INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
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IF 4.784
Jinyu Li,Hao Pan,Sen Qiao,Yunjian Li,Jie Wang,Wei Liu,Weisan Pan
In the present investigation, we have synthesized the dalteparin which is a kind of low molecular weight heparin (LMWH) and possess the antitumor and antiangiogenic efficacy with carboxylates poloxamer 407 to form a heparin-poloxamer nanogel (HP copolymer). The complex HP is capable of enhancing the efficacies, minimizing the side effects of dalteparin and exhibiting a good thermosensitivity. Therewith, the synthetic Laponite RDS (LR) nanosilicate embarked with doxorubicin (DOX) at a satisfactory high drug entrapment efficiency was integrated with the complex HP and thus constituted a newfangled biocompatible injectable temperature-sensitive hydrogel. To our delight, consociation with 2.5 w/v % of LR nanodisks, HP at the concentration of 5 w/v % was sufficient to execute the solution-gel transition at animal heat, while 17.5 w/v % of P-407 was needed for fabricating the LR-P hydrogel. Simultaneously, LR-HP possesses a more preferable syringeability. Furthermore, the release behavior in vitro for the DOX@LR-HP demonstrated as extended and controlled manner, wherein, the drug-eluting profile was regulated by the LR nanocomposites. Moreover, based on synergic action of heparin and drug, DOX@LR-HP hydrogels demonstrated the best antitumor efficacy in vitro and in vivo. What is noteworthy is that through the course of treatment, the reflected anticancer efficacy direct at the established xenograft S180 sarcoma tumor was provided by the single administration of the DOX@LR-HP hybrid gel. This excellent long-term sustainable-anticancer function in vivo demonstrating the prospect of this nanohybrid-gel combination as an estimable focal drug delivery vehicle for treatment of cancer.
研究领域:
药学
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生物材料
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肿瘤学
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DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2014
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IF 4.908
Chuanxiong Nie,Lang Ma,Yi Xia,Chao He,Jie Deng,Lingren Wang,Chong Cheng,Shudong Sun,Changsheng Zhao
Nowadays, polymeric membrane based hemodialysis is considered to be the most practical approach for the treatment of kidney failure. To develop advanced hemodialysis membrane integrated with favorable blood and cell compatibilities and efficient blood purification ability, novel biocompatible composite membranes consisting of heparin-mimicking polymer brush functionalized carbon nanotubes (f-CNTs) and polyethersulfone (PES) are designed. Firstly, surface initiated atom transfer polymerization (SI-ATRP) is applied to synthesize heparin-mimicking polymer brush (contained the sodium styrene sulfonate (SS) and methyl ether methacrylate (EGMA) units) grafted CNT. Then, the f-CNT/PES composite membranes are prepared by a liquid–liquid phase separation technique. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) results indicated that the f-CNT would not cause severe damage on the membrane morphologies. Systemic protein ultrafiltration experiment indicated that the heparin-mimicking composite membranes owned satisfied antifouling property and protein rejection ratio. Further blood compatibility evaluation revealed that the composite membranes had decreased protein adsorption, prolonged clotting time, and suppressed platelet adhesion compared to pristine PES membrane. The results of human embryonic hepatocytes (LO-2) culture revealed that the cyto-compatibility of the modified membrane was enhanced by the blending of heparin mimicking polymer functionalized CNT. Furthermore, with the addition of f-CNT, the composite membranes showed remarkably increased removal efficiency of uremic toxin. In general, the fabricated heparin-mimicking f-CNT/PES composite membranes exhibited anti-fouling ability in ultrafiltration, excellent blood and cell compatibility and efficient toxic molecules removal ratio, thus present great potential for various applications, such as hemodialysis and bio-artificial liver support. Furthermore, the proposed method might forward the fabrication of advanced hemodialysis membrane by integrating functional nanomaterials and bioactive polymers.
研究领域:
生物医学工程
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材料科学
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医学
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高影响因子
Advanced Healthcare Materials
·
2018
·Vol. 7
·期 16
·1800380
·
IF 5.609
Hao-Ran Jia,Ya-Xuan Zhu,Ke-Fei Xu,Fu-Gen Wu
Melittin (MEL) is recognized as a highly potent therapeutic peptide for treating various human diseases including cancer. However, the clinical applications of MEL are largely restricted by its severe hemolytic activity and nonspecific cytotoxicity. Here, it is found that MEL can form a stable supramolecular nanocomplex of ≈60 nm with the photosensitizer chlorin e6 (Ce6), which after hyaluronic acid (HA) coating can achieve robust, safe, and imaging-guided tumor ablation. The as-designed nanocomplex (denoted as MEL/Ce6@HA) shows largely reduced hemolysis and selective cytolytic activity toward cancer cells. Upon laser irradiation, the loaded photosensitive Ce6 can synergistically facilitate the membrane-lytic efficiency of melittin and greatly increase the tumor penetration depth of the complexes in multicellular tumor spheroids. In vivo experiments reveal that MEL/Ce6@HA can realize enhanced tumor accumulation, reduced liver deposition, and rapid body clearance, which are beneficial for highly efficient and safe chemo-photodynamic dual therapy. This work develops a unique supramolecular strategy for optimized in vivo delivery of melittin and may have implications for the development of peptide-based theranostics.
研究领域:
药学
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纳米技术
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癌症研究
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治疗学
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DOI
PubMed
高影响因子
RSC Advances
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2018
·Vol. 8
·期 70
·39967-39975
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IF 2.936
Yazhou Chen,Guodong Xu,Xupo Liu,Qiyun Pan,Yunfeng Zhang,Danli Zeng,Yubao Sun,Hanzhong Ke,Hansong Cheng
Concentration polarization issues and lithium dendrite formation, which associate inherently with the commercial dual-ion electrolytes, restrict the performance of lithium ion batteries. Single ion conducting polymer electrolytes (SIPEs) with high lithium ion transference numbers (t+ ≈ 1) are being intensively studied to circumvent these issues. Herein, poly(ethylene-co-vinyl alcohol) (EVOH) is chosen as the backbone and then grafted with lithium 3-chloropropanesulfonyl(trifluoromethanesulfonyl)imide (LiCPSI) via Williamson's reaction, resulting in a side-chain-grafted single ion polymer conductor (EVOH-graft-LiCPSI). The ionomer is further blended with poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) by solution casting for practical use. The SIPE membrane with ethylene carbonate and dimethyl carbonate (EC/DMC = 1 : 1, v/v) as plasticizer (i.e., gel SIPE) exhibits an ionic conductivity of 5.7 × 10−5 S cm−1, a lithium ion transference number of 0.88, a wide electrochemical window of 4.8 V (vs. Li/Li+) and adequate mechanical strength. Finally, the gel SIPE is applied in a lithium ion battery as the electrolyte as well as the separator, delivering an initial discharge capacity of 100 mA h g−1 at 1C which remains at 95 mA h g−1 after 500 cycles.
研究领域:
材料科学
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能源技术
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Qiuyu Chen,Xiaoxi Zuo,Huiying Liang,Tianming Zhu,Yaotang Zhong,Jiansheng Liu,Junmin Nan
A blended membrane based on poly(oxyphenylene benzimidazole) (PBI) and ethyl cellulose (EC) exhibits heat resistance and good electrochemical performance. The prepared blended polymer gel membranes show no visible dimensional change after being held at 350 °C for 30 min, whereas the polyethylene (PE) separator almost completely melts. In addition to excellent thermal stability, the self-supporting blended membranes also exhibit a uniform thermal distribution during the heating process from 60 to 200 °C. Additionally, the ionic conductivities of the PBI/EC blended membranes with different ratios are 1.24 mS cm–1 (1:1), 2.58 mS cm–1 (1:2), and 1.68 mS cm–1 (1:3), which are much higher than those of the PE separator (0.39 mS cm–1). Compared to that of the PE separator (113 mAh g–1), the cell with a separator of PBI/EC = 1:2 retained a discharge capacity of 131 mAh g–1 after 150 cycles at 0.5C. Meanwhile, the rate performance of the cell was also better than that of the PE separator, especially at high currents (5C). All of the results indicate that this blended polymer gel membrane with good thermal stability is expected to be applied to high-performance lithium-ion batteries.
研究领域:
材料科学
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能源存储
·
高分子化学
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DOI
PubMed
高影响因子
CELLULOSE
·
2023
·Vol. 30
·期 4
·2441-2452
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IF 5.7
Yi Caifu,Yuan Tianzhong,Ren Hao,Xiao Huining,Zhai Huamin
With the popularity of air fryer, there is an increasing demand for air frying paper. Here, we successfully prepared an air frying paper with good barrier capacity, cytocompatibility and degradability by coating chitosan, zein and lignin containing cellulose nanofibers (LCNFs), in sequence. The obtained triple-coated paper has a high kit number of 12 and a low Cobb 60 value of 4.93 g/m 2 . Importantly, it had excellent hot oil resistance, which was no penetration even at oil temperature of 210 °C. The triple-coated paper also showed good resistance to ethanol, acid and alkali solutions. These excellent barrier capacities were due to the smooth and dense barrier layer formed by chitosan, zein and LCNFs. Thus, the triple-coated paper was successfully used in the air fryer to fry fries and chicken drumsticks. And the good cytocompatibility and degradability of the coated paper further promote its practical application.
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高影响因子
JOURNAL OF CONTROLLED RELEASE
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2016
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IF 7.441
Yuling Bao,Mingxing Yin,Xiaomeng Hu,Xiangting Zhuang,Yu Sun,Yuanyuan Guo,Songwei Tan,Zhiping Zhang
A pH-sensitive prodrug , TPGS-CH N -DOX, was introduced by conjugating anticancer drug , doxorubicin (DOX), onto d -α-tocopherol polyethylene glycol 1000 succinate (TPGS) via a cleavable Schiff base linkage. The prodrug was mixed with a PEGylated lipid to form a simple but multifunctional hybrid micelle system, which can realize high drug loading capability and biocompatibility , extended blood circulation time, inhibited drug resistance in cancer cells, improved therapeutic response, reduced side effects, and easy functionalities for targeting delivery. The hybrid micelles exhibited in vitro pH-sensitive drug release, enhanced cellular uptake and strengthened cytotoxicity on both drug-sensitive human breast cancer MCF-7 and resistant MCF-7/ADR cells. P-glycoprotein functional inhibition and mitochondria-associated cell apoptosis induced by TPGS were thought to play an important role in overcoming the multidrug resistance . As a result, the hybrid micelles demonstrated good anticancer efficacy in MCF-7/ADR xenograft model. Additionally, after modifying with a tumor-specific targeting peptic ligand, cRGD, the tumor growth/metastasis inhibition was further evidenced in integrin receptor overexpressed melanoma cancer B16F10 and even murine hepatocarcinoma H22 models. This TPGS-based pH-sensitive prodrug provides a safe and “Molecular economical” way in the rational design of prodrugs for overcoming multidrug resistance and targeting delivery, which can improve the potency for clinical use.
研究领域:
药学
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肿瘤学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2019
·
IF 8.456
Shaoshuai Ma,Yunhui Shi,Yan Zhang,Liting Zheng,Qian Zhang,Xinhua Xu
Thermal runaway has always been a significant safety issue that high-performance electronic devices urgently need to solve. These existing strategies are limited by the lack of reversibility and low conductivity. Here, we propose a novel thermoreversible self-protection microsupercapacitor (TS-MSC) based on a thermoresponsive polymer electrolyte to prevent thermal runaway. When heating above the low critical solution temperature (LCST), a gelation process occurs in the smart electrolyte and effectively inhibits the migration of ions, leading to a decreased specific capacitance and an increased internal resistance of the MSC. However, the electrolyte transforms to a solution state at room temperature in which ions can freely migrate. Benefiting by sol–gel transition of the smart electrolyte, the TS-MSCs can exhibit different electrochemical performances at elevated temperatures, demonstrating an active method of achieving thermoreversible and dynamic self-protection. In addition, 3D printing technology and substrate versatility provide an attractive method in the design of integrated micropower devices. Therefore, such functional TS-MSCs offer a promising strategy to solve the safety issues of the nowadays portable microelectronic devices.
研究领域:
材料科学
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电子工程
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能源存储
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产品关联
DOI
PubMed
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
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2024
·
IF 8.1
Quanqing Cui,Na Sun,Hongliang Ding,Xiaowei Mu,Wei Wang,Yan Zhang,Keqing Zhou,Liancong Wang,Bin Yu
The flammable nature of thermoplastic elastomer (TPE) leads to poor fire safety performance. It is difficult to be flame-retardant. A large amount of flame retardant (30–46 wt%) is usually added, weakening their mechanical properties heavily. To address these issues, this study prepared a novel core–shell flame retardant, PAPP@MF@TA, by encapsulating melamine formaldehyde resin (MF) and tannic acid (TA) on the surface of piperazine pyrophosphate (PAPP). Benefiting by the bridging effect of the core–shell structure, the compatibility between TPE and PAPP@MF@TA was improved, and the tensile strength of TPE/PAPP@MF@TA increased by 25.6% compared to TPE/PAPP. The flame-retardant performance was also enhanced. Compared to pure TPE, the peak heat release rate, total heat release and total smoke production of TPE/PAPP@MF@TA decreased by 73.7%, 37.9% and 35.5%, respectively. Besides, the flame-retardant mechanism was studied. This study provides a new approach for designing of TPE composites with comprehensively enhanced flame retardancy and mechanical properties.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2023
·
IF 10
Huimin Zhu,Jinfa Ye,Yiming Wu,Yuhang Cheng,Min Su,Qixuan Dai,Yun Han,Jintao Pan,Zhenyu Wu,Chuan Chen,Chenyue Qiu,Wei Li,Gang Liu,Chengchao Chu
Corneal neovascularization (CNV) is one of the leading causes of blindness in the world. In clinical practice, however, it remains a challenge to achieve a noninvasive and safe treatment. Herein, a biocompatible shell with excellent antioxidant and antivascular is prepared by co-assemly of epigallocatechin gallate (EGCG)/gallic acid (GC) and Copper (Cu II). Afther loading gluocose oxidase (GOx) inside, the shell is modified with dimeric DPA-Zn for codelivering vascular endothelial growth factor (VEGF) small interfering RNA (VEGF-siRNA. Meanwhile, the Arg-Gly-Asp peptide (RGD) peptide-engineered cell membranes coating improves angiogenesis-targeting and biocompatible for the multifunctional nanomedicine (CEGs/RGD). After eye drops administration, CEGs/RGD targets enrichment in neovascularization and CEGs NPs enter cells. Then, the inner GOx consumes glucose with a decrease in local pH, which in turn leads to the release of EGCE and VEGF-siRNA. As a result, the nanomedicines significantly reduce angiogenesis and inhibit CNV formation through synergistic effect of antioxidant and antivascular via down-regulation of cluster of differentiation 31(CD31) and VEGF. The nanomedicine represents a safe and efficient CNV treatment through the combined effect of antioxidant/gene, which provides important theoretical and clinical significance. This article is protected by copyright. All rights reserved
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PubMed
高影响因子
Molecular Therapy-Nucleic Acids
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2023
·
IF 8.8
Xin Chang,Chang Liu,Yu-Mo Han,Qiu-Ling Li,Bin Guo,Hu-Lin Jiang
Pulmonary fibrosis (PF) is an interstitial lung disease with complex pathological mechanism, and there is currently a lack of therapeutics that can heal it completely. Using gene therapy with drugs provides promising therapeutic strategies for synergistically reversing PF. However, improving the intracellular accumulation and transfection efficiency of therapeutic nucleic acids is still a critical issue that urgently needs to be addressed. Herein, we developed lipid nanoparticles (PEDPs) with high transfection efficiency coloaded with pDNA of nuclear factor erythroid 2-related factor 2 (pNrf2) and pirfenidone (PFD) for PF therapy. PEDPs can penetrate biological barriers, accumulate at the target, and exert therapeutic effects, eventually alleviating the oxidative stress imbalance in type II alveolar epithelial cells (AECs II) and inhibiting myofibroblast overactivation through the synergistic effects of Nrf2 combined with PFD, thus reversing PF. In addition, we systematically engineered various liposomes (LNPs), demonstrated that reducing the polyethylene glycol (PEG) proportion could significantly improve the uptake and transfection efficiency of the LNPs, and proposed a possible mechanism for this influence. This study clearly reveals that controlling the composition ratio of PEG in PEDPs can efficiently deliver therapeutics into AECs II, improve pNrf2 transfection, and synergize with PFD in a prospective strategy to reverse PF.
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DOI
PubMed
高影响因子
Molecular Catalysis
·
2023
·
IF 4.6
Xuan Gao,Zhihui Li,Dongsheng Zhang,Baoquan Zhang,Yanji Wang
Efficient and safe conversion of 5-hydroxymethylfurfural (HMF) to 5-hydroxymethyl-2-furancarbonitrile (HMFC) with hydroxylamine zinc chloride salt (ZnCl 2 ·2NH 2 OH) obtained from a novel method was developed. Without a catalyst, free NH 2 OH could react with HMF to produce HMFC with a yield of 41% at 55 °C. ZnCl 2 was an appropriate catalyst that increased HMFC yield to 64%. However, the reaction has a potential explosion safety hazard and a low effective utilization rate of NH 2 OH due to the easy decomposition property of free NH 2 OH. To address these issues, ZnCl 2 ·2NH 2 OH was prepared to serve as a hydroxylamine stabilizer, catalyst, and nitrogen source in the synthesis of HMFC. Therefore, NH 2 OH could be slowly released to participate in the reaction, slowing the invalid decomposition and increasing the utilization rate of elemental N. Under optimal conditions of n(HMF): n(NH 2 OH) = 1:1.5, 100 °C for 20 min with acetonitrile as solvent, the yield of HMFC was 100%. A plausible reaction mechanism for HMFC synthesis was also proposed.
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高影响因子
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