosecond-laser reshaping of gold nanoparticles (AuNPs). In particular, 500 nm SiO 2 microspheres were etched with a hydrofluoric acid solution to form a uniform microbowl array, and AuNPs were synthesized in situ on the SiO 2 microbowls via irradiation with a femtosecond laser. Subsequently, the AuNPs were reshaped into nanorods using a nanosecond laser. The resulting bowl-shaped AuNP@SiO 2 substrate showed a SERS enhancement factor of 10 6 and a limit of detection of 3.84 × 10 −8 M, as evaluated on Rhodamine 6G. Notably, the limits of detection of the AM biomarkers were lower than 6 pg/mL, enabling the accurate detection of their trace quantities. For AM prediction, a fuzzy logic model was trained, enabling the accurate and quantitative analysis of biomarkers, with a mean relative error of less than 25.7%. Thus, the proposed SERS platform is a reliable tool for the early noninvasive diagnosis of AM.
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Polymers
·
2026
·Vol. 18
·期 15
·1798
·
IF 5.8
Wei Zhang,Haifeng Gao,Xuran Zhu,Yanzong Meng,Leyu Shen,Zhongyao Jiang,Hongjian Gao
To address the persistent challenge of membrane wetting during oil-gas separation in transformer condition monitoring, an omniphobic composite membrane was developed to facilitate the reliable online detection of dissolved gases. An F-CNTs/Teflon AF/PVDF composite membrane, featuring a loofah-like hierarchical structure and omniphobic properties, was fabricated via spraying-deposition strategy on the polyvinylidene fluoride (PVDF) substrate. The morphology, surface chemical composition, wettability and stability of the F-CNTs/Teflon AF/PVDF composite membrane were systematically characterized. Subsequently, the oil-gas separation performance of the composite membrane was evaluated using standard transformer oil containing dissolved gases as the feed solution. The results indicated that fluorinated carbon nanotubes (F-CNTs) were successfully modified onto the membrane surface, creating a re-entrant morphology composed of an intersecting nanotube network that mimics the hierarchical architecture of a loofah. The F-CNTs/Teflon AF/PVDF composite membrane exhibited exceptional omniphobicity, achieving contact angles of 168.2 ± 1.5° and 127.5 ± 1.0° towards DI water and mineral insulating oil, respectively. Additionally, the loofah-inspired composite membrane demonstrated robust thermal and ultrasonic stability. In oil-gas separation tests, the omniphobic membrane displayed a rapid response and high efficiency for dissolved gas extraction, achieving dynamic equilibrium within 64 min. Furthermore, the modification improved permeation efficiency by 25.6%. These results suggest that the developed omniphobic membrane is a promising alternative for oil-gas separation in the condition monitoring of oil-filled electrical equipment.
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Small
·
2026
·
IF 11.8
Lixun Zhang,Xuewu Shen,Han Hu,Shengyin Tang,Sunny Jiang,Yuntao Guan
Microcystin contamination caused by harmful cyanobacterial blooms is a growing global challenge for water safety. Here we reported a self-assembled living microreactor that encapsulated microcystin-degrading bacteria within a biochar-reinforced double-network hydrogel, enabling integrated molecular sieving, adsorption, and enzymatic degradation. The system exhibited size- and charge-selective removal of microcystin over coexisting organic matters, while maintaining high degradation efficiency under harsh stress conditions, including pH (5−9), inorganic ions (10−200 mg/L), and natural organic matters (5−20 mg/L). The microreactor demonstrated excellent mechanical stability, negligible cell leakage, and high bioactivity, and achieved nearly complete removal of microcystin-LR during five repeated operation cycles and continuous biofiltration in environmental water, confirming its scalable application potential. Mechanistic investigations revealed a cascade process involving shell-confined molecular sieving, adsorption-mediated toxin enrichment on biochar, and localized biodegradation within the living core. This work establishes a generalizable design paradigm for programmable living materials, offering new opportunities for selective biodegradation and remediation in complex aqueous systems.
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Small
·
2026
·
IF 11.8
Jiadong Wu,Linyu Yang,Kunjie Zhu,Ablat Abliz,Shuying Wang,Hongmei Zhang,Haibing Li,Hongyu Mi,Anqiang Pan
Hydrogen evolution reaction (HER) and uncontrolled dendrite growth remain persistent challenges for aqueous Zn-ion batteries (AZIBs). In this study, the Y element is utilized to adjust the bandgap width of the anode coating, thereby serving as electron transfer gating and consequently suppressing HER from a dynamic perspective. The Gibbs free energy ( ΔG H* ) data for H * adsorption reveal that the presence of the Y can hinder the desorption of H 2 from the surface of the semiconductor coating. It effectively restrains HER from a thermodynamic viewpoint. Furthermore, the improved zincophilicity of the amorphous wide-bandgap semiconductor coating offers a multitude of uniform nucleation sites for Zn 2+ deposition. A balance between H * adsorption and Zn 2+ affinity is achieved by this wide bandgap semiconductor, enabling strong HER inhibition and highly efficient Zn-induced deposition. The symmetric cell achieves stable cycling for over 6700 h at 2 mA cm −2 and 1 mAh cm −2 . Even under a high current density of 10 mA cm −2 and 5 mAh cm −2 , a cycle life of 1200 h is maintained. The Zn–V full cell exhibits a cycling lifespan of 3800 cycles at 5 A g −1 .
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高影响因子
Coatings
·
2026
·Vol. 16
·期 7
·853
·
IF 3.4
Lianmeng Wang,Jianke Luo,Jiang Wang,Ying Xu,Hui Dong,Yongsheng Zhu
Steel components in thermal power plants are vulnerable to severe wear and wall thinning induced by the high-velocity impact of pulverized coal, which significantly compromises their service life and structural integrity. To address this issue, a TiC-reinforced AlCoCrFeNi high-entropy alloy (HEA) composite coating was fabricated via laser cladding, aiming to substantially enhance the wear resistance of these critical components. The phase composition, microstructure, microhardness and tribological behaviors of the coatings were systematically investigated by XRD, SEM, EDS and dry sliding wear tests. Results show that both coatings possess dense microstructures and reliable metallurgical bonding with the substrate. The AlCoCrFeNi coating consists of a single BCC solid solution phase, while the TiC/AlCoCrFeNi composite coating contains a BCC phase and a TiC ceramic phase without brittle intermetallic compounds. The average microhardness of the TiC/AlCoCrFeNi composite coating was measured to be 823 HV0.3, which is 85.66% greater than that of the AlCoCrFeNi coating (443 HV0.3). Under identical wear test conditions, the AlCoCrFeNi coating exhibits a mass loss of 31.4 mg and a volumetric wear rate of 24 × 10−3mm3/min, whereas the TiC/AlCoCrFeNi composite coating exhibits a mass loss of 15.6 mg and a wear rate of 13 × 10−3mm3/min, corresponding to reductions of approximately 50.32% and 45.83%, respectively. The wear mechanism of the AlCoCrFeNi coating is dominated by severe abrasive wear coupled with adhesive wear, while the addition of TiC converts the wear mechanism into mild abrasive wear and oxidative wear. The incorporation of TiC particles effectively enhances the microhardness and reduces the mass loss, thereby contributing to a marked improvement in the wear properties of the laser-clad AlCoCrFeNi coating. This research provides experimental data and theoretical support for the engineering application of TiC/AlCoCrFeNi composite coatings on wear-resistant components in thermal power units.
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危险品化学品经营许可证（带存储）