Nature Communications
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2026
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IF 18.1
Liu Minmin,Yang Liting,Chen Guanyu,Wu Zhengchen,Yang Xiaofen,Liang Guisheng,Che Renchao
Terminational chemistry traditionally influences MXenes’ carrier concentration and inter-flake spacing, and thereby electronic properties. Herein, the unusual terminational effect on the periodic atomic displacement, namely ripple, has been demonstrated. The rippling structure strongly depends on the atomic radii of halogen terminations, including -Cl, -Br, and -I. This originates from the atomic response to local strain fluctuation induced by terminations. The atomic ripple in Ti 3 C 2 Br x enhances electric coupling among adjacent atoms and promotes their charge transfer, thereby improving the electrical conductivity. Meanwhile, it significantly strengthens dielectric properties and markedly boosts the electromagnetic wave absorption capability. The maximum reflection loss value reaches −44.33 dB, and the effective absorption bandwidth is up to 3.94 GHz with a matching thickness of 1.40 mm. This work elucidated the effect of MXenes’ microstructure on their dielectric properties on the atomic scale and paved an avenue for the development of MXenes-based devices.
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Food Analytical Methods
·
2026
·Vol. 19
·期 6
·196
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IF 3
Liu Tao,Shu Jiaqi,Xiao Jiajun,Zhou Jing,Chen Zhenhua,Yu Qi,Lu Limin,Chen Hui
Aflatoxin B 1 (AFB 1 ), a potent hepatocarcinogen, continually poses a serious threat to food safety and public health owing to its stability and propensity for bioaccumulation within the food chain. Monitoring its trace levels across various food matrices remains challenging, necessitating highly efficient and selective sample pretreatment materials. In this study, a novel covalent organic framework-based magnetic composite (3D-N/OCNS@TpPa-1) was rapidly synthesized via a solvent-free mechanochemical method within 30 min. The mechanochemical grinding method enabled not only the rapid and green synthesis of the COF but also its immediate integration with a carbon matrix. This composite strategy was specifically designed to mitigate the common challenges of COF aggregation and poor dispersibility. When employed as a solid-phase extraction sorbent, it demonstrated rapid adsorption/desorption kinetics (10 min and 8 min, respectively) and high affinity for AFB 1 . Coupled with HPLC-FLD, the method enabled the sensitive detection of AFB 1 across a complete food chain transmission pathway—corn, corn oil, chicken, and human plasma—with a wide linear range (0.25–250 μg·kg⁻ 1 ), a low detection limit (10 ng·kg⁻ 1 ), and high precision. The study not only provides a robust and green analytical approach for tracing AFB 1 propagation in agri-food systems but also highlights critical control points for intervention in food safety management.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 3
·204
·
IF 5.4
Feng Yueyue,Xu Shiwei,Wang Guofeng,Huang Liying,Yang Zhongyu,Dong Jiacheng,Zhang Yu,Liu Nannan,Deng Chao,Wang Yajun
A novel microchannel-based chiral sensor leveraging silica nanowires self-assembled with maltosyl-cyclodextrin (SiNWs/G2-β-CD) on glass microchannel (GMC) is reported. This innovative SiNWs/G2-β-CD/GMC sensor achieves ultrasensitive detection of L-tryptophan over a wide linear range (1-10 5 aM) with exceptional selectivity, enabling accurate discrimination in mixtures of tryptophan enantiomers. Its application to milk sample analysis demonstrates high recognition performance and practical reliability. The SiNWs/G2-β-CD/GMC sensor offers a rapid, cost-effective, and highly sensitive platform, holding great promise for dietary monitoring and enantiomeric analyses in complex matrices.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Tu Maopu,Deng Xiaoyu,Zhou Zhiyong,Li Xiaodong,Mao Shengxun,Lai Bin,Pang Lisong,Zhong Qilin,Cao Jiaqing,Liu Haipeng,Ouyang Xi
Microsatellite-stable (MSS) colorectal cancer (CRC) resists immunotherapy due to its immunosuppressive tumor microenvironment (TME). The cGAS-STING pathway, a key regulator of innate immunity, offers a promising strategy to overcome the immunotherapy resistance in CRC. However, its limited endogenous activation, coupled with the immunosuppression driven by lactate accumulation, significantly compromises the efficacy of standalone STING activation. In response, we developed a multifunctional copper-based metal-organic framework (Cu-MOF) nanoparticle co-loaded with the STING agonist SR-717 and the glycolysis inhibitor 3-bromopyruvate (3-BP), coated with tumor cell membranes (termed BR@CuM@CM), to achieve integrated metabolic modulation and immune activation. BR@CuM@CM nanoparticle achieves tumor-specific accumulation via homotypic targeting and undergo glutathione-responsive degradation to trigger drug release. The released SR-717 activates the STING pathway, promoting dendritic cell (DC) maturation and thereby enhancing cytotoxic T-cell recruitment. Concurrently, Cu²⁺ triggers Fenton-like reactions to generate reactive oxygen species (ROS), inducing mitochondrial DNA release and further amplifying STING signaling. Meanwhile, 3-BP suppresses lactate production by inhibiting glycolysis, which not only repolarizes M2-type tumor-associated macrophages toward the M1 phenotypes and suppresses regulatory T cell (Treg) infiltration, but also alleviates cGAS lactylation to enhance cGAS activity and amplifying STING-mediated immune responses. When combined with anti-PD-1, the nanoparticle significantly inhibits tumor growth and liver metastasis. Collectively, BR@CuM@CM synergistically modulates metabolism and immune signaling to convert immunologically “cold” tumors into “hot” tumors, demonstrating translational potential to overcome immunotherapy resistance in CRC. Graphical
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NEUROCHEMICAL RESEARCH
·
2026
·Vol. 51
·期 2
·94
·
IF 4.5
Lin Yang,Zhang Kun,Zhang Meijie,Yin Lida,Liu Zhixin,Meng Yanru,Li Yue,Meng Jinhui,Yin Xueyong,Wang Liping
VCAN-AS1 is a novel long non-coding RNA that participates in diverse disease processes, but the mechanism of its action in cerebral infarction secondary epilepsy (CISE) is unclear. The potential action mechanism of VCAN-AS1 in CISE was explored by this study. VCAN-AS1 and its downstream targets, namely miR-885-3p and Netrin G1 (NTNG1), were screened by the GEO, LncRNASNP2, and miRDB databases. The epileptic mouse and cell models were constructed using pilocarpine and the Mg 2+ -free medium, respectively. ELISA kits or RT-qPCR was used for the measurement of TNF-α/IL-1/IL-6 levels. The levels of Fe 2+ , GSH, and ROS were detected by the specific biochemical kits. GPX4 expression was analyzed by RT-qPCR. Dual-luciferase reporter assay was used to detect the interactions between miR-885-3p and VCAN-AS1 or NTNG1. Meanwhile, the expression levels of VCAN-AS1, miR-885-3p, and NTNG1 were detected by RT-qPCR. Elevated serum levels of VCAN-AS1 were observed in patients with CISE, and silencing of VCAN-AS1 attenuated inflammation and ferroptosis in epilepsy-associated neurons and the hippocampus of epileptic mice. VCAN-AS1 negatively regulated miR-885-3p which subsequently repressed NTNG1 expression. Up-regulation of miR-885-3p inhibited inflammation and ferroptosis in epileptic mouse and cell models, and overexpression of NTNG1 reversed these effects of miR-885-3p. The suppression of VCAN-AS1 expression mitigated neuronal inflammation and ferroptosis in epileptic conditions by targeting the miR-885-3p/NTNG1 regulatory axis, which may be an important molecular mechanism of CISE.
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MOLECULAR NEUROBIOLOGY
·
2026
·Vol. 63
·期 1
·467
·
IF 5.5
Zhang Bin,Bian Weiming,Zhu Kaiyuan,Dai Yuzhen,Cai Miao,Cheng Jiaqi,Chen Xinyan,Xiang Zheng,Liu Yixiu,Lu Wen
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by cognitive decline and neuropsychiatric symptoms, among which impaired fear responses are particularly notable. While studies have established that learned fear is compromised in AD, the status of innate fear in this context remains unclear. We found that young adult female APP/PS1 mice exhibited reduced freezing and avoidance responses to 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) compared to their wild-type littermates, indicating an impaired innate fear response. Additionally, c-Fos-positive cells in the basolateral amygdala (BLA), a key region for fear processing, were significantly lower in the APP/PS1 mice. Notably, metformin treatment significantly restored TMT-induced freezing behavior and increased c-Fos-positive cells in the BLA, suggesting that it can reverse the innate fear deficit in this AD model. Mechanistically, chemogenetic inactivation of the BLA abolished the therapeutic effects of metformin on the innate fear deficit. Our study suggests metformin as a promising candidate for therapeutic intervention aimed at improving innate fear-related behavioral deficits in AD.
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WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 11
·638
·
IF 3.5
Peng Xue,Zhang Xinyi,Zhang Shuxian,Lin Qingwei,Zhang Haokun,Zhang Xiaowen,Zhang Yi,Xu Steven Jing-Liang,Lee Fred Wang-Fat,Tam Nora Fung-yee,Wu Zhenbin,Liu Biyun
The widespread use of aluminum-based coagulants in ecological restoration projects has raised increasing concerns regarding the potential ecological impacts of residual aluminum (Al) in aquatic ecosystems. Epiphytic biofilms on submerged plants play a vital role in regulating nutrient cycling and energy flow in aquatic environments. However, the effects of Al on the biological and abiotic components of epiphytic biofilms on submerged macrophyte leaves remain poorly understood. In this study, we investigated the Al content in epiphytic biofilms on Vallisneria natans and its relationships with nitrogen, phosphorus and bacterial composition in Hangzhou West Lake, China. This location was selected due to the potential for residual Al into the lake from the daily pretreatment of the Qiantang River water diversion project—a water quality improvement project. Our results showed that Al contents in epiphytic biofilms decreased with increasing distance from the inlet and were positively correlated with total phosphorus, Chlorophyll-a and ash-free dry mass ( P < 0.05), but showed no significant correlation with total nitrogen. Al accumulation enhanced Chl-a levels in biofilms by increasing the inorganic phosphorus content. Furthermore, Al content was positively correlated with the abundance of Cyanobacteria and negatively correlated with the abundance of Proteobacteria. Al also showed a significant negative correlation with key denitrifying bacteria, such as Vogesella and Phreatobact er, suggesting that elevated Al levels might affect the nitrogen cycling function in epiphytic biofilms. These findings provide important reference data for for ecological risk assessment and inform management strategies for aquatic systems undergoing restoration or exposed to aluminum-based treatments. Graphical
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BIOLOGICAL TRACE ELEMENT RESEARCH
·
2026
·
IF 4.3
Abbas Mubbashar,Suliman Khan,Chen Min,Ying Zhao,Ashaq Muhammad Sameer,Asif Ali,Khan Muhammad Ali,Chen Dongmei,Xie Shuyu
Ulcerative colitis (UC) is characterized by excessive cytokine production, epithelial barrier disruption, and oxidative stress. It necessitates therapeutics with immunomodulation and mucosal integrity restoration. This study aimed to evaluate in-vivo and in-vitro therapeutic potential of Fe-MOF, Cr-MOF, and Co-MOF. RAW264.7 macrophages and DSS-induced murine colitis model were used. SEM, FTIR, XRD, and ICP-MS were used for characterization of MOFs. Cytotoxicity, immunofluorescence, ELISA, histopathology, immunoblotting, and qPCR analyses were used to evaluate effects of MOFs. Co-MOF showed a significant immunomodulatory effect by reducing LPS-induced TNF-α, IL-6, and IL-1β expression at both mRNA and protein levels in RAW264.7 macrophages. It also alleviated DSS-induced TNF-α, IL-6, and IL-1β levels in mouse colon, as indicated by ELISA and immunofluorescence. Co-MOF also reduced DAI score, improved body weight loss, and preserved colon length in the DSS-induced colitis model. Co-MOF also restored tight-junction proteins such as Occludin and ZO-1, significantly reduced by DSS in colon. Histopathological examination validated substantial protection of mucosal architecture, including intact crypts, restored goblet cell populations, and attenuated immune-cell infiltration. A notable antioxidant effect of Co-MOF was also observed, as it increases SOD and CAT activities while reducing MDA. Co-MOF significantly normalized platelets, lymphocytes, and neutrophils, elevated by DSS. Co-MOFs did not induce systemic toxicity and vital organ injury, predicting their biosafety. Conclusively, Co-MOF showed better immunomodulatory effects and barrier protection compared to Fe-MOF and Cr-MOF in UC, which further requires mechanistic validation.
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Nature Communications
·
2026
·
IF 18.1
Shaojie Chen,Hao Tang,Xiaoliang Fan,Bohan Li,Yaomin Wang,Wei Zhou,Xiaoyu Jiang,Xiaomin Dong,Yanyi Wang,Peng Zhao,Tianwen Ye,Bolin An,Yijun Zheng,Chao Zhong
Bacterial cellulose possesses excellent biocompatibility and mechanical strength but lacks the bioactivity needed for many biomedical and healthcare applications. To address this limitation, we develop a metabolic glycoengineering–click chemistry strategy that enables in situ incorporation of azide groups into bacterial cellulose, followed by mild and selective conjugation of alkyne-bearing functional molecules. This approach avoids harsh chemical treatments, preserves the native properties of bacterial cellulose, and supports stable attachment of diverse bioactive agents, including antibacterial porphyrins, arginine-glycine-aspartic acid peptides, and recombinant proteins with fluorescent or enzymatic functions. As a proof-of-concept, a cascade catalytic system comprising glucose oxidase and superoxide dismutase is immobilized onto azide-modified bacterial cellulose, yielding a multifunctional wound dressing designed to address hyperglycemia and oxidative stress—key barriers to chronic wound healing. In male diabetic mice, this glucose oxidase/superoxide dismutase-integrated bacterial cellulose dressing (low endotoxin <0.1 EU/mL) accelerates wound closure to 92.1% by day 14, significantly outperforming the controls. Our strategy highlights a scalable and bio-orthogonal route for enhancing bacterial cellulose with user-defined bioactivities, thereby expanding its utility in advanced biomaterials development. Bacterial cellulose (BC) possesses excellent biocompatibility and mechanical strength but lacks the bioactivity needed for many biomedical applications. Here the authors use glycoengineering–click chemistry to incorporate azide groups into BC in situ, and show enhanced BC-mediated wound healing.
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CELL DEATH AND DIFFERENTIATION
·
2026
·
IF 13.6
Li Yitao,Zheng Weijia,Ma Jiao,Liu Lu,Yang Xintong,Kuang Junliang,Chan Nickie,Wang Chengqiang,Li Yang,Zhao Aihua,Wang Ruonan,Zheng Xiaojiao,Melino Gerry,Lu Aiping,Yang Xiaolu,Jia Wei
Autoimmune uveitis (AU) lacks targeted therapies beyond immunosuppression. We identified hyodeoxycholate (HDCA), a gut-derived secondary bile acid, as a key immunometabolic regulator in AU. Metabolomics revealed systemic depletion of HDCA and oleic acid (C18:1n9) in AU patients and experimental AU (EAU) mice, correlating with disease severity. HDCA administration effectively attenuated EAU by reducing pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) and elevating IL-10. Mechanistically, HDCA inhibits Farnesoid X Receptor in splenic red pulp macrophages, activating SREBP1c-dependent fatty acid synthase, which enhances oleic acid production. Systemic oleic acid suppresses ocular Th17 responses and promotes M2 macrophage polarization, enhancing anti-inflammatory immunity. These findings define a spleen-to-eye immunometabolic axis driven by HDCA-mediated macrophage reprogramming, positioning HDCA as a promising therapeutic for AU.
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Communications Materials
·
2026
·
IF 9.1
Li Chao,Meng Qichao,Bai Yunfei,Zhao Hongyuan,Wen Ziying,Huang Li,Huang Dan,Wang Liang,Yu William W.,Chen Haibin,Liu Feng
Rare earth-doped luminescent materials typically produce characteristic fluorescence emissions associated with the rare earth elements. Here, we report remarkable non-characteristic blue emissions from ytterbium (Yb 3+ )- and erbium (Er 3+ )-doped organic-inorganic metal halides, (BDPA) 2 MCl 4 (BDPA + = benzyldimethylphenylammonium; M 2+ = Cd 2+ , Zn 2+ ). Both Yb 3+ and Er 3+ ions are commonly used as dopants in phosphors, which generally lead to near-infrared emissions. Theoretical calculations suggest the unique blue emission arises from Yb 3+ /Er 3+ -induced exciton radiative recombination from BDPA + to Cl − , which suppresses the characteristic emissions of these rare earth ions. More notably, owing to structural stability of (BDPA) 2 MCl 4 , the Yb 3+ /Er 3+ -activated phosphors demonstrate high water resistance, maintaining both stability and photoluminescence (PL) in water for over two months. Further, when these crystals are dissolved in N,N-dimethylformamide or dimethyl sulfoxide, the resulting solution continues to exhibit PL with a high quantum yield of ~90%, making it suitable for use as liquid-phase X-ray scintillators.
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Nature Communications
·
2026
·
IF 18.1
Lu Zhe,Liu Wenxuan,Zhang Zeshu,Chen Zhongyi,Sun Junchuan,Gao Wanguo,Zhuo Xiaolu,Tu Wenguang,Hu Guoping,Yao Yingfang,Ji Dongxu,Zhao Junhua,Zou Zhigang,Wang Lu
Hydrogen migration is a process of key importance in hydrogenation reactions. In past decades, surface oxygen has been considered the major pathway for hydrogen migration, whereas the reduction reaction may occur to yield water and inhibit the migration. Thus, extending hydrogen migration via precise surface decoration could potentially be beneficial to the activity of hydrogenation reactions, yet it remains challenging. Herein, the Sabatier reaction is chosen as the archetype reaction, in which the catalytic performance is highly dependent on the activity of hydrogen migration. By decorating a minor amount of non-reducible alkylsilane over the benchmark Ni/CeO 2 catalyst, the hydrogen activation, migration, and overall hydrogenation reaction have been enhanced significantly. As a result, with the help of the exothermic nature of the Sabatier reaction, the solely solar-driven reaction can be conducted with a CO 2 single pass conversion of 99.9%, a near-unity CH 4 selectivity, and an energy conversion efficiency of ~25.0% for outdoor practice.
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